Analysis of One Model of the Immune System

2003 ◽  
Vol 8 (2) ◽  
pp. 55-63
Author(s):  
A. Kavaliauskas
Keyword(s):  
Immune System ◽  
Tumor Cells ◽  
Stationary Point ◽  
Software Package ◽  
Medical Intervention ◽  
Research Results ◽  
Two Parameters ◽  
The Relationship ◽  
Special Parameter

The article deals with development of a tumor in the cylindrical space. A model with two parameters – lymphocytes and tumor cells – described in [1] is taken as a base of the research. Some generalization of the model is done. The research, results of which are described in [2, 3], was continued. The relationship between the surface and volumetric tumor cells of classical forms is obtained. It turns out, that even in general case the trivial stationary point is of a saddle type.The article particularly deals with the development of a cylindrical tumor. It is considered, that lymphocytes and the medical intervention (chemotherapy or irradiation) keeps down the cell fission of the tumor. Some special parameter is introduced to indicate the influence of the medical cure. In respect of that parameter the bifurcation values of the system are surveyed using the theory of [1, 4]. Some results of the survey are tested with the help of the software package MAPLE.

Academic motivation and professional skills development in the Specialty of Social Sciences and Tourism at a public university [Motivación académica y desarrollo de competencias profesionales en la Especialidad de Ciencias Sociales y Turismo de una universidad pública]

2019 ◽  
Vol 1 (2) ◽  
pp. 96
Author(s):  
Ana Cecilia De Paz Lazaro ◽  
Jessica Luz Palomino Collantes
Keyword(s):  
Social Sciences ◽  
Academic Motivation ◽  
Public University ◽  
Skills Development ◽  
Professional Skills ◽  
Research Results ◽  
Competencias Profesionales ◽  
High Level ◽  
The Relationship

The objective of the research is to determine the relationship between academic motivation and the professional skills development in the specialty of Social Sciences and Tourism. The study is quantitative and the design is non-experimental correlational translational. The results indicate that there is a high level relationship (0.914) between the independent academic motivation variable and the professional competences development in the Specialty of Social Sciences and Tourism. In conclusion, motivation is directly related to the professional skills development in the specialty of Social Sciences and Tourism. The research results conclude that there is a high relationship between the variables.

Influence of the Intestinal Microbiota on Diabetes Management

2020 ◽  
Vol 21 (15) ◽  
pp. 1603-1615
Author(s):  
Eva Alvarez-Vieites ◽  
Arora López-Santamarina ◽  
José M. Miranda ◽  
Alicia del Carmen Mondragón ◽  
Alexandre Lamas ◽  
...  
Keyword(s):  
Immune System ◽  
Intestinal Microbiota ◽  
Diabetes Management ◽  
Scientific Evidence ◽  
Focused Attention ◽  
Economic Implications ◽  
Experimental Animals ◽  
Low Intensity ◽  
New Treatments ◽  
The Relationship

In recent decades, there has been a very rapid increase in the prevalence of diabetes globally, with serious health and economic implications. Although today there are several therapeutic treatments for this disease, these do not address the causes of the disease and have serious side effects, so it is necessary to seek new treatments to replace or complement the existing ones. Among these complementary treatments, a strong link between the intestinal microbiota and diabetes has been demonstrated, which has focused attention on the use of biotherapy to regulate the function of the intestinal microbiota and, thus, treat diabetes. In this way, the main objective of this work is to provide a review of the latest scientific evidence on diabetes, gathering information about new trends in its management, and especially, the influence of the intestinal microbiota and microbiome on this pathology. It is possible to conclude that the relationship between the intestinal microbiota and diabetes is carried out through alterations in energy metabolism, the immune system, changes in intestinal permeability, and a state of low-intensity systemic inflammation. Although, currently, most of the experimental work, using probiotics for diabetes management, has been done on experimental animals, the results obtained are promising. Thus, the modification of the microbiota through biotherapy has shown to improve the symptoms and severity of diabetes through various mechanisms related to these alterations.

Exergy analysis of a turboprop engine at different flight altitude and speeds using novel consideration

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ali Dinc ◽  
Yousef Gharbia
Keyword(s):  
Fuel Consumption ◽  
Thermal Efficiency ◽  
Exergy Efficiency ◽  
Specific Fuel Consumption ◽  
Flight Altitude ◽  
Fuel Flow ◽  
Turboprop Engine ◽  
Shaft Power ◽  
Two Parameters ◽  
The Relationship

Abstract In this study, exergy efficiency calculations of a turboprop engine were performed together with main performance parameters such as shaft power, specific fuel consumption, fuel flow, thermal efficiency etc., for a range of flight altitude (0–14 km) and flight speeds (0–0.6 Mach). A novel exergy efficiency formula was derived in terms of specific fuel consumption and it is shown that these two parameters are inversely proportional to each other. Moreover, a novel exergy efficiency and thermal efficiency relation was also derived. The relationship showed that these two parameters are linearly proportional to each other. Exergy efficiency of the turboprop engine was found to be in the range of 23–33%. Thermal efficiency of the turboprop engine was found to be around 25–35%. Exergy efficiency is higher at higher speeds and altitude where the specific fuel consumption is lower. Conversely, exergy efficiency of the engine is lower for lower speeds and altitude where the specific fuel consumption is higher.

721 AT1412, a patient-derived CD9 antibody in preclinical development promoting tumor immune infiltration and inducing tumor rejection

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A763-A763
Author(s):  
Remko Schotte ◽  
Julien Villaudy ◽  
Martijn Kedde ◽  
Wouter Pos ◽  
Daniel Go ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
T Cell ◽  
Tumor Cells ◽  
Tumor Rejection ◽  
Human Immune System ◽  
Preclinical Development ◽  
High Affinity ◽  
Human Immune ◽  
A375 Melanoma

BackgroundAdaptive immunity to cancer cells forms a crucial part of cancer immunotherapy. Recently, the importance of tumor B-cell signatures were shown to correlate with melanoma survival. We investigated whether tumor-targeting antibodies could be isolated from a patient that cured (now 13 years tumor-free) metastatic melanoma following adoptive transfer of ex vivo expanded autologous T cells.MethodsPatient‘s peripheral blood B cells were isolated and tested for the presence of tumor-reactive B cells using AIMM’s immmortalisation technology. Antibody AT1412 was identified by virtue of its differential binding to melanoma cells as compared to healthy melanocytes. AT1412 binds the tetraspanin CD9, a broadly expressed protein involved in multiple cellular activities in cancer and induces ADCC and ADCP by effector cells.ResultsSpontaneous immune rejection of tumors was observed in human immune system (HIS) mouse models implanted with CD9 genetically-disrupted A375 melanoma (A375-CD9KO) tumor cells, while A375wt cells were not cleared. Most notably, no tumor rejection of A375-CD9KO tumors was observed in NSG mice, indicating that blockade of CD9 makes tumor cells susceptible to immune rejection.CD9 has been described to regulate integrin signaling, e.g. LFA-1, VLA-4, VCAM-1 and ICAM-1. AT1412 was shown to modulate CD9 function by enhancing adhesion and transmigration of T cells to endothelial (HUVEC) cells. AT1412 was most potently enhancing transendothelial T-cell migration, in contrast to a high affinity version of AT1412 or other high affinity anti-CD9 reference antibodies (e.g. ALB6). Enhanced immune cell infiltration is also observed in immunodeficient mice harbouring a human immune system (HIS). AT1412 strongly enhanced CD8 T-cell and macrophage infiltration resulting in tumor rejection (A375 melanoma). PD-1 checkpoint blockade is further sustaining this effect. In a second melanoma model carrying a PD-1 resistant and highly aggressive tumor (SK-MEL5) AT1412 together with nivolumab was inducing full tumor rejection, while either one of the antibodies alone did not.ConclusionsThe safety of AT1412 has been assessed in preclinical development and is well tolerated up to 10 mg/kg (highest dose tested) by non human primates. AT1412 demonstrated a half-life of 8.5 days, supporting 2–3 weekly administration in humans. Besides transient thrombocytopenia no other pathological deviations were observed. No effect on coagulation parameters, bruising or bleeding were observed macro- or microscopically. The thrombocytopenia is reversible, and its recovery accelerated in those animals developing anti-drug antibodies. First in Human clinical study is planned to start early 2021.Ethics ApprovalStudy protocols were approved by the Medical Ethical Committee of the Leiden University Medical Center (Leiden, Netherlands).ConsentBlood was obtained after written informed consent by the patient.

scholarly journals The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3596
Author(s):  
Reza Bayat Mokhtari ◽  
Manpreet Sambi ◽  
Bessi Qorri ◽  
Narges Baluch ◽  
Neda Ashayeri ◽  
...  
Keyword(s):  
Immune System ◽  
Cancer Immunotherapy ◽  
Tumor Cells ◽  
Tumor Antigens ◽  
Response Rates ◽  
Viral Proteins ◽  
Tumor Rejection ◽  
Therapeutic Approaches ◽  
Patient Response ◽  
Specific Antigens

Cancer immunotherapy harnesses the immune system by targeting tumor cells that express antigens recognized by immune system cells, thus leading to tumor rejection. These tumor-associated antigens include tumor-specific shared antigens, differentiation antigens, protein products of mutated genes and rearrangements unique to tumor cells, overexpressed tissue-specific antigens, and exogenous viral proteins. However, the development of effective therapeutic approaches has proven difficult, mainly because these tumor antigens are shielded, and cells primarily express self-derived antigens. Despite innovative and notable advances in immunotherapy, challenges associated with variable patient response rates and efficacy on select tumors minimize the overall effectiveness of immunotherapy. Variations observed in response rates to immunotherapy are due to multiple factors, including adaptative resistance, competency, and a diversity of individual immune systems, including cancer stem cells in the tumor microenvironment, composition of the gut microbiota, and broad limitations of current immunotherapeutic approaches. New approaches are positioned to improve the immune response and increase the efficacy of immunotherapies, highlighting the challenges that the current global COVID-19 pandemic places on the present state of immunotherapy.

scholarly journals Three-dimensional relationships between tumor cells and microcirculation with double cyanine immunolabeling, laser scanning confocal microscopy, and computer-assisted reconstruction: an alternative to cast corrosion preparations.

1994 ◽  
Vol 42 (5) ◽  
pp. 681-686 ◽  
Author(s):  
V Rummelt ◽  
L M Gardner ◽  
R Folberg ◽  
S Beck ◽  
B Knosp ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Blood Vessels ◽  
Tumor Cells ◽  
Laser Scanning ◽  
Three Dimensional ◽  
Melanoma Cells ◽  
Tumor Blood Vessels ◽  
The Relationship ◽  
Scanning Electron

The morphology of the microcirculation of uveal melanomas is a reliable market of tumor progression. Scanning electron microscopy of cast corrosion preparations can generate three-dimensional views of these vascular patterns, but this technique sacrifices the tumor parenchyma. Formalin-fixed wet tissue sections 100-150 microns thick from uveal melanomas were stained with the lectin Ulex europaeus agglutinin I (UEAI) and proliferating cell nuclear antigen (PCNA) to demonstrate simultaneously the tumor blood vessels and proliferating tumor cells. Indocarbocyanine (Cy3) was used as a fluorophore for UEAI and indodicarbocyanine (Cy5) was used for PCNA. Double labeled sections were examined with a laser scanning confocal microscope. Images of both stains were digitized at the same 5-microns intervals and each of the two images per interval was combined digitally to form one image. These combined images were visualized through voxel processing to study the relationship between melanoma cells expressing PCNA and various microcirculatory patterns. This technique produces images comparable to scanning electron microscopy of cast corrosion preparations while permitting simultaneous localization of melanoma cells expressing PCNA. The microcirculatory tree can be viewed from any perspective and the relationship between tumor cells and the tumor blood vessels can be studied concurrently in three dimensions. This technique is an alternative to cast corrosion preparations.

scholarly journals Psychoneuroimmunology: stress effects on pathogenesis and immunity during infection.

1994 ◽  
Vol 7 (2) ◽  
pp. 200-212 ◽  
Author(s):  
J F Sheridan ◽  
C Dobbs ◽  
D Brown ◽  
B Zwilling
Keyword(s):  
Infectious Disease ◽  
Immune System ◽  
Disease Susceptibility ◽  
Stress Effects ◽  
Response To Stress ◽  
Specific Receptors ◽  
Sympathetic Nervous ◽  
Effects Of Stress ◽  
The Relationship ◽  
Pituitary Adrenal Axis

The mammalian response to stress involves the release of soluble products from the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. Cells of the immune system respond to many of the hormones, neurotransmitters, and neuropeptides through specific receptors. The function of the immune system is critical in the mammalian response to infectious disease. A growing body of evidence identifies stress as a cofactor in infectious disease susceptibility and outcomes. It has been suggested that effects of stress on the immune system may mediate the relationship between stress and infectious disease. This article reviews recent psychoneuroimmunology literature exploring the effects of stress on the pathogenesis of, and immune response to, infectious disease in mammals.

Derivation Mathematical Equations for Future Calculation of Potential Evapotranspiration in Iraq, A Review of Application of Thornthwaite Evapotranspiration

2019 ◽  
Vol 60 (5) ◽  
pp. 1037-1048
Author(s):  
Hussein Ilaibi Zamil Al-Sudani
Keyword(s):  
Water Balance ◽  
Potential Evapotranspiration ◽  
Coefficient Of Determination ◽  
Research Review ◽  
Climate Conditions ◽  
Average Temperature ◽  
Mean Temperature ◽  
Mathematical Equations ◽  
Two Parameters ◽  
The Relationship

     In any natural area or water body, evapotranspiration is one of the important outcomes in the water balance equation. As a significant method and depending on monthly average temperature, estimating of potential Evapotranspiration depending on Thornthwaite method was adopted in this research review. Estimate and discuss evapotranspiration by using Thornthwaite method is the main objectives of this research review with considerable details as well as compute potential evapotranspiration based on climatologically data obtained in Iraq. Temperature - evapotranspiration relationship can be estimated between those two parameters to reduce cost and time and facilitate calculation of water balance in lakes, river, and hydrogeological basins. The relationship was obtained using Thornthwaite method in Iraq by dividing the area into seven sectors according to geographic latitude. Each sector has multi meteorological stations where thirty two stations were used with different periods of records. A mathematical relationship was obtained between mean temperature and corrected potential evapotranspiration with (97.45) to (99.84) coefficient of determination. The mean temperature has a decreasing pattern from southern east towards northern west of Iraq affected by Mediterranean Sea climate conditions, while corrected potential evapotranspiration has the opposite direction regarding increased value because of a direct relationship with temperature.

PRAGMATIC CHARACTERISTICS OF HUMOROUS APHORISMS IN THE CONTEXT OF LIFE SPACE

2020 ◽  
Vol 76 (4) ◽  
pp. 18-23
Author(s):  
LARISA V. Burmistrova ◽  
Keyword(s):  
Positive Attitude ◽  
Negative Attitude ◽  
The Internet ◽  
Study Guide ◽  
Life Space ◽  
Research Results ◽  
The Relationship

The analysis of pragmatic characteristics of humorous aphorisms in the context of life space. Author's humorous aphorisms of famous writers, poets, historians of the 17th, 18th, 19th centuries and modern humorous aphorisms posted on the Internet; collection of sayings, quotes and aphorisms “Big Book of Wisdom” (edited by Yuri Lavrov). The relevance of the research is determined by the interest in comic universal expressions, network discourse, comical texts. The research results are applicable when compiling a study guide for students or can be used to compile a psychological portrait of the hero of the work. The aim of the present study is to investigate the pragmatic characteristics of humorous aphorisms. It is analyzed that humorous aphorisms of famous writers, poets, historians of the 17th, 18th, 19th centuries and modern humorous aphorisms affect the main aspects of life. Pragmatic characteristics of humorous aphorisms are analyzed. It was found that the humorous aphorisms most vividly reflect the relationship and love between a man and a woman, the intellect of a woman and a man, care of women, the image of a strong, ambitious man, relationships in marriage, feelings (love and happiness), positive attitude (purposefulness, necessity of education), negative attitude (duplicity, laziness, stupidity, slight knowledge, exaggeration of material value), the contrary opinion of an optimist and a pessimist.

Research on the Attenuation Law of Stress Wave Propagation in Concrete Media

2013 ◽  
Vol 671-674 ◽  
pp. 758-767
Author(s):  
Wei Sun ◽  
Shi Yan ◽  
Shao Fei Jiang
Keyword(s):  
Wave Propagation ◽  
Attenuation Coefficient ◽  
Polynomial Function ◽  
Piezoelectric Ceramics ◽  
Stress Waves ◽  
Stress Wave Propagation ◽  
Research Results ◽  
Cubic Polynomial ◽  
The Relationship ◽  
Main Factor

This paper presents an experimental method to investigate the attenuation performance of stress waves in concrete structures embedded in piezoelectric ceramics. To get the research objective, a series of test were hold. The relationship curve between the frequency and the attenuation coefficient was fit. The calculation method for propagation distances of stress waves with constant amplitudes and frequencies in the concrete medium was proposed. The research results show that the relationship curve of attenuation coefficient and frequency conform to the cubic polynomial function approximately. The attenuation performance for the concrete structure embedded into piezoelectric ceramics is relevant to the frequency, the amplitude and the medium character, and the frequency is the main factor. The research results of this paper can provide an effective evidence for correctly placing transducers.

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