scholarly journals Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262271
Author(s):  
Maya Hioki ◽  
Nana Kanehira ◽  
Teruhiko Koike ◽  
Akira Saito ◽  
Kiyoshi Shimaoka ◽  
...  
Keyword(s):  
Older Adults ◽  
Waist Circumference ◽  
Biochemical Parameters ◽  
Hemoglobin A1c ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Normal Weight ◽  
Echo Intensity ◽  
The Relationship ◽  
Necrosis Factor

Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose of this study, therefore, was to elucidate the relationship between adiponectin and echo intensity–estimated IntraMAT using ultrasonography in normal-weight older adults (men 9, women 13) and examine biochemical parameters. Blood tests were performed to determine fasting levels of glucose, insulin, hemoglobin A1c, total cholesterol (Total-C), high-density-lipoprotein cholesterol, low-density-lipoprotein cholesterol (LDL-C), free fatty acid, triglycerides (TGs), adiponectin, leptin, high-sensitivity C-reactive protein, and high-sensitivity tumor necrosis factor, and homoeostasis model assessment index of insulin resistance (HOMA-IR). Mean gray-scale echo intensity was calculated as the IntraMAT index of the vastus lateralis. Waist circumference was measured at the level of the navel as the visceral adipose tissue (VAT) index. Echo intensity was significantly inversely correlated with adiponectin or LDL-C, and that was significantly positively correlated with TG. Adiponectin level was inversely correlated with waist circumference. Partial correlation analysis with waist circumference as the control variable revealed that adiponectin was inversely correlated with echo intensity, independent of waist circumference, whereas no such correlation was observed after controlling for LDL-C and TG levels. When biochemical parameters were grouped in the principal component analysis, among men, Total-C, insulin, and HOMA-IR or hemoglobin A1c, and high-sensitivity tumor necrosis factor–alpha were grouped with the same distribution for factors 1 and 2. Among women, glucose, insulin, HOMA-IR, and Total-C or TGs were grouped with the same distribution for factors 1 and 2. These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women.

scholarly journals Variation in the Association of Body Types to Decreased High-Density Lipoprotein in Older Adults (NHANES 2005-2014)

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 213-213
Author(s):  
Queendaleen Chukwurah
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Waist Circumference ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
High Density ◽  
Sample Population

Abstract General obesity and central obesity represent cardiovascular disease risk factors and are known to be related to dyslipidemia. I examine the variation in the association of combined body mass index/waist circumference classification to decreased high-density lipoprotein cholesterol (HDL-C). Body mass index /waist circumference (WC) cut off values were used to create six body types: normal weight with normal WC (NWT-NWC), overweight with normal WC (OWT-NWC), obese with normal WC (O-NWC), normal weight with high WC (NWT-HWC), overweight with high WC (OWT-HWC), and obese with high WC (O-HWC). HDL-C was defined as decreased if < 40 mg/dl for men or < 50 mg/dl for women and normal if ≥ 40 mg/dL for men or ≥ 50 mg/dL for women. Sample population included 5,772 participants of the National Health and Nutrition Examination Survey (NHANES 2005-2014) aged 50 years and older. The mean (SD) age was 61.8 (0.2), and 50.5% were females, while 10% were minority. The prevalence of decreased HDL-C was 29.1%. Analysis involved weighted multivariable logistic regression adjusted for age, race-ethnicity, gender, education, poverty-income-ratio, smoking, and alcohol intake. Regression reveals a higher likelihood of decreased HDL-C for OWT-NWC (aOR 2.12 95% CI 1.43,3.15 ), NWT-HWC (aOR 2.57 95% CI 1.59,4.16 ), OWT-HWC(aOR 3.09 95% CI 2.29,4.15 ), and O-HWC (aOR 5.30 95% CI 4.01,6.86 ) when compared to NWT-NWC. These associations are important to public health practice and policies as it demonstrates the implications of the parallel use of anthropometric measures for all body weights in health-risk assessments of older adults.

scholarly journals Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyun Ji Lee ◽  
Kyung Do Han ◽  
Hae Eun Park ◽  
Ju Hee Han ◽  
Chul Hwan Bang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Health Insurance ◽  
Waist Circumference ◽  
Confidence Interval ◽  
Density Lipoprotein ◽  
Population Based ◽  
Control Group ◽  
Newly Diagnosed ◽  
Population Based Study ◽  
The Relationship

AbstractMetabolic syndrome (MetS) is associated with psoriasis, but it remains unclear whether risk of psoriasis remains in patients whose MetS diagnosis changes. To assess the relationship between risk of psoriasis and changes in MetS components. We obtained data from the National Health Insurance Service of Korea and divided the participants into four groups: individuals without MetS (control); individuals with MetS in 2009, but without MetS in 2012 (pre-MetS); individuals without MetS in 2009, but with newly diagnosed MetS in 2012 (post-MetS); and individuals with MetS during the 2009–2012, period (continuous-MetS). We calculated the risk of psoriasis for each group. Risk of psoriasis was similar in the control and pre-MetS groups but was significantly higher in the post-MetS group (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.04–1.12) and in the continuous-MetS group (HR, 1.11; 95% CI, 1.07–1.15) than in the control group. Among MetS components, waist circumference showed the strongest association with psoriasis, followed by high-density lipoprotein and triglyceride levels. Risk of psoriasis was higher in patients with continuous- or post-MetS than in those with pre-MetS (regardless of prior MetS status).

scholarly journals On the Severity of Carpal Tunnel Syndrome: Metabolic Syndrome or Obesity

2020 ◽  
Vol 8 (A) ◽  
pp. 606-610
Author(s):  
Angelo Vasiliadis ◽  
George Charitoudis ◽  
Theofanis Kantas ◽  
George Giovanidis ◽  
George Biniaris
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol ◽  
Cholesterol Levels ◽  
Tunnel Syndrome ◽  
The Mean ◽  
The Relationship

AIM: This study aimed to determine the relationship between CTS, metabolic syndrome and obesity and to compare the severity of CTS between patients with or without metabolic syndrome (MS) and patients with or without obesity. METHODS: In this prospective study, patients with clinical and electrophysiological confirmed diagnosis of CTS were included. The waist circumference, blood pressure, fasting blood glucose, fasting triglycerides and high/low density lipoprotein cholesterol levels were recorded. Patients were categorized having metabolic syndrome according to Adult Treatment Panel III definition, while body mass index was used to identify obesity. RESULTS: A total of 65 patients with a mean age of 58.91 ± 12.49 years were included. MS was found in 39 (60%) patients and obesity in 27 (41.5%) patients. The CTS was described as mild, moderate and severe in 8, 12 and 19 hands of those with MS and in 2, 6, and 18 of those without MS respectively (p = 0.207). There were no statistically significant results observed between BMI and the severity of CTS (p > 0.05). The mean waist circumference was 94.75 ± 7.36, 98.78 ± 9.64, 106.42 ± 10.78, 86.41 ± 6.77 for patients with MS+_O–, MS–O+_, MS+_O+_ _and MS–O– _respectively (p < 0.002). CONCLUSION: CTS appears to be more severe in patients with MS than in patients with obesity. Central obesity is one of the well-known risk factors for CTS, but components of MS may have a greater effect on the severity of CTS.

scholarly journals Association of Body Mass Index and Waist Circumference with Hypertension in Older Adults

2020 ◽  
Author(s):  
Wenli Zhang ◽  
Kun He ◽  
Hao Zhao ◽  
Xueqi Hu ◽  
Chunyu Yin ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Interaction Analysis ◽  
Synergistic Effects ◽  
Cubic Spline ◽  
Additive Interaction ◽  
Males And Females ◽  
The Relationship

Abstract Background: The relationship between obesity and prevalent hypertension in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with hypertension, and to assess the appropriate level of BMI and WC for hypertension. Methods: We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for hypertension. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for hypertension. Results: The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for hypertension were 1.084 (1.080-1.087) and 1.025 (1.024-1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with hypertension in both men and women (all P<0.001). The risk of hypertension increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of hypertension was significantly enhanced. Conclusion: These findings suggest increased hypertension prevalence in the elderly population with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of hypertension in older adults.

scholarly journals Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Aina M. Galmes-Panades ◽  
Veronica Varela-Mato ◽  
Jadwiga Konieczna ◽  
Julia Wärnberg ◽  
Miguel Ángel Martínez-González ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Older Adults ◽  
Metabolic Syndrome ◽  
Body Composition ◽  
Waist Circumference ◽  
Biochemical Parameters ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Time In Bed

Abstract Background This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55–75 years, BMI 27–40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. Trial registration The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

scholarly journals The Relationship Between Tri-ponderal Mass Index and Metabolic Syndrome and Its Components in Youth Aged 10–20 Years

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Young Suk Shim
Keyword(s):  
Metabolic Syndrome ◽  
Low Density Lipoprotein ◽  
Standard Deviation Score ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Analysis Of Covariance ◽  
Lipoprotein Cholesterol ◽  
Elevated Glucose ◽  
Overweight Group ◽  
The Relationship

Abstract The current study aimed to evaluate the distribution of the tri-ponderal mass index (TMI) according to sex and age and the relationship of obesity groups according to sex- and age-specific TMI with metabolic syndrome (MetS) and its components. A total of 8,464 subjects aged 10–20 years were classified into 4 groups according to sex- and age-specific TMI: (i) underweight, (ii) normal weight, (iii) overweight, and (iv) obese. The range of the 50th percentiles of TMI was from 13.24 kg/m3 at 10 years to 12.94 kg/m3 at 20 years among males and from 12.19 kg/m3 to 12.84 kg/m3 among females. In the analysis of covariance, obesity groups according to sex- and age-specific TMI were positively correlated with waist circumference (WC) standard deviation score; systolic blood pressure (BP); diastolic BP; and levels of glucose, total cholesterol, triglycerides (TGs), and low-density lipoprotein cholesterol, but for both sexes, the obesity groups were negatively related to high-density lipoprotein cholesterol (HDL-C). In the multiple logistic regression, subjects in the overweight group had higher odds ratios (ORs) for elevated WC (29.18), elevated BP (1.33), elevated TGs (2.55), reduced HDL-C (2.31), and MetS (8.93) than those with normal weight. Participants in the obesity group had increased ORs for elevated WC (154.67), elevated BP (2.22), elevated glucose (3.54), elevated TGs (4.12), reduced HDL-C (3.69), and MetS (25.57) compared to participants with normal weight after adjustment for confounders. Our results suggest that sex- and age-specific TMI may be applicable in the clinical setting as a useful screening tool.

Dysmetabolic features of the overweight patients receiving antipsychotic drugs: A comparison with normal weight and obese subjects

2014 ◽  
Vol 29 (3) ◽  
pp. 179-182 ◽  
Author(s):  
P. Manu ◽  
C.-U. Correll ◽  
M. Wampers ◽  
R. van Winkel ◽  
W. Yu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antipsychotic Drugs ◽  
Hemoglobin A1c ◽  
Density Lipoprotein ◽  
Tolerance Test ◽  
Normal Weight ◽  
Metabolic Health ◽  
Lipoprotein Cholesterol ◽  
Oral Glucose ◽  
Post Challenge

AbstractBackground:Extensive research indicates that obesity, defined by a body mass index (BMI) greater or equal to 30, is common in patients treated with antipsychotic drugs and is frequently associated with carbohydrate and lipid abnormalities leading to metabolic syndrome and diabetes. In contrast, the metabolic health of overweight patients (BMI = 25–29.9) without metabolic syndrome or diabetes has not been thoroughly investigated.Objective:To assess the metabolic health of overweight patients receiving antipsychotic drugs.Methods:We compared standard metabolic parameters (BMI; waist circumference; hemoglobin A1c; fasting lipids; and fasting and post-challenge glucose and insulin) of normal weight, overweight and obese individuals from a consecutive cohort of antipsychotic-treated patients without metabolic syndrome and/or diabetes.Results:Compared with the normal weight subjects (n = 286), overweight patients (n = 212) had higher fasting insulin resistance as assessed with the homeostatic model (P = 0.023), insulin secretion during the oral glucose tolerance test (P = 0.0037), triglycerides (P = 0.0004) and low-density lipoprotein cholesterol (P = 0.0089), and lower levels of high-density lipoprotein cholesterol (P = 0.0014). The obese (n = 50) were different from the overweight subjects only with respect to higher post-challenge insulin levels (P = 0.0002). The average fasting glucose, post-challenge glucose, and hemoglobin A1c, severity of psychiatric disorders and antipsychotics used were similar in the three groups.Conclusions:Overweight (BMI = 25–29.9) patients receiving antipsychotics are metabolically closer to the obese than to normal weight counterparts. The findings suggest that interventions promoting weight loss and metabolic health are required for overweight patients even in the absence of metabolic syndrome or diabetes.

scholarly journals C-Peptide Versus Insulin: Relationships with Risk Biomarkers of Cardiovascular Disease in Metabolic Syndrome in Young Arab Females

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
A. Abdullah ◽  
H. Hasan ◽  
V. Raigangar ◽  
W. Bani-Issa
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Health Concern ◽  
Cross Sectional ◽  
C Peptide

Background. Obesity is a major health concern and is associated with metabolic syndrome (MetS) that increases the risk for cardiovascular disease (CVD). Since little is known about the relationships between MetS components and CVD in overweight/obese young Arab females, our study aimed at examining these relationships and further to explore the associations between connecting peptide (C-peptide) and insulin with these biomarkers.Subjects and Methods. In this cross-sectional study, 80 apparently healthy young Arab females were recruited and grouped by their body mass index (BMI) into normal-weight (GI) and overweight/obese (GII) groups.Results. The two groups significantly differed in BMI, waist circumference (WC) and values of biomarkers, namely, leptin, fasting insulin, uric acid (UA), insulin resistance (HOMA-IR), C-peptide, high-sensitivity C-reactive protein (hs-CRP), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP). C-peptide significantly correlated with WC, leptin, UA, and HDL-C and was predicted by three biomarkers; UA, WC and HDL-C. Whereas, insulin significantly correlated with only two biomarkers including leptin and DBP and was predicted by UA and DBP.Conclusions. The present study highlighted the association between MetS and CVD in young Arab females and the possible role of C-peptide in the prediction of CVD.

scholarly journals Correlation of Small Dense Low Density Lipoprotein, Tumour Necrosis Factor - alpha with Liver Enzymes in Chronic Hepatitis B Patients

2019 ◽  
pp. 1-8
Author(s):  
Isaac Oluwole Adediji ◽  
Adeolu Sunday Oluremi ◽  
Ayodele Ademola Adelakun ◽  
Paul Olusegun Adepoju ◽  
Dominion Akingbade ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
The Relationship ◽  
Necrosis Factor

Aim: This study investigated the relationship between small dense low density lipoprotein (sdLDL), tumour necrosis factor-alpha (TNF-α), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in chronic hepatitis B patients. Duration of Study: June 2018- March 2019. Subjects and Methods: Sixty (60) participants were recruited for this cross sectional study. They comprised thirty (30) clinically diagnosed chronic hepatitis B virus (HBV) infected patients attending clinic at a tertiary hospital in Osogbo, Osun state, Nigeria. Thirty (30) apparently healthy volunteers were recruited as control subjects after fulfilling the inclusion criteria. Anthropometric measurements were performed using standard method. About 6mL of venous blood was collected from each study participant, serum was extracted and kept at -80oC until time of analysis. Small dense LDL, TNF-α, AST, ALT and ALP were determined using enzyme linked immunosorbent assay and colorimetric method as appropriate. Data analysis was done using Student’s t-test for comparison of variables and Pearson’s correlation was used to determine the relationship between variables. P–value less than 0.05 was considered significant.   Results: SdLDL, TNF-α, AST and ALT were significantly elevated in HBV patients when compared with the control subjects (P<0.05). SdLDL had a significant positive correlation with TNF-α (P=0.03), AST (P=0.01), ALT (P=0.00). TNF-α had a significant positive correlation with AST (P=0.02) and ALT (P=0.00). Conclusion: This study revealed a noteworthy positive relationship between sdLDL, TNF-α and hepatic aminotransferases in chronic hepatitis B patients.

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