scholarly journals Peculiarities of the construction of the placentary complex and the main causes of perinatal losses

2018 ◽  
Vol 9 (1) ◽  
pp. 5-10
Author(s):  
Lidiia A. Ivanova ◽  
Elena V. Titkova
Keyword(s):  
Fetal Death ◽  
Perinatal Death ◽  
Histological Study ◽  
Normal Structure ◽  
Placental Insufficiency ◽  
Control Group ◽  
Histological Structure ◽  
Fetoplacental Complex ◽  
Ascending Infection ◽  
And Control

The article presents the analysis of the massometric parameters of the fetoplacental complex (weight of the placenta of full-term newborns, placental-fetal coefficient (PPC), linear mass of the umbilical cord (LMU). Indicators that alarm the neonatologist doctor as possible markers of perinatal losses are: a decrease in the placenta mass, an increase in PPC, high LMU (a consequence of ascending bacterial infection (funiculitis) and the development of circulatory umbilical edema in acute right ventricular failure, for example, in viral atrial myocarditis). A histological study of newborn children of the main and control group was carried out to identify the main types of histological structure of the placenta: normal structure, ascending infection of the placenta, hematogenous infection of the placenta, chronic placental insufficiency, acute placental insufficiency. revealed a different frequency of occurrence of these conditions in patients of the main and control groups. The main causes of perinatal losses are analyzed. It is determined that more than half of cases of perinatal fetal death is infectious pathology: viral, bacterial and mixed viral-bacterial. About a quarter of cases of perinatal death is caused by acute heart failure with placental abruption and a complex of cardiovascular and respiratory disorders in premature infants. In 18% of cases, congenital malformations of the fetus lead to perinatal death. CRF causes perinatal fetal death in approximately 10% of cases.

scholarly journals Fetoplacental complex parameters’ changes during repeated increase of the blood volume in female rabbits

2020 ◽  
Vol 11 (6) ◽  
pp. 37-44
Author(s):  
Nataliya G. Pavlova ◽  
Anastasiya A. Yakovleva
Keyword(s):  
Blood Volume ◽  
Functional State ◽  
Saline Solution ◽  
Experimental Studies ◽  
Main Group ◽  
Placental Insufficiency ◽  
New Drugs ◽  
Control Group ◽  
Fetoplacental Complex ◽  
Preclinical Trials

One of the mandatory stages of introducing new drugs into obstetric practice is preclinical trials, the purpose of which is to study the effect of drugs on the development of fetuses and placentas. When conducting experimental studies, the main group of animals receiving the drug is compared with the control group of animals that do not receive drugs. At the same time, the volume of the test drug itself can significantly change the blood volume (BV) of an experimental animal, especially a small one, and such administration repeated repeatedly over several days can accumulate this effect, having an adverse effect on the functional state of the fetus. A model of chronic placental insufficiency created on the 18th day of pregnancy in female rabbits by ligating 1/3 of the preplacental vessels in one uterine horn was used to study the effect on the development of the brain and placenta of normally developed and retarded fetuses of multiple daily (1928 days of pregnancy) infusions of saline solution to females in a volume of 6% of the animals BV and comparable to the volume of medications used in the treatment of placental insufficiency in clinical practice (main group of rabbits). It was found that repeated daily administration of saline solution to a female rabbit in the second half of pregnancy, which is about 6% of the BV, causes a violation of the functional state of her normally developed and, to an even greater extent, retarded fetuses. This is manifested by a 1.4-fold reduced survival rate of fetuses in the intact horn of the uterus and a more pronounced violation of brain metabolism in fetuses of the intact and experimental horns compared to those of the control group of females.

scholarly journals PROGNOSTIC VALUE OF MORPHOMETRIC PARAMETERS OF ECHOCARDIOGRAPHY AND PLACENTOMETRY

2017 ◽  
Vol 19 (2) ◽  
pp. 31-36
Author(s):  
L A Ivanova ◽  
А V Ророvа ◽  
K P Karpov
Keyword(s):  
Fetal Death ◽  
Newborn Infants ◽  
Risk Groups ◽  
Morphometric Parameters ◽  
Control Group ◽  
Histological Structure ◽  
Leningrad Region ◽  
Integral Index ◽  
Maternity Hospitals ◽  
Group 2

Objective. The aim of the study was to compare the morphometric parameters of echocardiography in a normally occurring pregnancy. Comparison of the obtained data with the data of heart measurement in children perinatally perished, as well as the analysis of the mass indexes of the fetus and placenta in healthy fetuses and fetuses perinatally lost. Materials and methods. We analyzed 94 protocols for the investigation of post-mortem and the protocols for autopsy of fetuses and newborn infants perinatal in various maternity hospitals in St. Petersburg and the Leningrad Region (group 1). The control group 2 consisted of 12 patients who were registered for pregnancy, were examined according to the usual pattern, later they had urgent deliveries to healthy newborns, the histological structure of the placenta was represented by reactive and compensatory-adaptive changes characteristic of the placenta of the normal structure. Patients of control group 2 underwent evaluation of echocardiograms obtained during the third screening test during pregnancy, performed at the time of 32-34 weeks. Control group 3 included 335 observations of full term pregnancy, which resulted in the birth of a healthy fetus. In this group, an analysis was made of the mass indexes of the fetus, placenta, and the integral index of the placental-fetal ratio. Results of the study. Massometric parameters of the fetus, placenta and integral index of the placental-fetal ratio in the patients of the main and control groups were analyzed. Typical changes in the weight of the placenta and placental-fetal ratio in patients with perinatal fetal death were determined. Opportunities were identified for risk groups for perinatal fetal death according to the analysis of the sonocardiogram. Conclusion. 8 conclusions are presented that represent the possibility of predicting perinatal losses depending on the size of the placenta, placental-fetal ratio, the isolation of risk groups for perinatal fetal death according to the data of sonocardiography

scholarly journals Effect of Ligand Peptides on Post-Burn Inflammation of Damaged Corneal Tissue in Experiment

2019 ◽  
Vol 4 (4) ◽  
pp. 30-35
Author(s):  
A. V. Tereshchenko ◽  
I. G. Trifanenkova ◽  
A. M. Kodunov ◽  
A. A. Temnov ◽  
A. N. Sklifas
Keyword(s):  
Stem Cells ◽  
Burn Injury ◽  
Histological Study ◽  
Normal Structure ◽  
Control Treatment ◽  
Control Group ◽  
Corneal Tissue ◽  
Thermal Burn ◽  
Treatment And Prevention ◽  
Experimental Group

Background. In case of a corneal burn injury, cell transplantation into the damaged area must be performed within the first 12 hours, which makes it impossible to use autologous stem cells. One solution to this problem may be the use of peptides, derived from cultured stem cells in the treatment and prevention of complications in a burn eye disease. Aims: To study the dynamics of corneal tissue repair under the influence of a peptide solution on a corneal thermal burn model.Materials and methods. The study included 20 rabbits (20 eyes) of the gray Chinchilla breed weighing from 2.5 to 3.2 kg with a corneal thermal burn model. Depending on the method of treatment used, the animals were divided in two groups of 10 rabbits (10 eyes). In the experimental group, instillations of a peptide solution were used to treat corneal thermal burns; in the control treatment was carried out with a solution of moxifloxacin and gel “Solcoseryl”. On the 1st, 3rd, 7th, 14th, 30th days in each group, two animals were sacrificed to conduct a morphological study of the cornea. Results. In the experimental group, by the 30th day, according to a histological study, the inflammatory process was completed both on the surface and inside the cornea, with a tendency to restore its normal structure. In the control group of animals, significantly longer periods of corneal recovery and preservation of inflammation, despite the received therapy, were observed.Conclusions. The use of the peptide preparation is promising in the treatment of corneal thermal burn. Further research is needed in this area.

scholarly journals Effect of a bradykinin potentiating factor separated from honey bee venom on thyroid gland and testis in hypothyroid white rats

2022 ◽  
Vol 83 (1) ◽  
Author(s):  
Elsabry Abu Amra ◽  
Sohir Ali Abd El Rehim ◽  
Fakhr Mostafa Lashein ◽  
Heba Seleem Shoaeb
Keyword(s):  
Thyroid Gland ◽  
Honey Bee ◽  
Sex Hormones ◽  
Histological Study ◽  
Bee Venom ◽  
Male Rats ◽  
Control Group ◽  
Histological Structure ◽  
White Rats ◽  
Male Sex

Abstract Background Animal venoms have been known as a source of drugs beneficial to human health. Accordingly, this study was designed to determine the effect of bradykinin potentiating factor (BPF) separated from honey bee venom, Apis mellifera on histological structure, thyroid and male sex hormones of the thyroid gland and testis in a model of hypothyroid male white rats induced by carbimazole. Results This study includes male rats divided into 6 main and sub-groups (10 rats in each group). Control group, carbimazole group, levothyroxine group, BPF group, carbimazole group treated with levothyroxine and carbimazole group treated with BPF. At the end of experiments (60 days) rats were sacrificed and dissected; the blood was collected for determination of thyroid and male sex hormones. Also, the thyroid gland and testis were taken to histological study. The results indicated that, carbimazole group showed a highly significant decrease in thyroid hormones (T4, T3, Ft4 and Ft3) and male sex hormones (LH, FSH and testosterone), but a significant increase in TSH compared to control group. The results revealed that, treated groups with levothyroxine or BPF have significant increase in thyroid and male sex hormones and significant decreasein TSH. A significant improvement was detected in co-treated groups (hypothyroid groups) with levothyroxine or (BPF). Also, the present study showed a histopathological change in thyroid gland and testis of hypothyroid male rats. Conclusion Treated hypothyroid rats with levothyroxine as a drug and BPF as a natural product showed an improvement of these complications induced by carbimazole in thyroid gland and testis. Therefore, BPF may be benefical in treatment of hypothyroidism.

PENGARUH LINAMARIN TERHADAP PENAMPILAN REPRODUKSI INDUK MENCIT (Mus musculus L.)

2017 ◽  
Vol 11 (4) ◽  
pp. 289
Author(s):  
Fitra Wahyuni ◽  
Sony Heru Sumarsono
Keyword(s):  
Body Weight ◽  
Statistical Analysis ◽  
Reproductive Performance ◽  
Fetal Death ◽  
Control Group ◽  
Average Weight ◽  
Treatment Groups ◽  
Pregnant Mice ◽  
And Control ◽  
Average Weight Gain

<p align="center"><strong><em>ABSTRACT</em></strong></p><p><em>This study was performed to observe the effect of linamarin on reproductive performance, that consist of the number of live fetuses, reabsorption embryo or fetal, fetal death and fetal body weight together with length. Pregnant mice were divided into one control group with administration of distilled water (0 mg/kgb.w/days) and six treatment groups linamarin dose is 0.36; 0.72; 1.26 mg; 2; 4; and 8 mg/kgb.w./days. Linamarin dosing and control begins at 5<sup>th</sup> to 16<sup>th</sup> gestation days, at 17-days of gestation caesarean section were performed to pregnant mice to remove foetuses. Statistical analysis used was a variation analysis by ANOVA followed by comparisons between treatments HSD test (Tukey). Giving linamarin observed in the parent mice led to a decrease in average weight gain of the mother during pregnancy compared with controls. In linamarin dose 8 mg/kgb.w/day an increase in embryo reabsorption and fetal death, as well as the observed decrease in fetal body weight and length, but after statistical analysis of the decrease was not significantly different. Linamarin with the doses given in this study is not expected to interfere with pregnancy based on reproductive performance were observed.</em></p><p><em> </em></p><p><strong><em>Keywords:</em></strong><em> Linamarin, reproductive performance, fetal weight, fetal body length</em></p><p><em> </em></p><p align="center"><strong><em>ABSTRAK</em></strong></p><p><em>Penelitian ini dilaksanakan bertujuan untuk mengamati pengaruh linamarin pada penampilan reproduksi yang meliputi jumlah fetus hidup, embrio resorpsi, fetus mati dan berat beserta panjang badan fetus. Induk mencit yang bunting dikelompokkan ke dalam satu kelompok kontrol dengan pemberian akuades (0 mg/kgb.b./hari) dan enam kelompok perlakuan dosis linamarin yaitu 0,36; 0,72; 1,26 mg; 2; 4; dan 8 mg/kgb.b./hari. Pemberian dosis linamarin dan kontrol dimulai pada umur kebuntingan 5 sampai 16 hari, setelah itu pada umur kebuntingan 17 hari mencit dikorbankan nyawanya untuk pengambilan fetus. Analisis statistik yang digunakan adalah analisis variasi dengan ANOVA dan dilanjutkan dengan uji perbandingan antar perlakuan HSD (Tukey). Pemberian linamarin pada induk mencit diamati menyebabkan penurunan rata-rata pertambahan berat badan induk selama kebuntingan dibandingkan dengan kontrol. Pada dosis linamarin 8 mg/kgb.b./hari terjadi peningkatan embrio resorpsi dan fetus yang mati, serta diamati penurunan berat dan panjang badan fetus, namun setelah dilakukan analisis statistik penurunan tersebut tidak berbeda nyata. Linamarin dengan dosis yang diberikan pada penelitian ini diduga tidak mengganggu kebuntingan berdasarkan penampilan reproduksi yang diamati.</em></p><p><em> </em></p><p><strong><em>Kata kunci:</em></strong><em> Linamarin, penampilan reproduksi, berat badan fetus, panjang badan fetus</em></p>

Study of Walnut Oil Supplementation on Serum Biochemical Parameters and Histopathology of Male Rats

2021 ◽  
Vol 19 (6) ◽  
pp. 08-14
Author(s):  
Mohammed Zuheir Hassan ◽  
Mohammed Jaffer AL- Anssari ◽  
Hayder Hasan Rajab ◽  
Ali Abbas Abo Ajon ◽  
Ashraf Raoof Mohammed Ali ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Protein ◽  
Histological Study ◽  
Treated Group ◽  
Male Rats ◽  
Whole Body ◽  
Control Group ◽  
Walnut Oil ◽  
Significant Difference ◽  
And Control

The purpose of the experiment is an investigate the association of walnut oil with lipid profiles, glucose as well as total proteins and assessment its side effect on some sensitive organs such as the liver and spleen tissues. The experiment divided into two main groups are treated group with walnut oil and the control group, where the former divided into two subgroups 0.25 and 0.5 ml of oil per each. We found a statistically non-significant difference between treated and control groups (for total protein, lipid profile, and glucose). There was no change in total protein, but cholesterol decreased by 0.25 ml but a little increased by 0.5 ml. HDL was increased for the treated group. While on 0.25 ml LDL decreased in treated animals, on another hand no change for 0.5 ml. Also, no change for VLDL between treated and control. The only triglyceride was increased but non-significant for the treated group compared with the control. Both doses decreased in treated animals for glucose. We also found an increase in whole-body weight and on sensitive organs such as the liver and spleen. Even no change in a histological study for the mentioned organs. The conclusion: By walnut oil, all parameters have changed despite the treated group was normal without any induced diseases. So, recommended the researchers induce the disorders in the liver and assessment the extracted oil on the lipid profile.

Prevention of previous treatments in pregnant women with benign cervical pathology in anamnesis

2017 ◽  
pp. 59-64
Author(s):  
О.O. Korchynska ◽  
◽  
N.Yu. Bysaha ◽  
Keyword(s):  
Perinatal Death ◽  
Fetal Distress ◽  
Main Group ◽  
Laboratory Evaluation ◽  
Control Group ◽  
Primary Group ◽  
Perinatal Complications ◽  
Fetoplacental Complex ◽  
Benign Pathology ◽  
Two Stages

The article presents the prophylactic and therapeutic complex developed by us, which reduces the frequency of early and late spontaneous abortions, premature births, reduces placental dysfunction, anomalies of labor, fetal distress, the percentage of cesarean sections, the pathology of the postpartum period in women with benign pathology of the cervix ) in the anamnesis. The objective: was to decrease the frequency of preterm labor in women with benign pathology of CM in the anamnesis on the basis of studying clinical and microbiological and endocrinological features, as well as using the developed complex of preventive and curative measures. Materials and methods. The study was conducted in two stages. At the first stage, the features of the course of pregnancy, childbirth, the postnatal and neonatal periods were studied in 50 patients with a benign pathology of CM in a history, which was carried out by conventional preventive and therapeutic measures (first group); for the comparative characteristics, similar parameters were studied in 50 obstetric and somatically healthy primiparas (control group). At the second stage, clinical and instrumental-laboratory evaluation of the prophylactic-therapeutic complex developed by us was carried out, which was used before and during pregnancy in 50 women with a benign pathology of CM in the anamnesis (II main group). Results. The use of the proposed treatment-and-prophylactic complex prevented recurrence of benign pathology of CM by results of colposcopic and cytological studies – 26% in the 2-nd main group against 62% in the I primary group (p<0.05). No cases of prematurity or perinatal death in newborns from mothers assigned to the prophylactic-therapeutic complex proposed by us have been recorded. Сonclusion. The prophylactic and therapeutic complex developed by us includes the use, starting from early pregnancy, of natural micronized progesterone, diosmin, succinic acid, levocarnitine and a local antiseptic with probiotic, which allows reducing the frequency of preterm birth and other obstetric and perinatal complications. This helps to improve the results of delivery in women with benign cervical pathology in history. Key words: pregnancy, childbirth, benign pathology of the cervix, fetoplacental complex.

scholarly journals Identification of carbendazim carcinogenicity: experimental study in cba mice СВА мice

2019 ◽  
Vol 87 (3) ◽  
pp. 18-23 ◽  
Author(s):  
V.S. Lisovska ◽  
N.M. Nedopytanska ◽  
O.V. Reshavska ◽  
N.V. Tereschenko ◽  
E.A. Bahlii
Keyword(s):  
Experimental Study ◽  
Latent Period ◽  
Control Group ◽  
Histological Structure ◽  
Intragastric Administration ◽  
Experimental Animals ◽  
Cba Mice ◽  
Carcinogenic Potential ◽  
And Control ◽  
Key Words Pesticides

ABSTRACT. Introduction. Carbendazim is a systemic benzimidazole fungicide rated as a possible human carcinogen. In Ukraine, over 20 carbendazim-based preparative forms of fungicides, predominantly generics, are registered, therefore, oncogenicity study of carbendazim from different manufacturers is of immediate interest. Objective of the paper is to identify carcinogenicity of 98 % technical carbendazim under conditions of chronic experiment in mice Methods. A total of 280 male and 280 female CBA mice were included in the study. Carbendazim was intragastrically administered in these animals for 18 months 5 times per week via a gastric tube at the doses of 0, 5, 25 and 75 mg/kg body weight as 0, 0.1, 0.5 and 1.5 % ex tempore prepared a suspension. Dead as well as sacrificed animals according to the experimental schedule were subjected to autopsy. Carcinogenicity was assessed using direct effect parameters — tumour ratio and their latent period. Results and Discussion. Clinical parameters of the condition of experimental animals, survival and incidence of premalignancy did not differ from those in the control animals. The main cause of death in animals throughout the study were non-specific intercurrent diseases developed with approximately the same rate in the experimental and control group. Tumour incidence (n = 37) in experimental and control groups did not statistically differ and complied with the spontaneous level in CBA mice. Conclusion. Incidence of tumours, their histological structure, location and latent period in experimental animals on carbendazim at the dose of 5, 25 and 75 mg/kg did not differ from those in the control group. Thus, the experimental study of carbendazim in CBA mice after intragastric administration for 78 weeks did not reveal the carcinogenic potential of the substance. Key Words: pesticides, carbendazim, carcinogenicity, mice.

scholarly journals EFFECT OF TESTOSTERONE REPLACEMENT ON EPITHELIAL AND STROMAL TISSUE IN PROSTATIC LOBE IN ORCHIDECTOMIZED WISTAR

2013 ◽  
Vol 20 (1) ◽  
Author(s):  
Yudi Irawan ◽  
Aaron T. Sihombing
Keyword(s):  
Prostate Gland ◽  
Normal Structure ◽  
Test Method ◽  
Testosterone Replacement ◽  
Control Group ◽  
Distributed Data ◽  
Stromal Tissue ◽  
Epithelial Structure ◽  
Prostatic Atrophy ◽  
And Control

Objective: To evaluate the effect of testosterone replacement on epithelial and stromal changes of prostatic lobes in castrated wistar rats. Material & Method: The subjects were 30 wistars equally assigned to castrated + testosterone replacement group (n = 10), castrated group (n = 10), and control group (n = 10). After 60 days, prostatectomy was performed in all rats and prostatic specimens were analyzed by haematoxylin eosin (HE) staining under microscope. Semi–quantitative analysis was performed by evaluating growth of epithelial structure and loss of fibromuscular stroma. Results were analyzed using ANOVA test method for normally distributed data. The statistical analysis was performed using SPSS. Results: There was significant reversibility in castration + testosterone replacement groups in all prostatic lobes compared with castration groups (p = 0,010).There were 5 rats showing normal structure of prostate gland compared to control groups in all prostatic lobes (50%), and 5 showed hyperplasia in all prostatic lobes (50%). Conclusion: Testosterone deprivation can cause prostatic atrophy. Dominant atrophy was found in ventral and lateral lobes. Testosterone replacement can prevent atrophy in all prostatic lobes regardless of specific prostatic lobes.Keywords: Testosterone deprivation, testosterone replacement, prostatic lobes.

scholarly journals Early prediction of placental insufficiency in obese women

2021 ◽  
Vol 8 (1) ◽  
pp. 40-47
Author(s):  
Natalya S. Datsenko ◽  
Igor O. Marinkin ◽  
Tat’yana M. Sokolova ◽  
Tat’yana V. Kiseleva ◽  
Anna V. Yakimova
Keyword(s):  
Pregnant Women ◽  
Placental Insufficiency ◽  
Reproductive Age ◽  
Control Group ◽  
Obese Women ◽  
Growth State ◽  
Pregnancy And Childbirth ◽  
Paired Samples ◽  
Fetoplacental Complex ◽  
Prevalence Of Obesity

Obesity is one of the most important problems in modern health care. The high prevalence of this pathology also affects women of reproductive age, which leads to an increase in the prevalence of obesity in pregnant women. Purpose of the work ‒ analysis of the effect of adipokine indicators on predicting the development of placental insufficiency in obese women. Materials and methods. 225 women were examined who were subdivided by such a parameter as obesity into 4 groups: 3 main and 1 control. The control group consisted of 55 pregnant women with an initially normal BMI value (18.5‒24.9 kg/m2). Group 1st included 109 pregnant women with grade I obesity (BMI 31.88 1.4 kg/m2), group 2nd ‒ 34 pregnant women with grade II obesity (BMI 36.6 1.1 kg/m2), group 3rd ‒ 31 pregnant women with grade III obesity (BMI 42.2 1.9 kg/m2). We studied the data of the anamnesis of pregnant women (somatic and obstetric-gynecological), indicators of adiponectin and omentin, peculiarities of the course of pregnancy and childbirth (data of cardiotocography (CTG), ultrasound markers of disturbances in the formation and functioning of the fetoplacental complex), indicators of labor activity, parameters of newborns (mass-growth, state on the Apgar scale, ponderal index, fetal-placental ratio) and the course of the postpartum period. When conducting statistical analysis in the case of comparing two dependent (paired) samples of parameters, the paired Students t-test was used. The results were considered statistically significant if the р was less than 0.05. With this indicator, the value of the probability of difference between the compared categories was more than 95%. Results. The possibility of predicting the development of placental insufficiency depending on the concentrations of omentin and adiponectin was confirmed. The development of placental insufficiency is most likely with omentin values in the range of 177.6‒191.2 g/ml and adiponectin in the range of 16.0‒22.5 g/ml. Conclusion. Determination of adipokine levels at 8‒9 weeks gestation may be practically significant in predicting the development of placental insufficiency in obese women.

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