Role of metformin pregravid preparation patients with prediabetes impaired glucose toletance

Tasks of investigation were concluded the characterization of insulin resistence (IR) and hormonal features in patients with prediabetes and influence of diet or metformin on the course of pregnancy and perinatal complications. There were examined 61 womans. The OGTT, definition of insulin levels in plasma and index IR were performed in all patiens. OGTT and index IR were normal in 14 womans (control group I). OGTT was normal but index IR was impared in 33 womans (group IR - II). From this group 22 womans were treated with diet (II A group) and 11 womans treated with metformin (IIB group). OGTT and index IR were abnormal in 14 womans (impared OGTT - III group), they were treated with metformin. Dose of metformin was 1500 mg/d, threatment was continueted for 3-4 manths. Conclusion: Used indexes IR basal and two hour after glucose load were significant in definition of normal and decreased insulin sensitivity (IR). Presence of IR is accompanied by high level of free testosterone in blood without impared secretion of ovarian and suprarenal androgens. There was impared sensitivity of endometrium of secretory stage. The frequency of obstetric and perinatal complications in patients receiving diet not differ from patients treated with metformin. There was only a tendercy to low frequency of threatening miscarriages befor 12 weeks of gestations in paitiens receiving metformin. Development of GDM was observed in 13,1 % of patiens only with presence of IR. The use of metformin in pregravidal stage preserved the development of macrosomia in offsprings of patients with prediabetes.

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The role of metastin in pathogenesis of genital endometriosis

Journal of obstetrics and women s diseases ◽

10.17816/jowd66316-24 ◽

2017 ◽

Vol 66 (3) ◽

pp. 16-24 ◽

Cited By ~ 1

Author(s):

Edvard K. Aylamazyan ◽

Mariya I. Yarmolinskaya ◽

Nigar F. Ganbarli ◽

Natalia N. Tkachenko ◽

Gulrukhsor Kh. Tolibova ◽

...

Keyword(s):

Menstrual Cycle ◽

Histological Examination ◽

Peripheral Blood ◽

Ovarian Tissue ◽

Free Testosterone ◽

Immunohistochemical Method ◽

Control Group ◽

Healthy Women ◽

Definition Of

Materials and methods. 28 patients with GE of I-II degrees of prevalence (R-AFS) were included in the study. Control group consisted of 11 healthy women. All the patients underwent laparoscopy and hysteroscopy with histological examination of ovarian tissue, peritoneum and endometrium; patients with GE also were performed histological examination of endometrioid of heterotopies. Definition of levels of kisspeptin, FSH, LH, prolactin, AMH, estradiol, estrone, androgens (free testosterone, dehydroepiandrosterone – DHEA) in peripheral blood in healthy women and in patients with GE were conducted by ELISA on the 2nd and 8th days of menstrual cycle. Immunohistochemical method was used to evaluate expression of metastine (kisspeptin) and its receptor in ovarian tissue, peritoneum, in endometrioid heterotopies and in endometrium. Results. Hormonal survey has revealed that the level of kisspeptin in peripheral blood was reliably higher compared to its level in the control group. Immunohistochemical study found that in patients with GE area of expression of KISS and KISS1R receptor in endometrium was reliably lower when compared with these values in the control group. In the foci of endometrioid heterotopies, which were located on the pelvic peritoneum, it was observed a reliable increase in protein КІЅЅ1 expression and receptor KISS1R compared to fragments of intact peritoneum. The area of expression of receptor KISS1R in endometrioid heterotopies was reliably higher than the area of its expression in endometrium of patients with GE and in endometrium of women of the control group. Direct correlation between the area of protein expression (KISS) in endometrium with level kisspeptin on the 8th day of menstrual cycle in peripheral blood (rs = 0,90) has been revealed. It has been determined that the level of kisspeptin on the 2nd day of menstrual cycle in peripheral blood correlates with the area of expression of receptor KISS1R in peritoneum (rs = 0,57). A direct correlation between the area of expression of receptor KISS1R in peritoneum with the level of kisspeptin on the 8th day of menstrual cycle in serum has been found (rs = 0,90). Conclusion. The obtained data show a definite role of kisspeptin in pathogenesis of genital endometriosis. It can be assumed that the increase in the level of metastine (kisspeptin) in peripheral blood and increased expression of KISS1 in endometrioid heterotopies and especially its receptor KISS1R are compensatory-adaptive response aimed at deterrence of further spread of endometriosis. The obtained results justify the need to continue research in this direction for a deeper understanding of pathogenesis of the disease and possible use of kisspeptin as biomarker for non-invasive diagnostics as well as potential targeted therapy of GE.

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Clinical and diagnostic aspects of testosterone deficiency in women of fertile age

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.17.1.2021.226436 ◽

2021 ◽

Vol 17 (1) ◽

pp. 81-85

Author(s):

Z.Yu. Khalimova ◽

A.A. Almakhmatova

Keyword(s):

Free Testosterone ◽

Reproductive Age ◽

Control Group ◽

Androgen Deficiency ◽

Testosterone Deficiency ◽

Overweight Women ◽

Diagnostic Aspects ◽

The Third ◽

Definition Of

Background. The role of androgens in a woman has not been fully appreciated. Currently, there is no clear and generally accepted definition of the concept of androgen deficiency in women by analogy with that in men. The purpose of the study was to investigate the clinical and diagnostic aspects of testosterone deficiency in women of fertile age. Materials and methods. The study included 60 women with testosterone deficiency without other concomitant pathology. The average age of the patients was 28.3 years. The control group consisted of 20 healthy women. The patients were divided into three groups based on their body mass index (BMI). The first group consisted of 20 overweight women (BMI 25–29.9 kg/m2), the second group — 20 women with first-degree obesity, and the third group — 20 women with second-degree obesity. Results. On the 14th day of the ovarian-menstrual cycle, the patients from the first group showed a tendency towards a decrease in the basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone against the background of significant hypoandrogenaemia. Patients with obesity (II degree) showed a significant decrease in basal levels of LH, FSH, estradiol, progesterone against the background of significant hypoandrogenaemia. The correlation analysis revealed a direct relationship between testosterone deficiency and obesity. Thus, the lowest testosterone values were found in patients of the third group (< 0.05 nmol/l). At the same time, the testosterone level in the patients of the first and second groups was also significantly reduced — from 0.02 to 0.05 nmol/l, respectively. The levels of dehydroepiandrosterone and 17-hydroxycorticosteroids were significantly reduced, especially in the third group — 0.3 μg/ml and 0.1 nmol/l, respectively. Conclusions. Most women of reproductive age with testosterone deficiency have hypomenorrhea with low free testosterone. A direct correlation was established between testosterone deficiency and the degree of obesity in women with androgen deficiency.

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Effective Role of Emotions in Teaching

International Journal of Indian Psychology ◽

10.25215/0401.080 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Sujit Dhanraj Kumavat

Keyword(s):

Teaching Methods ◽

Teaching Method ◽

Negative Emotion ◽

Junior College ◽

Control Group ◽

Neutral Group ◽

Group I ◽

Group Control Group ◽

Experimental Group

The objective of the present study was to find out the role of emotion in effective teaching of junior college students. The sample for the present research selected from the grantable junior college in Ahmednagar. For the research 11th class 90 students of Commerce faculty was selected. Among them 30 student selected for the positive emotion teaching group (Experimental group I). 30 students selected for the negative emotion (Experimental group II). And 30 students were selected for the neutral group (Control group III). The age range of the students were 17 to 18 years (M=35.00 SD=7.38). In the research Simple random method was used. The first hypothesis of the research was positive emotional teaching method high in English retention than negative and neutral teaching methods. Tolls 11th class English syllabus selected for the study. Result first result was showed that positive emotional teaching had significantly high English retention than the negative and neutral emotional teaching methods.

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Percepción de los entrenadores de alto rendimiento de atletismo: caracterización de su perfil polifacético (Perception of high performance track and field coaches: characterization of their multifaceted profile)

Retos ◽

10.47197/retos.v0i29.36511 ◽

2015 ◽

pp. 42-47

Author(s):

Angeles Filgueira Perez

Keyword(s):

High Performance ◽

Target Population ◽

Track And Field ◽

Personal Qualities ◽

High Level ◽

Almost All ◽

Methodological Aspects ◽

The Ideal

En el presente estudio se ha tratado de obtener una aproximación al perfil ideal del entrenador de alto rendimiento en atletismo. En el mundo del deporte de alta competición, el entrenador debe desarrollar funciones de maestro, técnico y líder, lo cual hace difícil delimitar sus competencias (conocimientos, habilidades y cualidades personales). Por tanto, la principal motivación de este trabajo es establecer el papel que debe desempeñar el entrenador para la preparación física, técnica, táctica, psicológica y moral del deportista de alto nivel. Para ello, se ha considerado como población objeto de estudio al conjunto de entrenadores de alto rendimiento que en el momento de la investigación estuviesen activo, ya que interesaba realizar este estudio desde su propia perspectiva. Los datos recogidos forman parte de una investigación más amplia, llevada a cabo mediante encuesta, para la que se diseñó un cuestionario de 78 preguntas en el que se abarcaban tres temas: el perfil del entrenador y del deportista, así como la figura del formador de entrenadores en el Practicum. En este trabajo nos centramos en el primer tema y el análisis de la información obtenida nos permite concluir que la que práctica totalidad de los entrenadores de atletismo consideran necesario dominar con precisión los aspectos técnico-metodológicos. Además, consideran que su ética profesional debe estar regida por los principios de autonomía y beneficencia, de modo que valores como la honestidad y la justicia deben primar en el desarrollo de sus funciones.Abstract: In the current study, we have tried to get an approximation of the ideal profile of high performance coaches in athletics. In the high-level sports world, the coach must develop the role of teacher, technician and leader, which makes it difficult to delimit his/her competencies (knowledge, skills and personal qualities). Therefore, the main motivation of this work is to define the role that the coach plays in relation to the physical, technical, tactical, psychological and moral preparation of elite athletes. Keeping this aim as an objective, we have considered as the target population the high performance coaches who are active at the time of the investigation, since we were interested in knowing their own perspective. The data that was collected is a part of a wider investigation, conducted by a survey, for which we designed a questionnaire of 78 questions divided on three topics: the profile of the coach and the athlete, as well as the figure of the coach educator in the Practicum. In this work, we focus on the first topic and the analysis of the information that we obtained allows us to conclude that almost all the track and field coaches find it necessary to dominate the technical and methodological aspects. They also consider that professional ethics must be governed by the principles of autonomy and care that values like honesty and justice must prevail in the performance of their work.

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Dysmetabolic mechanisms of preeclampsia development

Obesity and metabolism ◽

10.14341/omet12330 ◽

2021 ◽

Vol 17 (4) ◽

pp. 346-356

Author(s):

I. S. Lipatov ◽

Yu. V. Tezikov ◽

A. R. Azamatov

Keyword(s):

Insulin Resistance ◽

Pregnant Women ◽

Metabolic Disorders ◽

Hematological Parameters ◽

Control Group ◽

Metabolic Disturbances ◽

Group Iii ◽

Inflammatory Status ◽

Group I

Background: An in-depth study of dismetabolic mechanisms in the genesis of pre-eclampsia (PE) has been updated because pregnancy is considered as a natural model of metabolic syndrome (MS), as well as the metabolic disorders are important in development of essential hypertension.Aims: to reveal clinical and laboratory parallels in pregnancy complicated by PE without MS and pregnancy proceeding on the background of MS to assess the role of metabolic disturbances in the development of PE.Materials and methods: 82 women with MS were examined in the dynamics of pregnancy and were divided into 2 groups depending on the implementation of PE: group I consisted of 50 women with PE on the background of MS, group II 32 women with MS without PE. We formed group III consisting of 44 pregnant women with PE without accompanying diseases to assess the pathogenetic value of metabolic disorders in the development of PE. The IV (control) group consisted of 30 healthy women with physiological pregnancy. Metabolic, hematological parameters, hormones, markers of the proinflammatory state, endothelial hemostasiological dysfunction, decidualization and placental angiogenesis, accumulation dynamics and distribution loci of adipose tissue were determined in all pregnant women.Results: In the groups of pregnant women with PE, changes similar to MS were revealed: pronounced diabetic and atherogenic disorders with the development of pathological insulin resistance, hyperinsulinemia and leptinemia, endothelial-platelet link hyperactivation, thrombotic and inflammatory status, visceral type of fat deposition, hyperuricemia, hypersympathicotonia. It is proved that in the hierarchy of mechanisms of PE formation, placental dysfunction is a secondary alteration factor, which additionally potentiates the insulin resistance increase and the effects of structural and functional destabilization of the vascular endothelium.Conclusions: The direction of metabolic changes during pregnancy, the common development of PE and MS indicate the important role of dismetabolic mechanisms in the formation of PE.

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CHANGES OF PSYCHO-EMOTIONAL STATE IN THE INFERTILE PREGNANT FEMALES DUE TO THE ANAMNESIS AND IVF

Wiadomości Lekarskie ◽

10.36740/wlek201904111 ◽

2019 ◽

Vol 72 (4) ◽

pp. 562-567

Author(s):

Volodymyr K. Likhachov ◽

Yanina V. Shymanska ◽

Yulia S. Savelieva ◽

Viktoriya L. Vashchenko ◽

Ludmyla М. Dobrovolska

Keyword(s):

Pregnant Women ◽

Art Therapy ◽

Emotional State ◽

Healthy Woman ◽

The Body ◽

Control Group ◽

Emotional States ◽

Psychological Component ◽

Group I ◽

High Level

Introduction: During pregnancy in the body of a healthy woman there are physiological and psychological changes that contribute to the bearing a child and prepare the female for future labour and motherhood. In women who experience failure at the stage of fertilization or during pregnancy, as a result of prolonged negative emotional states, psycho-emotional stress develops. The aim of the research was to study the psycho-emotional state of women with infertility in history, whose pregnancy resulted from extracorporal fertilization (IVF), and to develop methods for reducing their anxiety. Materials and methods: At the first stage, the initial psycho-emotional state of 60 women in the second trimester, whose pregnancy resulted from IVF (Group I), was studied; the control group consisted of 20 healthy women with a physiological course of pregnancy (Group II). At the second stage, 10 art therapy exercises with a requestioning of pregnant women from Group I were conducted for improving their psycho-emotional state. Results: Women of Group I had a high level of both situational anxiety (SA) and the personal one (PA). The prevalent type of the psychological component of gestational dominant was anxiety and euphoric types (58.3%). In one third of women with burdened gynecological history examined mild or masked depression was diagnosed. 43 pregnant women from Group I used a method of psychocorrection – art therapy, which included colouring “antistress” pictures of perinatal topic, making flowers from paper and creating a collage of dreams. Conclusions: After the art therapy course, a high level of SA (from 46.5% to 7.0%) and OA (from 48.8% to 32.6%) decreased, the index of the optimal type of the psychological component of gestational dominant increased from 25.6% to 53.5%. The number of women without depression increased from 62.8% to 93%.

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Effect of Using Different Rations in Nutrition of High-Productive Cows on Milk Quantity and Quality

Агрознање ◽

10.7251/agrsr1402185c ◽

2015 ◽

Vol 15 (2) ◽

pp. 185

Author(s):

Goce Cilev ◽

Živko Gacovski ◽

Biljana Petrovska ◽

Jovan Stojković

Keyword(s):

Chemical Composition ◽

Milk Production ◽

Milk Fat ◽

Dry Matter ◽

Control Group ◽

Daily Production ◽

Group I ◽

Production Increase ◽

High Level ◽

Experimental Group

This paper shows the results of production and chemical composition of cow’s milk on a farm MILKO-HF, Prilep, R. Macedonia with capacity of 100 cows of Holstein-Frisian breed divided into two groups (control and experimental). In control group I which was fed in a standard way of nutrition (ration used on the farm), average daily production of milk per cow ws 22.49 kg with the following chemical composition of milk: average daily content of milk fat is 3.75%, protein 3.57%, lactose 4.65%, nonfat dry matter 9.56% and total dry matter 13.31%. In experimental group II which were fed with the ration according to normatives, average daily production of milk per cow is 24.04 kg with the following chemical composition of milk: average daily content of milk fat is 3.99%, protein 3.57%, lactose 4.65%, non-fat dry matter 9.58% and total dry matter 13.57%. The obtained results show the increase in milk production for 1.55 kg-6.89% and better chemical composition of milk in the experimental group of cows. Thus, dry matter was increased from 13.31% to 13.57%-1.95%, milk fat content from 3.75% to 3.99%-6.4%, nonfat dry matter from 9.56% to 9.58%-0.21%, while the content of protein and lactose stayed on equal level. It was determined that the normed nutrition has influenced on production increase and better chemical composition of milk without unnecessary spent high level of nutrient i.e. nutrition of cows according to recommended normative.

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Common Coherence Witnesses and Common Coherent States

Entropy ◽

10.3390/e23091136 ◽

2021 ◽

Vol 23 (9) ◽

pp. 1136

Author(s):

Bang-Hai Wang ◽

Zi-Heng Ding ◽

Zhihao Ma ◽

Shao-Ming Fei

Keyword(s):

Coherent State ◽

Coherent States ◽

State Problem ◽

Properties And Characterization ◽

The Common ◽

High Level

We show the properties and characterization of coherence witnesses. We show methods for constructing coherence witnesses for an arbitrary coherent state. We investigate the problem of finding common coherence witnesses for certain class of states. We show that finitely many different witnesses W1,W2,⋯,Wn can detect some common coherent states if and only if ∑i=1ntiWi is still a witnesses for any nonnegative numbers ti(i=1,2,⋯,n). We show coherent states play the role of high-level witnesses. Thus, the common state problem is changed into the question of when different high-level witnesses (coherent states) can detect the same coherence witnesses. Moreover, we show a coherent state and its robust state have no common coherence witness and give a general way to construct optimal coherence witnesses for any comparable states.

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The Role of the Placenta in Perinatal Stroke: A Systematic Review

Journal of Child Neurology ◽

10.1177/0883073820929214 ◽

2020 ◽

Vol 35 (11) ◽

pp. 773-783

Author(s):

Bithi Roy ◽

Susan Arbuckle ◽

Karen Walker ◽

Catherine Morgan ◽

Claire Galea ◽

...

Keyword(s):

Low Frequency ◽

Indirect Evidence ◽

Control Group ◽

Causative Role ◽

Placental Pathology ◽

Inclusion Criteria ◽

Clinical Trial Registration ◽

Perinatal Stroke ◽

Causal Pathway

Context: Placental pathology may be an important missing link in the causal pathway of perinatal stroke. The study aim was to systematically review the literature regarding the role of the placenta in perinatal stroke. MEDLINE, Embase, Scopus, and Web of Science electronic databases were searched from 2000 to 2019. Studies were selected based on predefined criteria. To enable comparisons, placental abnormalities were coded using Redline’s classification. Results: Ten studies met the inclusion criteria. Less than a quarter of stroke cases had placental pathology reported. Placental abnormalities were more common among children with perinatal stroke than in the control group. The most frequent placental abnormality was Redline’s category 2 (thrombo-inflammatory process). Conclusions: Placental abnormalities appear to be associated with perinatal stroke, supporting additional indirect evidence and biological plausibility of a causative role. However, the results should be interpreted cautiously considering the low frequency of placental examination and lack of uniformity in placental pathology reporting. Clinical Trial Registration: PROSPERO Registration no: CRD42017081256.

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Characterization of Biofilm Formation and the Role of BCR1 in Clinical Isolates of Candida parapsilosis

Eukaryotic Cell ◽

10.1128/ec.00181-13 ◽

2013 ◽

Vol 13 (4) ◽

pp. 438-451 ◽

Cited By ~ 20

Author(s):

Srisuda Pannanusorn ◽

Bernardo Ramírez-Zavala ◽

Heinrich Lünsdorf ◽

Birgitta Agerberth ◽

Joachim Morschhäuser ◽

...

Keyword(s):

Biofilm Formation ◽

Candida Parapsilosis ◽

Clinical Isolates ◽

Wild Type ◽

Content Type ◽

Initial Adhesion ◽

High Level ◽

Increased Susceptibility

ABSTRACT In Candida parapsilosis , biofilm formation is considered to be a major virulence factor. Previously, we determined the ability of 33 clinical isolates causing bloodstream infection to form biofilms and identified three distinct groups of biofilm-forming strains (negative, low, and high). Here, we establish two different biofilm structures among strains forming large amounts of biofilm in which strains with complex spider-like structures formed robust biofilms on different surface materials with increased resistance to fluconazole. Surprisingly, the transcription factor Bcr1, required for biofilm formation in Candida albicans and C. parapsilosis , has an essential role only in strains with low capacity for biofilm formation. Although BCR1 leads to the formation of more and longer pseudohyphae, it was not required for initial adhesion and formation of mature biofilms in strains with a high level of biofilm formation. Furthermore, an additional phenotype affected by BCR1 was the switch in colony morphology from rough to crepe, but only in strains forming high levels of biofilm. All bcr1 Δ/Δ mutants showed increased proteolytic activity and increased susceptibility to the antimicrobial peptides protamine and RP-1 compared to corresponding wild-type and complemented strains. Taken together, our results demonstrate that biofilm formation in clinical isolates of C. parapsilosis is both dependent and independent of BCR1 , but even in strains which showed a BCR1 -independent biofilm phenotype, BCR1 has alternative physiological functions.

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