scholarly journals Malondialdehyde levels are higher and glutathione levels are lower in preeclampsia than in normal pregnancies

Author(s):  
Subandrate Subandrate ◽  
Mia Esta Poetri Afdal Faisal ◽  
Nurul Windi Anggraini ◽  
Sadakata Sinulingga

Background<br />Maternal mortality rate is still a health problem in Indonesia. One major contributor to maternal mortality rate in Indonesia is preeclampsia. One widely accepted theory is that preeclampsia is caused by oxidative stress. Placental hypoxia or ischemia among preeclampsia patients is thought to be the cause of the formation of free radicals such as malondialdehyde (MDA), which decreases endogenous antioxidants such as glutathione (GSH). This study aims to ascertain the difference in plasma malondialdehyde and glutathione levels between healthy and preeclamptic pregnant women.<br /><br />Methods<br />This was an observational analytic study of cross sectional design. Research subjects were 30  normal (healthy) pregnant women (NP), and 30 pre-eclamptic pregnant (PE) women. The measurement of plasma MDA and GSH levels was done at the Biochemistry and Molecular Biology laboratories, Faculty of Medicine, Sriwijaya University using Sigma-Aldrich MDA and GSH assay kits. Mann Whitney test was used to analyze the data. <br /><br />Results<br />Subjects aged &gt;35 years, with age of gestation &gt;35 weeks and multipara was significantly higher in the PE group compared to the NP group (p=0.016; p=0.01 and p=0.36; respectively). MDA level was significantly higher in the PE group than in the NP group (p=0.002). In contrast, GSH level was significantly lower in the PE group than in the NP group (p=0.003).<br /><br />Conclusion<br />MDA and GSH may reflect vascular complications of PE, and the ensuing increases in lipid peroxidation may play important pathogenic roles.

Author(s):  
Ni Nyoman Yeyen Abriyani

World Health Organization (2014) data shows that Maternal Mortality Rate in the world reached 289,000 inhabitants.  Indonesian  Demographic  Health  Survey  in  2012 mentioned that  the  maternal mortality rate  (MMR) in  Indonesia reached  359  /  100,000  live birth. Low hemoglobin levels in pregnant women can cause anemia. It can also increase the frequency of complications in pregnancy and childbirth as well as increase the risk of maternal mortality, the rate of prematurity, low birth weight. This study aims to determine the correlation between hemoglobin levels of pregnant women and birth weight at Kirana Maternal Hospital. This study applied a correlational study using cross sectional design. The data types used This study applied a correlational study using cross sectional design. The data types used         secondary data obtained from medical records and maternal health book. The results of the study later in the normality test and analyzed using Pearson test. The results showed that there was no study later in the normality test and analyzed using Pearson test. The results showed that there was no significant correlation between hemoglobin levels of pregnant women and birth weight in Kirana Maternal Hospital in 2016 with 0.00 significance value 0.05


Author(s):  
Yuhemy Zurizah Yuhemy Zurizah

  ABSTRACT Maternal Mortality Rate is a barometer of mother health service in a country. At this time maternal mortality rate in Indonesia is still very high. Indonesia Demography Survey on 2007, maternal mortality rate is about 28 per 100.000 of live births. The direct cause of maternal mortality in Indonesia as well as in the other country is hemorraghe (25%), sepsis (15%), eklampsia (12%), abstructed labor (8%). World Health Organization (WHO), 35-37% of pregnant women in developing coutries get anemy. Causing factor’s of anemy on pregnant women is age of pregnant, parity, economi socio, job, education, and nutritional status. Purpose of this research is to know the associated factors with incidence of anemy on pregnant women at the Health Center Talang Ratu Palembang in 2014. This research use analytic survey method with “cross sectional” approach. Population in this research is all of preganant women in medical treatment at Talang Ratu Palembang in 2014. Sample taking in this research with non random samplingmethod and accidental sampling technic. Analysis with univariatly and bivariatlywith Chi Square Statistic test with significant level α 0,05. The result of this research show that from 35 respondent there is (48,6%) respondent with anemy, high–risk age (28,6%), high parity (60,0%) and low economi socio (37,1%). This result show that there is significant relationship between age with incidence of anemy on pregnant women at the health center Talang Ratu Palembang in 2014 with p value0,027, there is significant relationship between parity with incidence of anemy on pregnant women at the health center Talang Ratu Palemabang in 2014 with p value0,023, and there is significant relationship between economi socio with incidence of anemy on pregnant women at the health center Talang Ratu Palembang in 2014 with p value0,026. Of the result, the author hope that health service worker at Talang Ratu health center can improve health service to pregnant women and often giving information about anemy on pregnant and nutritional for pregnant women during pregnancy.     ABSTRAK Angka Kematian Ibu (AKI) merupakan barometer pelayanan kesehatan ibu di suatu negara. Pada saat ini angka kematian ibu di Indonesia masih sangat tinggi. Menurut Survey Demografi dan Kesehatan Indonesia (SDKI) tahun 2007, angka kematian kematian ibu adalah 28 per 100.000 kelahiran hidup. Penyebab langsung kematian ibu di Indonesia seperti halnya Negara lain adalah perdarahan (25%), sepsis (15%), eklampsi (12%), partus lama (8%). Menurut World Health Organization (WHO), 35-37% ibu hamil di negara berkembang dan 18% di negara  maju mengalami anemia. Faktor penyebab terjadinya anemia pada ibu hamil secara tidak langsung adalah umur ibu, paritas, sosial ekonomi, pekerjaan, pendidikan, jarak kehamilan, dan status gizi.Tujuan penelitian ini adalah untuk mengetahui faktor - faktor apa saja yang berhubungan dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014. Penelitian ini menggunakan metode survey analitikdengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh ibu hamil yang berobat di Puskesmas Talang Ratu Palembang Tahun 2014. Pengambilan sampel pada penelitian ini dengan metode non random sampling dengan teknik Accidental sampling. Analisis dilakukan secara univariat dan bivariat. Dengan uji statistik chi square tingkat kemaknaan α 0,05. Hasil penelitian menunjukkan dari 35 responden terdapat (48,6%) responden yang anemia, umur yang beresiko  tinggi (28,6%), paritas tinggi (60,0%), dan sosial ekonomi rendah (37,1%). Hasil penelitian ini menunjukkan ada hubungan yang bermakna antara umur dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014 dengan  p value0,027,  ada hubungan bermakna antara paritas dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014 dengan p value0,023 dan ada hubungan yang bermakna antara sosial ekonomi dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014 dengan p value0,026. Dari hasil penelitian ini penulis berharap petugas kesehatan di Puskesmas Talang Ratu Palembang meningkatkan pelayanan kesehatan pada ibu hamil dan lebih sering melaksanakan penyuluhan anemia pada kehamilan dan nutrisi yang baik bagi ibu hamil.    


2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Nila Eza Fitria

<p><em>Maternal Mortality Rate (MMR) is one indicator of the success of health services in a country. Maternal deaths occur for several reasons, including anemia The purpose of this research is to know the relationship of knowledge of pregnant women with Fe tablet with anemia occurrence in jorong Koto Malintang Puskesmas Agam District 2014. This research is cross sectional research design conducted in Jorong Koto Malintang Puskesmas Kamih Agam on 23 s / d 29 August 2014. The sample in this study pregnant women in Jorong Koto Malintang 30 people. Univariate analysis has been done descriptive and bivariate analysis using chi-square test. The results showed 30 respondents classified as less knowledgeable (36.7%) and more than half of pregnant women (63.3%) suffered from anemia. The result of bivariate analysis with trust level 0,05 indicates a significant relationship between the existence of Knowledge about Tablet Fe Pregnancy with Genesis Anemia where value p = 0,002 (p = &lt;0,05). Can be concluded in this research there is a significant relationship between mother's knowledge about Fe tablet with anemia. It is expected to improve the knowledge of pregnant women about the importance of Fe tablets consumed by pregnant women during pregnancy to prevent anemia</em></p><p><em><br /></em></p><p>Angka Kematian Ibu (Maternal Mortality Rate / MMR) merupakan salah satu indikator keberhasilan pelayanan kesehatan di suatu negara. Kematian ibu terjadi karena beberapa alasan, termasuk anemia. Tujuan penelitian ini adalah mengetahui hubungan pengetahuan ibu hamil dengan tablet Fe dengan kejadian anemia di jorong Koto Malintang Puskesmas Kabupaten Agam tahun 2014. Penelitian ini adalah rancangan penelitian cross sectional yang dilakukan di Jorong Koto Malintang Puskesmas Kamih Agam pada 23 s/d 29Agustus 2014. Sampel dalam penelitian ini ibu hamil di Jorong Koto Malintang 30 orang. Analisis univariat telah dilakukan analisis deskriptif dan bivariat menggunakan uji chi-square. Hasilnya menunjukkan 30 responden tergolong kurang berpengetahuan (36,7%) dan lebih dari setengah ibu hamil (63,3%) menderita anemia. Hasil analisis bivariat dengan tingkat kepercayaan 0,05 menunjukkan adanya hubungan yang signifikan antara adanya Pengetahuan Tentang Tablet Fe Hamil dengan Anemia Genesis dimana nilai p = 0,002 (p = &lt;0,05). Dapat disimpulkan dalam penelitian ini ada hubungan yang signifikan antara pengetahuan ibu tentang tablet Fe dengan anemia. Diharapkandapat meningkatkan pengetahuan ibu hamil tentang pentingnya tablet Fe dikonsumsi oleh ibu hamil selama kehamilan untuk mencegah anemia. </p><p><em><br /></em></p>


Author(s):  
Mohammad Esmaeil MOTLAGH ◽  
Seiyed Davoud NASROLLAHPOUR SHIRVANI ◽  
Farahnaz TORKESTANI ◽  
Zahra HASSANZADEH-ROSTAMI ◽  
Seyed-Mozaffar RABIEE ◽  
...  

Background: Anemia is a common nutritional disorder that is more prevalent in pregnant women than other population groups. This study aimed to assess the frequency of anemia and its association with health care determinants among Iranian pregnant women from provinces with different Maternal Mortality Rate (MMR). Methods: This cross-sectional survey was carried out on 2737 pregnant women referred to public health centers in Iran, 2015. The participants were randomly selected by multistage sampling from six provinces with low, moderate or high MMR. The level of hemoglobin lower than 11 g/dl were defined as anemia in first and third trimester of pregnancy. Results: The rate of anemia in first and third trimester were respectively 8.2 and 26.7%. The most determinants of anemia among women in both first and third trimester of pregnancy were geographical classes with high MMR, no care before pregnancy, and type of house. Moreover, lower number of previous pregnancies (OR, 0.48; 95% CI, 0.27 to 0.85) and adequate care during pregnancy (OR, 0.66; 95% CI, 0.47 to 0.92) were protected women from anemia and high number of children (OR, 2.07; 95% CI, 1.13 to 3.80) enhanced risk of anemia in first trimester of pregnancy. Moreover, higher body mass index had lower odds of anemia in third trimester. Conclusion: The rate of anemia is differed in various parts of Iran, and this disorder gets worse in third trimester of pregnancy than first. Strengthening health care programs may be a useful strategies to prevent and control anemia.


2018 ◽  
Vol 4 (5) ◽  
pp. 510-517
Author(s):  
Widya Astutik ◽  
Djaswadi Dasuki ◽  
Djaswadi Dasuki ◽  
Djaswadi Dasuki ◽  
Herlin Fitriani Kurniawati ◽  
...  

Background: To decrease Maternal Mortality Rate until 70 per 100,000 living birth in 2030 (SDGs) has become the health priority. In fact, the Maternal Mortality Rate in Indonesia is still very high, and almost two-third maternal mortality is caused by maternal labor complications.Objective: The objective of the study was to investigate the factors influencing maternal labor complications in Kutai Kartanegara Region in 2017.Methods: This was a correlational study with cross sectional design. The populations in the study were women who had labor process in the area of Kutai Kartanegara Region. There were 95 respondents selected using purposive sampling. Data were collected using questionnaires and medical records. Chi-square and logistic regression were used for data analysis.Results: Most of respondents had maternal labor complication (53.7%). The highest complication occurred was prolonged labor (58.9%). Factors influencing maternal labor complication were antenatal care, mothers age, education level, parity, and distance of pregnancy. Age was identified as the most dominant variable influencing maternal complication, with the value of OR was 5.837, which indicated that high-risk-age mothers have 5.837 times of labor complication than mothers with no risk age.Conclusion: Antenatal care, age, education, parity and distance of pregnancy had correlation with maternal labor complications, and its most dominant variable was age.


2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Elviera Gamelia ◽  
Siti Masfiah ◽  
Indah Purnama Sari

Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) in Banyumas District are still below The Minimum Service Standard (MSS), especially in Puskesmas (Public Health Center) I Ajibarang. The strategies for reducing maternal mortality are conducted by increasing mothers health status during pregnancy. This study aims at determining the factors of husbands role in womens prenatal care. Cross-sectional method was used. The populations were all of the pregnant women in Puskesmas I Ajibarang. Proportional random sampling was applied to select 90 pregnant women. Logistic regression was used to determine factors. Theory of planned behavior was used to explore the determinants of husbands role. The results show that the level of education, family income, the knowledge, the attitude, and subjective norm are not related to husbands role in mother prenatal care. However, husbands behavior control (p=0.045) and intention (p=0.000) have relation with husbands role in women prenatal care. Variable of intention is the most dominant variable related to husbands role in womens prenatal care.


2019 ◽  
Vol 7 (14) ◽  
pp. 2277-2281 ◽  
Author(s):  
Rinang Mariko ◽  
Eryati Darwin ◽  
Yanwirasti Yanwirasti ◽  
Sri Rezeki Hadinegoro

BACKGROUND: Dengue virus infection is an infectious disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. Dengue virus (DEN-V) consists of 4 serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. The most feared result of DHF is death. Death in children is caused by hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelial dysfunction. AIM: This study aims to analyse difference in sVE-Cadherin levels in Dengue Hemorrhagic Fever (DHF) with and without shock. MATERIAL AND METHODS: The method of taking samples is consecutive sampling, namely the research subjects obtained based on the order of entry in the hospital with a comparative cross-sectional design. From the results of the calculation using the sample formula, the sample size for each group is set at 32 people. So that the total sample size used for both groups is 64 people. The serum sVE-Cadherin levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant. RESULTS: The result showed that there was no difference in mean sVE-Cadherin levels between DHF patients with shock and without shock (p > 0.05). CONCLUSION: This study concluded that there was no difference in mean of sVE-Cadherin level in DHF patients with shock and without shock.


2021 ◽  
Vol 8 (1) ◽  
pp. 33-37
Author(s):  
Russiska Russiska ◽  
Susan Yuliyantika ◽  
Merissa Laora Heryanto

The Maternal Mortality Rate (MMR) in Indonesia is around 90% at the time of delivery. in Indonesia until 2018 the Maternal Mortality Rate is still high at 305 per 1000 live births[1]. This is caused by postpartum bleeding due to several factors such as uterine atony and perineal rupture. The research objective was to determine the relationship between birth weight of infants and perineal rupture in Primipara at Japara Public Health Center, Kuningan Regency in 2019. The research method was analytic with a cross sectional approach, sampling with a total sampling technique with a total of 52 mothers giving birth. The instrument used was a checklist sheet and the analysis used Spearman Rank. Based on the results of the univariate analysis study, most mothers gave birth to babies with normal birth weight, namely around 59.6%, while most of the mothers experienced perineal rupture, namely around 51.9%. The results of the bivariate analysis showed a value (p = 0.09), this indicated that there was a significant relationship between birth weight of infants and perineal rupture in mothers who gave birth. It was concluded that there was a significant relationship between birth weight of infants and perineal rupture in mothers who gave birth. It is hoped that midwives will always carry out labor management in accordance with the standards of normal delivery care when giving birth and teach pregnant women how to massage the perineum.


2017 ◽  
Vol 3 (2) ◽  
pp. 18
Author(s):  
Muhammad Fakhri Ali ◽  
Yonas Hadisubroto ◽  
Jauhar Firdaus

Maternal Mortality Rate (MMR) in Indonesia is still high. The maternal mortality rate continues to rise due to hypertension, one of which is caused by pre-eclampsia and eclampsia. Many factors cause preeclampsia, including advanced maternal age. The purpose of this study was to determine the effect of advanced maternal age during pregnancy with severe preeclampsia and eclampsia in RSD dr. Soebandi Jember. This study used cross sectional approach using 264 samples were divided into two groups, there are pregnant women aged 20-34 years and >34 years. The results of data analysis using Chi Square for severe preeclampsia and obtained p = 0.015 and OR = 2.494, which means there is a significant difference in comparison severe preeclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 28 people suffering from severe preeclampsia (12.9%). Whereas at the age of mother> 34 years of 48 people found 13 people (27.1%) suffered severe preeclampsia Results of data analysis obtained eclampsia using Fisher and p = 0.554, which means there are no significant differences in comparison eclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 3 people suffering from eclampsia (1.38%). While at mother age> 34 years from 48 people found 1 person (2.08%) suffered eclampsia.


2019 ◽  
Vol 6 (1) ◽  
pp. 1-8
Author(s):  
Sri Mumpuni Yuniarsih ◽  
Anik Indriono ◽  
Siwi Sri Widhowati

Background: Maternal Mortality Rate (MMR) in Indonesia is still one of the highest in Southeast Asia (ASEAN). World Health Organization (WHO) as the international organization is targeting a decrease in the (MMR) as one of the targets in the achievement of the Millennium Development Goals (MDGs). However, based on the evaluation of part-time Development Plan 2010-2014, the target of reducing maternal mortality rate in Indonesia is still very difficult to achieve. One of the government's efforts to accelerate the decline of maternal mortality rate is a mother class program. Objective: This study aimed to analyze the achievement of the indicators of maternal health program in comparison with the class of pregnant women who do not attend pregnant women class. Methods: This research was a quantitative research with cross sectional design that compared the achievement of the nine indicators of the health of pregnant women in the two groups of pregnant women. The variable in this study was a comparison of weight gain, blood pressure, upper arm circumference (MUAC), high fundus, fetal heart rate (FHR), the consumption of iron tablets, hemoglobin levels, antenatal visits, and knowledge about healthy pregnancies. The number of samples in this study were 209 respondents which were divided into groups of 86 respondents in a class of pregnant women and 123 respondents in the non-class group of pregnant women. Chi square and t test was used to analyze the comparison of maternal health indicators achievement advance of two groups of respondents. Results and Discussion: The results showed that there were significant difference in knowledge about a healthy pregnancy, the consumption of iron tablet and number of antenatal visits. Pregnant women who attended classes had a better knowledge, more Fe tablet consumption and ANC visit. While indicators of weight gain, MUAC, TFU and DJJ of all respondents were within the normal range according to gestational age when the data retrieval. The other indicators such as hemoglobin level, systolic and diastolic blood pressure did not reveal any significant differences between the two groups of respondents. Keywords: Mother class program; maternal health indicators


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