Heterosexual Aversion in Homosexual Males

1973 ◽  
Vol 122 (567) ◽  
pp. 163-169 ◽  
Author(s):  
Kurt Freund ◽  
Ron Langevin ◽  
Stephen Cibiri ◽  
Yaroslaw Zajac
Keyword(s):  
High Frequency ◽  
Alternative Interpretation ◽  
Male Population ◽  
Neurotic Symptom ◽  
Difficult Situation ◽  
Homosexual Male ◽  
Heterosexual Male ◽  
Selection Of

Psychotherapists tend to view homosexuality as a neurosis or as a neurotic symptom (Sadger, 1909, 1921; Klein, 1932; Rado, 1940; Ellis, 1952, 1955; Bieber et al., 1962; Ovesey et al., 1963). In support of this viewpoint, several authors have observed that the frequency of typical neurotic phenomena in homosexual males is much higher than that in a heterosexual male population, and have concluded that homosexuality is one of the neurotic symptoms of their patients (Stekel, 1929; Henry, 1937; Ellis, 1959; Musaph, 1960; Doidge and Holtzman, 1960). However, an alternative interpretation is that such maladaptive patterns develop from the difficult situation of a homosexual male in a heterosexual society and from the general disapproval he encounters. Moreover, the finding of increased prevalence of neurotic symptoms in homosexual males has itself been challenged by Kronfeld (1923) and Hooker (1957), who pointed out that the investigated homosexual males represented a selection of people who sought psychiatric help. Hooker studied non-patient samples from homosexuals' clubs and did not find an abnormally high frequency of neurotic symptoms.

scholarly journals Interannual modulation of extratropical high frequency variability

1997 ◽  
Vol 40 (4) ◽  
Author(s):  
R. Caballero
Keyword(s):  
Normal Mode ◽  
Time Scales ◽  
High Frequency ◽  
Spherical Geometry ◽  
Simple Explanation ◽  
Space And Time ◽  
High Frequency Variability ◽  
Hemisphere Winter ◽  
Selection Of

A simple explanation is presented for the observed interannual changes in the dominant space and time scales of Northem Hemisphere winter extratropical high frequency variability. It is found that such changes can suc- cessfully be predicted by linearizing a 2-level quasi-geostrophic mode] in spherical geometry around the ob- served zona] mean states. The mechanisms responsible for the selection of the most unstable normal mode are investigated.

Observations of Meteors using an over-the-horizon Radar

1989 ◽  
Vol 8 (1) ◽  
pp. 88-93 ◽  
Author(s):  
R. M. Thomas ◽  
D. J. Netherway
Keyword(s):  
Signal Processing ◽  
High Frequency ◽  
Meteor Shower ◽  
Upper Atmosphere ◽  
High Frequency Band ◽  
Meteor Detection ◽  
Signal Environment ◽  
Frequency Management ◽  
Sporadic Meteors ◽  
Selection Of

AbstractWhen metre wavelength radars were first operated in the 1940s, echoes were obtained which could be attributed to backscatter from ionised trains produced by the ablation of meteroids in the upper atmosphere at altitudes near 100 km. Modern over-the-horizon skywave radars operating in the HF (High Frequency) band employ digital techniques for both radar control and signal processing and are aided by frequency management subsystems for the selection of appropriate frequencies for meteor detection based on real-time monitoring of the HF signal environment.This paper describes the results of using such a radar for meteor observations. We report the detection of the Eta Aquarid meteor shower and demonstrate that a large increase in the echo rate due to sporadic meteors is obtained as frequencies are reduced below 15 MHz and the underdense echo ceiling rises in altitude. Finally, we present preliminary observations of highly Doppler shifted echoes which travel at meteoric velocities and which we identify as meteor ‘head echoes’.

The needs of siblings of children with a life-threatening illness, part 1: Conceptualization and development of a measure

2017 ◽  
Vol 15 (6) ◽  
pp. 644-664 ◽  
Author(s):  
Marianne Olivier-D'Avignon ◽  
Serge Dumont ◽  
Pierre Valois ◽  
S. Robin Cohen
Keyword(s):  
Qualitative Methodology ◽  
Critically Ill Children ◽  
Second Phase ◽  
Difficult Situation ◽  
Promising Tool ◽  
Third Phase ◽  
Life Threatening Illness ◽  
Preliminary Version ◽  
Life Threatening ◽  
Selection Of

ABSTRACTObjective:The presence of a child afflicted with a life-threatening illness is a difficult situation for the child's siblings, especially when their own needs are left unmet. The present article describes the first three phases of research involved in the conceptualization, development, and content validation of an initial version of the Inventaire des Besoins de la Fratrie d'Enfants Malades Sévèrement (IBesFEMS) [Needs Inventory for Siblings of Critically ill Children].Method:The first phase of the development of this instrument was conducted using qualitative methodology (focus groups: 6 siblings, 8 parents). The second phase consisted of validating the content of a pool of items developed according to the needs identified in the first phase. Some 21 participants (3 psychometricians, 3 researchers, 9 clinicians, and 6 siblings) evaluated each item for relevance and clarity. Finally, during the third phase, the acceptability and administration procedures of the preliminary version of the instrument were assessed qualitatively by five siblings.Results:The first phase led to production of a typology made up of 43 needs in 10 different environments. The second phase allowed for selection of the items that were clearest and most relevant, based on expert opinion. This procedure gave rise to a first version of the IBesFEMS, which consisted of 48 items.Significance of results:The IBesFEMS appears to be a promising tool for specifically assessing the needs of the adolescent siblings of seriously ill children.

scholarly journals The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients

1996 ◽  
Vol 184 (6) ◽  
pp. 2393-2398 ◽  
Author(s):  
Abdelhadi Saoudi ◽  
Benedict Seddon ◽  
Debbie Fowell ◽  
Don Mason
Keyword(s):  
T Cells ◽  
T Cell ◽  
Intravenous Injection ◽  
High Frequency ◽  
Autoimmune Diabetes ◽  
T Cell Repertoire ◽  
Γ Irradiation ◽  
Cell Repertoire ◽  
Peripheral T Cells ◽  
Selection Of

Rats of the PVG.RT1u strain develop autoimmune diabetes when thymectomized at 6 wk of age and are rendered relatively lymphopenic by a cumulative dose of 1,000 rads 137Cs γ-irradiation given in four split doses. Previous studies have shown that the disease is prevented by the intravenous injection of 5 × 106 CD4+ CD45RC− TCRαβ+ RT6+ peripheral T cells from normal syngeneic donors. These cells have a memory phenotype and are presumably primed to some extrathymic antigen. However, we now report that the CD4+ CD8− population of mature thymocytes is a very potent source of cells, with the capacity to prevent diabetes in our lymphopenic animals. As few as 6 × 105 of these cells protect ∼50% of recipients and the level of protection increases with cell dose. It appears that one characteristic of the intrathymic selection of the T cell repertoire is the generation of cells that regulate the autoimmune potential of peripheral T cells that have been neither clonally deleted intrathymically nor rendered irreversibly anergic in the periphery.

α+-thalassemia protects African children from severe malaria

Blood ◽  
2004 ◽  
Vol 104 (7) ◽  
pp. 2003-2006 ◽  
Author(s):  
Frank P. Mockenhaupt ◽  
Stephan Ehrhardt ◽  
Sabine Gellert ◽  
Rowland N. Otchwemah ◽  
Ekkehart Dietz ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Natural Selection ◽  
Confidence Interval ◽  
Severe Malaria ◽  
High Frequency ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Selection Of

Abstract The high frequency of α+-thalassemia in malaria-endemic regions may reflect natural selection due to protection from potentially fatal severe malaria. In Africa, bearing 90% of global malaria morbidity and mortality, this has not yet been observed. We tested this hypothesis in an unmatched case-control study among 301 Ghanaian children with severe malaria and 2107 controls (62% parasitemic). In control children, α+-thalassemia affected neither prevalence nor density of Plasmodium falciparum. However, heterozygous α+-thalassemia was observed in 32.6% of controls but in only 26.2% of cases (odds ratio [OR], 0.74; 95% confidence interval [CI], 0.56-0.98). Protection against severe malaria was found to be pronounced comparing severe malaria patients with parasitemic controls (adjusted OR in children < 5 years of age, 0.52; 95% CI, 0.34-0.78) and to wane with age. No protective effect was discernible for homozygous children. Our findings provide evidence for natural selection of α+-thalassemia in Africa due to protection from severe malaria.

scholarly journals In Vitro Mutagenesis of Bacillus subtilis by Using a Modified Tn7 Transposon with an Outward-Facing Inducible Promoter

2008 ◽  
Vol 74 (11) ◽  
pp. 3419-3425 ◽  
Author(s):  
Christophe Bordi ◽  
Bronwyn G. Butcher ◽  
Qiaojuan Shi ◽  
Anna-Barbara Hachmann ◽  
Joseph E. Peters ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
High Frequency ◽  
Inducible Promoter ◽  
In Vitro Mutagenesis ◽  
Donor Plasmid ◽  
Positive Bacterium ◽  
Expression Of Genes ◽  
Regulated Expression ◽  
Selection Of

ABSTRACT A Tn7 donor plasmid, pTn7SX, was constructed for use with the model gram-positive bacterium Bacillus subtilis. This new mini-Tn7, mTn7SX, contains a spectinomycin resistance cassette and an outward-facing, xylose-inducible promoter, thereby allowing for the regulated expression of genes downstream of the transposon. We demonstrate that mTn7SX inserts are obtained at a high frequency and occur randomly throughout the B. subtilis genome. The utility of this system was demonstrated by the selection of mutants with increased resistance to the antibiotic fosfomycin or duramycin.

scholarly journals Genetic Footprinting in Bacteria

2001 ◽  
Vol 183 (5) ◽  
pp. 1694-1706 ◽  
Author(s):  
Roberta S. Hare ◽  
Scott S. Walker ◽  
Thomas E. Dorman ◽  
Jonathan R. Greene ◽  
Luz-Maria Guzman ◽  
...  
Keyword(s):  
Recombinant Proteins ◽  
High Frequency ◽  
Growth Conditions ◽  
Sequence Specificity ◽  
Bacteriophage Λ ◽  
E Coli ◽  
Genetic Footprinting ◽  
Transposon Insertions ◽  
Selection Of

ABSTRACT In vivo genetic footprinting was developed in the yeastSaccharomyces cerevisiae to simultaneously assess the importance of thousands of genes for the fitness of the cell under any growth condition. We have developed in vivo genetic footprinting forEscherichia coli, a model bacterium and pathogen. We further demonstrate the utility of this technology for rapidly discovering genes that affect the fitness of E. coli under a variety of growth conditions. The definitive features of this system include a conditionally regulated Tn10 transposase with relaxed sequence specificity and a conditionally regulated replicon for the vector containing the transposase and mini-Tn10transposon with an outwardly oriented promoter. This system results in a high frequency of randomly distributed transposon insertions, eliminating the need for the selection of a population containing transposon insertions, stringent suppression of transposon mutagenesis, and few polar effects. Successful footprints have been achieved for most genes longer than 400 bp, including genes located in operons. In addition, the ability of recombinant proteins to complement mutagenized hosts has been evaluated by genetic footprinting using a bacteriophage λ transposon delivery system.

scholarly journals Offline character recognition in transport logistic tables

2021 ◽  
Vol 2131 (2) ◽  
pp. 022098
Author(s):  
E Yu Bursian ◽  
A M Demin
Keyword(s):  
High Frequency ◽  
Character Recognition ◽  
Numerical Experiments ◽  
Software Implementation ◽  
Cosine Transformation ◽  
Transport Problems ◽  
Filtering Procedure ◽  
Selection Of ◽  
Discrete Complex

Abstract The paper proposes the improved skeleton method of handwritten characters recognition, which is based on the filtering procedure and the principle of alternating shading schemes of skeletonized area on the 4- and 8-timeslinked raster. The procedure of high-frequency filtration based on discrete real cosine transformation or discrete complex Fourier transform with automatic selection of filtration parameters makes it possible to significantly improve the image quality of handwritten symbols, in particular, to eliminate in many cases thin bridges between the areas of symbol element representation. The principle of alternating the painting schemes along the 4- and 8-timeslinked raster makes it possible to get the wave front of the skeletonized area close to a circle. In this case, the broken lines representing the branches of the skeleton graphs retain the shapes of the symbols. Numerical experiments on the construction of skeleton sets and skeleton graphs for recognizable handwritten symbols located in the cells of the tables of logistic transport problems have been performed. Software implementation of the method is proposed.

scholarly journals FAMCICLOVIR IN THERAPY OF ATOPIC DERMATITIS PATIENTS WITH HERPES SIMPLEX INFECTION

2013 ◽  
Vol 10 (5) ◽  
pp. 61-69
Author(s):  
I N Zuikova ◽  
A E Shulzhenko ◽  
E S Fedenko ◽  
O G Elisutina
Keyword(s):  
Atopic Dermatitis ◽  
Herpes Simplex ◽  
High Frequency ◽  
Age Groups ◽  
Antiviral Drug ◽  
Patterns Of Use ◽  
Simplex Infection ◽  
Acyclic Nucleoside ◽  
Simplex Virus ◽  
Selection Of

The prevalence of herpes simplex virus in different age groups, the high frequency of relapsing forms of infection, torpid course, postherpetic complications are relevant medical and social problems. Often, practitioners create significant difficulties in establishing the diagnosis, choice of strategy in patients with herpes simplex. The paper presents the methods of diagnosis of herpes simplex and their application in atopic dermatitis patients, issues of acyclic nucleoside therapy (acyclovir, famciclovir) in different clinical forms of herpes simplex with individual approach to the selection of an antiviral drug and patterns of use.

scholarly journals A method to enrich and purify centromeric DNA from human cells

2021 ◽  
Author(s):  
Riccardo Gamba ◽  
Giulia Mazzucco ◽  
Therese Wilhelm ◽  
Florian Chardon ◽  
Leonid Velikovsky ◽  
...  
Keyword(s):  
Chromosome Segregation ◽  
High Frequency ◽  
Human Cells ◽  
Size Fractionation ◽  
High Coverage ◽  
Centromeric Dna ◽  
Fold Enrichment ◽  
Sequence Variations ◽  
Single Dna Molecule ◽  
Selection Of

Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-stretches of tandem repetitive arrays. Despite being quite abundant compared to other loci, centromere sequences overall still represent only 2 to 5% of the human genome, therefore studying their genetic and epigenetic features is a major challenge. Furthermore, sequencing of centromeric regions requires high coverage to fully analyze length and sequence variations, which can be extremely costly. To bypass these issues, we have developed a technique based on selective restriction digestion and size fractionation to enrich for centromeric DNA from human cells. Combining enzymes capable of cutting at high frequency throughout the genome, except within most human centromeres, with size-selection of >20 kb fragments resulted in over 25-fold enrichment in centromeric DNA. Sequencing of the enriched fractions revealed that up to 60% of the enriched material is made of centromeric DNA. This approach has great potential for making sequencing of centromeric DNA more affordable and efficient and for single DNA molecule studies.

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