Development and implementation in medical practice of new information technologies and metrics for the analysis of subtle changes in the electromagnetic field of the human heart

The article details the concept of clinical information technology (IT), i.e. a set of methods and software and hardware combined into a technological chain, the product of which is an automated diagnostic report, prognostic report or recommendation on patient management tactics. There are several examples of innovative information technologies and metrics implemented by the authors in Ukraine and abroad, designed to register and evaluate subtle changes in the electromagnetic field of the heart for early diagnosis of the most common and dangerous heart diseases, especially coronary heart disease. It is shown that new metrics of analysis of spatial structure of 2D and 3D magnetocardiographic maps of current density distribution allow to diagnose with high accuracy various forms of myocardial ischemia. The new method of the electrocardiogram scaling is used in various areas of clinical medicine, sports medicine, occupational medicine, as well as in large-scale population studies.

Download Full-text

Automatic Method for Processing Mass Data in Clinical Medicine (FOSDIC)

Methods of Information in Medicine ◽

10.1055/s-0038-1636213 ◽

1963 ◽

Vol 2 (04) ◽

pp. 125-129 ◽

Cited By ~ 1

Author(s):

M. Volk ◽

M. L. Greenough ◽

H. V. Pipberger ◽

J. Cosma

Keyword(s):

Magnetic Tape ◽

Large Scale ◽

Clinical Medicine ◽

Clinical Information ◽

National Bureau ◽

Automatic Data ◽

Program Unit ◽

Computer Input ◽

Investigative Medicine ◽

Processing Techniques

1. The need for automatic data processing techniques in investigative medicine is briefly-stated and stresse’d.2. Among the more widely used methods for collection, storage and analysis of large scale data, the punch cards, although suitable for direct computer input, leave a limited input speed.3. A new system developed jointly by the Bureau of the Census and the National Bureau of Standards, called FOSDIC is described.4. FOSDIC is basically an analog scanner actuated by a digital computer. It automatically reads, recodes and transcribes the information on magnetic tape in binary language.5. FOSDIC. consists of four parts: a scanning unit, a program unit, a tape unit and a console.6. Printed documents of suitable size and format are used for data collection; they are microfilmed” and the information contained therein is automatically scanned and recorded on digital magnetic tape, suitable for direct input to a digital electronic computer.7. Some of the advantages offered by this system are stressed: they are speed and versatility in the scanning and transcribing process, flexibility in the size and format of the printed document and space saving in the storage of microfilmed documents.8. FOSDIC system is being used in several research projects in progress; in one project reduction of clinical information is the aim, in other ones correlation between analog records such as the electrocardiogram with clinical information is pursued. Since the clinical information is collected from more than one hospital, uniformity in the collected documents is an important factor.

Download Full-text

Preface to Special Issue on Large-scale Numerical Computing Technology for Electromagnetic Field Analysis

IEEJ Transactions on Power and Energy ◽

10.1541/ieejpes.139.636 ◽

2019 ◽

Vol 139 (11) ◽

pp. 636-636

Author(s):

Fumiaki Ikeda ◽

Daigo Yonetsu ◽

Takeshi Mifune ◽

Kengo Sugahara

Keyword(s):

Electromagnetic Field ◽

Large Scale ◽

Field Analysis ◽

Special Issue ◽

Computing Technology ◽

Numerical Computing

Download Full-text

Implementing an Integrated Large-Scale Clinical Information System for ISSSTE’s Hospital Network in Mexico

SN Comprehensive Clinical Medicine ◽

10.1007/s42399-020-00713-2 ◽

2021 ◽

Vol 3 (2) ◽

pp. 444-453

Author(s):

Arturo Cervantes Trejo ◽

Sophie Domenge Treuille ◽

Isaac Castañeda Alcántara

Keyword(s):

Health Care ◽

Information System ◽

Health Care Services ◽

Large Scale ◽

Clinical Information System ◽

Clinical Information ◽

Public Hospitals ◽

Care Services ◽

Cost Reductions

AbstractThe Institute for Security and Social Services for State Workers (ISSSTE) is a large public provider of health care services that serve around 13.2 million Mexican government workers and their families. To attain process efficiencies, cost reductions, and improvement of the quality of diagnostic and imaging services, ISSSTE was set out in 2019 to create a digital filmless medical image and report management system. A large-scale clinical information system (CIS), including radiology information system (RIS), picture archiving and communication system (PACS), and clinical data warehouse (CDW) components, was implemented at ISSSTE’s network of forty secondary- and tertiary-level public hospitals, applying global HL-7 and Digital Imaging and Communications in Medicine (DICOM) standards. In just 5 months, 40 hospitals had their endoscopy, radiology, and pathology services functionally interconnected within a national CIS and RIS/PACS on secure private local area networks (LANs) and a secure national wide area network (WAN). More than 2 million yearly studies and reports are now in digital form in a CDW, securely stored and always available. Benefits include increased productivity, reduced turnaround times, reduced need for duplicate exams, and reduced costs. Functional IT solutions allow ISSSTE hospitals to leave behind the use of radiographic film and printed medical reports with important cost reductions, as well as social and environmental impacts, leading to direct improvement in the quality of health care services rendered.

Download Full-text

Thyroidectomy for thyroid cancer via transareola single-site endoscopic approach: results of a case-match study with large-scale population

Surgical Endoscopy ◽

10.1007/s00464-021-08424-y ◽

2021 ◽

Author(s):

Juyong Liang ◽

Ling Zhan ◽

Ming Xuan ◽

Qiwu Zhao ◽

Lingxie Chen ◽

...

Keyword(s):

Thyroid Cancer ◽

Large Scale ◽

Endoscopic Approach ◽

Single Site ◽

Scale Population

Download Full-text

Publisher Correction: A link between appendectomy and gastrointestinal cancers: a large-scale population-based cohort study in Korea

Scientific Reports ◽

10.1038/s41598-021-85952-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Youn Young Park ◽

Kil‑yong Lee ◽

Seong Taek Oh ◽

Sang Hyun Park ◽

Kyung Do Han ◽

...

Keyword(s):

Cohort Study ◽

Large Scale ◽

Population Based ◽

Gastrointestinal Cancers ◽

Scale Population

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Download Full-text

Progressive alteration of DNA methylation of Alu, MGMT, MINT2, and TFPI2 genes in colonic mucosa during colorectal cancer development

Cancer Biomarkers ◽

10.3233/cbm-203259 ◽

2021 ◽

pp. 1-6

Author(s):

Ben Kang ◽

Hyun Seok Lee ◽

Seong Woo Jeon ◽

Soo Yeun Park ◽

Gyu Seog Choi ◽

...

Keyword(s):

Colorectal Cancer ◽

Dna Methylation ◽

Healthy Subjects ◽

Large Scale ◽

Methylation Status ◽

Clinical Information ◽

Field Cancerization ◽

Aberrant Methylation ◽

Clinical Value ◽

Mortality And Morbidity

BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is characterized by different pathways of carcinogenesis and is a heterogeneous disease with diverse molecular landscapes that reflect histopathological and clinical information. Changes in the DNA methylation status of colon epithelial cells have been identified as critical components in CRC development and appear to be emerging biomarkers for the early detection and prognosis of CRC. OBJECTIVE: To explore the underlying disease mechanisms and identify more effective biomarkers of CRC. METHODS: We compared the levels and frequencies of DNA methylation in 11 genes (Alu, APC, DAPK, MGMT, MLH1, MINT1, MINT2, MINT3, p16, RGS6, and TFPI2) in colorectal cancer and its precursor adenomatous polyp with normal tissue of healthy subjects using pyrosequencing and then evaluated the clinical value of these genes. RESULTS: Aberrant methylation of Alu, MGMT, MINT2, and TFPI2 genes was progressively accumulated during the normal-adenoma-carcinoma progression. Additionally, CGI methylation occurred either as an adenoma-associated event for APC, MLH1, MINT1, MINT31, p16, and RGS6 or a tumor-associated event for DAPK. Moreover, relatively high levels and frequencies of DAPK, MGMT, and TFPI2 methylation were detected in the peritumoral nonmalignant mucosa of cancer patients in a field-cancerization manner, as compared to normal mucosa from healthy subjects. CONCLUSION: This study identified several biomarkers associated with the initiation and progression of CRC. As novel findings, they may have important clinical implications for CRC diagnostic and prognostic applications. Further large-scale studies are needed to confirm these findings.

Download Full-text

Using Bus Ticketing Big Data to Investigate the Behaviors of the Population Flow of Chinese Suburban Residents in the Post-COVID-19 Phase

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18116066 ◽

2021 ◽

Vol 18 (11) ◽

pp. 6066

Author(s):

Yanbing Bai ◽

Lu Sun ◽

Haoyu Liu ◽

Chao Xie

Keyword(s):

Travel Behavior ◽

Large Scale ◽

Behavior Patterns ◽

Population Movements ◽

Economic Level ◽

Passenger Travel ◽

Scale Population ◽

Travel Behaviors ◽

Railway Passenger ◽

And Control

Large-scale population movements can turn local diseases into widespread epidemics. Grasping the characteristic of the population flow in the context of the COVID-19 is of great significance for providing information to epidemiology and formulating scientific and reasonable prevention and control policies. Especially in the post-COVID-19 phase, it is essential to maintain the achievement of the fight against the epidemic. Previous research focuses on flight and railway passenger travel behavior and patterns, but China also has numerous suburban residents with a not-high economic level; investigating their travel behaviors is significant for national stability. However, estimating the impacts of the COVID-19 for suburban residents’ travel behaviors remains challenging because of lacking apposite data. Here we submit bus ticketing data including approximately 26,000,000 records from April 2020–August 2020 for 2705 stations. Our results indicate that Suburban residents in Chinese Southern regions are more likely to travel by bus, and travel frequency is higher. Associated with the economic level, we find that residents in the economically developed region more likely to travel or carry out various social activities. Considering from the perspective of the traveling crowd, we find that men and young people are easier to travel by bus; however, they are exactly the main workforce. The indication of our findings is that suburban residents’ travel behavior is affected profoundly by economy and consistent with the inherent behavior patterns before the COVID-19 outbreak. We use typical regions as verification and it is indeed the case.

Download Full-text

Maternal adherence to micronutrient supplementation before and during pregnancy in Northwest China: a large-scale population-based cross-sectional survey

BMJ Open ◽

10.1136/bmjopen-2018-028843 ◽

2019 ◽

Vol 9 (8) ◽

pp. e028843 ◽

Cited By ~ 6

Author(s):

Danmeng Liu ◽

Yue Cheng ◽

Shaonong Dang ◽

Duolao Wang ◽

Yaling Zhao ◽

...

Keyword(s):

Pregnant Women ◽

Large Scale ◽

Northwest China ◽

Population Based ◽

Shaanxi Province ◽

Micronutrient Supplementation ◽

Cross Sectional Survey ◽

Start Time ◽

Cross Sectional ◽

Scale Population

ObjectivesTo report the situation of maternal micronutrient supplementation before and during pregnancy in Northwest China and to examine the rates of and factors related to the adherence to micronutrient supplementation among pregnant women in this region, where dietary micronutrient intake is commonly insufficient.DesignA large-scale population-based cross-sectional survey.SettingTwenty counties and ten districts of Shaanxi Province.ParticipantsA sample of 30 027 women were selected using a stratified multistage random sampling method. A total of 28 678 women were chosen for the final analysis after excluding those who did not provide clear information about nutritional supplementation before and during pregnancy.Main outcome measuresMaternal adherence to micronutrient supplementation (high and low) were the outcomes. They were determined by the start time and duration of use according to Chinese guidelines (for folic acid (FA) supplements) and WHO recommendations (for iron, calcium and multiple-micronutrient (MMN) supplements).ResultsIn total, 83.9% of women took at least one kind of micronutrient supplement before or during pregnancy. FA (67.6%) and calcium (57.5%) were the primarily used micronutrient supplements; few participants used MMN (14.0%) or iron (5.4%). Adherence to supplementation of all micronutrients was low (7.4% for FA, 0.6% for iron, 11.7% for calcium and 2.7% for MMN). Higher educational levels, higher income levels, urban residence and better antenatal care (including pregnancy consultation and a higher frequency of antenatal visits) were associated with high adherence to micronutrient supplementation.ConclusionMaternal micronutrient supplementation before and during pregnancy in Northwest China was way below standards recommended by the Chinese guidelines or WHO. Targeted health education and future nutritional guidelines are suggested to improve this situation, especially in pregnant women with disadvantaged sociodemographic conditions.

Download Full-text