Dissociative disorder in Mayer Rokitansky Küster Hauser syndrome with pulmonary agenesis: a case report

Abstract Background The Mayer Rokitansky Küster Hauser (MRKH) syndrome is a rare congenital disorder characterized by the absence of uterus and vagina in a patient who is phenotypically a female, with 46 XX karyotypes. It affects 1 in 4000 to 5000 female new-borns. Pulmonary agenesis is a rare association in this MRKH syndrome. Females with MRKH face various mental health issues and psychological disturbances, including dissociative disorder which is a stress-related psychiatric disorder. Dissociative disorder in MRKH syndrome is under-recognized and under-treated. Case presentation A 23-year-old unmarried woman presented to the emergency forabnormal behaviour attack. Recurrent episodes of dissociative convulsions were present most of the time with MRKH syndrome as the pertinent stressor. Both antidepressants and psychotherapy helped to decrease the frequency of dissociative convulsions and come interms with the syndrome. Conclusion This case describes dissociative disorder as the presentation and comorbid condition of MRKH syndrome and the impact of MRKH syndrome on the patient. We attempt to explain the occurrence of dissociative disorder in MRKH syndrome and the results of under-recognition and under-treatment of the same. We aim to highlight the presence of commonly treatable conditions associated with a rare syndrome and its effect when untreated and unrecognized.

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Role of Nutraceuticals in Health Promotion and Disease Prevention: A Review in the Indian Context

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.19:139-145 ◽

2020 ◽

Vol 19 (2) ◽

pp. 139-145

Author(s):

Sheena Chhabra ◽

Apurva Bakshi ◽

Ravineet Kaur

Keyword(s):

Health Promotion ◽

Disease Prevention ◽

Human Health ◽

Health Issues ◽

Scholarly Literature ◽

Indian Context ◽

The Impact ◽

Immense Potential ◽

Specific Health

Nutraceuticals have been around for quite some time. As the nomenclature suggests, they are placed somewhere between food (nutra-) and medicine (-ceuticals) in terms of their impact on human health. Researches have focused on the impact of various types of nutraceuticals on health, their efficacy in health promotion and disease prevention, and often on suitable uses of certain categories of nutraceuticals for specific health issues. However, we are still far from utilizing the immense potential of nutraceuticals for benefiting human health in a substantial manner. We review the available scholarly literature regarding the role of nutraceuticals in health promotion, their efficacy in disease prevention and the perception of nutraceuticals' health benefits by consumers. Thereafter we analyze the need for regulation of nutraceuticals and various provisions regarding the same.

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The Impact of Alkaloid-Producing Epichloë Endophyte on Forage Ryegrass Breeding: A New Zealand Perspective

Toxins ◽

10.3390/toxins13020158 ◽

2021 ◽

Vol 13 (2) ◽

pp. 158

Author(s):

Colin Eady

Keyword(s):

Seed Production ◽

Health Issues ◽

Abiotic Stressors ◽

Livestock Health ◽

The Right ◽

The Impact ◽

The Relationship ◽

And Storage ◽

Selection Of ◽

Epichloë Endophyte

For 30 years, forage ryegrass breeding has known that the germplasm may contain a maternally inherited symbiotic Epichloë endophyte. These endophytes produce a suite of secondary alkaloid compounds, dependent upon strain. Many produce ergot and other alkaloids, which are associated with both insect deterrence and livestock health issues. The levels of alkaloids and other endophyte characteristics are influenced by strain, host germplasm, and environmental conditions. Some strains in the right host germplasm can confer an advantage over biotic and abiotic stressors, thus acting as a maternally inherited desirable ‘trait’. Through seed production, these mutualistic endophytes do not transmit into 100% of the crop seed and are less vigorous than the grass seed itself. This causes stability and longevity issues for seed production and storage should the ‘trait’ be desired in the germplasm. This makes understanding the precise nature of the relationship vitally important to the plant breeder. These Epichloë endophytes cannot be ‘bred’ in the conventional sense, as they are asexual. Instead, the breeder may modulate endophyte characteristics through selection of host germplasm, a sort of breeding by proxy. This article explores, from a forage seed company perspective, the issues that endophyte characteristics and breeding them by proxy have on ryegrass breeding, and outlines the methods used to assess the ‘trait’, and the application of these through the breeding, production, and deployment processes. Finally, this article investigates opportunities for enhancing the utilisation of alkaloid-producing endophytes within pastures, with a focus on balancing alkaloid levels to further enhance pest deterrence and improving livestock outcomes.

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669 Increased Nightmares During the COVID-19 Pandemic: Exploring the Role of Resilience and Emotions

SLEEP ◽

10.1093/sleep/zsab072.667 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A261-A262

Author(s):

Jérémie Potvin ◽

Laura Ramos Socarras ◽

Geneviève Forest

Keyword(s):

Young Adults ◽

Protective Factor ◽

Negative Emotions ◽

Unique Contribution ◽

Health Issues ◽

Resilience Scale ◽

And Gender ◽

The Impact ◽

Tremendous Impact

Abstract Introduction COVID-19 had a tremendous impact on many aspects of our lives and has caused an increase in stress and mental health issues in many people. We have recently found that there was an increase in nightmares during the pandemic in young adults. Since emotions have been associated with both resilience and nightmares, the objective of this study was to investigate the role of resilience and emotional changes in the increase in nightmares observed during the pandemic, in a group of young adults. Methods Resilience, emotions and nightmares were assessed using the Connor-Davidson Resilience Scale-10, the Differential Emotions Scale-IV and an adapted version of the Pittsburgh Sleep Quality Index. Measures were administered to 209 young adults (18–25 years old, 76.1% females). Hierarchical multiple regression models were computed to examine the unique contribution of changes in positive and negative emotions during the pandemic to the increase in nightmares during the pandemic. Analyses were controlled for nightmares and emotions prior to COVID-19, and for gender. The sample was separated in two groups: resilient and less resilient young adults. Results Results show that in less resilient young adults, nightmares prior to COVID-19 (β=.79, p<.001) and increase in negative emotions (β=.21, p=.033) significantly predicted nightmares during the pandemic and explained 67.0% of their variance. In resilient young adults, nightmares prior to COVID-19 (β=.56, p<.001) and gender (β=-.15, p=.04) significantly predicted nightmares during the pandemic and explained 52.0% of the variance. Conclusion Our results show that increase in negative emotions during the pandemic is associated with an increase in nightmares in less resilient young adults, but not in resilient young adults. Furthermore, our results show that in resilient young adults, being a woman is associated with an increase in nightmares during the pandemic. These results suggest that resilience may be a protective factor in managing the impact of negative emotions on nightmares, but only in men. Support (if any):

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13.D. Workshop: SDGs in the focus of environmental and health issues

European Journal of Public Health ◽

10.1093/eurpub/ckaa165.648 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

◽

Keyword(s):

Public Health ◽

Climate Change ◽

Sustainable Development ◽

Community Engagement ◽

Health Professionals ◽

Health Issues ◽

The Sustainable Development ◽

The World ◽

Environmental And Health Issues ◽

The Impact

Abstract This workshop is dedicated on SDGs in the focus of environmental and health issues, as very important and actual topic. One of the characteristics of today's societies is the significant availability of modern technologies. Over 5 billion (about 67%) people have a cellphone today. More than 4.5 billion people worldwide use the Internet, close to 60% of the total population. At the same time, one third of the people in the world does not have access to safe drinking water and half of the population does not have access to safe sanitation. The WHO at UN warns of severe inequalities in access to water and hygiene. Air, essential to life, is a leading risk due to ubiquitous pollution and contributes to the global disease burden (7 million deaths per year). Air pollution is a consequence of traffic and industry, but also of demographic trends and other human activities. Food availability reflects global inequality, famine eradication being one of the SDGs. The WHO warns of the urgency. As technology progresses, social inequality grows, the gap widens, and the environment continues to suffer. Furthermore, the social environment in societies is “ruffled” and does not appear to be beneficial toward well-being. New inequalities are emerging in the availability of technology, climate change, education. The achievement reports on the Sustainable Development Goals (SDGs), also point out to the need of reviewing individual indicators. According to the Sustainable Development Agenda, one of the goals is to reduce inequalities, and environmental health is faced by several specific goals. The Global Burden of Disease is the most comprehensive effort to date to measure epidemiological levels and trends worldwide. It is the product of a global research collaborative and quantifies the impact of hundreds of diseases, injuries, and risk factors in countries around the world. This workshop will also discuss Urban Health as a Complex System in the light of SDGs. Climate Change, Public Health impacts and the role of the new digital technologies is also important topic which is contributing to SDG3, improving health, to SDG4, allowing to provide distance health education at relatively low cost and to SDG 13, by reducing the CO2 footprint. Community Engagement can both empower vulnerable populations (so reducing inequalities) and identify the prior environmental issues to be addressed. The aim was to search for public health programs using Community Engagement tools in healthy environment building towards achievement of SDGs. Key messages Health professionals are involved in the overall process of transformation necessary to achieve the SDGs. Health professionals should be proactive and contribute to the transformation leading to better health for the environment, and thus for the human population.

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The impact of a health introduction course for medical interpreters in the healthcare sector

Nordic Journal of Nursing Research ◽

10.1177/2057158520975188 ◽

2020 ◽

pp. 205715852097518

Author(s):

Leila Saud Abdulkadir ◽

Morten Sodemann ◽

Claire Gudex ◽

Sören Möller ◽

Dorthe Susanne Nielsen

Keyword(s):

Health Knowledge ◽

Knowledge Score ◽

University Hospital ◽

Healthcare Sector ◽

Health Issues ◽

Multiple Choice Questions ◽

Medical Interpreters ◽

The One ◽

The Individual ◽

The Impact

The aim was to examine the impact on interpreters’ health knowledge, attitudes and self-evaluated skills after they participated in a pilot health introduction course at a university hospital in Denmark. The study was conducted as an intervention study using a questionnaire with both closed and open-ended questions. The questionnaire was distributed to interpreters one week before the six-week course started, and again at one week and at three months after course completion. Level of knowledge was calculated based on the number of answers to 18 multiple-choice questions on common health issues, diagnoses and treatments. Of the 100 interpreters who registered for the course, 86 completed the course, and 61 of these participants (70%) completed both the baseline and the one-week questionnaire. The mean knowledge score increased from 48 ( SD 6.9) at baseline to 52 ( SD 3.4; p < 0.001) one week after the course and was 51 ( SD 7.3; p < 0.001) three months after the course ( n = 55). Participants who increased their knowledge score the most were those with the least interpreter experience ( p = 0.001). One week after the course, most participants (83–95%) agreed that the individual lessons had been useful in their subsequent interpreting activities and that they had gained useful information. The health introduction course appeared to be beneficial for interpreters. This study highlights the need for greater focus on education for interpreters working in the healthcare sector.

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Anemia of Inflammation

Hematology ◽

10.1182/asheducation-2010.1.276 ◽

2010 ◽

Vol 2010 (1) ◽

pp. 276-280 ◽

Cited By ~ 74

Author(s):

Cindy N. Roy

Keyword(s):

Inflammatory Diseases ◽

Underlying Disease ◽

Comorbid Condition ◽

Regulatory Pathways ◽

Hepcidin Expression ◽

Disease States ◽

Poor Outcomes ◽

The Impact ◽

Inflammatory Insult ◽

Anemia Of Inflammation

Abstract Inflammation arising from various etiologies, including infection, autoimmune disorders, chronic diseases, and aging, can promote anemia. The anemia of inflammation (AI) is most often normocytic and normochromic and is usually mild. Characteristic changes in systemic iron handling, erythrocyte production, and erythrocyte life span all contribute to AI. The preferred treatment is directed at the underlying disease. However, when the inflammatory insult is intractable, or the cause has not been diagnosed, there are limited options for treatment of AI. Because anemia is a comorbid condition that is associated with poor outcomes in various chronic disease states, understanding its pathogenesis and developing new tools for its treatment should remain a priority. Hepcidin antimicrobial peptide has taken center stage in recent years as a potent modulator of iron availability. As the technology for quantitative hepcidin analysis improves, hepcidin's role in various disease states is also being revealed. Recent insights concerning the regulatory pathways that modify hepcidin expression have identified novel targets for drug development. As the field advances with such therapeutics, the analysis of the impact of normalized hemoglobin on disease outcomes will confirm whether anemia is a reversible independent contributor to the morbidity and mortality associated with inflammatory diseases.

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Teaching health education

Health Education ◽

10.1108/he-10-2016-0051 ◽

2017 ◽

Vol 117 (3) ◽

pp. 323-340 ◽

Cited By ~ 1

Author(s):

Karen Pickett ◽

Willeke Rietdijk ◽

Jenny Byrne ◽

Jonathan Shepherd ◽

Paul Roderick ◽

...

Keyword(s):

Health Promotion ◽

Health Education ◽

Life Experience ◽

Education Programme ◽

Practical Experience ◽

Early Career ◽

Health Issues ◽

Structured Interviews ◽

Content Type ◽

The Impact

Purpose The purpose of this paper is to understand early career teachers’ perceptions of the impact of a pre-service health education programme on their health promotion practice in schools and the contextual factors that influence this. Design/methodology/approach Semi-structured interviews were conducted with 14 primary and secondary trainee and qualified teachers who had trained at a university in England. Data were analysed using thematic analysis. Findings The teachers found the training to be a useful introduction, particularly when it was relevant to their practice. They valued gaining practical skills at university, on placement and in school once qualified. They reported that witnessing pupils’ lives in school had increased their awareness that health education is important. Their personal qualities, life experience, the school’s ethos and competing pressures influenced their practice. Teachers considered that building relationships with colleagues, pupils and parents facilitated health promotion, and that health education needs to be relevant to pupils. Some teachers expressed that teaching about health could be a “minefield”. They also discussed whether schools or parents are responsible for educating pupils about health issues and the place of health promotion within education’s wider purpose. Originality/value Few studies have followed-up trainee teachers once they are in teaching posts to explore the longer-term perceived impact of pre-service health education training. The findings suggest that teachers’ development takes place via an interaction between training and practice, suggesting that training could particularly aim to provide teachers with a contextualised understanding of health issues and practical experience.

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Mayer-Rokitansky-Küster-Hauser syndrome with 22q11.21 microduplication: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02716-6 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Domenico Dell’Edera ◽

Arianna Allegretti ◽

Mario Ventura ◽

Ludovica Mercuri ◽

Angela Mitidieri ◽

...

Keyword(s):

Learning Difficulties ◽

Clinical Signs ◽

Mendelian Inheritance ◽

Comparative Genomic ◽

Chromosome 22 ◽

Case Presentation ◽

Mrkh Syndrome ◽

Altered Gene Expression ◽

Congenital Condition ◽

Altered Gene

Abstract Background Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome (Online Mendelian Inheritance in Man [OMIM] #277000) is a congenital condition characterized by the total or partial agenesis of vagina and uterus. Agenesis can be isolated (MRKH 1) or associated with other renal, vertebral or cardiac defects (MRKH 2). Case presentation In this paper, we report a case of a Caucasian patient showing the clinical signs associated with MRKH. Array-based comparative genomic hybridization (a-CGH) analysis revealed a microduplication of approximately 3.01 megabases (Mb) located on the long arm of chromosome 22 (22q11.21). Microduplications affecting the 22q11.21 region have been shown to be associated with MRKH syndrome and Müllerian aplasia. The phenotype of patients with 22q11.2 duplication (OMIM #608363) appears extremely variable, ranging from apparently normal to mild learning difficulties or with multiple defects, sharing features with DiGeorge/velocardiofacial (DGS/VCFS) syndrome. Conclusions The altered gene expression together with other genetic, nongenetic, epigenetic or environmental factors can cause the extremely variable phenotype in patients carrying such duplication. Therefore, we can consider MRKH syndrome to be one of the clinical features of DGS/VCFS syndrome.

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The impact of COVID-19 restriction measures on loneliness among older adults in Austria

European Journal of Public Health ◽

10.1093/eurpub/ckaa238 ◽

2020 ◽

Author(s):

Erwin Stolz ◽

Hannes Mayerl ◽

Wolfgang Freidl

Keyword(s):

Mental Health ◽

Older Adults ◽

Positive Association ◽

Health Issues ◽

Negative Consequences ◽

Cross Sectional ◽

Social Contacts ◽

Mental Health Issues ◽

The Impact ◽

Opening Phase

Abstract Background To halt the spread of COVID-19, Austria implemented a 7-week ’lockdown’ in March/April 2020. We assess whether the ensuing reduction in social contacts led to increased loneliness among older adults (60+). Methods Three analyses were conducted: (1) A comparison between pre-pandemic (SHARE: 2013-2017) and pandemic (May 2020) levels of loneliness (UCLA-3 scale), (2) an assessment of the cross-sectional correlation between being affected by COVID-19 restriction measures and loneliness (May 2020), and (3) a longitudinal analysis of weekly changes (March-June 2020) in loneliness (Corona panel). Results We found (1) increased loneliness in 2020 compared with previous years, (2) a moderate positive association between the number of restriction measures older adults were affected from and their loneliness, and (3) that loneliness was higher during ’lockdown’ compared to the subsequent re-opening phase, particularly among those who live alone. Conclusion We provide evidence that COVID-19 restriction measures in Austria have indeed resulted in increased levels of loneliness among older adults. However, these effects seem to be short-lived, and thus no strong negative consequences for older adults’ mental health are expected. Nonetheless, the effects on loneliness, and subsequent mental health issues, might be both more long-lasting and severe if future restriction measures are enacted repeatedly and/or over longer time periods.

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