The effect of additional protein, phosphatidylcholine, phosphatidylserine, and inulin on S100β levels of acute ischemic stroke patients at Dr. Kariadi Central Hospital, Semarang

Background: The brain releases biochemical substrates, such as S100β protein, into circulation in response to ischemic conditions as a sign of damage in nerve cells and disruption of the blood-brain barrier’s integrity. Thrombolytic therapy has led to the development of many neuroprotective therapies such as protein, phosphatidylcholine, phosphatidylserine, and inulin, which can be added to food products. Protein, phospholipids, and inulin, have a neuroprotective impact on nerve cells in the brain and blood-brain barrier.Objective: To prove the effect of protein, phosphatidylcholine, phosphatidylserine, and inulin on S100β levels and clinical outcomes in patients with acute ischemic stroke.Materials and Methods: This study was done in a single-blind RCT. Eighteen ischemic stroke patients were randomly divided into nine subjects for the intervention group and nine subjects for the control group. The Control group received 250 ml conventional formula milk (11.8 g protein) 3 times/day. The intervention group received 250 mL commercial milk 3 rimes/day which contained 15 g protein with 128 mg phosphatidylcholine, 32 mg phosphatidylserine, and 3 g inulin. All of the groups were given hospital-standard therapy for ischemic stroke. S100β levels were measured at pre and post-intervention.Results: Pre and post S100β levels in intervention and the control group did not show any statistically difference (p = 0.777 and p = 0.096), but there was a trend of decreasing levels of S100β in the intervention group (-24.6 + 252.0 pg/mL) versus control group (135.8 + 216.2 pg/mL).Conclusions: The addition of protein, phosphatidylcholine, phosphatidylserine, and inulin did not have a significant effect on S100β levels.

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The effect of addition protein, phosphatidylcholine, phosphatidylserine, and inulin on GFAP levels of acute ischemic stroke patients at Dr. Kariadi Hospital, Semarang

JURNAL GIZI INDONESIA ◽

10.14710/jgi.9.2.184-197 ◽

2021 ◽

Vol 9 (2) ◽

pp. 184-197

Author(s):

Diah Retno Wahyuningrum ◽

Retnaningsih Retnaningsih ◽

Martha Irene Kartasurya

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

G Protein ◽

Intervention Group ◽

Circulatory System ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Stroke Patients ◽

Significant Difference ◽

Enteral Formula

Background: The occurrence of ischemia causes a loss of energy to switch to anaerobic processes resulting in acidosis due to reduced Adenosina Triphosphate (ATP). This condition makes neuron cells apoptotic. Apoptotic of several biochemical substrates in the brain, such as Glial Fibrillary Acidic Protein (GFAP) exit into the circulatory system which is associated with dysbiosis through immunological pathways.Objectives: To determine the effect of giving enteral formula containing protein, phosphatidylcholine, phosphatidylserine, and inulin on GFAP levels in patients with acute ischemic stroke Dr. Kariadi Hospital.Materials and Methods: This study was done in a single-blind RCT. Eighteen ischemic stroke patients were randomly divided into intervention (9 subjects) and control groups (9 subjects). The intervention group received 69 g of the powdered enteral formula three times a day for seven days. The formula contained protein (15 g), phosphatidylcholine (128 mg), phosphatidylserine (32 mg), and inulin (3 g). The subject who had diabetes mellitus received for 14 days at a dose of 34.5 g per day (7.5 g protein with additions 64mg phosphatidylcholine, 16mg phosphatidylserine, 1.5 g inulin). The control group received the standard enteral formula from the hospital, which contains (11.8 g protein without additions protein, phosphatidylcholine, phosphatidylserine, and inulin). GFAP levels by ELISA method (Enzyme-linked immunosorbent Assay) at pre and post-intervention.Results: There was a trend of decreasing GFAP levels before and after in the intervention group towards a better direction from 8.37±4.25 to 8.30±4.9 compared with the control group which experienced an increasing trend from 5.4±1.8 to 7.5±4. There was no significant difference in GFAP levels after intervention between groups (p = 0.7).Conclusions: The addition of protein, phosphatidylcholine, phosphatidylserine, and inulin had no significant effect on GFAP levels.

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Protective effect of Saccharomyces cerevisiae in Rattus norvegicus Ischemic Stroke Model

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.01006 ◽

2021 ◽

pp. 5785-5789

Author(s):

Dedy Budi Kurniawan ◽

Mokhamad Fahmi Rizki Syaban ◽

Arinal Mufidah ◽

Muhammad Unzila Rafsi Zulfikri ◽

Wibi Riawan

Keyword(s):

Saccharomyces Cerevisiae ◽

Ischemic Stroke ◽

Brain Tissue ◽

Tissue Injury ◽

Intervention Group ◽

Positive Control ◽

Positive Control Group ◽

Control Group ◽

Hematopoietic Stem ◽

The Brain

Stroke is one of the leading causes of morbidity and mortality in all ages. Ischemic stroke activates excitotoxic glutamate cascade leading to brain tissue injury. Saccharomyces cerevisiae is a unicellular yeast widely found in nature. S. cerevisiae is neuroprotective and able to increase the differentiation of hematopoietic stem cells (HSCs) into neuronal cells. it may increase levels of neuroprotectant BDNF in the brain tissue, therefore increase the protection of neurons. BDNF may prevent glutamate-driven excitotoxicity by reducing glutamate levels. This study uses a randomized post-test only controlled group design. In this in vivo study, rodent models of ischemic stroke were divided into five groups comprising of the negative control group, positive control group, intervention group 1 (18mg/kgBW), intervention group 2 (36mg/kgBW) and intervention group 3 (72 mg/kgBW). Groups treated with Saccharomyces cerevisiae extract showed significantly increased BDNF levels in the brain tissue, and the expression of the glutamate level was significantly reduced (P <0.05) compared to the positive control group. Thus Saccharomyces cerevisiae has a promising potential to become a therapy against ischemic stroke disease. however further research is needed regarding the efficacy and toxicity of Saccharomyces cerevisiae.

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Abstract TP247: Impact of Helicopter Emergency Medical Services Flights on Recombinant Tissue Plasminogen Activator (rtpa) Integrity

Stroke ◽

10.1161/str.48.suppl_1.tp247 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Brett Faine ◽

Steven Lentz ◽

James Torner ◽

Sanjana Dayal ◽

Heena Olalde ◽

...

Keyword(s):

Ischemic Stroke ◽

Structural Integrity ◽

Intervention Group ◽

Recombinant Tissue Plasminogen Activator ◽

Control Group ◽

Stroke Patients ◽

Thrombolytic Activity ◽

Air Ambulance ◽

Hospital Transfer ◽

The Mean

Introduction: Inter-hospital transfer of ischemic stroke patients by Helicopter Emergency Medical Services (HEMS) is common in rural states. The administration of recombinant tissue plasminogen activator (rtPA) is often initiated at the outside hospital and continues during HEMS (drip and ship). Due to the unstable nature of rtPA after reconstitution in conjunction with strong, low frequency vibrations present during HEMS, there is potential for the physical integrity and thrombolytic activity of rtPA to be compromised during inter-hospital transfer. Hypothesis: Air ambulance transfer alters the antigen integrity of rtPA in ischemic stroke patients. Methods: Prospective cohort study of acute ischemic stroke patients receiving rtPA during air ambulance transfer to a comprehensive stroke center (CSC) (intervention group) compared to patients who presented directly to our CSC Emergency Department (control group). The duration of each flight was recorded to control for degree of exposure. To access the structural integrity and thrombolytic activity of rtPA, small residual samples (<0.5 mL) were taken from each patient’s vial after the infusion was completed. The structural integrity of rtPA antigen was evaluated with a specific rtPA protein ELISA. Results: Thirteen patients received rtPA and were transferred to our CSC via our air ambulance service. The mean flight time was 30.6±5.5 minutes. The mean concentration of rtPA in the control sample was 1.035±0.42 mg/mL. The mean difference in the concentration of the rtPA in the intervention group compared to the control group was 1.59±1.28 mg/mL. Conclusions: HEMS transfer appears to increase rtPA antigen concentrations possibly due to degradation. Future analysis will examine whether alteration in integrity of rtPA affects the thrombolytic activity.

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Abnormal EEG Complexity and Functional Connectivity of Brain in Patients with Acute Thalamic Ischemic Stroke

Computational and Mathematical Methods in Medicine ◽

10.1155/2016/2582478 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Shuang Liu ◽

Jie Guo ◽

Jiayuan Meng ◽

Zhijun Wang ◽

Yang Yao ◽

...

Keyword(s):

Ischemic Stroke ◽

Functional Connectivity ◽

Healthy Subjects ◽

Brain Network ◽

Control Group ◽

Stroke Patients ◽

Cerebral Disease ◽

Essential Information ◽

Stroke Group ◽

The Brain

Ischemic thalamus stroke has become a serious cardiovascular and cerebral disease in recent years. To date the existing researches mostly concentrated on the power spectral density (PSD) in several frequency bands. In this paper, we investigated the nonlinear features of EEG and brain functional connectivity in patients with acute thalamic ischemic stroke and healthy subjects. Electroencephalography (EEG) in resting condition with eyes closed was recorded for 12 stroke patients and 11 healthy subjects as control group. Lempel-Ziv complexity (LZC), Sample Entropy (SampEn), and brain network using partial directed coherence (PDC) were calculated for feature extraction. Results showed that patients had increased mean LZC and SampEn than the controls, which implied the stroke group has higher EEG complexity. For the brain network, the stroke group displayed a trend of weaker cortical connectivity, which suggests a functional impairment of information transmission in cortical connections in stroke patients. These findings suggest that nonlinear analysis and brain network could provide essential information for better understanding the brain dysfunction in the stroke and assisting monitoring or prognostication of stroke evolution.

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Range Of Motion (ROM) Spherical Grip dapat Meningkatkan Kekuatan Otot Ekstremitas Atas Pasien Stroke

Jurnal Ilmu dan Teknologi Kesehatan ◽

10.32668/jitek.v6i1.85 ◽

2018 ◽

Vol 6 (1) ◽

pp. 38-48

Author(s):

Gina Dwi Anggraini ◽

Septiyanti Septiyanti ◽

Dahrizal Dahrizal

Keyword(s):

Range Of Motion ◽

Intervention Group ◽

Clinical Manifestations ◽

The Body ◽

Control Group ◽

P Value ◽

Stroke Patients ◽

Muscle Testing ◽

The Difference ◽

The Brain

Stroke is lost brain function caused by stop his blood supply to the brain. As a result of the disruption of oxygen to the brain needs can occur the clinical manifestations included the weakness of some or all of the body limbs, one of over ekstremities so that the patient could not doing the activity because of the limbs weakness and they needs exercise for preveting disability. Objective is Know the effect of Range Of Motion (ROM) Spherical Grip on muscle strenght of upper extremity on stroke patients. The research used quasi-experimental with pretest and posttest with control group. The population in this study is all stroke patients in the neurological specialist RSUD dr. M. Yunus of Bengkulu City. The Sampling technique used is Cluster Sampling. The number of sample is 32. Instruments used for manual muscle testing. Test for normality using the Kolmogorov-Smirnov and analysis techniques using Wilcoxon Signed Ranks Test and Mann-Whitney with 95% confidence level ( = 0,05). Muscle strenght of the finger mean in the control group 2,44 increase to 2,63 with the difference 0,1875. In the intervention group mean 2,44 increase to 3,13 with the difference 0,6875. Muscle strenght of the wrist mean in the control group 2,38 increase to 2,56 with the difference 0,1875. In the intervention group mean 2,25 increase to 3,00 with the difference 0,75. The result obtained p-value 0,011 finger hand and p-value 0,027 wrist. Exercise Range Of Motion (ROM) Spherical Grip is effective in increase muscle strenght of over extremities on stroke patients.

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Pengaruh hidroterapi rendam kaki air hangat terhadap kekuatan otot pada pasien stroke non hemoragik

Caring : Jurnal Keperawatan ◽

10.29238/caring.v8i1.363 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Setiyawan Setiyawan ◽

Lina Pratiwi ◽

Noerma Shovie Rizqiea

Keyword(s):

Muscular Strength ◽

Hemorrhagic Stroke ◽

Blood Clot ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Stroke Patients ◽

Control Group Design ◽

Quasi Experimental ◽

The Brain

Non-hemorrhagic stroke is a disease which is related to a functional disorder of the brain due to the blood vessel blockage by a blood clot, or by the narrowing of an artery or some arteries that lead to the brain which causes weakness of muscular strength. One of the non-pharmacological therapies, which are beneficial to non-hemorrhagic stroke patients, is hydrotherapy. Hydrotherapy is a therapy which utilizes water to cure or relieve various complaints. One of which is the complaint of how to strengthen muscular strength. The objective of this research is to investigate the effect of warm footbath hydrotherapy to increase the muscular strength of non-hemorrhagic stroke patients. This research used the quasi-experimental research method ith pre-test and post-test nonequivalent control group design. Non-probability sampling with purposive sampling was used to determine its samples. The samples consisted of 40 respondents, into two groups: intervention and control group. The data of the research were analyzed by using the Wilcoxon’s Test and Mann Whitney’s Test. The result of the research shows that the footbath hydrotherapy had an effect on the muscular strength of the non-hemorrhagic stroke patients as indicated by the p-value = 0.000, and there was a difference between the control group and the intervention group where the p-value was 0. 008. The footbath hydrotherapy affected the muscular strength of non-hemorrhagic stroke patients. Thus, nurses as health practitioners are expected to administer warm footbath hydrotherapy to increase the muscular strength of non-hemorrhagic stroke patients.

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Multiparameter Biosignal Analysis in Elderly Ischemic Stroke Patients

Journal of Biomedical Science and Bioengineering ◽

10.14710/jbiomes.2021.v1i1.7-16 ◽

2021 ◽

Vol 1 (1) ◽

pp. 7-16

Author(s):

Muhammad Zakariyah ◽

Alvin Sahroni ◽

Erlina Marfianti

Keyword(s):

Ischemic Stroke ◽

Control Group ◽

P Value ◽

Stroke Patients ◽

Physiological Conditions ◽

Biosignal Analysis ◽

Nervous System Activity ◽

Stroke Group ◽

The Relationship ◽

The Brain

Biosignal can provide information about body conditions, including physiological conditions of ischemic stroke. The regulation of blood in the brain is regulated through the mechanism of Cerebral Autoregulation (CA). Some parameters that can be used to determine this mechanism are Blood Flow Velocity (BFV) and Blood Pressure (BP). Stroke is also related to nervous system activity, which is represented through the Heart Rate Variability (HRV). This study aims to determine the relationship between those biosignals and their effects on the physiology of ischemic stroke sufferers. The subjects were divided into two groups (20 strokes and 20 controls). BFV data is obtained in the Middle Cerebral Artery (MCA), BP is obtained through the arteries of the upper arms, and 3 leads electrocardiogram is placed in the chest. The results showed that there was a relationship between BP and BFV in the control group (p-value < 0.05; r = -0.574). This correlation was not found in the stroke group. The relationship between BP and HRV was only found in the stroke group, which was associated with high sympathetic activity and lower parasympathetic activity (p-values < 0.05 and r > 0.4). It was based on SDRR, RMSSD, CVRR, LF, and SD1 parameters. In the control group, there was no relationship between HRV and BP. The relationship between BFV and HRV in the control group was not found statistically. Still, in the stroke group, this relationship was found in the LF and LF/HF Ratio parameters (p-value < 0.05; r > 0.4). Based on this research, parameters on HRV that can be used to determine the characteristics of stroke patients in all positions are MeanRR, VLF, and LF

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Pengaruh Senam Stroke Terhadap Kualitas Tidur Pada Penderita Hipertensi

Jurnal Ilmiah Kesehatan ◽

10.48144/jiks.v14i1.528 ◽

2021 ◽

Vol 14 (1) ◽

pp. 24

Author(s):

Dewi Suryandari ◽

Irna Kartina

Keyword(s):

Research Method ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Quality Of Sleep ◽

Stroke Patients ◽

Physical Exercises ◽

Post Test ◽

The Brain

Abstrak. Stroke adalah cedera vaskuler pada otak atau adanya suatu cedera yang berat serta mendadak. Pencegahan adanya komplikasi lanjutan dari hipertensi yang mengarah pada stroke perlu dilakukan. Kesembuhan dan pencegahan pada pasien stroke dapat dilakukan melalui obat-obatan selama rumah sakit dan ditunjang dengan rehabilitasi atau latihan fisik. Salah satu latihan fisik adalah dengan melakukan senam. Senam stroke merupakan salah satu bentuk latihan fisioterapi yang disusun sedemikian rupa untuk dapat memberikan rangsangan kepada beberapa reseptor yang akan dibawa ke otak untuk diproses dan menghasilkan output berupa gerakan yang terkoordinasi. Metode penelitian ini adalah kuantitatif dengan Pre and Post Test Nonequivalent Control Group dengan sampel sebanyak 30 responden. Kualitas tidur telah diukur dengan PSQI. Hasil mean skor kualitas tidur pada kelompok intervensi sebesar 5.00 dan pada kelompok kontrol 8.71 dengan standar deviasi sebesar 1.309 pada kelompok intervensi dan 2.199 pada kelompok kontrol. Kesimpulan dari penelitian ini adalah senam stroke memiliki pengaruh yang signifikan p value < 0.00. terhadap kualitas tidur pada pasien dengan hipertensi. Kata kunci: senam stoke, hipertensi, kualitas tidur The Effect of Stroke gymnastics toward Quality of Sleep in Patients with Hypertension Abstract. Stroke is a vascular injury that can happen in the brain suddenly or immediately after ther accumulation of tension or obstruction, it is also incleded as severe injury. One condition can lead stroke attack is hypertension, regarding this complication, prevention of further complication needs to be prepared. Healing and prevention in stroke patients can be done through drugs during the hospital and supported by rehabilitation or physical exercise. One of physical exercises is to do gymnastics. Stroke gyme is a kind of physiotherapy exercises that arranged in such a way as to be able to provide stimulation to several receptors that will be brought to the brain to be processed and produce output in the form of coordinated movements. This research method was quantitative with Pre and Post-Test Nonequivalent Control Group with sample 30 respondents, quality of sleep was measured by PSQI, Results showed that mean of PSQI score in the intervention group was 5.00 and in the control group 8.71 with a standard deviation of 1.309 in the intervention group and 2,199 in the control group. Conclusion of this study is Stroke gymnastics significantly(p value <0.00) effected the quality of sleep in patients with hypertension . Keywords: stroke exercise, hypertension, sleep quality

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The Effect Of Combination Spherical Grip And Kinesio Taping Exercise To Enhance Of Muscle Strength In Ischemic Stroke Patients In Jemursari Islamic Hospital Surabaya

Jurnal Ners dan Kebidanan Indonesia ◽

10.21927/jnki.2018.6(2).29-39 ◽

2019 ◽

Vol 6 (2) ◽

pp. 29

Author(s):

Qori Mariyanto ◽

Handa Yani ◽

Wesiana Herisanti

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Ischemic Stroke ◽

Muscle Strength ◽

Intervention Group ◽

Rank Test ◽

Control Group ◽

Stroke Patients ◽

Control Group Design ◽

Signed Rank Test

Ischemic stroke patients are the main problem that occurs when disruption of cerebral blood flow. Data Global Burden Disease shows that all populations obtained 80% ischemic stroke and 20% hemorrhagic stroke with physical mobility barriers namely muscle weakness obtained 58%. Nursing actions that can be done, one of which is by giving activity to stroke patients who are useful to increase cerebral blood flow. This study aims to analyze the effect of the combination of spherical grip exercise and Kinesiotaping to the muscle strength of ischemic stroke patients in Jemursari Islamic Hospital Surabaya.This research is designed by Quasi Experiment with approach pre post test control group design. All populations are ischemic stroke patients in the azzahra room 1 as many as 41 people, a sample of 38 respondents divided into 19 treatment and control groups. In the intervention group was given a combination of Spherical Grip and Kinesiotaping Exercise for 20 minutes twice a day for 3 weeks. Whereas in the control group was given training accordance with Hospital procedures. Statistical analysis used Wilcoxon signed rank test and Mann-Whitneyα test< 0,05.The results of this study indicated that the mean increase in muscle constriction in the intervention group 2.83, and a big control group is 1.10. Analysis with Mann Whitney showed p= 0.000. So that H0 rejected this means that there is an effect of a combination of Spherical Grip and Kinesiotaping exercises on increasing muscle strength in ischemic stroke patients in Jemursari Islamic hospitals.The combination of Spherical Grip and Kinesiotaping exercises that are routinely performed can increase muscle strength, resulting in increased muscle strength in ischemic stroke patients. Nurses need to apply Spherical Grips and Kinesiotaping to ischemic stroke patients in the rehabilitation phase. Keyword : Ischemic stroke, Spherical Grip and Kinesiotaping, Muscle Strength.

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The effectiveness of discharge planning and range of motion (ROM) training in increasing muscle strength of nonhemorrhagic stroke patients

GHMJ (Global Health Management Journal) ◽

10.35898/ghmj-23271 ◽

2018 ◽

Vol 2 (3) ◽

pp. 57

Author(s):

Mohamat Iskandar

Keyword(s):

Muscle Strength ◽

Range Of Motion ◽

Rating Scale ◽

Discharge Planning ◽

Intervention Group ◽

Sampling Technique ◽

Control Group ◽

Planning Program ◽

Stroke Patients ◽

Central Java

Background: Non-hemorrhagic stroke patients experience hemiparesis, an improper handling results in joint contractures. Discharge planning combined with a range of motion (ROM) training given to patients and their families are expected to improve muscle strength in patients after returning from the hospital. Aims: This study is to identify the effectiveness of discharge planning in increasing muscle strength. Methods: This is a quasi-experimental study with a pre-posttest design. A total of 34 respondents were selected by cluster random sampling technique, from RAA Soewondo Pati General Hospital of Pati, Central Java, Indonesia. The respondents were divided equally into two groups; an intervention group (N = 17) was given a discharge planning program together with stroke information and range of motion (ROM) training while the control group (N = 17) received a standard discharge planning available in the hospital. Further, Muscle Rating Scale (MRS) was employed to assess the muscle strength on the 2nd, 7th, and 14th day after discharge planning presented to the nonhemorrhagic stroke patients. Results: This present study clearly acknowledges the standard discharge planning program available in the hospital improve the muscle strength of the upper and lower extremity in the nonhemorrhagic stroke patients just 2nd day after the care (pretest), and the significant improvement was observed until the day 14. Moreover, combining the care with ROM training at the intervention group faster the recovery and the muscle strength improved significantly at the 7th day and continue increase at the day 14. Looking to the muscle strength since the 2nd day to the day 14, respectively the muscle strength of upper and lower limb at the control group improved at the point of 0.588 and 0.882, while at the group received the ROM training reached the value of 1.472 and 1.412. Conclusions: The ROM training combined to the current discharge planning program will faster the muscle strength recovery of the nonhemorrhagic stroke patients. This research provide insight how family plays important role to the success in monitoring the rehabilitation and recovery progress.

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