scholarly journals Membrane-initiated estrogen, androgen and progesterone receptor signaling in health and disease

2021 ◽  
Author(s):  
Franck Mauvais-Jarvis ◽  
Carol A Lange ◽  
Ellis R Levin
Keyword(s):  
Steroid Hormones ◽  
Nuclear Import ◽  
Transcriptional Activity ◽  
Receptor Signaling ◽  
Cellular Functions ◽  
Current State ◽  
Steroid Signaling ◽  
Selective Modulation ◽  
Health And Disease ◽  
The Subject

Abstract Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein synthesis. This led to the paradigm that steroid hormones regulate growth, differentiation, and metabolism via binding a receptor in the nucleus. It took 30 years to appreciate not only that some cellular functions arise solely from membrane-localized (SRs) actions, but that rapid sex steroid signaling from membrane-localized SRs is a prerequisite for the phosphorylation, nuclear import, and potentiation of the transcriptional activity of nuclear SR counterparts. Here, we provide a review and update on the current state of knowledge of membrane-initiated estrogen (ER), androgen (AR) and progesterone (PR) receptor signaling, the mechanisms of membrane-associated SR potentiation of their nuclear SR homologues, and the importance of this membrane-nuclear SR collaboration in physiology and disease. We also highlight potential clinical implications of pathway-selective modulation of membrane-associated SR.

Muhammad Nejatullah Siddiqui. Issues in Islamic Banking: Selected Papers, Leicester: The Islamic Foundation. 1983 , I 52pp.Author and Subject Indexes.

1983 ◽  
Vol 22 (1) ◽  
pp. 57-61
Author(s):  
Shahrukh Rafi Khan
Keyword(s):  
Analytical Model ◽  
Significant Contribution ◽  
Profit Sharing ◽  
Islamic Banking ◽  
Current State ◽  
The Subject ◽  
Made In

The book under review is a compilation of the author's articles and lectures that highlight the prominent developments in the literature on the subject of Islamic banking and inform the reader of the current state of debate on it. One of the earliest and main contributors to this topic is the author himself. The focus of this review will mainly be on "Economics of Profit-Sharing", which is the title of the fourth chapter of the book and is among his latest contributions. This chapter is a significant contribution as it is the first attempt to formalise the concept of profit sharing into an analytical model and, therefore, demands closer scrutiny. However, in the remaining chapters of the book, the author has drawn attention to some of the fine points made in the literature on this topic. Since some of these points appear to be controversial to me, I will briefly discuss them before moving on to the analytical chapter of the book.

BASIC ASPECTS OF THE FISCAL POLICY OF THE STATE IN THE SUBJECT OF THE RUSSIAN FEDERATION

2020 ◽  
Vol 1 (6) ◽  
pp. 4-7
Author(s):  
B. Kh. ALIYEV ◽  
Keyword(s):  
Fiscal Policy ◽  
Russian Federation ◽  
Economic Management ◽  
Financial Flows ◽  
Constituent Entity ◽  
Current State ◽  
Management Measures ◽  
The Subject ◽  
The Russian Federation ◽  
The Republic

The article examines the current state of the fiscal policy of the constituent entity of the Russian Federation, which is a combination of diverse economic management measures based on the distribution and redistribution of financial flows. The analysis of fiscal policy on the example of the subject of the Russian Federation (Republic of Dagestan). The article outlines the problematic issues of the tax policy of the Republic of Dagestan and suggests ways to overcome the identified problems.

Neuroligin-2 as a central organizer of inhibitory synapses in health and disease

2020 ◽  
Vol 13 (663) ◽  
pp. eabd8379
Author(s):  
Heba Ali ◽  
Lena Marth ◽  
Dilja Krueger-Burg
Keyword(s):  
Synaptic Transmission ◽  
Synapse Formation ◽  
Current Knowledge ◽  
Protein Complexes ◽  
Inhibitory Synapses ◽  
Molecular Architecture ◽  
Cellular Functions ◽  
Altered Expression ◽  
Health And Disease ◽  
Flow Of Information

Postsynaptic organizational protein complexes play central roles both in orchestrating synapse formation and in defining the functional properties of synaptic transmission that together shape the flow of information through neuronal networks. A key component of these organizational protein complexes is the family of synaptic adhesion proteins called neuroligins. Neuroligins form transsynaptic bridges with presynaptic neurexins to regulate various aspects of excitatory and inhibitory synaptic transmission. Neuroligin-2 (NLGN2) is the only member that acts exclusively at GABAergic inhibitory synapses. Altered expression and mutations in NLGN2 and several of its interacting partners are linked to cognitive and psychiatric disorders, including schizophrenia, autism, and anxiety. Research on NLGN2 has fundamentally shaped our understanding of the molecular architecture of inhibitory synapses. Here, we discuss the current knowledge on the molecular and cellular functions of mammalian NLGN2 and its role in the neuronal circuitry that regulates behavior in rodents and humans.

Heuristische Textpraktiken in den Wissenschaften

2020 ◽  
Vol 48 (1) ◽  
pp. 1-46
Author(s):  
Michael Bender ◽  
Marcus Müller
Keyword(s):  
Science Research ◽  
Annotation Scheme ◽  
Scientific Debate ◽  
Domain Specific ◽  
Current State ◽  
Scientific Disciplines ◽  
Textual Practices ◽  
Collaborative Annotation ◽  
The Subject ◽  
State Of Research

AbstractThis article contains a comparative study of heuristic textual practices in various scientific disciplines. By this we mean formulation practices with which new knowledge is generated in institutionally influenced routines and connected to existing knowledge, e. g. ‚highlighting the relevance of a research topic‘, ‚defining a concept‘ or ‚supporting a statement argumentatively‘.The aim is to find out to what extent such textual practices occur in different scientific disciplines, how they are distributed and combined. Furthermore, we study the effects domain-specific contexts have on heuristic textual practices. The data basis of our study is a corpus of 65 dissertations from the 13 different faculties of the TU Darmstadt. In the pilot study we report here, we examined the introductory chapters of the dissertations. Methodologically, it is an annotation study: Based on the current state of research on the subject, we have derived a basic annotation scheme, which we have developed and refined in a collaborative process of guideline creation. Our study affiliates on socio-pragmatic research on text production and formulation routines in the sciences. It is theoretically informed by the philosophy of science research on heuristics, methodically we make a contribution to the scientific debate on collaborative annotation procedures.

Parnicki a Rosja. Rekonesans

2021 ◽  
Vol 12 (2) ◽  
pp. 325-338
Author(s):  
Piotr Gorliński-Kucik
Keyword(s):  
Literary Criticism ◽  
Interwar Period ◽  
Cultural Policy ◽  
Historical Novels ◽  
Russian Culture ◽  
Current State ◽  
The Subject ◽  
State Of Research ◽  
Critical Project

The article considers issue of the connections between Teodor Parnicki, the Polish author of historical novels, and Russia. His attitude has its origins in biographical experiences. Knowledge of Russian culture is evident especially in the early work of Parnicki, and above all – in literary criticism of the interwar period. Careful reading shows that the sketches and reviews are a conservative critical project, the subject of which is Soviet social and cultural policy and communism in general. This article also complements the current state of research (who did not address this issue), while being a contribution to further research.

Mainstreaming pre-manufactured offsite processes in construction – are we nearly there?

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Joseph Kwame Ofori-Kuragu ◽  
Robert Osei-Kyei
Keyword(s):  
Construction Industry ◽  
Relevant Literature ◽  
Future Research ◽  
Content Type ◽  
Technical Paper ◽  
Sustainable Systems ◽  
Technology Firms ◽  
Current State ◽  
Academic Publications ◽  
The Subject

Purpose The purpose of this paper is to explore the current state of popular modern methods of construction (MMC) and pre-manufactured construction in the construction industry and propose a framework for future implications for practice and future research. Design/methodology/approach This technical paper is based on a narrative review of the extant literature on the subject. First, the Scopus search engine was used to retrieve relevant papers on MMC, offsite and pre-manufactured construction. Second, institutional literature such as reports by industry professional and trade bodies, literature from leading technology firms and contractors with experience of MMC were extracted. These two strands of literature were synthesised and a comprehensive discussion on the topic was provided. Findings Results show that journal publications on MMC and pre-manufactured construction have increased in the past decade. The paper found significant advances in the development of premanufactured and offsite construction approaches with many benefits. Offsite and pre-manufactured construction are viable and sustainable systems currently suitable for wider adoption as the mainstream construction method. Research limitations/implications This technical paper based on an integrative review of relevant literature could have benefitted from interviews of professionals with experience of offsite and pre-manufacture techniques and from wider availability of current academic publications on the subject. Validation of the framework has not been undertaken. Originality/value Not much-published work has been undertaken on the current state of development globally and the viability of these construction approaches. This paper evaluates evidence from academic and industry sources to address this gap. A framework has been developed which can help the industry’s industrialisation drive.

scholarly journals Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

2018 ◽  
Vol 25 (5) ◽  
pp. 455-474 ◽  
Author(s):  
Colm Cunningham ◽  
Aisling Dunne ◽  
Ana Belen Lopez-Rodriguez
Keyword(s):  
Neural Circuit ◽  
Phenotypic Diversity ◽  
Significant Heterogeneity ◽  
Therapeutic Implications ◽  
Numerous Cell ◽  
Health And Disease ◽  
The Subject ◽  
The Brain ◽  
Substantial Heterogeneity ◽  
Homogenous Population

Astrocytes are the most numerous cell type in the brain and perform several essential functions in supporting neuronal metabolism and actively participating in neural circuit and behavioral function. They also have essential roles as innate immune cells in responding to local neuropathology, and the manner in which they respond to brain injury and degeneration is the subject of increasing attention in neuroscience. Although activated astrocytes have long been thought of as a relatively homogenous population, which alter their phenotype in a relatively stereotyped way upon central nervous system injury, the last decade has revealed substantial heterogeneity in the basal state and significant heterogeneity of phenotype during reactive astrocytosis. Thus, phenotypic diversity occurs at two distinct levels: that determined by regionality and development and that determined by temporally dynamic changes to the environment of astrocytes during pathology. These inflammatory and pathological states shape the phenotype of these cells, with different consequences for destruction or recovery of the local tissue, and thus elucidating these phenotypic changes has significant therapeutic implications. In this review, we will focus on the phenotypic heterogeneity of astrocytes in health and disease and their propensity to change that phenotype upon subsequent stimuli.

scholarly journals Progress in Measurements of 0.1–10 GeV Neutrino–Nucleus Scattering and Anticipated Results from Future Experiments

2018 ◽  
Vol 68 (1) ◽  
pp. 105-129 ◽  
Author(s):  
Kendall Mahn ◽  
Chris Marshall ◽  
Callum Wilkinson
Keyword(s):  
Cross Section ◽  
Neutrino Oscillation ◽  
Neutrino Interactions ◽  
Current State ◽  
Nucleus Scattering ◽  
The Subject ◽  
The Cross ◽  
Exotic Physics ◽  
Nuclear Targets

Neutrino interactions with nuclei have been the subject of intense interest during the last 15 years. Current and future measurements of neutrino oscillation and exotic physics use order 0.1–10 GeV neutrinos on a range of nuclear targets (12C,16O,40Ar). As the precision of these experiments has increased, information from their detectors and dedicated experiments has indicated deficiencies in the modeling of neutrino interactions on nuclear targets. Here, we present the current state of knowledge about neutrino–nucleus interactions, the challenge of extracting the cross section of these processes, and current experimental puzzles in the field. We also look forward to new and novel measurements and future efforts that seek to resolve these questions.

scholarly journals Toward a better understanding of folate metabolism in health and disease

2018 ◽  
Vol 216 (2) ◽  
pp. 253-266 ◽  
Author(s):  
Yuxiang Zheng ◽  
Lewis C. Cantley
Keyword(s):  
Cell Proliferation ◽  
Epigenetic Regulation ◽  
Historical Perspective ◽  
Mitochondrial Protein ◽  
Protein Translation ◽  
Folate Metabolism ◽  
Cellular Functions ◽  
Biochemical Processes ◽  
Health And Disease ◽  
Thymidine Monophosphate

Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration.

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