scholarly journals Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings

2020 ◽  
Vol 12 (3) ◽  
pp. 234-240
Author(s):  
I. Valchev ◽  
К. Stojanchev ◽  
N. Nicolov ◽  
R. Binev
Keyword(s):  
Aflatoxin B1 ◽  
Total Protein ◽  
Blood Chemistry ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Group Iii ◽  
Group I ◽  
Hepatotoxic Effect ◽  
Group 2 ◽  
Glutamyl Transferase

Abstarct. The aim of the present investigation was to evaluate the effects of aflatoxin B1 and Mycotox NG applied either independently or together, on blood total protein, albumin, blood glucose, total bilirubin, triglycerides, cholesterol, enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), gamma-glutamyl transferase (γ GT), lactate dehydrogenase (LDH) and changes in liver morphology. At the same time, the potential of supplementation of feed with a mycosorbent (Mycotox NG) was evaluated. Experiments were carried out with 40 1-day-old Toulouse geese from mixed sexes divided into one control and three treatment groups (n=10). Groups were as followed: Group I – control (0 mg/kg AFB1 not supplemented with Mycotox NG); Group II (0.5 g/kg Mycotox NG), Group III (0.5 mg/kg AFB1) and Group IV (0.5 mg/kg AFB1 and 0.5 g/kg Mycotox NG). In this study, commercially available geese of Toulouse strain were reared from day one to forty two days in the deep litter system of management and the birds were divided into four groups. Normal feed tested free of aflatoxin (AFB1), was given to the control (Group – 1). 0.5 g/kg Mycotox was supplemented with the feed to Group 2, Aflatoxin (0.5 mg/kg feed) was supplemented with the feed to Group 3 and Mycotox Ng (0.5 g/kg feed) + 0.5 mg/kg feed AFB1 was supplemented with the feed to Group 4. The duration of the experiments was 42 days. The monitored blood chemical parameters were analysed on post treatment days 21 and 42. In birds treated only with AFB1, (group III) increased blood activities of studied enzymes. At the same time, blood total protein, albumin, cholesterol, glucose and triglycerides were reduced as compared to controls. The observed histopathological changes in the liver consisted in various extent of dystrophy (congestion, vacuolar and granular dystrophy, round cell proliferation, necrobiotic changes, hyperplasia of gallbladder epithelium). The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions. The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions.

scholarly journals PROTECTIVE ROLE AND ANTIOXIDANT ACTIVITY OF AQUEOUS EXTRACT OF ROSMARINUS OFFICINALIS AGAINST TRICHLOROACETATE-INDUCED TOXICITY IN LIVER OF MALE RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 420
Author(s):  
Medhat Mostafa Abozid ◽  
Hoda Ea Farid
Keyword(s):  
Aqueous Extract ◽  
Liver Damage ◽  
Protective Role ◽  
Rosmarinus Officinalis ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Group I ◽  
Glutamyl Transferase

 Objective: The current study was designed to estimate the potential protective role of the aqueous extract of rosemary (AER) (Rosmarinus officinalis) against trichloroacetic acid (TCA)-created hepatotoxicity in male albino rats.Methods: Forty male albino rats were separated into four groups of ten: Group I served as control; Group II was given AER (200 mg/kg/day) by gavage; Group III received TCA at the dose 50 mg/kg/day, and Group V was treated with AER (200 mg/kg/day) and received TCA (50 mg/kg/day). The experiment was carried out for 2 months.Results: The toxicity of TCA for rats was revealed by an elevation in liver marker enzymes activities (gamma-glutamyl transferase [GGT], alkaline phosphatase [ALP], aspartate transaminase [AST], alanine aminotransferase [ALT]) and conjugated bilirubin (CB) level, and a decrease in albumin and total protein (TP) levels. The TCA administration also caused a significant increase in the activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), and also malondialdehyde (MDA) level in liver tissues. These biochemical effects were accompanied by histological indicators of liver damage. Treatment with ARE recovered the liver damage instigated by TCA, as showed by perfection of liver enzyme markers (GGT, ALT, AST, ALP), CB, TP and albumin; as well as antioxidant parameters (CAT, SOD, GPx) and lipid peroxidation (MDA) and amelioration of histopathology changes in the liver tissues.Conclusion: It could be concluded that AER supplementation for 2 months in TCA-induced toxicity in rats benefited hepatic antioxidant status and improved liver injury and damage in male albino rats exposed to TCA.

scholarly journals A preoperatív antibiotikus és antiszeptikus kezelés hatása a műtéti úton eltávolított alsó bölcsességfogak sebgyógyulására – prospektív randomizált vizsgálat

2017 ◽  
Vol 158 (1) ◽  
pp. 13-19 ◽  
Author(s):  
István Kaposvári ◽  
Kinga Körmöczi ◽  
Zsuzsa Beáta László ◽  
Ferenc Oberna ◽  
Ferenc Horváth ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Third Molar ◽  
Control Group ◽  
Surgical Removal ◽  
Group Iii ◽  
Prophylactic Dose ◽  
Group I ◽  
Mandibular Third Molar ◽  
Amoxicillin Clavulanate ◽  
Group 2

Abstract: Introduction and aim: The study compares the antibiotic prophylaxis combined with postoperative antibiotic therapy to preoperative chlorhexidine rinse combined with postoperative antibiotic therapy in preventing complications after surgical removal of a mandibular third molar. Method: 71 healthy patients in four groups were enrolled in the study: I. prophylactic dose of 2000 mg of amoxicillin clavulanate, continued with amoxicillin clavulanate postoperatively; II. prophylactic dose of 600 mg of clindamycin, continued with clindamycin postoperatively; III. prophylactic chlorhexidin rinsing, continued randomized amoxicillin clavulanate or clindamycin postoperatively; IV. control, with clindamycin postoperatively. Results: The pain was smaller in the prophylaxis groups. Alveolitis occurred only in the control group: 2 patients. Wound opening occurred in 22,2 % in group IV., 14,2 % in group II, 10 % in group I., 5 % in group III. Conclusion: We consider completing the indicated postoperative antibiotic prescription with antibiotic or antiseptic prophylaxis. Chlorhexidin prophylaxis could have the same positive effect. Orv. Hetil., 2017, 158(1), 13–19.

Effects of MOF6 Fraction from Ethanolic Extract of the Leaves of Moringa oleifera against Sodium Arsenite-Induced Hepatotoxicity in Rats

2021 ◽  
Vol 36 (2) ◽  
pp. 73-80
Author(s):  
Mubarak Ameen ◽  
Adelaja Akinlolu ◽  
Mukadam Abdulhamid ◽  
Muheen Biliaminu ◽  
Olaolu Ajiboye ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Sodium Arsenite ◽  
Ethanolic Extract ◽  
Control Group ◽  
Mean Values ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Biochemical Analyses ◽  
Glutamyl Transferase

Moringa oleifera (MO) is a plant of significant medicinal importance. The dried leaves of MO were pulverized, extracted with ethanol and fractionated using column chromatography to provide seven fractions (MOF1-7) with MOF6 having the best preliminary antioxidant  potential. Therefore, this study evaluated the hepatoprotective potentials of MOF6 in sodium arsenite (SA)-induced hepatotoxicity in rats. Thirty-five adult male Wistar rats were randomly divided into seven groups of five rats each. Control Group I received normal saline. Groups II and III received 20 mg/kg body weight (bw) of SA for 3 and 6 weeks, respectively. Groups IV and V received 20 mg/kg bw of SA for 3 weeks followed by treatment with 5.0 and 7.5 mg/kg bw of fraction MOF6, respectively, for 6 weeks. Groups VI and VII received only  5.0 and 7.5 mg/kg bw of fraction MOF6, respectively, for 6 weeks. Antioxidant (lipid peroxidation) and biochemical analyses of liver  enzymes of all rats were carried out after the completion of experimental procedures. Results showed statistically significant lower mean values (p ≤ 0.05) of malondialdehyde (MDA), acid phosphatase (ACP) and γ-glutamyl transferase (GGT) in rats of Groups IV and V compared with Group III. However, there were statistically significant higher mean values (p ≤ 0.05) of alkaline phosphatase (ALP) in Groups IV and V compared with Groups I and III. In conclusion, these results implied that fraction MOF6 has antioxidant and  hepatoprotective potentials. However, results of ALP analyses implied that MOF6 possibly augmented SA-induced hepatotoxicity in rats.

scholarly journals ISONIAZID (INH)

2018 ◽  
Vol 25 (10) ◽  
pp. 1587-1595
Author(s):  
Umer Aleem ◽  
Rahman Shah ◽  
Noor Khan ◽  
M. Suliman
Keyword(s):  
Serum Bilirubin ◽  
Statistical Significance ◽  
Negative Control Group ◽  
Protective Role ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Group 2

Objectives: Hepatotoxicity is the most complicated side effect of isoniazid (inh)in the patient treated for tuberculosis. In causes 8–30% hepatotoxicity in the developing world.Metabolism of INH produces a metabolite, called acetyl isoniazid. In this study hepatoprotectiveeffect of honey, in isoniazid induced animal model was assessed. Study Design: Randomizedcontrol trial. Setting: Saidu Medical College, Saidu Sharif Swat, KP. Period: October ToDecember 2017. Material and Methods: 40 healthy male rabbits were assigned randomly tothe group i, ii, iii and iv by using lottery method. Ten animals were grouped each row. Theisoniazid-induced hepatotoxic model was created by giving 50 mg inh/kg orally on daily basisfor eleven days. Group i was taken as negative control group ii as a positive control. Group iii andiv were experimental groups treated with 50 mg /kg/day and 100 mg /kg/day buckwheat honeyrespectively for eleven days. SPSS Version 16 software was used, mean, s.d. were determinedin all the groups. Values of serum bilirubin, sgpt, and alkaline phosphatase were comparedwith each other using pairt-test. Results: SGPT, Serum bilirubin, and alkaline phosphatasewere obtained in all the animals. Comparing group 1 negative control with group 2, 3 and 4shows statistical significance, (p=0.00). Comparing group 2 positive control with 3 and 4 showsstatistical significance, (p=0.00). Further comparing group 3 with group 4 also shows statisticalsignificance (p=0.00). Conclusion: From the above finding, it has been revealed that honeyhas got a protective effect in regressing hepatitis that has been induced in rabbit’s model byhigh doses of isoniazid. Related studies performed in which different chemicals and drugs havebeen tried for their protective role in isoniazid induced hepatitis also shows a similar type ofresults.

scholarly journals Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice

2020 ◽  
Vol 80 (3) ◽  
pp. 484-496 ◽  
Author(s):  
S. Ali ◽  
M. Ejaz ◽  
K. K. Dar ◽  
S. Nasreen ◽  
N. Ashraf ◽  
...  
Keyword(s):  
Body Weight ◽  
Plant Extract ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Artemisia Vulgaris ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Glutamyl Transferase ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract The main objective of current study was to investigate the chemopreventive and chemotherapeutic activity of Artemisia vulgaris extract on diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice. Diethylnitrosoamine (DEN: 0.9%) was prepared to induce hepatocarcinoma in Balb C mice. The extract Artemisia vulgaris (AV) was prepared by maceration technique. Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), group 2 (N=14) received diethylnitrosoamine (3.5 μl/mg) intraperitoneally once in a week for eight consecutive weeks, group 3 (N=7) received only plant extract (AV: 150 mg/kg (Body weight) once in a week, while group 4 (N=7) was given in combination of diethylnitrosoamine (3.5 μl/mg) and plant extract (AV: 150 mg/kg (body weight). After eight weeks of DEN administration, mice of group 2 were divided into two subgroups containing seven mice each; subgroup 1 was sacrificed while subgroup 2 was treated with plant extract only (150 mg/kg (body weight)) once in a week for eight consecutive weeks. The DEN injected mice significant decline in levels of albumin with concomitant significant elevations such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alpha feto protein, gamma glutamyl transferase, 5 nucleotidase, glucose-6-phosphate dehydrogenase and bilirubin. The administration of A. vulgaris significantly decreased the DEN induced hepatotoxicity. Present study revealed the potential anti-cancerous nature of Artemisia vulgaris, both in case of chemopreventive and post-treatment of A. vulgaris. Further studies are needed to explore the mechanism of prevention and therapy.

scholarly journals Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachlorideinduced Hepatotoxicity in Rats

2018 ◽  
Vol 16 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Riaz Ullah ◽  
Mansour S. Alsaid ◽  
Abdelaaty A. Shahat ◽  
Almoqbil Abdulaziz Naser ◽  
Abdullah A. Al-Mishari ◽  
...  
Keyword(s):  
Liver Toxicity ◽  
Unmet Need ◽  
Serum Levels ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Methanolic Extracts ◽  
Group 5 ◽  
Group 2 ◽  
Glutamyl Transferase ◽  
Antioxidant Effects

AbstractThe detoxification, metabolism, and excretion of various endogenous and exogenous materials occur mainly in the liver. Liver diseases are a global concern, and classified as chronic hepatitis, cirrhosis, and hepatosis. The development of safe hepatoprotective agents remains an unmet need. Therefore, we investigated the antioxidant effects of methanolic and n-hexane fractions of Zilla spinosa (ZSM and ZSH, respectively) and Hammada elegans (HEM and HEH, respectively) against carbon tetrachloride (CCl4)-induced liver toxicity in rats. Antioxidant activity was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The rats were divided into 11 groups (n=6)–group, 1 (control), group 2 (CCl4 only), group 3 (CCl4+silymarin 10 mg/kg), group 4 (CCl4+HEM 250 mg/kg), group 5 (CC14+HEM 500 mg/kg), group 6 (CCl4+HEH 250 mg/kg), group, 7 (CCl4+HEH 500 mg/kg), group, 8 (CCl4+ZSM 250 mg/kg), group 9 (CCl4+ZSM 500 mg/kg), group 10 (CCl4+ZSH 250 mg/kg), and group 11 (CCl4+ZSH 500 mg/kg). Serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transferase, and total bilirubin were measured. The extent of hepatic injury was histopathologically assessed. Treatment with ZSM and ZSH at 250 and 500 mg/kg did not significantly affect biochemical results compared with the CCl4 only group. However, treatment with both HEM and HEH at 250 and 500 mg/kg provided significant (p<0.001) results compared with the CCl4 only group. These results were consistent with histological findings. HEM and HEH at 250 μg/mL significantly inhibited DPPH radical formation by 38.E6 and 35.65%, rerpectively. However antioxidant effects of ZSM and ZSH were insignificant.

scholarly journals Non-Dose-Dependent Changes in Liver Enzyme Levels of Children With Epilepsy on Treatment With Sodium Valproate

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582091844
Author(s):  
Aduragbenro Deborah A. Adedapo ◽  
Winifred Eseoghene Demaki ◽  
IkeOluwa Lagunju
Keyword(s):  
Sodium Valproate ◽  
Transaminase Level ◽  
Significant Negative Correlation ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transferase ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
The Mean ◽  
Glutamyl Transferase

Background: Sodium valproate (VPA) is considered as the drug of choice for the treatment of generalized epilepsy in children. Sodium Valproate may be hepatotoxic. Aim: To assess the level of derangement of liver enzymes in children with epilepsy on treatment with sodium valproate. Methods: A cohort study. One hundred fifty-three children, comprising 51 with epilepsy on treatment with VPA (group I), 51 with epilepsy on treatment with other antiepileptic drugs (AEDs) but not VPA (group II), and 51 with nonconvulsive disorders (group III) had liver function tests performed for them. Data were analyzed by SPSS version 23.0. Results: There were 85 males and 68 females, aged 6 months to 14 years (median = 7.0 years). There was no significant difference in the mean plasma levels of alanine transaminase (ALT), alkaline phosphatase, and gamma glutamyl transferase across the three groups of children. The mean aspartate transaminase level was significantly higher in children in group III. There was a statistically significant negative correlation between the duration of AED therapy and the mean serum level of AST ( r = −0.266, P = 0.016). The serum ALT level showed a statistically significant positive correlation with the duration of AED therapy ( r = 0.268, P = 0.015). Conclusion: Sodium valproate monotherapy does not appear to be associated with significant hepatotoxicity in children in our cohort.

scholarly journals Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity

2020 ◽  
Author(s):  
Elias Adikwu ◽  
Nelson Clemente Ebinyo
Keyword(s):  
Control Group ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Therapeutic Benefits ◽  
Hepatotoxic Effect ◽  
Dose Dependent Fashion ◽  
Group A ◽  
Hepatocyte Necrosis ◽  
Serum Aminotransferases ◽  
Glutamyl Transferase

Background: The hepatotoxic effect of 5-fluorouracil (5-FU) can deprive cancer patients of its maximum therapeutic benefits. Selenium (Se) is a trace element with potential benefits in some animal models of diseases. Objectives: This study assessed the ability of Se to nullify the hepatotoxic effect of 5-FU in albino rats.  Methods: In this study, 40 adult male albino rats were grouped into A to D (each 5 rats). Rats in group A (control) were treated intraperitoneally (IP) with normal saline (0.2 mL) daily for 5 days. Rats in groups B1 to B3 were treated IP with Se (0.125, 0.25, and 0.50 mg/kg) daily for 5 days, respectively. Rats in group C were treated IP with 5-FU (20 mg/kg) daily for 5 days. Rats in groups D1to D3 were treated IP with Se with 0.125, 0.25, and 0.50 mg/kg before treatment with 5-FU (20 mg/kg) daily for 5 days, respectively. After treatment, the rats were euthanized, and their blood samples were collected and evaluated for serum liver function. Liver samples were evaluated for biochemical and histological parameters. Results: Liver and serum aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were significantly (P<0.001) high in 5-FU-treated rats in comparison to the control group. Liver glutathione peroxidase, superoxide dismutase (SOD), catalase, and glutathione levels were significantly (P<0.001) low whereas the malondialdehyde level was significantly (P<0.001) high in 5-FU-treated rats compared with the control group. Moreover, hepatocyte necrosis was observed in 5-FU-treated rats.  Conclusion: Nonetheless, 5-FU-induced hepatotoxicity was significantly nullified in rats supplemented with Se (0.125 mg/kg, P<0.05; 0.25 mg/kg, P<0.01, and 0.5 mg/kg, P<0.001) in a dose-dependent fashion in comparison to 5-FU-treated rats. Thus, Se may have a clinical benefit in 5-FU-induced hepatotoxicity

scholarly journals Effect of Tannin-Rich Extract of Chasmanthera dependens on Piroxicam-induced Liver Damage in Male Wistar Rats

2021 ◽  
Vol 5 (1) ◽  
pp. 27
Author(s):  
Tijani Stephanie Abiola ◽  
Olori Ogaraya David ◽  
Farombi Ebenezer Olatunde
Keyword(s):  
Oxidative Stress ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Significant Rise ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Glutamyl Transferase

Background: Piroxicam is one of the nonsteroidal anti-inflammatory drugs used as antipyretic, analgesic and anti-inflammatory drug often used for the relief of nonspecific fever condition and in arthritis. This study investigated the protective potential of tannin-rich extract of Chasmanthera dependens (TRECDS) against piroxicam-induced hepatotoxicity in male Wistar rats.Materials and Methods: Thirty two rats were divided into four groups. Group 1 received normal saline and served as the control group, group 2 were given 20 mg/kg piroxicam only, while groups 3 and 4 were given 20 mg/kg piroxicam with the addition of 200 and 400 mg/kg of tannin-rich extract of Chasmanthera dependens, respectively. All rats were treated orally once daily for ten days.Results: Administration of piroxicam caused liver atrophy demonstrated by significant rise in serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), glucose-6-phosphate dehydrogenase (G6PDH) levels of albumin (ALB), bilirubin (BIL), total cholesterol (TCHOL), triglyceride (TRIGS) and low-density lipoprotein (LDL). Piroxicam also decreased high-density lipoprotein (HDL) level, enzymatic and nonenzymatic antioxidant levels significantly (p>0.05) with attendant increase in oxidative stress indices in the liver of rats compared with control group. Histological assessment reveled severe damaged to the liver of rats. However, co-administration with TRECDS reversed these observations as evidenced in the histological results.Conclusion: The findings of this study showed that exposure of rats to piroxicam provoked damage to the liver via oxidative damage and TRECDS has the potential of ameliorating the damage.Keywords: hepatotoxicity, piroxicam, Chasmanthera dependens, oxidative stress

Effect of aqueous extract of Gangronema latifolium (G. latifolium) (Utazi) on n-acetyl-para-aminophenol (acetaminophen) - induced hepatic injury on Wistar albino rats

2021 ◽  
Vol 20 (2) ◽  
pp. 119-125
Author(s):  
Godwin Delight Chigamezu ◽  
Wilfred Obaalologhi ◽  
Okure Victoria
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Treated Group ◽  
Oral Dosage ◽  
Control Group ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Glutamyl Transferase

The present study investigated the effect of leaf extract of Gangronema latifolium (G. latifolium) on acetaminophen (APAP) - induced liver injury in Wistar albino rats. In this study, sixty (60) male Wistar albino rats were divided into five (5) groups of twelve (12) rats each. Animals in group 1 served as control group and received a placebo of 0.9% saline solution. Group 2 served as APAP control group, administered with 800 mg/kg body weight of APAP only. Groups 3, 4 and 5 served as the experimental groups and received oral dosage of 800 mg/kg body weight of APAP plus 150 mg/kg, 200 mg/kg and 250 mg/kg body weight of G. latifolium respectively. The results showed that the enzymatic activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) in the serum were decreased significantly (p ≤ 0.05) in the experimental groups dosed with 150 mg/kg, 200mg/kg and 250 mg/kg of G. latifolium respectively. For 150 mg/kg G. latifolium treated group, ALT decreased from 23.3 ± 7.31 to 9.00 ± 1.52 IU/L, while AST and ALP decreased from 17.6 ± 2.66 to 15.00 ± 1.00 IU/L and 92.8 ± 2.34 to 83.8 ± 7.94 IU/L respectively. In conclusion, the results showed that aqueous extract of G. latifolium has a protective effect on rat liver induced with APAP injury.

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