scholarly journals Anthelmintic Resistance in Equine Nematodes – A Review on the Current Situation, with Emphasis in Europe

2019 ◽  
Vol 76 (2) ◽  
pp. 132
Author(s):  
Pedro Afonso SILVA ◽  
Mihai CERNEA ◽  
Luís MADEIRA de CARVALHO
Keyword(s):  
Broad Spectrum ◽  
Preventive Measures ◽  
Anthelmintic Resistance ◽  
Current Situation ◽  
Diagnostic Methods ◽  
New Drugs ◽  
General Review ◽  
New Methods ◽  
Further Development ◽  
Horse Farm

Since the introduction of the last equine broad-spectrum anthelmintic group in the 1980’s, the investment in new drugs to control horse’s parasites did not result in new advancements. These drugs allowed a very effective and extensive control of equine nematodes through successful interval dosing programs, firstly introduced in the 1960’s. However, the widespread and indiscriminate use of anthelmintics in these intensive treatments have led to increasing resistance in the major equine nematodes. Reports of reduced effectiveness are virtually worldwide and repercussions in livestock production farms have already been seen.Based on recent questionnaires about horse farm practices, preventive measures and international recommendations, it is clear that most of them are still not being widely implemented. It is also clear that these recommendations are outdated and new approaches must be considered to correctly tackle this rapidly evolving issue in horse management, as more accurate diagnostic methods are currently available, such as Mini-FLOTAC. This article intends to do a general review of the history and current situation of anthelmintic resistance in horses, with emphasis in Europe, as well as, how to diagnose and delay or even prevent its further development, mentioning new methods of diagnostic and directions in which to develop research.

Cartographic production in Russia: main stages and trends

2020 ◽  
Vol 963 (9) ◽  
pp. 30-43
Author(s):  
M.Yu. Orlov
Keyword(s):  
Chronological Order ◽  
Xviii Century ◽  
New Methods ◽  
Current State ◽  
Factors Influencing ◽  
The Future ◽  
History Of ◽  
State Enterprises ◽  
Further Development

Studying the current state of cartography and ways of further developing the industry, the role of the map in the future of the society, new methods of promoting cartographic products is impossible without a deep scientific analyzing all the paths, events and factors influencing its formation and development throughout all the historic steps of cartographic production in Russia. In the article, the history of cartographic production in Russia is considered together with the development of private, state and military cartography, since, despite some differences, they have a common technical, technological and production basis. The author describes the stages of originating, formation and growth of industrial cartographic production from the beginning of the XVIII century until now. The connection between the change of political formations and technological structures with the mentioned stages of maps and atlases production is considered. Each stage is studied in detail, a step-by-step analysis was carried out, and the characteristics of each stage are described. All the events and facts are given in chronological order, highlighting especially significant moments influencing the evolution of cartographic production. The data on the volumes of printing and sales of atlases and maps by commercial and state enterprises are presented. The main trends and lines of further development of cartographic production in Russia are studied.

scholarly journals In Vitro Activity of LK-157, a Novel Tricyclic Carbapenem As Broad-Spectrum β-Lactamase Inhibitor

2008 ◽  
Vol 53 (2) ◽  
pp. 505-511 ◽  
Author(s):  
Susanne Paukner ◽  
Lars Hesse ◽  
Andrej Preželj ◽  
Tomaž Šolmajer ◽  
Uroš Urleb
Keyword(s):  
Clavulanic Acid ◽  
Broad Spectrum ◽  
Clinical Settings ◽  
In Vitro Activity ◽  
Bacterial Strains ◽  
Class A ◽  
Class C ◽  
Further Development ◽  
Lactamase Inhibitor

ABSTRACT LK-157 is a novel tricyclic carbapenem with potent activity against class A and class C β-lactamases. When tested against the purified TEM-1 and SHV-1 enzymes, LK-157 exhibited 50% inhibitory concentrations (IC50s) in the ranges of the clavulanic acid and tazobactam IC50s (55 nM and 151 nM, respectively). Moreover, LK-157 significantly inhibited AmpC β-lactamase (IC50, 62 nM), as LK-157 was >2,000-fold more potent than clavulanic acid and approximately 28-fold more active than tazobactam. The in vitro activities of LK-157 in combination with amoxicillin, piperacillin, ceftazidime, cefotaxime, ceftriaxone, cefepime, cefpirome, and aztreonam against an array of Ambler class A (TEM-, SHV-, CTX-M-, KPC-, PER-, BRO-, and PC-type)- and class C-producing bacterial strains derived from clinical settings were evaluated in synergism experiments and compared with those of clavulanic acid, tazobactam, and sulbactam. In vitro MICs against ESBL-producing strains (except CTX-M-containing strains) were reduced 2- to >256-fold, and those against AmpC-producing strains were reduced even up to >32-fold. The lowest MICs (≤0.025 to 1.6 μg/ml) were observed for the combination of cefepime and cefpirome with a constant LK-157 concentration of 4 μg/ml, thus raising an interest for further development. LK-157 proved to be a potent β-lactamase inhibitor, combining activity against class A and class C β-lactamases, which is an absolute necessity for use in the clinical setting due to the worldwide increasing prevalence of bacterial strains resistant to β-lactam antibiotics.

scholarly journals Retroperitoneal abscess due to dropped gallstones after laparoscopic cholecystectomy

2012 ◽  
Vol 2 (1) ◽  
pp. 20 ◽  
Author(s):  
Farah Adel ◽  
Jose M Ramia ◽  
Roberto De la Plaza ◽  
Jose Quilñones ◽  
Vladimir Arteaga ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Preventive Measures ◽  
Diagnostic Methods ◽  
Retroperitoneal Abscess ◽  
Therapeutical Options

Complications of dropped gallstones after laparoscopic cholecystectomy are infrequent but retroperitoneal abscess is extremely rare. We present a new case, discuss causes, diagnostic methods, preventive measures and therapeutical options.

scholarly journals Comparison of Acid Fast Bacilli Smear and Culture for the Diagnosis of Extra-Pulmonary Tuberculosis

2004 ◽  
Vol 43 (155) ◽  
Author(s):  
Basista Rijal ◽  
P Ghimire ◽  
N R Tuladhar
Keyword(s):  
Lymph Node ◽  
Pulmonary Tuberculosis ◽  
Pericardial Fluid ◽  
The Body ◽  
Diagnostic Methods ◽  
Isolation Rate ◽  
Extra Pulmonary Tuberculosis ◽  
Acid Fast Bacilli ◽  
New Methods ◽  
Extra Pulmonary

The study was conducted with the objectives to compare the Acid Fast Bacilli (AFB) staining and Culture for the diagnosis of extra-pulmonary tuberculosis and to find out the burden of extra-pulmonary tuberculosis from the different site of the body in suspected TB patients. The standard Ziehl-Neelsen Technique was done for AFB staining and culture was done in Ogawa Medium. Of the 292 extra-pulmonary samples examined by AFB smear only 2(0.7%) were positive and of the 1058 extra-pulmonary samples cultured 20 (1.9%) were positive. The isolation rate for extra-pulmonary samples was three fold higher in culture in comparison to AFB Smear. The confirmation rate of extra-pulmonary tuberculosis was approximately 1/ 8th of the pulmonary tuberculosis by conventional bacteriological diagnostic methods. Of the extra-pulmonary tuberculosis renal, endometrial or pelvic and cold abscess were common in this study. M.tuberculosis was also isolated from peritoneal fluid, pericardial fluid, Synovial fluid, lymph node and cerebro spinal fluids only by culture. In conclusion, the standard AFB culture has significant role for diagnosis of extra-pulmonary tuberculosis, even though the conventional bacteriological technique could diagnose very low number of extra-pulmonary tuberculosis. The new methods of diagnosis should be considered to confirm more extra- pulmonary  tuberculosis.Key Words: Extra-pulmonary tuberculosis, AFB Smear, Culture, Diagnosis, Nepal.

scholarly journals Plant-Based Solutions to Global Livestock Anthelmintic Resistance

2018 ◽  
Vol 9 (2) ◽  
pp. 110-123 ◽  
Author(s):  
Katherine E. French
Keyword(s):  
Rural Communities ◽  
Medicinal Plants ◽  
Management Practices ◽  
Anthelmintic Resistance ◽  
Intestinal Parasites ◽  
Plant Secondary Metabolites ◽  
Ecological Factors ◽  
New Drugs ◽  
Promising Alternative ◽  
Livestock Health

Anthelmintic resistance in livestock is increasing globally. Livestock intestinal parasites now develop resistance to synthetic anthelmintics within 2–10 years, collectively costing billions of dollars annually in lost revenue around the world.  Over-reliance on commercial drugs and dips and changes in livestock management practices are key drivers of this trend.  To date, current research has focused on identifying new anthelmintics from bacterial and fungal sources or even synthesizing new drugs that target parasite metabolism or reproduction. Plant-derived anthelmintics are a promising alternative, yet to date major research funders and scientists have overlooked this option. Until the mid-20th century, rural communities relied on plant-based methods of controlling livestock parasites. These methods include feeding livestock specific medicinal plants and trees, grazing livestock on herbal leys, and changing where livestock grazed based on ecological factors (e.g., flooding) that increased parasite burdens. Many historic texts and ethnological accounts record the ethnobotanical knowledge of rural communities and the plants they used to control livestock intestinal parasites. Some traditions persist today yet the farmers, graziers, and shepherds who hold this knowledge are rapidly disappearing and with them perhaps a potential long-term solution to anthelmintic resistance. This short perspective piece will cover recent research using ethnobotanical data as a means to identifying potential new anthelmintics; the morphological, physiological, and metabolic effect of plant secondary metabolites on parasites; and an overview of “best practices” which can reduce bias in assessments of plant bioactivity and increase reproducibility of test results. This will hopefully bring recent advances in ethnobiology, chemistry, and ecology to new audiences, and, potentially, spark new interest in using medicinal plants to improve livestock health.

scholarly journals 26 Copper oxide wire particles to complement control of gastrointestinal nematodes with levamisole and/or albendazole in lambs

2020 ◽  
Vol 98 (Supplement_2) ◽  
pp. 73-73
Author(s):  
Joan M Burke ◽  
James E Miller ◽  
Mohan Acharya ◽  
Erin Wood
Keyword(s):  
Copper Oxide ◽  
Haemonchus Contortus ◽  
Repeated Measures ◽  
Mixed Model ◽  
Anthelmintic Resistance ◽  
Gastrointestinal Nematodes ◽  
High Prevalence ◽  
The Mean ◽  
Further Development

Abstract Due to high prevalence of anthelmintic resistance (AR), complementary approaches to anthelmintic use to control gastrointestinal nematodes (GIN) in sheep are necessary. Copper oxide wire particles (COWP) are effective against Haemonchus contortus but not other GIN, and FAMACHA aids to minimize further development of AR. The objective was to determine the efficacy of COWP alone or in combination with levamisole, albendazole, or a 3-way combination to control GIN known to have AR to these anthelmintics. Naturally infected Katahdin lambs were selectively dewormed based on FAMACHA© and/or packed cell volume (PCV). If FAMACHA© scores were 3, 4, or 5, lambs received 1 g COWP alone (n = 120), COWP and levamisole (n = 47) or albendazole (n = 6), or a 3-way combination (n = 10), respectively. Untreated lambs were included (CON; n = 31). Feces and blood were collected on days 0 (day of deworming) and 14 for determination of fecal egg counts (FEC) and FEC reduction (FECRED) and PCV. Data were analyzed using repeated measures in a mixed model. The mean FECRED was greater for the combination of levamisole and COWP than COWP alone (P < 0.001). In a mixed GIN population, COWP in combination with levamisole increased the efficacy of FECRED of H. contortus and other GIN genera present, offering greater GIN management in the presence of resistance to these anthelmintics.

scholarly journals JAPAN: IS THERE A CHANCE TO INCREASE AGRICULTURAL COMPETITIVENESS? (analyzing statistics)

2020 ◽  
pp. 71-86
Author(s):  
Seda Markarian ◽  
Keyword(s):  
Labor Force ◽  
Agricultural Sector ◽  
Global Market ◽  
Current Situation ◽  
Agriculture Sector ◽  
Food Market ◽  
Hired Labor ◽  
Further Development ◽  
Global Food

Given the expanding needs of the global food market, it is not surprising that the Japanese are trying hard to make their agriculture sector competitive n the global market. The article discusses the current situation in agriculture and the potential for its further development, most of all, the situation with the cultivated area and labor force. The results of government measures taken to increase the efficiency of production, a change in its structure, and increase in the value of hired labor, changes in the forms of production participants themselves are shown: along with rural yards with small land allotments, sometimes various associations appear; in other words, the pattern of development of the agricultural sector is gradually changing. But to achieve this goal there are still many obstacles administrative economic, social.

scholarly journals Potential of open data in the Czech Republic

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Jan Boubin
Keyword(s):  
European Union ◽  
Economic Development ◽  
Czech Republic ◽  
Innovation Management ◽  
Open Data ◽  
Current Situation ◽  
The European Union ◽  
The Czech Republic ◽  
The Government ◽  
Further Development

The paper Potential of open data in the Czech Republic deals with the current situation of open data government and autonomous institutions in the Czech Republic in comparison with other European Union countries (Great Britain, France, Belgium, Austria, Estonia, ...) and defines the possibilities of open data economic development of the Czech Republic. Methodology of the paper includes a search resources dealing with the issue of open data in the Czech Republic and the European Union, comparing the obtained data, the analysis of obtained data and draft of recommendations for further development. The first part is an evaluation of the current situation and the situation compared with other EU countries. Further conditions for further development and evaluation of the potential of open data for the Czech Republic. The final section of the paper deals with evaluation of possibilities open application data management processes of companies in the Czech Republic in terms of strategic and innovation management. The result is an overview of the potential use of open data in the context of economic development and an estimate of the trend in applications open at the government level.

Anthelmintic Resistance as a Guide to the Discovery of New Drugs?

2009 ◽  
pp. 17-32 ◽  
Author(s):  
Georg v. Samson-Himmelstjerna ◽  
Roger K. Prichard ◽  
Adrian J. Wolstenholme
Keyword(s):  
Anthelmintic Resistance ◽  
New Drugs

CHARACTERISTICS OF ORGANIZING AND MANAGING SALES ACTIVITIES USING THE EXAMPLE OF “OOO LAMZUR”

2020 ◽  
Vol 10 (6) ◽  
pp. 1001-1015
Author(s):  
E.A. Leonenko ◽  
◽  
S.V. Kunev ◽  
N.N. Chindyaykina ◽  
◽  
...  
Keyword(s):  
Economic Activity ◽  
Visual Analysis ◽  
Distribution Channels ◽  
Enterprise Management ◽  
Competitive Advantages ◽  
New Methods ◽  
Confectionery Products ◽  
Marketing Activities ◽  
Further Development

In modern conditions, the further development of the market economy puts each subject of economic activity in very difficult conditions. For the survival and effective functioning of an organization, it is no longer enough to simply produce goods in the maximum possible volume, it is especially important to sell these goods. The significant role of sales activities in the enterprise management requires searching for new methods of improvement, one of which is the revision of existing and the development of new optimal distribution channels under conditions of environmental uncertainty. Currently, distribution channels for final products are a complex multi-structure system with active elements, operating in a dynamically developing market environment. Studies by economists show that the complexity (complexity) of this system is based not on the number of elements, but on the nature of the network structure (the complexity of the structure of the system and the interactions of its components). This article presents a visual analysis of the sales activities of one of the largest Russian confectionery manufacturers - “OOO Lamzur”. For this kind of enterprises, the organization of sales activities is very important in ensuring economic efficiency and achieving high competitive advantages. In the marketing activities of the investigated enterprise, a number of problem areas are identified that impede its development. In the process of analyzing sales activities, a number of shortcomings were noted, the key of which is the loss by the enterprise of such sales functions as establishing feedback with consumers. In the course of the study, the effectiveness of the marketing activities of “OOO Lamzur” was assessed based on the analysis of the dynamics of sales of confectionery products, as well as by interviewing customers.

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