scholarly journals Evaluation of the Ophthalmotoxic Effect of Quantum Dots InP/ZnSe/ZnS 660 and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research. Part 2 (Stage 1)

2021 ◽  
Vol 18 (4) ◽  
pp. 876-884
Author(s):  
V. O. Ponomarev ◽  
V. N. Kazaykin ◽  
A. V. Lizunov ◽  
A. S. Vokhmintsev ◽  
I. A. Vainshtein ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Animal Model ◽  
Antibiotic Resistance ◽  
Inflammatory Diseases ◽  
Modern Medicine ◽  
Adaptation Process ◽  
Relevant Today ◽  
The World ◽  
Stage 1 ◽  
Anatomical Outcomes

The problem of chemo/antibiotic resistance in modern medicine remains relevant today. The sensitivity of microorganisms (MO) determines the range of drugs used, which ultimately affects the effectiveness of treatment and the prognosis for the patient. However, taking into account the adaptation process of individual strains of MO, the uncontrolled use of antibiotics will inevitably lead to the maintenance of the so-called crisis of antibiotic resistance throughout the world, as well as the formation of a vicious circle that reduces the functional and anatomical outcomes of the treatment of any inflammatory diseases, including ophthalmological ones. This article presents the process of experimental creation and certification, assessment of the physicochemical properties of quantum dots, as well as biological nanoconjugates as an option for overcoming the antibiotic resistance of certain strains of microorganisms in the treatment of infectious and inflammatory pathology in ophthalmology, in particular endophthalmitis. Also, an animal model has demonstrated the safety of using InP / ZnSe / ZnS 660 quantum dot solutions for intravitreal administration in pure form and in combination with antibiotics.

scholarly journals Ayurvedic Dentistry: A Review

2018 ◽  
Vol 2 (5) ◽  
pp. 105-107
Author(s):  
Ravneet Sandhu ◽  
Gurnoor Kaur Pannu
Keyword(s):  
Antibiotic Resistance ◽  
Oral Health ◽  
Side Effects ◽  
Well Being ◽  
Modern Medicine ◽  
Entire Body ◽  
Oral Diseases ◽  
The World ◽  
Micro Organisms ◽  
Craniofacial Complex

Oral health is an integral part of the general well-being of a person and is not only closed related to the craniofacial complex but the entire body. We face numerous challenges in maintaining the oral health, we seek help from western/ modern medicine and also search for remedies from the herbal medicine. Modern medicine is a blessing but is limited by the glut of side effects associated with its use. Most oral diseases are infections from caries to periodontal problems are caused by micro-organisms. Antibiotics can be successfully used in their treatment but the world is facing the threat of antibiotic resistance. Considering all these factors, we have been striving to find alternatives to the modern medicines and have started switching back to ayurveda and homeopathy.

scholarly journals Evaluation of the Ophthalmotoxic Effect of Quantum Dots and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research (Stage 1)

2021 ◽  
Vol 18 (3) ◽  
pp. 476-487
Author(s):  
V. O. Ponomarev ◽  
V. N. Kazaykin ◽  
A. V. Lizunov ◽  
A. S. Vokhmintsev ◽  
I. A. Vainshtein ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Animal Model ◽  
Technical Specification ◽  
Vitreous Cavity ◽  
Alternative Methods ◽  
Intravenous Injections ◽  
Semiconductor Crystals ◽  
Complications Of Surgery ◽  
Stage 1 ◽  
Physical And Chemical

Endophthalmitis remains one of the most formidable complications of surgery in ophthalmology, leading to significant functional and anatomical changes. The “gold” standard of treatment for this pathology is the installation of intravenous injections of antibacterial drugs, but taking into account the number and type of pathogens, the growth of antibiotic resistance, the search for alternative methods of treatment of endophthalmitis remains relevant. Colloidal quantum dots, which are nanoscale semiconductor crystals with simulated optical and electronic properties due to changes in their volume, composition, and surface connections, are of interest for research in this direction. This article presents the process of synthesis of CT and bioconjugates based on them in order to assess ophthalmotoxicity with the prospect of further use in the treatment of endophthalmitis. The study was divided into 4 stages, starting with the determination of the required technical specification in order to select the appropriate type of quantum dots taking into account the physical and chemical characteristics (Stage 1), the synthesis of quantum dots (Stage 2), the preparation and titration of a solution of quantum dots of various concentrations for implantation in the vitreous cavity (Stage 3). The final stage was to evaluate the toxic effect of the quantum dot solution in its pure form, as well as in combination with antibiotics (ceftazidime and vancomycin) when administered intravitreally on an animal model. As a result of the study, quantum dots were synthesized and a solution based on them was obtained for introduction into the vitreous cavity. Based on the testing of the animal model (rabbits), a safe dose of the solution was determined, as well as the possibility of its use in combination with antibiotics.

The gut microbiota resistome provides development of drug resistance in causative agents of human infectious diseases

2017 ◽  
pp. 20-32 ◽  
Author(s):  
Е.Н. Ильина ◽  
Е.И. Олехнович ◽  
А.В. Павленко
Keyword(s):  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Integrated Approach ◽  
Modern Medicine ◽  
Pathogenic Microorganisms ◽  
Human Pathogens ◽  
Potential Source ◽  
Causative Agents ◽  
Bacterial Genes

С течением времени подходы к изучению резистентности к антибиотикам трансформировались от сосредоточения на выделенных в виде чистой культуры патогенных микроорганизмах к исследованию резистентности на уровне микробных сообществ, составляющих биотопы человека и окружающей среды. По мере того, как продвигается изучение устойчивости к антибиотикам, возникает необходимость использования комплексного подхода для улучшения информирования мирового сообщества о наблюдаемых тенденциях в этой области. Все более очевидным становится то, что, хотя не все гены резистентности могут географически и филогенетически распространяться, угроза, которую они представляют, действительно серьезная и требует комплексных междисциплинарных исследований. В настоящее время резистентность к антибиотикам среди патогенов человека стала основной угрозой в современной медицине, и существует значительный интерес к определению ниши, в которых бактерии могут получить гены антибиотикорезистентности, и механизмов их передачи. В данном обзоре мы рассматриваем проблемы, возникшие на фоне широкого использования человечеством антибактериальных препаратов, в свете формирования микрофлорой кишечника резервуара генов резистентности. Over the time, studies of antibiotic resistance have transformed from focusing on pathogenic microorganisms isolated as a pure culture to analysis of resistance at the level of microbial communities that constitute human and environmental biotopes. Advancing studies of antibiotic resistance require an integrated approach to enhance availability of information about observed tendencies in this field to the global community. It becomes increasingly obvious that, even though not all resistance genes can geographically and phylogenetically spread, the threat they pose is indeed serious and requires complex interdisciplinary research. Currently, the antibiotic resistance of human pathogens has become a challenge to modern medicine, which is now focusing on determining a potential source for bacterial genes of drug resistance and mechanisms for the gene transmission. In this review, we discussed problems generated by the widespread use of antibacterial drugs in the light of forming a reservoir of resistance genes by gut microflora.

Antibiotic resistance in urological patients with inflammatory diseases of the upper urinary tract

2019 ◽  
Vol 11 (2) ◽  
pp. 106-110
Author(s):  
A.B. Bochkarev ◽  
◽  
S.V. Kostuykov ◽  
E.I. Shamatrina ◽  
D.S. Merinov ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Inflammatory Diseases ◽  
Upper Urinary Tract

1+1 > 2: Integration of the Host-directed Traditional Chinese Medicine and the Virus-targeted Modern Medicine in Control of COVID-19

2020 ◽  
Vol 7 (2) ◽  
pp. 89-94
Author(s):  
Jianjun Sun
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Infectious Diseases ◽  
Modern Medicine ◽  
The World ◽  
Plausible Mechanism

The COVID-19 pandemic has caused millions of infections and hundreds of thousands deaths in the world. The pandemic is still ongoing and no specific antivirals have been found to control COVID-19. The integration of Traditional Chinese Medicine with supportive measures of Modern Medicine has reportedly played an important role in the control of COVID-19 in China. This review summarizes the evidence of TCM in the treatment of COVID-19 and discusses the plausible mechanism of TCM in control of COVID-19 and other viral infectious diseases.

scholarly journals Traditional and Modern Medicine in Worker Health Care

AAOHN Journal ◽  
1987 ◽  
Vol 35 (10) ◽  
pp. 454-455
Author(s):  
Catherine Yuan ◽  
Jin Yu
Keyword(s):  
Health Care ◽  
Occupational Health ◽  
World Wide ◽  
Modern Medicine ◽  
International Perspective ◽  
Health Care Settings ◽  
Worker Health ◽  
The World ◽  
Health Nursing ◽  
Occupational Health Nursing

Nurses from occupational health care settings around the world, interpreting the theme “Communication, Health Care, and the Community,” presented papers at the First International Conference on Occupational Health Nursing in Edinburgh, Scotland in October, 1986. In keeping with AAOHN's commitment to an international perspective, this article is Part II of a five part series of articles that will be printed in the AAOHN JOURNAL. Next month, Part III of the series will feature, “Occupational Health Nursing World Wide.”

scholarly journals Staphylococcus aureus RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 438
Author(s):  
Lorenzo Suigo ◽  
Michaelle Chojnacki ◽  
Carlo Zanotto ◽  
Victor Sebastián-Pérez ◽  
Carlo De Giuli Morghen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Rna Degradation ◽  
Modern Medicine ◽  
Biological Evaluation ◽  
Mrna Degradation ◽  
Design Synthesis ◽  
Small Molecule Screening ◽  
Structure Activity ◽  
Bacterial Rna

Antibiotic resistance is spreading worldwide and it has become one of the most important issues in modern medicine. In this context, the bacterial RNA degradation and processing machinery are essential processes for bacterial viability that may be exploited for antimicrobial therapy. In Staphylococcus aureus, RnpA has been hypothesized to be one of the main players in these mechanisms. S. aureus RnpA is able to modulate mRNA degradation and complex with a ribozyme (rnpB), facilitating ptRNA maturation. Corresponding small molecule screening campaigns have recently identified a few classes of RnpA inhibitors, and their structure activity relationship (SAR) has only been partially explored. Accordingly, in the present work, using computational modeling of S. aureus RnpA we identified putative crucial interactions of known RnpA inhibitors, and we used this information to design, synthesize, and biologically assess new potential RnpA inhibitors. The present results may be beneficial for the overall knowledge about RnpA inhibitors belonging to both RNPA2000-like thiosemicarbazides and JC-like piperidine carboxamides molecular classes. We evaluated the importance of the different key moieties, such as the dichlorophenyl and the piperidine of JC2, and the semithiocarbazide, the furan, and the i-propylphenyl ring of RNPA2000. Our efforts could provide a foundation for further computational-guided investigations.

Defective Ag-In-S/ZnS Quantum Dots: An Oxygen-derived Free Radicals Scavenger for Mitigating the Macrophage Inflammation

2021 ◽  
Author(s):  
Na Gao ◽  
Jing Jing ◽  
Hengzhi Zhao ◽  
Yazhou Liu ◽  
Chunlei Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quantum Dots ◽  
Heart Disease ◽  
Free Radicals ◽  
Inflammatory Diseases ◽  
Antioxidant Therapy ◽  
Oxygen Derived Free Radicals ◽  
Promising Strategy

Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterials-mediated antioxidant therapy is regarded as a promising strategy to treat...

scholarly journals Imunocompetent Mice Model for Dengue Virus Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Denise Gonçalves ◽  
Rafael de Queiroz Prado ◽  
Eric Almeida Xavier ◽  
Natália Cristina de Oliveira ◽  
Paulo Marcos da Matta Guedes ◽  
...  
Keyword(s):  
Animal Model ◽  
Virus Infection ◽  
Dengue Virus ◽  
Viral Disease ◽  
Mice Model ◽  
Rt Pcr ◽  
Dengue Virus Infection ◽  
Dengue Disease ◽  
The Family ◽  
The World

Dengue fever is a noncontagious infectious disease caused by dengue virus (DENV). DENV belongs to the familyFlaviviridae, genusFlavivirus, and is classified into four antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. The number of nations and people affected has increased steadily and today is considered the most widely spread arbovirus (arthropod-borne viral disease) in the world. The absence of an appropriate animal model for studying the disease has hindered the understanding of dengue pathogenesis. In our study, we have found that immunocompetent C57BL/6 mice infected intraperitoneally with DENV-1 presented some signs of dengue disease such as thrombocytopenia, spleen hemorrhage, liver damage, and increase in production of IFNγand TNFαcytokines. Moreover, the animals became viremic and the virus was detected in several organs by real-time RT-PCR. Thus, this animal model could be used to study mechanism of dengue virus infection, to test antiviral drugs, as well as to evaluate candidate vaccines.

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