Prevalence and risk factors of sarcopenia in patients with diabetes: A meta-analysis

2021 ◽  
Author(s):  
Liyuan Feng ◽  
Qianqian Gao ◽  
Kaiyan Hu ◽  
Mei Wu ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Nephropathy ◽  
Visceral Fat ◽  
Diabetic Patients ◽  
Early Screening ◽  
Visceral Fat Area ◽  
Duration Of Diabetes ◽  
Pooled Prevalence ◽  
Patients With Diabetes ◽  
Hs Crp

Abstract Context The prevalence of sarcopenia in patients with diabetes is three times higher than that in non-diabetic patients and is associated with a poor prognosis. Objective To investigate the global pooled prevalence and risk factors of sarcopenia in patients with diabetes. Data Sources Relevant studies published until November 30, 2020, were identified from the PubMed, Embase, Web of Science, WanFang, CNKI, VIP, and CBM databases. Study Selection Participants with age ≥18 years with clinically diagnosed diabetes. Sex and diabetes type were not restricted. Data Extraction The data were extracted by two reviewers independently using a standard data collection form. Data Synthesis The pooled prevalence of sarcopenia in patients with diabetes was 18% (95% CI,16-20); subgroup analysis showed that sarcopenia was more prevalent in males than in females, as well as being more prevalent in Asia than in South America and Oceania. Age (OR, 1.10), HbA1c (OR, 1.16), visceral fat area (VFA) (OR, 1.03), diabetic nephropathy (OR, 2.54), duration of diabetes (OR, 1.06), and HS-CRP (OR, 1.33) were risk factors for sarcopenia in patients with diabetes. Conclusions Sarcopenia was more prevalent in patients with diabetes. Age, HbA1c, visceral fat area (VFA), diabetic nephropathy, duration of diabetes, and HS-CRP were the probable risk factors. In the future, medical staff should not only pay attention to the early screening of sarcopenia in high-risk groups but also provide information on its prevention.

scholarly journals A study to assess the correlation between HbA1c and microalbuminuria among diabetics

2020 ◽  
Vol 8 (1) ◽  
pp. 16
Author(s):  
Sruthi Kare ◽  
Vishwanath N. Reddy ◽  
Thejdeep Mahamkali
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Socioeconomic Development ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Duration Of Diabetes ◽  
Medical College ◽  
Significant Linear Correlation ◽  
Patients With Diabetes

Background: India is one of the epicentres of the global diabetes mellitus pandemic. Rapid socioeconomic development and demographic changes, along with increased susceptibility for Indian individuals, have led to the explosive increase in the prevalence of diabetes mellitus in India over the past four decades. Diabetic Nephropathy is a common consequence of long-standing diabetes mellitus. The development of diabetic nephropathy has a dramatic increase on the morbidity and mortality of patients with diabetes. Objective of this study was to evaluate the prevalence of microalbuminuria in patients with diabetes mellitus patients.  Methods: This cross-sectional study was conducted on T 2 diabetes mellitus patients visiting medicine OPD of R L Jalappa hospital constituent hospital of Sri Deveraj Urs Medical College, Tamaka, Kolar from May 2016 to July 2016. A total of 60 type-2 diabetes patients were enrolled in the study.Results: Average duration of diabetes among study group was 8 years and most of the patients were between 6-10 years. In type 2DM patients, microalbuminuria and glycemic control have shown a significant linear correlation with duration of diabetes (p<0.05). Also, micro albuminuria has a significant correlation with increase in level of glycosylated haemoglobin.  Conclusions: The prevalence of microalbuminuria in diabetic patients was found to be high and being a developing country; there is a dire need that microalbuminuria and HbA1c testing should be done in both, newly diagnosed as well as already diagnosed type 2DM patients as an early marker of renal risk factor.

scholarly journals PREVALENCE OF NEPHROPATHY AND ITS PARAMETERS IN PATIENTS WITH DIABETES MELLITUS- A PROSPECTIVE STUDY IN A CENTRAL INDIAN POPULATION

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Suresh Kumar Sethi ◽  
Rajesh Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Diabetic Patients ◽  
Early Screening ◽  
Patients With Diabetes ◽  
Mdrd Formula ◽  
A Prospective Study

Background: Hyperglycemia is an important risk factor for the development of diabetic nephropathy. In the initial stages ie micro albuminuria the DKD is clinically detectable and can even be reversed. Hence early screening of diabetic patients is important. Hence the aim of this study was to evaluate the prevalence of nephropathy in a cross section of diabetic patients. Objectives: The Aim of our study was to evaluate the prevalence of nephropathy in recently detected diabetic patients by evaluating microalbuminuria, serum creatinine and creatinine clearance. Methods: A total of 120 patients above 18 years were included in the study and were divided into three groups according to age and were further divided into three groups as per the duration of diseases Patients were again divided into two groups according to the gender. The GFR was calculated as per the MDRD formula and the patients were divided further as per the stage of CKD. Serum Creatinine levels were calculated and the variables associated with CKD were adjusted by Logistic Regression. Results: Our results suggests that 41.25% of subjects were in mild to severe nephropathy out of which 16.25 % were within the three years of diagnosis, thus suggesting the role of early and routine investigation in diabetic patients. Conclusion: Hence the role of life style is clearly emphasized by our results. Although when the variables were adjusted with the logistic regression the occupation was not that significant. Keywords: Albuminuria, Diabetes mellitus (DM), Diabetic Kidney Disease (DKD), Diabetic nephropathy (DN), Serum Creatinine.

scholarly journals PREVALENCE OF NEPHROPATHY AND ITS PARAMETERS IN PATIENTS WITH DIABETES MELLITUS- A PROSPECTIVE STUDY IN A CENTRAL INDIAN POPULATION

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Suresh Kumar Sethi ◽  
Rajesh Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Diabetic Patients ◽  
Early Screening ◽  
Patients With Diabetes ◽  
Mdrd Formula ◽  
A Prospective Study

Background: Hyperglycemia is an important risk factor for the development of diabetic nephropathy. In the initial stages ie micro albuminuria the DKD is clinically detectable and can even be reversed. Hence early screening of diabetic patients is important. Hence the aim of this study was to evaluate the prevalence of nephropathy in a cross section of diabetic patients. Objectives: The Aim of our study was to evaluate the prevalence of nephropathy in recently detected diabetic patients by evaluating microalbuminuria, serum creatinine and creatinine clearance. Methods: A total of 120 patients above 18 years were included in the study and were divided into three groups according to age and were further divided into three groups as per the duration of diseases Patients were again divided into two groups according to the gender. The GFR was calculated as per the MDRD formula and the patients were divided further as per the stage of CKD. Serum Creatinine levels were calculated and the variables associated with CKD were adjusted by Logistic Regression. Results: Our results suggests that 41.25% of subjects were in mild to severe nephropathy out of which 16.25 % were within the three years of diagnosis, thus suggesting the role of early and routine investigation in diabetic patients. Conclusion: Hence the role of life style is clearly emphasized by our results. Although when the variables were adjusted with the logistic regression the occupation was not that significant. Keywords: Albuminuria, Diabetes mellitus (DM), Diabetic Kidney Disease (DKD), Diabetic nephropathy (DN), Serum Creatinine.

scholarly journals When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis

2021 ◽  
Vol 7 (4) ◽  
pp. 298
Author(s):  
Teny M. John ◽  
Ceena N. Jacob ◽  
Dimitrios P. Kontoyiannis
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Clinical Features ◽  
The Other ◽  
Diabetic Patients ◽  
Epidemiological Factors ◽  
Uncontrolled Diabetes ◽  
Diagnostic Certainty ◽  
Patients With Diabetes ◽  
Perfect Storm

Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes. CAMCR was typically seen in patients with diabetes mellitus (DM) (94%) especially the ones with poorly controlled DM (67%) and severe or critical COVID-19 (95%). Its presentation was typical of MCR seen in diabetic patients (mostly rhino-orbital and rhino-orbital-cerebral presentation). In sharp contrast to reported COVID-associated aspergillosis (CAPA) cases, nearly all CAMCR infections were proven (93%). Treating physicians should have a high suspicion for CAMCR in patients with uncontrolled diabetes mellitus and severe COVID-19 presenting with rhino-orbital or rhino-cerebral syndromes. CAMR is the convergence of two storms, one of DM and the other of COVID-19.

Features of Stroke in Chinese Diabetes Patients: A Hospital-based Study

2007 ◽  
Vol 35 (4) ◽  
pp. 540-546 ◽  
Author(s):  
X-D Zhang ◽  
Y-R Chen ◽  
L Ge ◽  
Z-M Ge ◽  
Y-H Zhang
Keyword(s):  
Risk Factors ◽  
Hospital Mortality ◽  
Ischaemic Stroke ◽  
Cerebral Haemorrhage ◽  
Mortality Rates ◽  
Demographic Characteristics ◽  
Major Influence ◽  
Diabetic Patients ◽  
Clinical Factors ◽  
Patients With Diabetes

In this study, demographic characteristics, risk factors, stroke subtypes and outcome were compared in 2532 patients with and without diabetes hospitalized for first-ever stroke. Diabetes was present in 471 (18.6%) of the patients. Patients with diabetes presented more frequently with ischaemic stroke (92.1% versus 71.3%), especially lacunar infarction (41.2% versus 35.2%), compared with non-diabetics. Cerebral haemorrhage was less frequent in diabetics than non-diabetics (4.2% versus 18.1%). In-hospital mortality rates from ischaemic stroke were similar in the two groups (18.2% in diabetics and 16.9% in non-diabetics). Predictors of in-hospital mortality in diabetic patients included decreased consciousness, congestive heart failure and atrial fibrillation. In conclusion, stroke in diabetic patients was different to stroke in non-diabetic patients: in diabetics the frequency of cerebral haemorrhage was lower and the rate of lacunar infarct syndrome was higher, but in-hospital mortality from ischaemic stroke was not increased. Clinical factors evident at the onset of stroke have a major influence on in-hospital mortality and may help clinicians provide a more accurate prognosis.

Prevalence of Toenail Onychomycosis in Patients with Type 2 Diabetes Mellitus and Evaluation of Risk Factors

2011 ◽  
Vol 101 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Aynur Gulcan ◽  
Erim Gulcan ◽  
Sukru Oksuz ◽  
Idris Sahin ◽  
Demet Kaya
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Essential Components ◽  
Patients With Diabetes ◽  
Epidemiologic Risk

Background: We sought to determine the frequency of toenail onychomycosis in diabetic patients, to identify the causative agents, and to evaluate the epidemiologic risk factors. Methods: Data regarding patients’ diabetic characteristics were recorded by the attending internal medicine clinician. Clinical examinations of patients’ toenails were performed by a dermatologist, and specimens were collected from the nails to establish the onycomycotic abnormality. All of the specimens were analyzed by direct microscopy and culture. Results: Of 321 patients with type 2 diabetes mellitus, clinical onychomycosis was diagnosed in 162; 41 of those diagnoses were confirmed mycologically. Of the isolated fungi, 23 were yeasts and 18 were dermatophytes. Significant correlations were found between the frequency of onychomycosis and retinopathy, neuropathy, obesity, family history, and duration of diabetes. However, no correlation was found with sex, age, educational level, occupation, area of residence, levels of hemoglobin A1c and fasting blood glucose, and nephropathy. The most frequently isolated agents from clinical specimens were yeasts. Conclusions: Long-term control of glycemia to prevent chronic complications and obesity and to promote education about the importance of foot and nail care should be essential components in preventing onychomycosis and its potential complications, such as secondary foot lesions, in patients with diabetes mellitus. (J Am Podiatr Med Assoc 101(1): 49–54, 2011)

scholarly journals Risk Factors of Hypertension among Diabetic Patients from Yaoundé Central Hospital and Etoug-Ebe Baptist Health Centre, Cameroon

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Beryl Kemche ◽  
Brice Ulrich Saha Foudjo ◽  
Elie Fokou
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Health Centre ◽  
Diabetic Patients ◽  
Central Hospital ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Duration Of Diabetes ◽  
Stage 1

Uncontrolled blood pressure is a threat to diabetic patients’ life. The aim of this study was to identify risk factors of hypertension among diabetic patients at different stages from Yaoundé Central Hospital and Etoug-Ebe Baptist Health Center of Cameroon. A hospital-based cross-sectional study was conducted for 6 months, and 109 participants (types 1 and 2), aged 24–81 years, were enrolled using simple random sampling. A pretested structured questionnaire was used to collect sociodemographic data, habitual behaviors, clinical history blood pressure, and anthropometric measures. The prevalence of hypertension was 86.2%. Of the total, 13.8% participants were normotensive, 32.1% stage 1 hypertensive, and 54.1% stage 2 hypertensive. Being a male (p=0.046) and not smoking (p=0.036) were negatively associated with stage 1 hypertension whereas eating less than 3 times (p=0.046) and duration of diabetes greater than 9 years among women (p=0.039) were positively associated. Age above 40 years (p=0.002) was negatively associated with stage 2 hypertension. However, age above 40 years had a negative effect among Christian, less educated diabetics, people having diabetes for more than 9 years, and those on medical treatment (5.556≤specific OR≤10.278). Duration of diabetes (age-adjusted OR=1.155; p=0.003) and abnormal waist circumference (crude OR=4.074; p=0.024) were positively associated with stage 2. Abnormal waist-to-hip ratio (crude OR=3.773; p=0.028) and feeding rate greater than 2 times a day (WHR-adjusted OR=3.417; p=0.046) were positively associated with hypertension (stages 1 and 2). This study suggests that hypertension, present at its two stages, is a serious health issue among diabetic patients. Thus, appropriate intervention should be put in place to prevent and control hypertension by managing identified risk factors.

scholarly journals CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Mohd Jokha Yahya ◽  
Patimah Binti Ismail ◽  
Norshariza Binti Nordin ◽  
Abdah Binti Md Akim ◽  
Wan Shaariah Binti Md Yusuf ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Manganese Superoxide Dismutase ◽  
Multiplicative Model ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic ◽  
Mode Of Inheritance

Type 2 diabetes mellitus (T2DM) is associated with a high incidence of nephropathy. The aim of this study was to investigate the association of a genetic polymorphism of carnosinase (CNDP1-D18S880and -rs2346061), endothelial nitric oxide synthase (NOS3-rs1799983), and manganese superoxide dismutase (MnSOD-rs4880) genes with the development of diabetic nephropathy among Malaysian type 2 diabetic patients. A case-control association study was performed using 652 T2DM patients comprising 227 Malays (without nephropathy = 96 and nephropathy = 131), 203 Chinese (without nephropathy = 95 and nephropathy = 108), and 222 Indians (without nephropathy = 136 and nephropathy = 86). DNA sequencing was performed for theD18S880ofCNDP1, while the rest were tested using DNA Sequenom MassARRAY to identify the polymorphisms. DNA was extracted from the secondary blood samples taken from the T2DM patients. The alleles and genotypes were tested using four genetic models, and the best mode of inheritance was chosen based on the leastpvalue. Thers2346061ofCNDP1was significantly associated with diabetic nephropathy among the Indians only with OR = 1.94 and 95% CI = (1.76–3.20) and fitted best the multiplicative model, whileD18S880was associated among all the three major races with the Malays having the strongest association with OR = 2.46 and 95% CI = (1.48–4.10), Chinese with OR = 2.26 and 95% CI = (1.34–3.83), and Indians with OR = 1.77 and 95% CI = (1.18–2.65) in the genotypic multiplicative model. The best mode of inheritance for bothMnSODandNOS3was the additive model. ForMnSOD-rs4880, the Chinese had OR = 2.8 and 95% CI = (0.53–14.94), Indians had OR = 2.4 and 95% CI = (0.69–2.84), and Malays had OR = 2.16 and 95% CI = (0.54–8.65), while forNOS3-rs1799983, the Indians had the highest risk with OR = 3.16 and 95% CI = (0.52–17.56), followed by the Chinese with OR = 3.55 and 95% CI = (0.36–35.03) and the Malays with OR = 2.89 and 95% CI = (0.29–28.32). The four oxidative stress-related polymorphisms have significant effects on the development of nephropathy in type 2 diabetes patients. The genes may, therefore, be considered as risk factors for Malaysian subjects who are predisposed to T2DM nephropathy.

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