scholarly journals A Critical Review on the Effect of Particulate Matter (PM) in Air on Public Health

Author(s):  
Debraj Mukhopadhyay ◽  
◽  
Dr. J. Swaminathan ◽  
Dr. Arun Kumar Sharma ◽  
Dr. Soham Basu ◽  
...  

According to the World Health Organization (WHO), particulate matter (PM) contamination causesaround 800,000 premature deaths per year, ranking 13th in the world in terms of mortality.However, several findings revealed that the correlation is much stronger and more complicated thanpreviously believed. PM is an element of emissions comprised of very small, acidic, organiccompounds, metals, and particulate soil or dust particles or fluid droplets. The most consistent airquality component linked to human illness is PM, which is categorized by size. PM is likely to developcardiovascular and cerebrovascular disorders due to the mechanisms of inflammation, overt andindirect coagulation activation, and direct translocation to the systemic circulation. The evidence onthe cardiovascular system that shows a PM effect is strong. Coronary incidence and mortality ratesin populations prone to long-term PM toxicity were significantly higher. Short-term acute emissionsincrease coronary incidence rates subtly within days of the pollution peak.

Author(s):  
Elisa Gallo ◽  
Franco Folino ◽  
Gianfranco Buja ◽  
Gabriele Zanotto ◽  
Daniele Bottigliengo ◽  
...  

Several epidemiological studies found an association between acute exposure to fine particulate matter of less than 2.5 μm and 10 μm in aerodynamic diameter (PM2.5 and PM10) and cardiovascular diseases, ventricular fibrillation incidence and mortality. The effects of pollution on atrial fibrillation (AF) beyond the first several hours of exposure remain controversial. A total of 145 patients with implantable cardioverter-defibrillators (ICDs), cardiac resynchronization therapy defibrillators (ICD-CRT), or pacemakers were enrolled in this multicentric prospective study. Daily levels of PM2.5 and PM10 were collected from monitoring stations within 20 km of the patient’s residence. A Firth Logistic Regression model was used to evaluate the association between AF and daily exposure to PM2.5 and PM10. Exposure levels to PM2.5 and PM10 were moderate, being above the World Health Organization (WHO) PM2.5 and PM10 thresholds of 25 μg/m3 and 50 μg/m3, respectively, on 26% and 18% of the follow-up days. An association was found between daily levels of PM2.5 and PM10 and AF (95% confidence intervals (CIs) of 1.34–2.40 and 1.44–4.28, respectively) for an increase of 50 µg/m3 above the WHO threshold. Daily exposure to moderate PM2.5 and PM10 levels is associated with AF in patients who are not prone to AF.


2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Iara Fabricia Kretzer ◽  
Andrea do Livramento ◽  
Joel da Cunha ◽  
Sabrina Gonçalves ◽  
Iraci Tosin ◽  
...  

Hepatitis C virus (HCV) is endemic worldwide and according to the World Health Organization (WHO), there are about 150 million chronic carriers worldwide. The infection is a leading cause of liver diseases like cirrhosis and hepatocellular carcinoma (HCC); thus, HCV infection constitutes a critical public health problem. There are increasing efforts worldwide in order to reduce the global impact of hepatitis C through the implementation of programmatic actions that may increase the awareness of viral hepatitis and also improve surveillance, prevention, and treatment. In Brazil, about 1,5 million people have been chronically infected with HCV. The country has a vast territory with uneven population density, and hepatitis C incidence rates are variable with the majority of cases concentrated in the most populated areas. Currently, the main priorities of Brazilian Ministry of Health's strategies for viral hepatitis management include the prevention and early diagnosis of viral hepatitis infections; strengthening of the healthcare network and lines of treatment for sexually transmitted diseases, viral hepatitis, and AIDS; improvement and development of surveillance, information, and research; and promotion of universal access to medication. This review aims to summarize the available data on hepatitis C epidemiology and current status of efforts in prevention and infection control around the world and in Brazil.


2020 ◽  
Vol 10 (28) ◽  
Author(s):  
Musibau O. Jelili ◽  
Adeniyi S. Gbadegesin ◽  
Abimbola T. Alabi

Background Airborne particulates are an issue in many urban regions around the world and their detrimental impact on human health has increasingly become a public health concern. Objectives The aim of the present study was to examine particle pollution in an urban settlement in Nigeria. This study examines the extent, spatial variation, and sources of indoor and outdoor particulate matter (PM) concentrations in Ogbomoso, Nigeria. Methods The survey research method was adopted. Sampling included 385 buildings across selected precincts and different residential zones in the town of Ogbomoso. Particulate matter analytes (PM1, PM2.5 and PM10) within/around each building were measured with a particle counter and details on domestic utilities/practices were obtained with a questionnaire. Analysis of variance was used to determine inter-zonal variations in PM levels and simple linear regression was used to analyze the relationship between indoor and outdoor air quality. Results Indoor and outdoor respirable particle (PM2.5) concentrations were lower than the World Health Organization (WHO) Interim Target limit of 75 μg/m3, while concentrations of inhalable particles (PM10) were higher than the set limit of 150 μg/m3 for daily averages. Coarse particles dominated, with an accumulative PM2.5/PM10 ratio of 0.24. The inter-zonal analysis of PM concentrations revealed that indoor and outdoor PM levels varied significantly by residential zone (p = 0.0005; p = 0.01, respectively). Regression analysis showed a significant but weak relationship between indoor and outdoor PM levels (r = +0.221), while the coefficient of determination (R2 = 0.049) showed that only about 5% of the variation in indoor air quality was associated with outdoor air quality. Particle pollution inducers were identified in the residents' waste disposal methods and adopted fuels/energy sources, with firewood and charcoal linked with increased concentrations of particulate matter. Conclusions Air quality was relatively poor in the study area given observed particulate matter concentrations. Cleaner fuels, effective waste management systems and improved roads are needed to foster better air quality in the study area. Competing Interests The authors declare no competing financial interests


GYNECOLOGY ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 44-50
Author(s):  
Tatyana Yu Pestrikova ◽  
Elena A Yurasova

Relevance. Despite the achievements of modern medicine, the problem of reducing complications of the gestational period and perinatal outcomes still does not lose its relevance. Lack of security and/or unbalanced consumption of vital micronutrients are factors of constant negative impact on health, growth, development and formation of organs and systemogenesis in all age periods. Unbalanced nutrition, in particular vitamin deficiency conditions, is considered by the World Health Organization as a problem of starvation, which has a direct impact on the incidence and mortality of the population. Aim. Analysis of literary sources to identify the effect of vitamin-mineral complexes on pregnancy and perinatal outcomes. Materials and methods. To write this review, we searched for domestic and foreign publications in Russian and international search engines (PubMed, eLibrary, etc.) over the past 30 years. The review included articles from peer-reviewed literature. Results. The review addresses balanced nutrition for pregnant women who receive close attention throughout the world. The optimal provision of vitamins and minerals for women during the gestational period, when the need for essential micronutrients is significantly increased, is a prerequisite for the physiological course of pregnancy and the full development of the fetus. This is especially important in the conditions of the northern and equivalent territories. The need for vitamins in women during pregnancy and lactation increases by 1.5 times, due to the intensive work of the endocrine system of women, the transfer of some nutrients to the fetus. Deficiency of certain vitamins is a risk factor for the development of birth defects, premature birth, and the birth of children with low body weight. Conclusions. The domestic combined vitamin-mineral preparation with micro and macro elements was created specifically taking into account the changing needs of the woman’s body for vitamins and minerals at different stages of pregnancy. Compatibility of components in 1 tablet is provided by special production technology.


2021 ◽  
Author(s):  
Pavankumar Mulgund ◽  
Raj Sharman ◽  
Sandeep Purao ◽  
Sagarika Suresh ◽  
Peter Winklestein

BACKGROUND According to the World health organization (WHO), more than one million sexually transmitted infections are acquired each day across the world. The incidence rates of STDs in the US are at a record high for the fourth consecutive year. Due to the stigma associated with the incidence of STD, there is a general reluctance to seek information in person, and online information sources remain the primary avenues of information seeking. However, these sources are designed without a comprehensive understanding of the information needs of individuals who have contracted STDs. OBJECTIVE To discover the information needs of individuals who (suspect they) have contracted a sexually transmitted disease (STD). A better understanding of their information needs can drive the design of more effective online forums. METHODS This is a qualitative and analytical study of 549 transcripts (consisting of queries posted over the last ten years) from online forums of the American Sexual Health Association, which allows patients, volunteers, and healthcare providers to connect anonymously. The analysis follows a grounded theory (GT) approach with multiple coding stages to discover categories and themes. RESULTS Three categories of information needs emerge. The first two, Clinical and Logistical, are similar to other contexts. However, our analysis shows that there is a significant need for the last category - Psychosocial information. Approximately 59% of instances are linked to concerns such as confusion, discretion, remorse, and others. These needs vary across the stages of a patient journey (from symptom manifestation to treatment maintenance). CONCLUSIONS Responding to the needs of individuals who (suspect they) have contracted an STD requires compassionate and personalized responses (beyond factual clinical and logistical information). Online forums provide anonymity but do not adequately incorporate mechanisms, practices, or incentives to respond to diverse psychosocial concerns. Innovative approaches to add such support can make the online forums more effective for this group of individuals.


Author(s):  
Shulakova Nadezhda Ivanovna Shulakova Nadezhda Ivanovna ◽  
Natal’ya Borisovna Sipacheva ◽  
Elena Viktorovna Guseva ◽  
Olga Grigorievna Nikolaeva ◽  
Аnna Valer’evna Nozdracheva ◽  
...  

Hepatitis B is an infectious disease that leads to severe health problems, with the risk of chronicity and death. The World Health Organization (WHO) has shown that about 4.5 million premature deaths from the infection could be prevented by 2030 in low- and middle-income countries through vaccination, diagnostic tests, drugs, and education campaigns. The main goal of the WHO global hepatitis strategy is to reduce new infections by 90 % and deaths by 65 % between 2016 and 2030. The successes of hepatitis B vaccine prophylaxis are the basis for setting the ambitious goal of eliminating the disease in the future. However, to date, many questions about the organization and planning of regional vaccination programs remain unresolved and provoke discussions among specialists around the world, including in Russia. In order to systematize and summarize the scientific literature on prevention, as well as to evaluate its effectiveness, we performed a literature search using the electronic bibliographic resources https://pubmed.ncbi.nlm.nih.gov/ and https://elibrary.ru/ using the key words «hepatitis B» and «vaccine prophylaxis». Analysis of scientific papers allowed us to characterize some manifestations of hepatitis B epidemic process and reveal its modern features in the territory of Russia, including risk groups. Aspects of genetic heterogeneity of HBsAg pathogen circulating in Russian territory as well as in adjoining states are given in details. The organization of vaccine prophylaxis is considered; the used immunobiological preparations are characterized. The results of the work define the role of serological studies in the system of epidemic surveillance for hepatitis B, as well as their significance for formation of adequate tactics of vaccination of the population, including in risk groups.


2019 ◽  
Vol 220 (Supplement_3) ◽  
pp. S91-S98 ◽  
Author(s):  
Claudia M Denkinger ◽  
Samuel G Schumacher ◽  
Christopher Gilpin ◽  
Alexei Korobitsyn ◽  
William A Wells ◽  
...  

Abstract Existing high-priority target product profiles (TPPs) of the World Health Organization (WHO) establish important needs for tuberculosis (TB) diagnostic development. Building on this earlier work, this guidance series aims to provide study guidance for performing accuracy studies of novel diagnostic products that may meet the 4 high-priority WHO TPPs and thus enable adequate evidence generation to inform a WHO evidence review process. Diagnostic accuracy studies represent a fundamental step in the validation of all tests. Unfortunately, such studies often have limitations in design, execution, and reporting, leading to low certainty of the evidence about true test performance, which can delay or impede policy and scale-up decisions. This introductory paper outlines the following: (1) the purpose of this series of papers on study guidance; (2) WHO evidence needs and process for the development of policy guidelines for new TB diagnostic tests; and (3) study design considerations, ie, general diagnostic study considerations, intended use of test and role in the clinical pathway, choice of population and setting, index-test specific issues, suitable reference standard and comparators, study flow and specimen issues, and finally key issues beyond accuracy that should be considered. The other 4 papers in this series will provide more detailed guidance for each of the 4 WHO high-priority TPPs. By increasing the clarity around the clinical evaluation needs for tests that have the potential to meet the TPP specifications, we hope to support harmonized evidence generation and enable the WHO review process towards meeting the WHO End TB Strategy targets for reducing the incidence and mortality associated with TB.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  

Abstract Since emerging from a market in Wuhan China in December 2019, SARS-CoV-2, the pathogen causing COVID-19, has spread worldwide. On January 30th 2020 the World Health Organization declared the COVID19 outbreak a Public Health Emergency of International Concern, and declared it a pandemic on March 11th 2020. With over 2.4 million cases and 180,000 deaths reported by mid-June, Europe has been the second most affected region in the world. Individual countries such as Italy and the UK have been amongst the hardest hit in the world. However, the COVID19 situation in Europe is marked by wide variations both in terms of how countries have been affected, and in terms of how they have responded. The proposed workshop will provide compare and contrast the situation and response in five countries in the European region: The UK, Italy, Poland, Portugal and Sweden, moderated by a firm and charismatic chair. This interactive workshop will enable better understanding of the disease's spread and trajectory in different EU countries. International comparisons will help to describe the growth and scale of the pandemic in the selected EU countries. The choice of countries reflects those that have reported high and low incidence and mortality, as well as represent a range in the strictness of the control measures implemented, from full lockdown to the most permissive. The session will go beyond describing those and will be an opportunity to discuss the pros and cons of these different approaches and lessons learnt around the different components of the response such as case identification, contact tracing, testing, social distancing, mask use, health communication and inequalities. We plan to have short and effective 5 min presentations followed by a longer and constructively provocative moderated discussion. Importantly, the five European case studies will offer ground to discuss the public health principles behind outbreak management preparedness and balancing public health with other imperatives such as economic ones, but also social frustration. The audience will be engaged through a Q&A session. Key messages The approach to managing the COVID19 outbreak has varied among European countries, and the optimal approach is likely to be context specific. The effect of the pandemic will be long term and public health imperatives must take population attitudes and behavior as well as economic and indirect health effects into account.


Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 317
Author(s):  
Pek Xyen Tan ◽  
Krishnapriya Thiyagarasaiyar ◽  
Cheng-Yau Tan ◽  
You-Jin Jeon ◽  
Mohd Shahrul Mohd Nadzir ◽  
...  

Air pollution has recently become a subject of increasing concern in many parts of the world. The World Health Organization (WHO) estimated that nearly 4.2 million early deaths are due to exposure to fine particles in polluted air, which causes multiple respiratory diseases. Algae, as a natural product, can be an alternative treatment due to potential biofunctional properties and advantages. This systematic review aims to summarize and evaluate the evidence of metabolites derived from algae as potential anti-inflammatory agents against respiratory disorders induced by atmospheric particulate matter (PM). Databases such as Scopus, Web of Science, and PubMed were systematically searched for relevant published full articles from 2016 to 2020. The main key search terms were limited to “algae”, “anti-inflammation”, and “air pollutant”. The search activity resulted in the retrieval of a total of 36 publications. Nine publications are eligible for inclusion in this systematic review. A total of four brown algae (Ecklonia cava, Ishige okamurae, Sargassum binderi and Sargassum horneri) with phytosterol, polysaccharides and polyphenols were reported in the nine studies. The review sheds light on the pathways of particulate matter travelling into respiratory systems and causing inflammation, and on the mechanisms of actions of algae in inhibiting inflammation. Limitations and future directions are also discussed. More research is needed to investigate the potential of algae as anti-inflammatory agents against PM in in vivo and in vitro experimental models, as well as clinically.


2017 ◽  
Vol 59 (2) ◽  
pp. 4
Author(s):  
Gboyega A Ogunbanjo

South Africa accounts for the worst global tuberculosis epidemics fuelled by the spread of HIV infection. The tuberculosis (TB) incidence increased from 300 per 100,000 people in the early 1990s to more than 950 per 100,000 in 2012.1 In addition, the country remains one of the countries with the highest TB burden globally, with the World Health Organisation (WHO) statistics giving an estimated incidence of 454,000 cases of active TB in 2015.2 This means that about 0.8% of South Africa’s population of 54 million develop active TB disease annually. Of the 454 000 TB cases in South Africa in 2015, WHO estimated that about 57% (258,000) were HIV positive. It also estimated that of 157,505 whose status was known, and who were known to be HIV positive, some 85% (133,116) were on antiretroviral therapy.3 From the same 2015 report, Eastern Cape, KwaZulu-Natal and Western Cape provinces had the highest incidence rates of 692, 685 and 681 per 100,000 respectively. The most notable decline was in KwaZulu-Natal where the incidence decreased from 1,185 to 685 per 100,000 over the last five years.1


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