scholarly journals Effect of rosella-based kombucha tea on the lipid profile on hyperlipidemic rats (Rattus norvegicus)

2018 ◽  
Vol 1 (2) ◽  
pp. 42 ◽  
Author(s):  
Ahmad Edi Darmawan ◽  
Sunarno Sunarno ◽  
Vinsensius M Dhani ◽  
Garin F Fairuzzaki
Keyword(s):  
Lipid Profile ◽  
Rattus Norvegicus ◽  
Low Density Lipoprotein ◽  
White Male ◽  
Density Lipoprotein ◽  
Male Rats ◽  
White Rats ◽  
Randomized Design ◽  
Kombucha Tea ◽  
Food And Drink

The purpose of this study was to determine the lipid profile of white rats (Rattus norvegicus) with high-fat feed after fermentation of rosella kombucha with various concentrations. This study used 20 white male rats (Rattus norvegicus) aged two months, with rosella kombucha treatment fermented for five days at 25oC per oral. This study used Completely Randomized Design with four treatments (for 21 days) and four replications, namely: P0 = Control, rats were only given food and drink as usual (with the same type of rat feed). P1 = 1 ml of pork oil/day for 14 days + 1.8 ml of rosella kombucha 50% in the morning and evening for seven days. P2 = 1 ml of pork oil/day for 14 days + 1.8 ml of 75% rosella kombucha morning and afternoon for seven days. P3 = 1 ml of pork oil/day for 14 days + 1.8 ml of 100% kombucha rosella morning and afternoon for seven days. The variables measured were levels of LDL (Low-Density Lipoprotein) and HDL (High-Density Lipoprotein). The data obtained were analyzed using ANOVA followed by Duncan Test with 95% confidence level using SPSS 16.0 software. The results showed that administration of rosella kombucha did not have a significant effect on LDL and HDL levels of white rats (Rattus norvegicus). Based on the results of the study, it can be concluded that the 5-day fermentation of kombucha rosella with various concentrations did not affect LDL and HDL levels. 

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

scholarly journals Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Tengku Anggun Lestari ◽  
Nour Athiroh ◽  
Nurul Jadid Mubarakati
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Toxicity Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
One Way Anova

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus

scholarly journals Evaluation of the hypolipidemic effect of Gangaria de flush herbal mixture in streptozotocin-induced diabetic male rats

2021 ◽  
Vol 11 (3) ◽  
pp. 066-071
Author(s):  
Babafemi Tosin Ogunbiyi ◽  
Gogonte Hezekiah Amah ◽  
Laide Omoyiola Olajide ◽  
Olubunmi Esther Ogunbiyi ◽  
Oluwafunmilola Christiana Adetunji ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Herbal Mixture ◽  
Chronic Hyperglycemia

Diabetes mellitus is a complex multifarious metabolic disorder characterized by chronic hyperglycemia that requires non-stop treatment with multiple factors that will reduce the risk of long-term complications and drug side effects. Streptozotocin is well known for its selective pancreatic islet β-cell cytotoxicity used to induce diabetes mellitus in animals. It also interferes with cellular metabolic oxidative mechanisms. Phytomedicine has been in existence since the primitive age and has proven to be effective in treating this condition. This study was aimed at evaluating the effect of Gangaria de flush (Gdf) herbal mixture on lipid profile in streptozotocin (STZ) (60mg/kg) induced diabetic rat. The diabetic rats were treated with Gangaria de flush (0.3ml/kg body weight) and Glibenclamide (5mg/kg body weight) for 7days. The effects of both Gangaria de flush herbal mixture and glibenclamide were analyzed. Gangaria de flush showed a reduction in the lipid profile with a significant percentage reduction of 45.9% for the total cholesterol, 65.7% for the total triglyceride, 63.5% for the low-density lipoprotein, 65.8% for the very low-density lipoprotein as against the negative control and a 7.6% significant increase in the high density lipoprotein. Gangaria de flush showed a significant (p<0.05) positive effect on the lipid profile. Hence, it can be suggested that Gangaria de flush herbal mixture has a significant effect in maintaining the lipid level.

scholarly journals PENGARUH PEMBERIAN EKSTRAK ETANOL KEMBANG SEPATU (Hibiscus rosa-sinensis L.) TERHADAP JUMLAH SPERMATOZOA, BERAT BADAN, DAN BERAT TESTIS TIKUS JANTAN WISTAR (Rattus norvegicus)

2019 ◽  
Vol 19 (1) ◽  
pp. 6
Author(s):  
Nabila S Petta ◽  
Edwin De Queljoe ◽  
Rooije R.H. Rumende
Keyword(s):  
Body Weight ◽  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
The Body ◽  
Male Rats ◽  
White Rats ◽  
Hibiscus Rosa Sinensis ◽  
Randomized Design ◽  
Male Wistar Rats ◽  
Ethanol Extracts

PENGARUH PEMBERIAN EKSTRAK ETANOL KEMBANG SEPATU (Hibiscus rosa-sinensis L.) TERHADAP JUMLAH SPERMATOZOA, BERAT BADAN, DAN       BERAT TESTIS TIKUS JANTAN WISTAR (Rattus norvegicus)ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol kembang sepatu terhadap jumlah spermatozoa tikus jantan wistar (Rattus norvegicus). Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan menggunakan 24 ekor tikus putih jantan galur wistar (Rattus norvegicus) yang dibagi atas beberapa kelompok dimana kelompok 1 sebagai kelompok kontrol tanpa perlakuan, kelompok 2, 3 dan 4 sebagai kelompok perlakuan dengan dosis secara berturut-turut 3,6 mg/ml; 7,2 mg/ml; dan 14,4 mg/ml. Perlakuan diberikan secara oral sekali sehari sebanyak 1 ml selama 50 hari sesuai siklus spermatogenesis. Variabel yang diamati yakni jumlah sel spermatozoa, berat badan, dan berat testis. Hasil penelitian ini menunjukkan bahwa ekstrak etanol kembang sepatu dapat menurunkan jumlah sel spermatozoa, serta menyebabkan adanya perbedaan berat badan dan berat testis namun, berdasarkan hasil analisis varians, ekstrak etanol daun kembang sepatu tidak dapat menurunkan jumlah sel spermatozoa, berat badan dan berat testis tikus putih jantan galur wistar (Rattus norvegicus) secara signifikan.Kata Kunci: Sel spermatozoa, Kembang sepatu (Hibiscus rosa-sinensis L.),                    Tikus jantan Wistar (Rattus novergicus) THE INFLUENCE OF THE ETHANOL EXTRACTS  OF GRANTING HIBISCUS (Hibiscus Rosa-sinensis L.) AGAINST THE NUMBER OF SPERMATOZOA, WEIGHT AND THE WEIGHT OF THE TESTES MALE WISTAR RATS (Rattus norvegicus) ABSTRACTThis research’s objective is to know the influence of injecting ethanol extract from a hibiscus into a number of common male rats (Rattus norvegicus). This research uses the approach of complete randomized design (CRD) onto 24 common white rats (Rattus norvegicus) that is divided into groups, where group 1’s approach is control without treatment, groups 2, 3, and 4’s approach is with treatment, with consecutive doses being 3.6 mg/ml; 7.2 mg/ml; and 14.4 mg/ml.  The treatment is induced orally as large as 1cc per day for a total of 50 days following the spermatogenesis cycle. The variables that are being observed are the amount of spermatozoon cells, body weight, and testicle weight. The results of this research indicates that ethanol extract from hibiscuses, from a quantity perspective, can decrease spermatozoon cells, and it may also influence the body weight and testicle weight of the subject, in this case are common rats (Rattus norvegicus) but, from the mathematical results from Analysis Of Variance, ethanol extract from the leaves of a hibiscus cannot decrease the amount of spermatozoon, body weight, and testicle weight  of a common white rat (Rattus norvegicus).Keywords: Spermatozoon Cells, Hibiscus (Hibiscus rosa-sinensis L.), Common (white) rat (Rattus novergicus)

scholarly journals Influence of iodine on the indicators of lipid profile of rats’ blood of different age in experimental obesity

2018 ◽  
Author(s):  
N. H. Kopchak ◽  
О. S. Pokotylo ◽  
M. D. Kuhtyn ◽  
M. I. Koval
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
White Male ◽  
Density Lipoprotein ◽  
Biologically Active ◽  
Male Rats ◽  
Low Density ◽  
Inorganic Iodine

Introduction. Today, obesity is an extremely common phenomenon that negatively affects on the functional state of the organism, metabolism, and this in turn leads to the increase of a number of diseases. The thyroid gland has a significant effect on lipid metabolism, and especially negative in the case of iodine deficiency in the diet, which leads to hypothyroidism. Comparative study of the effect of various iodine-derived lipid metabolism in obesity is perspective.The aim of the study – to investigate the comparative affect of biologically active iodine in the composition of “Jodis-Concentrate” and inorganic iodine (J-C) as a part of “Iodomarine” on the indicators of lipid metabolism in blood of white male rats with experimental alimentary obesity.Research Methods. The object of the study was the blood serum of white rats, and the subject – separate indicators of lipid metabolism in it. The study was conducted on 48 white male rats. Animals were divided into 3 age groups of 16 animals in each: 1st group – 1.5 months; 2nd – 2.5 months; 3rd – 5th month. In each age group there were 4 subgroups of 4 animals: 1st – control, had a typical diet; 2nd, 3rd and 4th subgroup were with experimental alimentary obesity (EAO), which was formed through the inductor food craving – the sodium salt of glutamic acid in a ratio of 0.6 : 100.0 and high-calorie diet that included standard meals (47 %), sweet condensed milk (44 %), corn oil (8 %) and vegetable starch (1 %). Daily for 45 days, animals of the 3rd subgroup received biologically active iodine in the composition of “Jodis-Concentrate” (J-C) as of 0.1 ml (0.4 mcg of iodine) per kg of body weight a day and 4th subgroup were intragastric administered in the form of inorganic iodine as potassium iodide in medicine “Iodomarin” (IM) as of 0.4 mcg of potassium iodide per kg of body weight a day. In the serum blood, the content of total lipids, total cholesterol, triglycerides, high and low density lipoprotein were determined.Results and Discussion. The obtained results suggest that with the help of biologically active iodine in the composition of “Jodis-Concentrate” there was a significant decrease of the content of common lipids, triglycerides, total cholesterol, low density lipoprotein in blood serum of males with different age than with “Iodomarin”.Conclusions. Given the effective results of the study of the hypolipidemic effect of J-C it is advisable to use it as a preventive and therapeutic agent for reducing the content of common lipids of triglycerides, total cholesterol, and low density lipoproteins in the blood.

scholarly journals The effect of feeding fermented kombucha tea on HLD, LDL and total cholesterol levels in the duck bloods

2011 ◽  
Vol 27 (4) ◽  
pp. 1749-1755 ◽  
Author(s):  
L. Adriani ◽  
N. Mayasari ◽  
A Angga ◽  
R. Kartasudjana
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Animal Husbandry ◽  
Cholesterol Levels ◽  
Randomized Design ◽  
Kombucha Tea ◽  
Completely Randomized Design ◽  
Different Levels ◽  
Effect Of Feeding

Kombucha have high content of glucoronic acid, a substance that could neutralized cholesterol deposit, changed to another compound that more soluble in water. The experiment concerns the effects of supplementary fermented kombucha tea on HDL, LDL, and total cholesterol levels in the duck bloods. It was carried out at the Faculty of Animal Husbandry, Universitas Padjadjaran. The objective of this research was to determine the effect of giving different levels of fermented kombucha tea on High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and the total cholesterol levels of duck bloods. This research used an experimental methods with completely randomized design (CRD). There were five treatments (P0 = 0%, P1 = 10%, P2 = 15%, P3 = 20%, and P4 = 25%) and four replications. Results indicated that all treatment decreased significantly LDL and total cholesterol levels, and increased HDL. The conclusion is, the addition of fermented kombucha tea up to 25% will decrease LDL and total cholesterol, and increase HDL in the duct blood.

scholarly journals Effect of Phyllanthus niruri Extract on Low Density Lipoprotein of Dyslipidemic White Rats (Rattus norvegicus)

2019 ◽  
Vol 05 (02) ◽  
Author(s):  
Anastasia Feliciana ◽  
Andre Stefanus ◽  
Felix Evanda ◽  
Yosua Anthony P ◽  
Iin Suryanti ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Phyllanthus Niruri ◽  
White Rats

scholarly journals PREPARATION OF SALVIA OFFICINALIS L. EXTRACT AND STUDY OF ITS EFFECT ON SOME PHYSIOLOGICAL VARIABLES IN ALBINO RATS

2021 ◽  
Vol 12 (01) ◽  
Author(s):  
Wijdan I.A. Abd- Alwahab ◽  
Wijdan I.A. Abd- Alwahab ◽  
Wijdan I.A. Abd- Alwahab
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Salvia Officinalis ◽  
Male Rats ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Low Density ◽  
Physiological Variables ◽  
White Rats ◽  
Salvia Officinalis L

Salvia officinalis is one of the most valued herbs because of its high amount of essential oil and its many components. It has many health-related uses such as improving cognition, as well as reducing the amount of nursing mother's milk during weaning, also recommended for the gargling of the infectious throat, and to treat cardiovascular diseases and nervous disturbance, depression, cerebral ischemia and acts as an antiseptic for wounds. This study aim was to prepare the plant extract of Salvia officinalis L. from the Iraq local areas, determine its chemical properties and study its effect on some physiological and immunological variables in white rats. The plant leave Extract was Prepared and its effects were assessed on several physiological parameters using 20 male rats. The rats were divided into four groups. the control group(G1) received standard food and water; the negative control group (G2) received fat rich diet; G3 rats were given Salvia officinalis with a concentration of 100 mg\ kg\day. G4: rats were given Salvia officinalis 100mg/kg body weight and received fat rich diet. Roche/Hitachi, cobas c 501/502 were used to evaluate the levels of aminotransferase Enzymes, Aspartate transaminase (AST), Alanine aminotransferase (ALT), alkaline phosphatase enzyme (ALP), serum creatinine, serum urea, total protein, albumin, cholesterol, triglyceride, and high-density lipoprotein (HDL). While Globulin concentration, very Low-Density Lipoprotein (VLDL), and Low-Density Lipoprotein (LDL) were calculated according to some referred equations. The phytochemical analysis showed that the compounds identified in the sample were found to be alkaloids, phenols, tannins, coumarins glycosides, flavonoids, quinines, Carbohydrates and steroids. The results showed a significant increase (P <0.01) in the level of liver enzymes ALT, AST and ALP, in the G2 treated with the high fat diet compared with a control group and showed a significant increase (P <0.01) in the level of urea an

scholarly journals EFFECT OF NIFEDIPINE ON APOPTOSIS, NECROSIS AND VIABILITY OF GERMINAL EPITHELIAL CELLS IN THE CONTRALATERAL TESTICLE AND PLASMA TESTOSTERONE LEVELS IN MALE WHITE RATS (RATTUS NORVEGICUS, WISTAR STRAIN) AFTER UNILATERAL TESTICULAR TORSION

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Hajid Rahmadianto Mardihusodo ◽  
Fikri Rizaldi ◽  
Lukman Hakim
Keyword(s):  
Epithelial Cells ◽  
Rattus Norvegicus ◽  
Testicular Torsion ◽  
White Male ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
White Rats ◽  
Wistar Strain

Objective: To compare the number of apoptosis, necrosis and viability of germinal epithelial cells in the contralateral testicle (CT) and plasma testosterone (PT) levels in white male rats which administered Nifedipine after unilateral testicular torsion (TT) compared with control group. Material & Methods: This research was an experimental study using male white rats (Rattus Norvegicus, Wistar strain) aged 10-12 weeks and body weight 150-200 gram. A total of 30 rats were then randomly divided into 5 groups (n=6) which were negative control group (KN), positive control group (KP1 and KP2) and Nifedipine-administered group (N1 and N2). Each group performed unilateral left side torsion of testicular of 1080o anticlockwise except the KN group. There was 4-hour ischemic duration in the KP1 and N1 groups while 10 hours in the KP2 and N2 groups. Administration of Nifedipine 30 minutes before detorsion by intraperitoneal injection dosed 100 μg/kgBW. All groups performed right orchidectomy and plasma blood sampling. Measurement of apoptosis, necrosis and viability of germinal epithelial cells in the CT using flowcytometry. Measurement of PT levels using Enzyme-Linked Immunosorbent Assay (ELISA). Results: The number of apoptosis, necrosis and viability of contralateral testicular germinal epithelial cells and PT levels in the KN group compared with KP1 and KP2 groups were significantly different (p<0.05). There was no significant discrepancy in apoptosis (p>0.05) in KP1 group compared with N1 group, as well as in KP2 group compared with N2 groups. The number of necrosis, viability of germinal epithelial cells in the CT and PT level in KP1 group in compared with N1 group, as well as in KP2 group in compared with N2 group were significantly different (p<0.05). Conclusion: Nifedipine administration prior to testicular detorsion can maintain cell viability and decrease the amount of necrotic germinal epithelial cells in the CT and prevent the decrease in PT levels after unilateral TT.

scholarly journals Effects of Sambiloto Ethanol Extract on Fatty Liver, SGOT/SGPT Levels and Lipid Profile of Wistar Strain White Rat (Rattus norvegicus) Exposed to High-Fat Diet

2018 ◽  
Vol 54 (2) ◽  
pp. 89
Author(s):  
FX Himawan Haryanto Jong ◽  
Ari Gunawan ◽  
Mochamad Wirono Aman Santoso ◽  
Susilowati Anjani ◽  
Ni Wayan Tirthaningsih ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Lipid Profile ◽  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Homogeneity Test ◽  
High Fat ◽  
White Rats ◽  
Wistar Strain

The aim of this study was to analyze the effects of ethanol extract of sambiloto (Andrographis paniculata) on fatty liver percentage, serum glutamic oxaloacetic transaminase (SGOT) level and lipid profile of wistar strain white rat exposed to high fat diet. The study used randomized post test only control group design. Total sample was 50 male wistar strain rats (Rattus norvegicus) divided randomly into 5 groups (randomization). The normality test used was Kolmogorov Smirnov test (a=0.05). The homogeneity test used was Levene test (a=0.05). The comparative test was done using Anova test (analysis of variance) (a=0.05) or Brown-Forsythe test (a=0.05). The correlation test was done using Pearson test (a=0.05). The administration of sambiloto ethanol extract with doses of 100, 200 and 400 milligrams (mg)/kilogram (kg) body weight (BW) decreased the percentage of fatty liver (r=-0.950), SGOT (r=-0.964)/SGPT (r=(R=-0.973)/LDL (low-density lipoprotein) (r=-0.960) and increased HDL (high-density lipoprotein) levels (r=-0.923)=0.956) in white rats exposed to a high-fat diet. In conclusion, increased dose of ethanol extract of sambiloto can decrease the percentage of fatty liver, SGOT/SGPT and total cholesterol/TG/LDL and increase HDL level of white rats exposed to high fat diet.

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