Null allele polymorphisms in the GSTT1 and GSTM1 genes in 705 women from a mammographic breast cancer screening program (NMPOA) in southern Brazil

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21091-21091
Author(s):  
E. Aguiar ◽  
J. Giacomazzi ◽  
E. I. Palmero ◽  
L. Kalakun ◽  
L. Schuler-Faccini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Screening Program ◽  
Public Health Problem ◽  
Mammographic Screening ◽  
Clinical Findings ◽  
Null Alleles ◽  
Porto Alegre ◽  
Incidence And Mortality ◽  
Prevention Project ◽  
Significant Public Health

21091 Background: Several genetic polymorphisms in genes related with metabolism have been associated with breast cancer (BC) risk. Among these, the gluthatione-S-transferase M1 and T1 null genotypes have been associated with slightly increased BC risk in some populations. In Brazil, BC is a significant public health problem, due to its high incidence and mortality rates. In Porto Alegre, Brazil`s southernmost capital, a multidisciplinary BC Prevention Project - the Nucleo Mama Porto Alegre Cohort (NMPOA)- was started in 2004 and includes a mammographic screening program for women ages 40–69 years. Goal:Determine the allelic and genotypic frequencies of GSTM1 and GSTT1 null alleles in women undergoing annual mammographic screening and correlate its presence with mammography results and presence of additional BC risk factors at baseline and after 10 years. Methods: A sample of 705 women from the NMPOA BC screening program was consecutively enrolled from November/2005 until March/2006. Mammography results (BIRADS categories) and BC risk information (5-yr and vital estimates using the Gail model, family history of BC, body mass index) were obtained by chart review. Genotyping was performed by multiplex polymerase chain reaction (PCR). Results: Of the 705 patients studied, 145 (20.6%) and 314 (44.5%) had the GSTT1 and GSTM1 null alleles, respectively. Genotypically, 67 (9,5%) were null homozygous for both genes (GSTM1- and GSTT1- ); 78 (11,1%) were GSTT1- and non-null for GSTM1 (GSTT1- and GSTM1+); 247 (35%) were GSTT1+ and GSTM1- and 313(44,4%) were GSTM+ and GSTT+. There was a statistically significant association of the GSTT1+ allele with low-risk mammographic findings (category BIRADS 1; p<0,05). Conclusions: The genotypic and allelic frequencies of the GSTT1 and GSTM1 null alleles were not significantly different from those reported previously for other populations. The non-null GSTT1 allele was associated with lower category mammographic findings. Prospective clinical evaluation of the women followed in this program and correlation of genotype with clinical findings may elucidate additional risks associated with the presence of these polymorphisms. No significant financial relationships to disclose.

Progesterone receptor gene polymorphism (PROGINS) in 701 women from a mammographic breast cancer screening program (NMPOA) in Southern Brazil

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21048-21048
Author(s):  
J. Giacomazzi ◽  
E. Aguiar ◽  
E. I. Palmero ◽  
L. Kalakun ◽  
L. Schuler-Faccini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Family History ◽  
Progesterone Receptor ◽  
Body Mass ◽  
Screening Program ◽  
Gail Model ◽  
Porto Alegre ◽  
Incidence And Mortality ◽  
History Of

21048 Background: Several genetic polymorphisms in hormone receptor genes have been associated with breast cancer (BC) risk. Among these, a 306 base-pair insertion of the Alu subfamily in intron 7 of the progesterone receptor (PR) gene, (PROGINS), has been associated with decreased BC risk in several populations. In Brazil, BC is a significant public health problem, due to its high incidence and mortality rates. In Porto Alegre, Brazil`s southernmost capital, a multidisciplinary Breast Cancer Prevention Project - the Nucleo Mama Porto Alegre Cohort (NMPOA) was started in 2004 and includes a mammographic screening program for women ages 40–69 years. Goal: Determine the allelic and genotypic frequencies of PROGINS in women undergoing annual BC screening and correlate its presence with mammography results and presence of additional BC risk factors (family history of BC, body mass index, estimated BC risk by the Gail model and age) at baseline and after 10 years. Methods: A sample of 701 women from the NMPOA BC screening program was consecutively enrolled in the study from November/2005 until March/2006. Clinical data, mammography results (as BIRADS categories) and BC risk information was obtained by chart review. PROGINS genotyping was performed by polymerase chain reaction (PCR). Results: Of the 701 patients studied, 504 (71,0%) were wild-type homozygous, 184 (26,2%) heterozygous and 13 (1,8%) homozygous for the PROGINS polymorphism. These genotypic frequencies are similar to those of other reports in different populations. Genotype was correlated with 5-year and vital BC risk estimates (Gail model), body mass index, family history of BC and mammography findings. A statistically significant association was found between the presence of PROGINS and a positive family history of BC (p< 0,05). Conclusions: The genotypic and allelic frequencies of the PROGINS polymorphism were not significantly different from those reported previously for other populations. Prospective clinical evaluation of the women followed in this program and correlation of genotype with clinical findings may be important to elucidate additional risks associated with the PROGINS polymorphism. No significant financial relationships to disclose.

scholarly journals What do women know about breast density? A public screening program perspective

2020 ◽  
Author(s):  
Monique Robertson ◽  
Ellie C Darcey ◽  
Evenda K Dench ◽  
Louise Keogh ◽  
Kirsty McLean ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Screening Program ◽  
Mammographic Screening ◽  
Descriptive Data ◽  
Additional Information ◽  
Dense Breasts ◽  
Increased Risk ◽  
Main Message ◽  
First Time

AbstractBackgroundThis study assesses knowledge of breast density, one of breast cancer’s strongest risk factors, in women attending a public mammographic screening program in Western Australia that routinely notifies women if they have dense breasts.MethodsSurvey data was collected from women who were notified they have dense breasts and women who had not (controls). Descriptive data analysis was used to summarize responses.ResultsOf the 6183 women surveyed, over 85% of notified women knew that breast density makes it difficult to see cancer on a mammogram (53.9% in controls). A quarter of notified women knew that having dense breasts puts women at increased risk for breast cancer (13.2% in controls). Overall, 50.1% of notified women indicated that they thought the amount of information provided was “just right” and 24.9% thought it was “too little”, particularly women notified for the first time (32.1%).ConclusionThe main message of reduced sensitivity of mammography in women with dense breasts provided by the screening program appears to be getting though. However, women are largely unaware that increased breast density is associated with increased risk. Women notified of having dense breasts for the first time could potentially benefit from additional information.

scholarly journals Readmissions and complications in breast ductal carcinoma in situ: A retrospective study comparing screen- and non-screen-detected patients

2020 ◽  
Vol 16 ◽  
pp. 174550652096589
Author(s):  
Julieta Politi ◽  
María Sala ◽  
Laia Domingo ◽  
María Vernet-Tomas ◽  
Marta Román ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Confidence Interval ◽  
Ductal Carcinoma In Situ ◽  
Odds Ratio ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Screening Program ◽  
Population Based ◽  
Mammographic Screening

Objective: Population-wide mammographic screening programs aim to reduce breast cancer mortality. However, a broad view of the harms and benefits of these programs is necessary to favor informed decisions, especially in the earliest stages of the disease. Here, we compare the outcomes of patients diagnosed with breast ductal carcinoma in situ in participants and non-participants of a population-based mammographic screening program. Methods: A retrospective cohort study of all patients diagnosed with breast ductal carcinoma in situ between 2000 and 2010 within a single hospital. A total of 211 patients were included, and the median follow-up was 8.4 years. The effect of detection mode (screen-detected and non-screen-detected) on breast cancer recurrences, readmissions, and complications was evaluated through multivariate logistic regression analysis. Results: In the majority of women, breast ductal carcinoma in situ was screen-detected (63.5%). Screen-detected breast ductal carcinoma in situ was smaller in size compared to those non-screen-detected (57.53% < 20 mm versus 78.03%, p = 0.002). Overall, breast-conserving surgery was the most frequent surgery (86.26%); however, mastectomy was higher in non-screen-detected breast ductal carcinoma in situ (20.78% versus 9.7%, p = 0.024). Readmissions for mastectomy were more frequent in non-screen-detected breast ductal carcinoma in situ. Psychological complications, such as fatigue, anxiety, and depression, had a prevalence of 15% within our cohort. Risk of readmissions and complications was higher within the non-screen-detected group, as evidenced by an odds ratio = 6.25 (95% confidence interval = 1.95–19.99) for readmissions and an odds ratio = 2.41 (95% confidence interval = 1.95–4.86) for complications. Conclusions: Our findings indicate that women with breast ductal carcinoma in situ breast cancer diagnosed through population-based breast cancer screening program experience a lower risk of readmissions and complications than those diagnosed outside these programs. These findings can help aid women and health professionals make informed decisions regarding screening.

scholarly journals Hyperopia in preschool and school children

2007 ◽  
Vol 60 (3-4) ◽  
pp. 115-121 ◽  
Author(s):  
Sofija Bolinovska
Keyword(s):  
Refractive Error ◽  
Screening Program ◽  
Public Health Problem ◽  
Visual Development ◽  
Older Children ◽  
Adequate Treatment ◽  
Significant Public Health Problem ◽  
Light Rays ◽  
Significant Public Health ◽  
Age Range

Hypermetropia (hyperopia) is a refractive error of the eye in which parallel light rays focus behind the macula luthea without accommodation giving an unclear retinal image. The involvement of accommodation in correction of far-sightedness leads to the following three clinical types of hyperopia: total, latent and manifest. Minor hyperopias can be successfully corrected by accommodation higher than +3.0D. If not corrected timely, they may cause amblyopia and esotropia, while high hyperopic anisometropia of a hyperopic eye, usually results in an amblyopic eye. The study included 200 children (400 eyes) within the age range of 3 to 18 years, and it was done following the assigned protocol in the course of clinical ophthalmologic check-ups. The most frequent refractive error in the examined children was hyperopia with hyperopic astigmatism, while anisometropia was found in 22% of children but the frequency was reduced in older children. Refractive family history was found in 60.50% of children. Hyperopia can result in poor visual development, occurrence of amblyopia and strabismus and therefore it represents a significant public health problem. As one of the most frequent amblyogenic factors in children, it can be eliminated/prevented by a screening program and adequate treatment providing prevention of amblyopia, which is a form of blindness. .

scholarly journals Public Policies and patents for breast cancer in Brazil, India and Australia

2018 ◽  
Vol 6 (10) ◽  
pp. 287-298
Author(s):  
Áurea Machado de Aragão ◽  
Antônio Martins De Oliveira Júnior
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Public Policies ◽  
Public Health Problem ◽  
Access To Medicines ◽  
Self Awareness ◽  
Cancer Breast ◽  
Incidence And Mortality ◽  
Breast Breast Cancer ◽  
Research Investments

This article illustrates that public policies to facilitate access to medicines, research investments, and self-awareness for breast cancer are the way to change the scenario of breast cancer in Brazil, India and Australia. The motivation was due to the fact that the literature reports breast cancer as a public health problem due to high incidence and mortality rates, whether the country is developed or not. The method adopted was the review study based on the data analysis on public policies and patents for breast cancer in Brazil, India and Australia available in official websites, INPI, Espacenet and Patentscope databases, journals and international newspapers Specialized and physical literature related to the theme. The descriptors used were cancer, breast, breast cancer, breast cancer and Australia, cancer patents, breast cancer and India. The following inclusion criteria used were year and period of publication, availability of the article in full and the intersection between the descriptors. The research concluded that there is an urgent need to prioritize public health with more investment in breast cancer research and awareness programs on the importance of early detection in those countries, primarily in India.

scholarly journals Breast Cancer Mortality After Implementation of Organized Population-Based Breast Cancer Screening in Norway

2019 ◽  
Vol 112 (8) ◽  
pp. 839-846 ◽  
Author(s):  
Sofie Sebuødegård ◽  
Edoardo Botteri ◽  
Solveig Hofvind
Keyword(s):  
Breast Cancer ◽  
Screening Program ◽  
Evaluation Model ◽  
Breast Cancer Mortality ◽  
Population Based ◽  
Mammographic Screening ◽  
Similar Reduction ◽  
Individual Level ◽  
Parametric Survival Model ◽  
Model Counting

Abstract Background We estimated breast cancer (BC) mortality reduction associated with invitations to a nationwide population-based screening program and with changes in treatment. Materials and methods BreastScreen Norway started in 1996 and became nationwide in 2005. It invites women aged 50–69 years to biennial mammographic screening. We retrieved individual-level data for 1 340 333 women from national registries. During 1996–2014 (screening window), women contributed person-years in noninvited and invited periods. We created comparable periods for 1977–1995 (prescreening window) by dividing the follow-up time for each woman into pseudo-noninvited and pseudo-invited periods. We estimated BC mortality for the four periods, using the so-called evaluation model: counting BC deaths in each period for all women diagnosed within the period and counting BC deaths and person-years after screening-age for those diagnosed within screening age. We used a multivariable flexible parametric survival model to estimate hazard ratio (HR) for the effect of invitation and improved treatment. Results Using the regression approach, we found 5818 BC deaths across 16 533 281 person-years. Invitations to screening reduced BC mortality by 20% (HR = 0.80, 95% confidence interval [CI] = 0.70 to 0.91) among women 50 years and older and by 25% (HR = 0.75, 95% CI = 0.65 to 0.86) among screening-aged women. The treatment effect was 23% (HR = 0.77, 95% CI = 0.65 to 0.92) for women 50 years and older and 17% (HR = 0.83, 95% CI = 0.74 to 0.94) for screening-aged women. Conclusion We observed a similar reduction in BC mortality associated with invitations to screening and improvements in treatment during 1977–2014, among women 50 years and older.

scholarly journals Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Timothy R. Rebbeck ◽  
Susan S. Devesa ◽  
Bao-Li Chang ◽  
Clareann H. Bunker ◽  
Iona Cheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African Descent ◽  
Public Health Problem ◽  
Tumor Stage ◽  
Sub Saharan Africa ◽  
Incidence And Mortality ◽  
African Caribbean ◽  
Significant Public Health ◽  
The Usa ◽  
Sub Saharan

Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.

scholarly journals The impact of breast density notification on rescreening rates within a population-based mammographic screening program

2022 ◽  
Vol 24 (1) ◽  
Author(s):  
Sarah Pirikahu ◽  
Helen Lund ◽  
Gemma Cadby ◽  
Elizabeth Wylie ◽  
Jennifer Stone
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Density ◽  
Screening Program ◽  
Population Based ◽  
Mammographic Screening ◽  
Younger Women ◽  
Screening Programs ◽  
The Impact

Abstract Background High participation in mammographic screening is essential for its effectiveness to detect breast cancers early and thereby, improve breast cancer outcomes. Breast density is a strong predictor of breast cancer risk and significantly reduces the sensitivity of mammography to detect the disease. There are increasing mandates for routine breast density notification within mammographic screening programs. It is unknown if breast density notification impacts the likelihood of women returning to screening when next due (i.e. rescreening rates). This study investigates the association between breast density notification and rescreening rates using individual-level data from BreastScreen Western Australia (WA), a population-based mammographic screening program. Methods We examined 981,705 screening events from 311,656 women aged 40+ who attended BreastScreen WA between 2008 and 2017. Mixed effect logistic regression was used to investigate the association between rescreening and breast density notification status. Results Results were stratified by age (younger, targeted, older) and screening round (first, second, third+). Targeted women screening for the first time were more likely to return to screening if notified as having dense breasts (Percentunadjusted notified vs. not-notified: 57.8% vs. 56.1%; Padjusted = 0.016). Younger women were less likely to rescreen if notified, regardless of screening round (all P < 0.001). There was no association between notification and rescreening in older women (all P > 0.72). Conclusions Breast density notification does not deter women in the targeted age range from rescreening but could potentially deter younger women from rescreening. These results suggest that all breast density notification messaging should include information regarding the importance of regular mammographic screening to manage breast cancer risk, particularly for younger women. These results will directly inform BreastScreen programs in Australia as well as other population-based screening providers outside Australia who notify women about breast density or are considering implementing breast density notification.

Sign in / Sign up

Export Citation Format

Share Document