scholarly journals Bio-Synthesis of Gold Nanoparticles Through Bioreduction using the Aqueous Extract of Muntingia Calabura L. LEAF

2018 ◽  
Vol 34 (1) ◽  
pp. 401-409 ◽  
Author(s):  
Abdul Wahid Wahab ◽  
Abdul Karim ◽  
Asmawati Asmawati ◽  
I. Wayan Sutapa
Keyword(s):  
Gold Nanoparticles ◽  
Aqueous Extract ◽  
Muntingia Calabura ◽  
Bio Synthesis

Antibacterial and Anti-Biofilm Biosynthesised Silver and Gold Nanoparticles for Medical Applications: Mechanism of Action, Toxicity and Current Status

2020 ◽  
Vol 17 (2) ◽  
pp. 88-100 ◽  
Author(s):  
Sundos Suleman Ismail Abdalla ◽  
Haliza Katas ◽  
Fazren Azmi ◽  
Mohd Fauzi Mh Busra
Keyword(s):  
Gold Nanoparticles ◽  
Synthesis Method ◽  
Chemical Characterization ◽  
Current Status ◽  
Silver And Gold Nanoparticles ◽  
Physical And Chemical Characterization ◽  
Biosynthesized Agnps ◽  
Physical And Chemical ◽  
Insight Into ◽  
Bio Synthesis

Fast progress in nanoscience and nanotechnology has contributed to the way in which people diagnose, combat, and overcome various diseases differently from the conventional methods. Metal nanoparticles, mainly silver and gold nanoparticles (AgNPs and AuNPs, respectively), are currently developed for many applications in the medical and pharmaceutical area including as antibacterial, antibiofilm as well as anti-leshmanial agents, drug delivery systems, diagnostics tools, as well as being included in personal care products and cosmetics. In this review, the preparation of AgNPs and AuNPs using different methods is discussed, particularly the green or bio- synthesis method as well as common methods used for their physical and chemical characterization. In addition, the mechanisms of the antimicrobial and anti-biofilm activity of AgNPs and AuNPs are discussed, along with the toxicity of both nanoparticles. The review will provide insight into the potential of biosynthesized AgNPs and AuNPs as antimicrobial nanomaterial agents for future use.

scholarly journals Green Synthesis of Gold Nanoparticles from Leaf Extracts of Ginkgo biloba L. and its Antibiotic Potential Against Escherichia coli and Bacillus subtilis

2020 ◽  
Vol 2 (1) ◽  
pp. 29
Keyword(s):  
Gold Nanoparticles ◽  
Bacillus Subtilis ◽  
Aqueous Extract ◽  
Ginkgo Biloba ◽  
Bacterial Pathogens ◽  
Sem Analysis ◽  
Leaf Extracts ◽  
Living Fossil ◽  
E Coli ◽  
Global Environmental

Based on the global environmental pollution problems, the main focus of every nano-research is to produce the nanomaterial in a green and eco-friendly way without any interference of chemical synthesis. By the way, the present study was intended to use an aqueous extract of the living fossil plant viz., Ginkgo biloba L., to synthesize the gold nanoparticles and evaluate their antibiotic activity against bacterial pathogens. The gold nanoparticles (AuNps) were successfully synthesized by mixing the Ginkgo biloba aqueous extract and the auric chloride solution for approximately 24 hours. The UV-Vis spectra of Gold nanoparticles (AuNps) showed the maximum absorption peak at 520nm. The SEM analysis also showed the gold nanoparticles synthesized from Ginkgo biloba were spherical with particle size ranging from 40 to 60nm. During our study, the gold nanoparticles exhibited significant antimicrobial activity against bacterial pathogens, i.e., E. coli and Bacillus subtilis. The later bacterium was found to be more susceptible to the nanoparticles as well as the extracts of G. biloba in comparison to the former bacterium.

THEVETIA PERUVIANA ROOTS EXTRACT MEDICATED GOLD NANOPARTICLES AND ITS UREASE INHIBITORY ACTIVITY

2021 ◽  
pp. 79-82
Author(s):  
SAUD BAWAZEER
Keyword(s):  
Gold Nanoparticles ◽  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Enzyme Inhibitor ◽  
Research Work ◽  
Thevetia Peruviana ◽  
Urease Enzyme ◽  
Urease Inhibitory ◽  
Microscopy Techniques

Objective: The main objective of the current research work was synthesized of gold nanoparticles (AuNPs) of Thevetia peruviana aqueous extract,characterization, and screening for urease enzyme inhibitory activity.Methods: AuNPs were synthesized by mixing 1 mM gold salt solution with T. peruviana aqueous extract without any reducing agents. The preparedAuNPs were characterized using UV–visible spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy techniques. Thesynthesized AuNPs were assessed for in vitro urease enzyme inhibitory activity at 0.2 μg in comparison with the aqueous extract.Results: In this finding, we synthesized the AuNPs of T. peruviana aqueous extract for the 1st time. The AuNPs exhibited significant stability atroom temperature. The AuNPs showed significant urease inhibitory activity with IC50 67.56±1.67 at 0.2 μg as compared to aqueous extract whichexhibited good activity with IC50 39.21±1.32 μ at 0.2 mg, against standard thiourea (IC50=21.00±1.16). The formation of AuNPs correlates due to activephytochemical present in extract which is responsible for synthesizing NPs.Conclusion: T. peruviana extract and prepared AuNPs are an outstanding urease enzyme inhibitor and are capable of making fine NPs. Application:The synthesized AuNPs of T. peruviana aqueous extract which significant urease inhibitory activity may allow us to discover NPs for potentiallyeffective and safe nanoherbal therapy.

scholarly journals IN VITRO CYTOTOXICITY AND ANTIOXIDANT EVALUATION OF BIOGENIC SYNTHESIZED GOLD NANOPARTICLES FROM MARSILEA QUADRIFOLIA ON LUNG AND OVARIAN CANCER CELLS

2018 ◽  
Vol 10 (5) ◽  
pp. 153 ◽  
Author(s):  
Balashanmugam P. ◽  
Mosa Christas K. ◽  
Kowsalya E.
Keyword(s):  
Gold Nanoparticles ◽  
Cell Lines ◽  
Aqueous Extract ◽  
A549 Cell ◽  
In Vitro Cytotoxicity ◽  
Spherical Particles ◽  
X Ray ◽  
Marsilea Quadrifolia ◽  
Wide Range

Objective: The biogenic gold nanoparticles are considered to be extremely impressive for its wide range of applications in pharmaceutics and therapeutics. The present study was aimed at the biogenic synthesis of gold nanoparticles (AuNPs) from Marsilea quadrifolia aqueous extract and to investigate its antioxidant property and cytotoxic effect on human ovarian teratocarcinoma (PA-1) and lung adenocarcinoma (A549) cell lines.Methods: The biogenic AuNPs was synthesized using an aqueous extract of Marsilea quadrifolia. The synthesized biogenic AuNPs were characterized by ultraviolet (UV) visible spectroscopy, transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDX) and X-ray diffraction (XRD). The biogenic AuNPs was assessed for its stability over a period of time and antioxidant activity. The cytotoxicity of biogenic AuNPs against PA-1 and A549 cell lines was studied using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.Results: The synthesized biogenic AuNPs showed peculiar ruby red color and a surface plasmon resonance (SPR) peak at 544 nm in the UV-Vis spectrum. The characterization of biogenic AuNPs by TEM, EDX and XRD revealed well dispersed spherical particles ranging from 10-40 nm and the presence of elemental gold and its crystalline nature, respectively. The AuNPs showed good stability and the scavenging activity at 50 μg/ml. The in vitro cytotoxicity of biogenic AuNPs against PA-1 and A549 cell lines recorded half maximal inhibitory concentration (IC50) of 45.88 μg/ml and 52.015 μg/ml, respectively.Conclusion: The biogenic AuNPs demonstrated superior antioxidant and antiproliferative activities against cancer cell lines.

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