scholarly journals Clinical and laboratory evaluation of treatment efficiency in patients with prolactinoma

2021 ◽  
Vol 38 (3) ◽  
pp. 6-14
Author(s):  
S. D. Shukyurov
Keyword(s):  
Biochemical Parameters ◽  
Hormone Level ◽  
Clinical Laboratory ◽  
Mean Value ◽  
Laboratory Evaluation ◽  
Laboratory Studies ◽  
Healthy Individuals ◽  
Treatment Efficiency ◽  
Blood Samples ◽  
Practical Medicine

Introduction. Prolactinomas are rarely detected in children and are very often characterized by aggressive growth. Objective. The aim of the study was to increase the effectiveness of drug treatment with prolactin based on the results of clinical and laboratory studies. Material and methods. In order to determine clinical, laboratory, hormonal, functional and instrumental markers, 63 patients with microprolactinomas and 53 patients with macroprolactinomas were examined. Some biochemical parameters of blood samples, such as TSH, T4, T3, FSH, LH, GH, IGF, ACTH, cortisol and prolactin were studied in healthy individuals, in patients with microprolactinoma and macroprolactinoma 4 times: 3, 6 and 12 months after the start of treatment with cabergoline. Results. During the study, it was determined that a mean value of FSH in blood samples obtained during hormonal studies conducted before treatment with cabergoline was 4.94 0.41 IU/L, that is slightly lower than that of healthy women (n = 24) who participated in the study (5.49 0.52 IU/L) (p = 0.4037). Statistical analysis within the 6th month of treatment with the appropriate drug showed a reliable decrease in a mean value of LH hormone to 1.93 0.25 IU / L (p = 0.0002, p1 = 0.0232). In biopsies obtained during this study period, the minimum hormone level was 0.1 IU/L, and the maximum 4.18 IU L. Conclusions. Thus, the treatment of patients with macro- and microprolactinoma using cabergoline can play an important role in correcting their physical, hormonal and other parameters, and will expand the use of its analogs in practical medicine.

Visfatin concentration and anthropometric/biochemical parameters in healthy individuals-preliminary study

2018 ◽  
Author(s):  
Justyna Nowak ◽  
Karolina Kulik-Kupka ◽  
Joanna Kowalska ◽  
Iwona Zielen-Zynek ◽  
Bartosz Hudzik ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Healthy Individuals ◽  
Preliminary Study

Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt

2020 ◽  
Vol 20 (5) ◽  
pp. 382-389 ◽  
Author(s):  
Shimaa EL-Sharawy ◽  
Osama El- Sayed Negm ◽  
Sherief Abd-Elsalam ◽  
Hesham Ahmed EL-Sorogy ◽  
Mona Ahmed Helmy Shehata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Gene Polymorphism ◽  
Clinical Laboratory ◽  
Treatment Options ◽  
Laboratory Evaluation ◽  
Toll Like Receptor ◽  
Focal Lesions ◽  
Tlr3 Gene ◽  
Cirrhotic Patients

Background & Aims: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with few treatment options. Toll-like receptor 3 (TLR3) plays a key role in innate immunity and may affect the development of cancers. This study aimed to investigate the association between TLR3 gene polymorphism and HCV-related hepatocellular carcinoma in Egypt. Methods: This work was conducted on 70 individuals; fifty HCV cirrhotic patients were included in two groups; with HCC (30 patients) and without HCC (20 patients) compared with a group of 20 apparently healthy controls. All of the studied individuals underwent clinical-laboratory evaluation. TLR3 gene single-nucleotide polymorphism (SNP) (+1234C/T) was tested by polymerase chain reaction- restriction fragment length polymorphism. Results: This study reported that the prevalence of TLR3 +1234TT genotype was significantly increased in cirrhotic patients with HCC than without HCC, while it was not detected at all among the controls. When analyzing the TLR3 SNP +1234C/T with different clinical parameters in HCC patients, there was a significant association between+1234C/T SNP; namely TT genotype and each of the hepatic focal lesions᾽ number, size and the patients᾽ higher Okuda and BCLC stages. No association could be detected between TLR3 SNP and the age, sex, Child-Pugh grades, MELD score or AFP of the studied HCC cases. Conclusion: TLR3 gene SN P +1234C/T could be a novel risk factor for the HCV-related HCC among the Egyptian population.

scholarly journals Influence of Pesticide on Biochemical and Hematological Parameters in Beninese Vegetable Farmers

2018 ◽  
Vol 9 (1) ◽  
pp. 65
Author(s):  
Lucie AYI-FANOU
Keyword(s):  
Blood Cell ◽  
Biochemical Parameters ◽  
Mean Corpuscular Volume ◽  
Hematological Parameters ◽  
Control Group ◽  
Study Group ◽  
Blood Samples ◽  
Vegetable Farmers ◽  
Insignificant Difference ◽  
Hematological And Biochemical Parameters

In several countries, a lot of researches have shown the toxicity of pesticides on farmers. Meanwhile, few of them have dealt with vegetable farmers in Benin. Therefore, this study has been carried out to assess the effects of pesticides on vegetable farmers’ health. This study is conducted on 30 vegetable farmers who used pesticides and 20 subjects as control group. Pesticides used by vegetable farmers and their risky behavior were investigated. Their blood samples were collected and some tests were performed for hematological and biochemical parameters. For the statistical analysis of the results, Student’s test was used. Our investigations revealed that vegetable farmers of Benin were exposed to different active ingredients of pesticides such as (Abamectin, Acetamiprid, Chlorpyriphos ethyl, Cyfluthrin, Cypermethrin, Emamectin benzoat, Flubendiamid, Lambdacyhalothrin, Mancozeb, Profenofos, Spinosad and Spirotétramate). The hematological parameters showed significant decrease in White blood cell (WBC), Red blood cell (RBC), Hemoglobin (HGB), Hematocrit (HTC), Mean Corpuscular Volume (MCV), Platelet (PLT) count among study group. The enzymatic activities of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) have significantly raised between vegetable farmers and the control group, while the serum concentration in urea and creatinine showed insignificant difference in the study group. These results suggest that pesticides have adverse effects on vegetable farmers of South of Benin.

Pre-clinical laboratory evaluation of the new ‘AF’ arterial line filter range

Perfusion ◽  
2010 ◽  
Vol 25 (4) ◽  
pp. 267-276 ◽  
Author(s):  
Gemma Yarham ◽  
John Mulholland
Keyword(s):  
Pressure Drop ◽  
Surface Area ◽  
Heart Surgery ◽  
Clinical Laboratory ◽  
Open Heart Surgery ◽  
Global Market ◽  
Individual Characteristics ◽  
Laboratory Evaluation ◽  
Arterial Line ◽  
Experimental Conditions

Introduction: The presence of emboli was recognised relatively early in the history of open heart surgery. The emboli produced during cardiopulmonary bypass have the predisposition to distribute into, and ultimately obstruct, microvessels of all tissues. The Sorin Group has recently developed a new range of arterial line filters. Before the Sorin AF range of filters was released for pre-launch clinical trials, our group performed in vitro laboratory testing of the AF range against a selection of commercially available filters on the global market. Results: The Sorin AF620 and AF640 demonstrate both the smallest prime volume and smallest surface contact area (92ml and 290cm2, respectively).The results of the GME Handling Efficiency experiments ranged by 39.6%, from 95.9% to 56.3%. In terms of an air bolus handling, the results of the Limit Bolus experiment ranged by 97ml, from 147.5ml down to 50ml. The pressure drop across all the filters was measured under steady state experimental conditions. All of the above investigations were considered against surface area and prime volume. Conclusion: It is clear from the results that some commercially available arterial line filters perform better than others, not only in overall performance, but also with regard to individual characteristics. Evaluating arterial line filters for hospital-specific use has to balance pressure drop, surface area, micro air handling, prime volume and gross air handling; all points need to be considered. In the AF620 and AF640, Sorin boast that they are the two smallest prime and smallest surface area filters commercially available on the global market. The Sorin AF filter range performs well in all of the areas we investigated and will be a competitive option for centres, irrespective of which characteristics they use to evaluate and select their arterial line filter.

scholarly journals Comparing Ethnicity-Specific Reference Intervals for Clinical Laboratory Tests from EHR Data

2018 ◽  
Vol 3 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Nadav Rappoport ◽  
Hyojung Paik ◽  
Boris Oskotsky ◽  
Ruth Tor ◽  
Elad Ziv ◽  
...  
Keyword(s):  
Race And Ethnicity ◽  
Laboratory Tests ◽  
Clinical Laboratory ◽  
Local Population ◽  
Reference Intervals ◽  
Medical Decision ◽  
Specific Reference ◽  
Healthy Individuals ◽  
Electronic Health Record Data ◽  
Novel Approach

Abstract Background The results of clinical laboratory tests are an essential component of medical decision-making. To guide interpretation, test results are returned with reference intervals defined by the range in which the central 95% of values occur in healthy individuals. Clinical laboratories often set their own reference intervals to accommodate variation in local population and instrumentation. For some tests, reference intervals change as a function of sex, age, and self-identified race and ethnicity. Methods In this work, we develop a novel approach, which leverages electronic health record data, to identify healthy individuals and tests for differences in laboratory test values between populations. Results We found that the distributions of >50% of laboratory tests with currently fixed reference intervals differ among self-identified racial and ethnic groups (SIREs) in healthy individuals. Conclusions Our results confirm the known SIRE-specific differences in creatinine and suggest that more research needs to be done to determine the clinical implications of using one-size-fits-all reference intervals for other tests with SIRE-specific distributions.

scholarly journals Serum biochemical properties of Vietnamese indigenous Noi chicken at 56 days old

2020 ◽  
Vol 36 (3) ◽  
pp. 329-339
Author(s):  
Nguyen Giang ◽  
Nguyen Hien ◽  
Huynh Loan ◽  
Phan Phuc ◽  
Nguyen Dai ◽  
...  
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Animal Health ◽  
Correlation Coefficients ◽  
Biochemical Properties ◽  
Blood Samples ◽  
Male And Female ◽  
Native Breed ◽  
Serum Biochemical ◽  
The Relationship

Serum profile is generally considered as comprehensive data which directly reflected animal health and their potential resistance to environmental, nutritional and pathological stress. The present study aimed to provide physiological reference values for selected biochemical parameters in Noi chickens, a famous Vietnamese native breed, at 56 days old. The collected blood samples of 355 Noi birds (164 males and 191 females) were used to evaluate biochemical serum profile. Glucose, total protein, albumin, globulin, albumin/globulin ratio, triglycerides, cholesterol, creatinine, and uric acid in the serum were measured. The variation in these values arising from different sexes was also investigated. The results indicated that there were no differences (P>0.05) in the assessed indices between male and female Noi chickens. In overall for the whole group, these values were obtained as 250.86 mg/dL, 7.34 g/dL, 3.40 g/dL, 3.94 g/dL, 1.75, 148.54 mg/dL, 190.86 mg/dL, 0.44 mg/dL, and 1.44 mg/dL, respectively. The relationship among the biochemical parameters showed relatively low coefficients (r=0.79 in maximum). The females obtained higher correlation coefficients between levels of total protein and glucose (r=0.42) as well as between total protein and globulin (r=0.79), compared to the males. It was concluded that the male and female chickens performed similar values of serum indices. The contribution of this study might expand the knowledge on the biochemical profile and improved breeding strategies of Vietnamese indigenous Noi chickens.

scholarly journals Effects of Hamo NK hard capsule on experimental atherosclerosis model

2021 ◽  
Vol 141 (5) ◽  
pp. 95-103
Author(s):  
Pham Thuy Phuong ◽  
Pham Thi Van Anh ◽  
Dang Thi Thu Hien ◽  
Nguyen Trong Thong ◽  
Pham Quoc Binh
Keyword(s):  
Oral Administration ◽  
Triglyceride Level ◽  
High Fat Diet ◽  
Biochemical Parameters ◽  
Serum Triglyceride ◽  
Experimental Atherosclerosis ◽  
Serum Triglyceride Level ◽  
High Fat ◽  
Blood Samples ◽  
Aortic Artery

This study evaluated the effects of Hamo NK hard capsule on athresclerosis using experimental atherosclerosis model. NewZealand White rabbits were fed a high-fat diet (HFD) containing cholesterol and peanut oil. The animals received oral administration of HFD and Hamo NK hard capsule at two doses of 0.126 and 0.378 g/kg bw/day for 8 consecutive weeks. Blood samples were collected for analyis of biochemical parameters at before treatment, week 4 and week 8. Histopathology assessments of the aortic artery and liver were carried out at the end of the experiment. Hamo NK was effective in reducing serum triglyceride level after 8 weeks of the experiment. In addition, Hamo NK at two doses of 0.126 g/kg b.w and 0.378 g/kg b.w for 8 consecutive weeks did not affect the cholesterol, LDL-C and HDL-C concentrations induced by a HFD. Hamo NK at the dose of 0.126 g/kg bw/day was not only able to decrease significant aortic surface lesions but also capable of managing atherosclerosis plaques formation in aorta; whereas theses activities were not notiaceable at the dose of 0.378 g/kg b.w.

scholarly journals Heat waves and health impact on human in Baghdad

2020 ◽  
Vol 29 (2) ◽  
pp. 212-222
Author(s):  
Zahraa Hassan ◽  
Hazima Al-Abassi ◽  
Monim Al-Jiboori
Keyword(s):  
Heat Wave ◽  
Heat Waves ◽  
Health Impact ◽  
Mean Value ◽  
Blood Samples ◽  
Normal Value ◽  
Atmospheric Sciences ◽  
Medical City ◽  
The Mean

This investigation aim to evaluate the effect of heat wave on health of human, so to achieve this 40 blood samples for person exposed to heat wave were drawn most patients were attend to specialists in hospital laboratories (Medical City, Ibn al-Baladi, Sheikh Zayed, Kadhimiya Educational). The patients aged 10–60 years, male (20) and female (20). CBC analyzes was performed. The result of the presents study recorded a highly signifi cant difference in total (mean and percent) as compared with the normal value of the CBC analyze the result for total (mean and percent) for male the factors CRP, ESR, WBC, PCV, PL (15.5, 43, 11.35, 28.5, 215) respectively (100%, 100%, 100%, 100%, 100%) and the result for total (mean and percent) for female the factors CRP, ESR, WBC, PCV, PL (15, 43.5, 11.35, 31, 220.5) respectively (100%, 100%, 100%, 100%, 100%). According to the result we can conclude that there was a highly significant deferent in mean value for patient compared with the normal value which is the mean cause of hard attack which lead to death. The study is the fi rst of its kind in the Department of Atmospheric Sciences in Iraq.

scholarly journals The effects of different anticoagulants on biochemical parameters in blood of dairy cows

2015 ◽  
Vol 69 (1-2) ◽  
pp. 13-20
Author(s):  
Branislava Belic ◽  
Marko Cincovic ◽  
Maja Dosenovic ◽  
Dragica Stojanovic ◽  
Zorana Kovacevic
Keyword(s):  
Alkaline Phosphatase ◽  
Dairy Cows ◽  
Alkaline Phosphatase Activity ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Biochemical Analysis ◽  
Blood Parameters ◽  
Albumin Level ◽  
Blood Samples ◽  
Holstein Friesian

Routine analysis of blood parameters requires high precision. Therefore a significant number of methods and recommendations has been developed to ensure the obtaining of precise results. The aim of this study was to investigate whether the type of anticoagulant affects the values of biochemical parameters in the blood of dairy cows in relation to the values obtained from the serum. The study was carried out on 20 healthy cows of Holstein- Friesian breed in the second month of lactation. The blood was taken by venipuncture from v.coccigea. There were used five types of vacutainers as follows: for the serum separation, with heparin, EDTA, citrate, and fluoride. Samples from each cow were taken in all five types of vacutainers respectively. There was determined the concentration of: albumin, total protein, glucose, Ca, P, BHB, NEFA, urea, cholesterol, triglycerides, ALT, AST, AP, GGT and bilirubin. The results of the analysis of samples that contained anticoagulants were compared statistically with analysis in serum that was considered to be the control one. It was also calculated the percentage of deviation in average values of concentration of metabolites obtained from samples with different anticoagulants in regard to the serum value. The results of the investigation show that anticoagulants influence the values of biochemical parameters in the blood of cows. In the samples where heparin was used as anticoagulant there was found higher albumin level (deviation 4.1%) as well as total protein (1.4%), but lower value of alkaline phosphatase activity relative to the serum (-33%). In the samples in which EDTA was used there were significantly lower levels of total protein (-5.8%), Ca (-49.6%), P (-17.7%), AP (-32%) and higher value AST (10.6%) compared to serum. In the samples where citrate or fluoride were used as anticoagulants there were found lower values of total protein, albumin, glucose (only citrate), Ca, P, BHB, NEFA, urea (only citrate), cholesterol, AP and GGT (only fluoride) and lower bilirubin when using citrate or higher when using fluoride, in comparison to the serum. Deviations of biochemical parameters measured from blood samples that were in citrate or fluoride were as follows: total protein (-5.3%, -5.2%), albumin (-7%, -5.7%), glucose (only citrate -6.2%), Ca (-55%, -82%), P (-29%, -24%), BHB (-53%, -80%), NEFA (-62.1%, -79 , 4%), urea (only citrate, -25.5%), cholesterol (-28.6%, -28.4%), AP (-38%, -32%), and GGT (only -17 fluoride, 8%) and higher bilirubin (-22.8%, 64.4%). For routine clinical biochemical analysis of blood of cows it is the most reliable to use the samples with heparin as an anticoagulant, because the use of other anticoagulants gives large variations in the values of biochemical parameters in relation to serum.

scholarly journals Serum Protein Profile Of Iraqi Hydatidosis Patients with Different Sites of Infection

2007 ◽  
Vol 4 (4) ◽  
pp. 612-616
Author(s):  
Baghdad Science Journal
Keyword(s):  
Serum Protein ◽  
Protein Profile ◽  
The Body ◽  
The Other ◽  
Control Group ◽  
Healthy Individuals ◽  
Banding Patterns ◽  
Blood Samples ◽  
Molecular Weights ◽  
Serum Protein Profile

Blood samples of One hundred and twenty patients from different hospitals in Baghdad infected with hydatidosis in different sites of the body (Liver, Lung, multiorgans and kidney) were collected for this study. On the other hand, 30 healthy individuals were included as a control group. This study was conducted to evaluate the effect of this disease on the serum protein profile of the patients using electrophoresis. The results revealed four different protein banding patterns with difference in number of bands and their molecular weights in comparison to the control group, and these differences depended on the site of infection. However the data showed a presence of the same band in all patients with different site of infection.

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