scholarly journals EXTRACTION SPECIMENS BASED ON THE BUCKTHORN BARK AND METHODOLOGICAL APPROACHES TO IDENTIFY ANTHRACENE DERIVATIVES INCLUDED

2018 ◽  
pp. 73-81
Author(s):  
Natal'ya Anatol'yevna Borovikova
Keyword(s):  
Quantitative Determination ◽  
Russian Federation ◽  
Raw Materials ◽  
Sodium Hydroxide Solution ◽  
The State ◽  
Raw Material ◽  
Extraction Temperature ◽  
Anthracene Derivatives ◽  
The Russian Federation

The article provides an overview of drugs based on buckthorn bark included in the State register of medicines of the Russian Federation and patented in recent years. The methods of quantitative determination of anthracenes-derived raw materials of buckthorn according to the state Pharmacopoeia of the Russian Federation XI and XIII editions and the European Pharmacopoeia are analyzed and presented in the comparative aspect. The main representatives of the anthracene-derived buckthorn are shown for a number of sources, taking into account modern phytochemical studies. The algorithm of development of a technique of spectrophotometric quantitative determination of anthracenes derivatives in buckthorn bark and extraction preparations from it is gradually presented. Studied and selected the optimal conditions of extraction: raw material grinding – 1 mm, extractant – 10% sodium hydroxide solution, the ratio of raw materials and extractant – 0.1 : 100, the extraction temperature in a water bath 100 °C, the duration of extraction – 30 minutes. The analytical maximum of 510 nm was established, a certified sample of frangul-emodin was used as a standard substance, and an experimental calculation of the specific absorption rate of frangul-emodin interaction products with an alkaline-ammonia mixture was presented. In the research we describe an optimized pharmacopoeial methodology, metrological characterizations and results of quantitative determination of the anthracene derivatives in aqueous and alcohol extracts based on the buckthorn bark. The content of the amount of anthracenes in the samples of raw materials of five domestic producers. The content varies from 4.35 to 4.85%.

scholarly journals DEvELopMENT of TEOHNiQuEs FoR THE DETERMiNATioN oF MoisTuRE (Loss oN DRYING) oF MEDiOiNAL PLANT RAW MATERiALS oF MoRPHoLoGiOAL group “FRUiT” by infrared thermogravimetric method

2019 ◽  
Vol 19 (1-2) ◽  
pp. 13-18
Author(s):  
D. A Zhdanov ◽  
V. B Braslavsky
Keyword(s):  
Medicinal Plant ◽  
Russian Federation ◽  
Raw Materials ◽  
The State ◽  
Moisture Loss ◽  
Anethum Graveolens ◽  
Thermogravimetric Method ◽  
Plant Raw Materials ◽  
The Russian Federation

The article is devoted to the development of new and perspective for the State Pharmacopoeia of the Russian Federation (SP RF) techniques for determining of the moisture (loss on drying) of medicinal plant raw materials of the morphological group “Fruit” and medicinal plant preparations by the use of infrared thermogravimetric (IRTGM) method. The techniques for determination of moisture (loss on drying) IRTGM-method as exemplified by the fruit of the following medicinal plants: Silybum marianum (L.) Gaertn., Rosa cinnamomea L. and Anethum graveolens L. were developed. The comparable results for determining of the moisture (loss on drying) of the medicinal plant raw materials of investigated plants were obtained by means of two methods: IRTGM and pharmacopoeial method, which allow us to recommend the developed techniques for inclusion into the relevant monographs of the State Pharmacopoeia of the Russian Federation.

scholarly journals PHOSPHORITE ORES OF THE SOUTH URALS AS AN AGROCHEMICAL RAW MATERIAL: GEOLOGY, COMPOSITION, STATE OF KNOWLEDGE AND DEVELOPMENT PROSPECTS

2021 ◽  
Author(s):  
S.K. Mustafin ◽  
◽  
A.V. Rasskazov ◽  
◽  
Keyword(s):  
Russian Federation ◽  
Raw Materials ◽  
Geological Structure ◽  
The State ◽  
Raw Material ◽  
South Urals ◽  
The South ◽  
Integrated Development ◽  
The Russian Federation ◽  
Development Prospects

The state and prospects of development of phosphorite ore resources as agrochemical raw materials of the Russian Federation are analyzed. The geological structure, composition of ores and the prospects for forecasting, assessing and integrated development of phosphorite deposits of the South Ural phosphorite basin are characterized.

scholarly journals THE DEVELOPMENT OF METHOD OF QUANTITATIVE DETERMINATION OF TOTAL FLAVONOIDS IN THE FLOWERS OF CRATAEGUS SUBMOLLIS SARG.

2019 ◽  
pp. 137-144 ◽  
Author(s):  
Vladimir Aleksandrovich Kurkin ◽  
Ol'ga Yevgen'yevna Pravdivtseva ◽  
Tat'yana Vladimirovna Morozova ◽  
Anna Vladimirovna Kurkina ◽  
Il'nur Khyasyainovich Shaikhutdinov ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Raw Materials ◽  
Specific Weight ◽  
Raw Material ◽  
High Yield ◽  
Total Flavonoids ◽  
Plant Raw Materials ◽  
The Russian Federation ◽  
Promising Type

The flowers and fruits of various species of the hawthorn genus (Crataegus L.) are widely used in domestic and foreign medical practice as cardiotonic preparations. In our opinion, Crataegus submolls Sarg. is a perspective species for collection of the raw materials. Crataegus submolls Sarg. is successfully cultivated in the Russian Federation and is distinguished by its rapid growth and high yield compared with wild-growing species. Moreover, the fresh fruits of Crataegus submolls Sarg. are used in nutrition. The flowers of Crataegus submollis Sarg. contain flavonoids, among of which, like in the case of Hawthorn blood-red the hyperoside is present. It was determined that the maximum of the absorption curve of the solution of Crataegus submollis Sarg. flowers with a solution of aluminum chloride is 412 nm. The method of quantitative determination by the differential spectrophotometry of the total flavonoids calculated on hyperoside in the Crataegus submollis Sarg. flowers has been developed. It was established that the appropriate extragent for this raw material is 70% ethanol. The level of total flavonoid in Crataegus submollis Sarg. flowers has been studied. It was established that separate parts of Crataegus submollis Sarg. flowers differ markedly in the content of total flavonoids and their specific weight in raw materials. It was established that the content of total flavonoids calculated on hyperoside is varied from 2.05±0.08% tо 3.00±0.12%. It was determined that the content of total flavonoids calculated on hyperoside in different parts of hawthorn flowers ranges from 0.98% (receptacle and calyx) to 4.53% (petals). In our opinion, Crataegus submollis Sarg. flowers are the promising type of medicinal plant raw materials.

scholarly journals Application of HPLC for Evaluation and Standardisation of Hawthorn Flower Herbal Substance

2019 ◽  
Vol 9 (3) ◽  
pp. 177-183
Author(s):  
N. P. Antonova ◽  
E. P. Shefer ◽  
N. E. Semenova ◽  
A. M. Kalinin ◽  
S. S. Prokhvatilova ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Russian Federation ◽  
High Performance ◽  
Primary Standard ◽  
Test Procedure ◽  
Total Content ◽  
The State ◽  
Assay Method ◽  
The Russian Federation

The process of harmonisation of Russian and foreign approaches and requirements in the field of medicines quality assurance calls for revision of quality control procedures included in various regulations and guidelines. The monograph FS.2.5.0062.18 “Hawthorn flowers” of the State Pharmacopoeia of the Russian Federation XIV edition includes a test procedure for determination of flavonoids by a chromatospectrophotometric method. This procedure does not take into account current scientific capabilities and has a number of shortcomings, therefore it was necessary to revise the existing test procedure and develop a new approach to the standardisation of the hawthorn flower herbal substance.The objective of the study was to develop an assay method for standardisation and evaluation of hawthorn flower using high performance liquid chromatography (HPLC).Materials and methods: the study was performed using samples of hawthorn flowers by Russian manufacturers. Quercetin (USP RS) and Hyperoside (HWI, primary standard) were used as the reference standards. The HPLC analysis was performed using an Infinity II 1260 DAD LC system (Agilent), and the UV spectra were recorded on a Cary 100 Varian spectrophotometer. A TLC Visualizer (CAMAG) was used to obtain digital images of thin layer chromatography plates.Results: the authors developed an HPLC test procedure for quantitative determination of total flavonoids, expressed as hyperoside, in hawthorn flowers. The developed procedure gives reliable and reproducible results and is characterised by high sensitivity and selectivity. The results of quantitative determination of the total flavonoid content in hawthorn flowers were used to propose the standard for the total content of flavonoids, expressed as hyperoside, of “not less than 0.5%”.Conclusions: the developed assay method for determination of active pharmaceutical ingredients in hawthorn flower products by HPLC can be recommended for inclusion into the Assay part of the “Hawthorn Flowers” monograph of the State Pharmacopoeia of the Russian Federation.

scholarly journals Physical and Chemical Fundamentals and Technical Solutions for Recovery of Non-ferrous and Rare Metals from Industrial Wastes

2020 ◽  
Author(s):  
P.A. Kozlov ◽  
A.M. Panshin ◽  
L.I. Leontiev
Keyword(s):  
Russian Federation ◽  
Raw Materials ◽  
Block Diagram ◽  
Industrial Wastes ◽  
Raw Material ◽  
Material Base ◽  
Waelz Process ◽  
Zinc Cadmium ◽  
The Russian Federation ◽  
Increasing Demand

The increasing demand for zinc and a range of zinc-related metals (for example: lead; indium; tin; cadmium; and copper) in the Russian Federation cannot be satisfied by the existing production plants due to the lack of raw materials. At the same time, ferrous and non-ferrous metallurgy and the chemical industry have accumulated hundreds of millions of tons of zinc wastes (falling into the hazard categories 2 to 4), the processing of which could not only make up the raw material base, but also improve the environmental situation. In the world, over 85% of ferrous dust is recycled using the Waelz process. The Waeltz process is used for distilling separation of elements under reducing conditions. In this study, a block diagram for production of the following elements from industrial wastes is proposed: zinc, cadmium and indium in form of massive metals; zinc and indium in the form of fine powders; and clinker as a raw material for cement production. The technical and scientific details of this new process have been patented in the Russian Federation and abroad. For the first time, the following operations have been implemented with the use of large-sized Waelz kilns: vapour-oxidized Waeltz treatment of polymetallic wastes; recycling of heat from gases and solid products with generation of process fumes; and implementation of alternative flux (dolomite) and alternative fuel (petroleum coke). Keywords: Waelz process, industrial wastes, heat recycling, vapour-oxidized Waelz processing

scholarly journals Comparative anatomical and histological research of the roots of Rheum Palmatum L. And Rheum Officinale B.

2020 ◽  
Vol 19 (5-6) ◽  
pp. 155-159
Author(s):  
Ksenia N. Semenyuta ◽  
Anna A. Shmygareva ◽  
Anatoly N. Sankov
Keyword(s):  
Histological Analysis ◽  
Raw Materials ◽  
Raw Material ◽  
Histochemical Reaction ◽  
Closely Related Species ◽  
Histological Studies ◽  
Rheum Palmatum ◽  
Anthracene Derivatives ◽  
The Russian Federation ◽  
The Difference

Introduction. The aim of the study is to perform the anatomical and histological analysis of the roots of Rheum palmatum L. and Rheum officinale B., and also to check histochemical reactions for the presence of anthracene derivatives. Material and methods. The methodological basis of the anatomical and histological studies was the standard method for the preparation of micro-preparations of roots of Rheum palmatum L. and Rheum officinale B. described in the State Pharmacopoeia of the Russian Federation, XIV edition (OFS.1.5.3.003.15). Results and discussion. Anatomical and histological studies of Rheum palmatum L. and Rheum officinale B. raw materials confirmed the roots of Rheum palmatum L. to have classical secondary structure, while the roots of Rheum officinale B. have classical primary structure. The histochemical reaction to anthracene derivatives with 10% alkali solution was carried out, it resulted in cherry-red staining of core rays and some structures of cortical parenchyma of the fragment of Rheum palmatum L., while the roots of Rheum officinale B. failed to stain. Conclusions. The anatomical and histological studies of the rhizomes and roots of Rheum palmatum L. and Rheum officinale B. demonstrate the difference in the structure of closely related species of plants. It makes possible to identify the medicinal raw material of these plants.

Production Waste as a Component of Raw Materials for Construction Ceramics

2020 ◽  
Vol 839 ◽  
pp. 184-188
Author(s):  
Victoria A. Gurieva ◽  
Anastasia A. Ilyina
Keyword(s):  
Mechanical Characteristics ◽  
Raw Materials ◽  
Raw Material ◽  
Material Base ◽  
Technological Properties ◽  
Orenburg Region ◽  
Existing Problems ◽  
Ceramic Mixture ◽  
The Russian Federation

The paper considers the existing problems of the production of ceramic products in the territory of the Russian Federation, presents the priority directions of development of this industry. The study includes the determination of the properties of samples based on the raw material base of the Orenburg region, namely, waste generated during the development of brown coal from the Tyulgansk deposit - white and red clays and nickel slag of OJSC Yuzhuralnickel Combine of the Orenburg region. The study presents data from the study of the technological properties of the raw materials, the development of the composition of the ceramic mixture. The influence of the material composition of the clay / slag mixture on the physic mechanical characteristics of the products of the experimental compositions was determined: compressive strength, fire shrinkage, water absorption and density.

scholarly journals Determination of deoxynivalenol in feed, feed raw materials and food

2020 ◽  
Vol 64 (12) ◽  
pp. 28-33
Author(s):  
Nailya N. Mishina ◽  
◽  
Ivan N. Shtyrov ◽  
Zukhra H. Sagdeeva ◽  
Ramziya M. Potekhina ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Russian Federation ◽  
Raw Materials ◽  
Food Products ◽  
Technical Documentation ◽  
Veterinary Services ◽  
The Russian Federation ◽  
Layer Chromatography

The article presents the survey data of 1830 average samples of feed, feed raw materials and food products received through the Test Center of the FSBSI «FCTRBS-RRVI»", provided by livestock and feed enterprises, agricultural companies, food manufacturers and 152 samples of feed provided by specialists of veterinary services , livestock enterprises, owners of peasant farms to determine the death of animals and birds, for the content of mycotoxin deoxynivalenol (DON) in the period from 2018 to 2020. Determination of the DON content in the samples was carried out according to a certified procedure based on the method of thin layer chromatography. In the course of summarizing the results, it was found that samples of feed, feed raw materials and food products received through the Test Center of the of the FSBSI «FCTRBS-RRVI» from different regions of the Russian Federation in terms of DON content corresponded to the normative indicators specified in the current regulatory and technical documentation. When determining the cause of death of animals and birds, 152 samples were examined, received from farms of different regions of the Republics of Tatarstan, Bashkortostan, Mordovia, Kostroma and Ryazan regions. It was found that 1.97% of samples were contaminated with DON at concentrations from 0.2 to 0.5 mg/kg of feed, in the rest, the content of mycotoxin was below the sensitivity of the method (< 0.2 mg/kg), which does not exceed the limit permissible concentration. It was recommended to exclude feed contaminated with mycotoxin from the diet of animals, since at the established concentrations, DON is not the main etiological factor in the death of animals, but due to the presence of carcinogenic, mutagenic, teratogenic, embryotoxic and immunosuppressive properties, together with other factors, it is contributing.

scholarly journals QUANTITATIVE DETERMINATION OF THE AMOUNT OF CAROTENOIDS IN THE FRUITS OF CHINESE LYCIUM CHINENSE MILL.

2020 ◽  
pp. 139-144
Author(s):  
Yevgeniy Yevgen'yevich Kurdyukov ◽  
Yelena Fedorovna Semenova ◽  
Inessa Yakovlevna Moiseyeva ◽  
Natal'ya Aleksandrovna Gavrilova ◽  
Tat'yana Andreyevna Ponomareva
Keyword(s):  
Quantitative Determination ◽  
Raw Materials ◽  
Raw Material ◽  
Lycium Chinense ◽  
Optimal Conditions ◽  
Single Determination ◽  
Layer Chromatography ◽  
Β Carotene ◽  
Acetone Hexane

The objects of the study were Mature dried fruits of Chinese birch (Lycium chinense Mill., this. Solanaceae (Solanaceae)). Four samples were examined: No. 1 (Gifts of Pamir, Russia), No. 2 (Gullin Tianhe Pharmaceutical, China), No. 3 (A. J. Alliance, Russia), No. 4 (Globaltorg, Russia). The purpose of this work is to determine the amount of carotenoids in the fruits of Chinese by spectrophotometry. The quantitative determination of the amount of carotenoids in the raw material of Chinese Dereza was carried out. Thin-layer chromatography was used to confirm the presence of carotenoids in the fruits of Dereza. The expediency of using the spectrophotometric method for the detection and quantitative determination of carotenoids in extracts from the fruits of Chinese birch is substantiated. The electron spectra of hexane, acetone and acetone-hexane solutions in the wavelength range 400–500 nm have a maximum optical density at 450±2 nm, characteristic of β-carotene. The optimal conditions of extraction of carotenoids from the raw materials of this plant (extractant – hexane; ratio "raw material–extractant" – 1 : 5; extraction time – 90 minutes; the degree of grinding of raw materials – 0.5 mm). It was determined that the error of a single determination of the content of carotenoids in the fruits of Chinese Dereza with a confidence probability of 95% is ±3,49%. It was revealed that the content of carotenoids in the raw material of Chinese Dereza varies in the range of 33–39 mg%.

Переработка овощей в России: настоящее и будущее

2018 ◽  
Author(s):  
Sh.V. Gasparyan ◽  
S.A. Maslovskii
Keyword(s):  
Growth Rate ◽  
Russian Federation ◽  
Raw Materials ◽  
Raw Material ◽  
Material Base ◽  
Processing Industry ◽  
Strategy Of Development ◽  
The Russian Federation ◽  
Vegetable Raw Materials ◽  
High Level

Приоритет Стратегии развития пищевой и перерабатывающей промышленности Российской Федерации до 2020 года – обеспечение населения страны безопасным и качественным продовольствием. Сырьевая база овощеперерабатывающей промышленности – основа производства. Как инвесторы, так и государство предпринимают конкретные меры для решения проблем. Вместе с тем, несмотря на динамику улучшения, многие проблемы остаются нерешенными. Темпы роста производства овощного сырья недостаточны для промышленности и сдерживают рост производства из отечественного сырья. Это объясняет высокий уровень импорта.The priority of the Strategy of development of the food and processing industry of the Russian Federation until 2020 is to provide the population with safe and quality food. The raw material base of the vegetable processing industry is the basis of production. Both investors and the state are taking concrete measures to solve the problems. However, despite the momentum for improvement, many challenges remain. The growth rate of vegetable raw materials production is not enough for the industry and hinders the growth of production from domestic raw materials. This explains the high level of imports.

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