scholarly journals Efficacy of low dose magnesium sulphate regime and Pritchard’s regime in controlling of eclamptic convulsion and prevention of recurrence

2019 ◽  
Vol 8 (2) ◽  
pp. 536
Author(s):  
Suryaprakash Jagdevappa Karande ◽  
Archana S. Shah
Keyword(s):  
Magnesium Sulphate ◽  
Low Dose ◽  
Post Partum ◽  
Serum Magnesium ◽  
Signs And Symptoms ◽  
Simple Random Sampling ◽  
Mortality And Morbidity ◽  
Dose Regime ◽  
Insignificant Difference ◽  
Prevention Of Recurrence

Background: Eclampsia is defined as the onset of convulsions or coma during pregnancy or in post-partum period in a patient who has signs and symptoms of pre-eclampsia. It is life threatening emergency that continues to be a major cause of serious maternal morbidity and mortality also along with high perinatal mortality and morbidity. The present study undertaken to determine the efficacy of low dose magnesium sulphate regime and Pritchard’s regime in controlling eclamptic convulsion and prevention of recurrence of convulsion.Methods: Out of total 60 patients enrolled in the study; 30 were given low dose magnesium sulphate regime and remaining 30 with Pritchard’s regime. Selection of patients was done with simple random sampling. Relevant history was obtained from the patient, if conscious, or from the relatives. Through clinical examination was done and blood samples were collected for investigations after securing IV line.Results: There was insignificant difference regarding type of eclampsia in both groups. Recurrence of convulsion in Pritchard’s regime group was 6.67% and in Low dose regime group found to be 10% but this was statistically insignificant. Total dose of magnesium sulphate required in Low dose regime group was less than that required for Pritchard’s regime.Conclusions: Low dose magnesium sulphate Regime proved equally effective as that of Pritchard’s regime in control of convulsion in spite of less amount of drug and comparatively low serum magnesium levels and hence there is hardly any fear of intoxicator.

scholarly journals Role of low dose Magnesium sulphate in eclampsia

2019 ◽  
Vol 8 (2) ◽  
pp. 729
Author(s):  
Kajal Sinha ◽  
Shail K. Sinha
Keyword(s):  
Magnesium Sulphate ◽  
Low Dose ◽  
Serum Magnesium ◽  
Tertiary Care ◽  
Secondary Outcome ◽  
Care Hospital ◽  
Dose Regime ◽  
Low Body Mass Index ◽  
Developing Area ◽  
A Prospective Study

Background: Eclampsia is one of the challenging medical complications seen during pregnancy. With the use of magnesium sulphate for control of convulsion in eclampsia, it can be managed effectively.Methods: This is a prospective study done in a tertiary care hospital. Considering low body mass index of patients of developing area, authors had used low dose regime of magnesium sulphate. 100 patients had been enrolled for low dose magnesium sulphate regime after categorizing patients as per inclusion and exclusion criteria. The primary outcome to be measured was recurrence of fits in any patients who received low dose magnesium sulphate. The secondary outcome measured were development of any toxicity, level of serum magnesium level, maternal and perinatal outcome.Results: It was observed that 93% of the patients responded to low dose regime. 7% developed  recurrence of fits for that additional dose of 2 gram of 20% magnesium sulphate was given to the patients. Not even a single patient developed signs of toxicity. 94% and 95% of the patients acquired therapeutic level of serum magnesium at 4 hours and 10 hours of magnesium sulphate administration, respectively. Maternal mortality was 5% and perinatal mortality was 24.4%.Conclusions: Low dose of magnesium sulphate can prevent and treat eclampsia. Low dose regimen also reduces incidence of toxicity with improved maternal and perinatal outcome.

scholarly journals Efficiency and safety of single dose Magnesium sulphate in eclamptic convulsion

2017 ◽  
Vol 6 (7) ◽  
pp. 3058
Author(s):  
Vinaya Goudar ◽  
Rashmi Naganagoudaru
Keyword(s):  
Single Dose ◽  
Magnesium Sulphate ◽  
Urban Areas ◽  
Low Dose ◽  
Post Partum ◽  
Efficacy And Safety ◽  
Medical Sciences ◽  
Life Threatening ◽  
Clonic Seizures ◽  
Life Threatening Complication

Background: An acute and life-threatening complication of pregnancy is characterized by the appearance of tonic clonic seizures, in a patient with pre-eclampsia. Objective of the study was to study the efficacy and safety of a ‘single dose’ of magnesium sulphate in treatment of eclamptic convulsions.Methods: The present prospective study was undertaken among women aged between 18-35 years outpatient’s Department of gynecology in Karnataka Institute of Medical Sciences (KIMS) Hubli, Karnataka, India. The study was undertaken during December 2009 to November 2010.Results: The incidence of eclampsia in our study was 2.12%. Eclapmsia is more common in patients from rural (89%) as compared to urban areas (11%) in our study. In our study eclampsia is more common in unbooked cases (80%). Majority of patients (72%) in our study group were illiterates. 61%, 28% of patients had antepartum and intrapartum eclampsia respectively in our study. We had only 11 post-partum convulsions Table 2. 80% of patients in our study were more than 28 weeks of gestations. 65% of the patients had <5 episodes of convulsions. The number of convulsions did not affect the recurrence, and 35% had >5 episodes. In present study 5 Patients had Systolic Blood Pressure less than 140 mmHg. Majority (52) had more than 160 mmHg 42 had in between 140 and 160 mmHg. Diastolic arterial pressure was >110 in 81% of cases. The convulsions were controlled in 75% of women. Recurrence of convulsions occurred in 25% of women after receiving the single dose magnesium sulphate regime. In our study 75% of cases, there was no recurrence of convulsions and in 25% of cases, there was recurrence of convulsions, out of which 20 cases received low dose magnesium sulphate regime and the other 5 cases received Phenytoin regime as 2nd line of treatment.Conclusions: Hence the single dose Magnesium sulphate is safe and effective in controlling convulsions.

scholarly journals A comparative study of low dose magnesium sulphate therapy with Pritchard’s regime in management of Eclampsia

2019 ◽  
Vol 8 (10) ◽  
pp. 3907
Author(s):  
Vijay M. Kansara ◽  
Payal Sureshkumar Patel ◽  
Ajesh N. Desai
Keyword(s):  
Perinatal Mortality ◽  
Magnesium Sulphate ◽  
Low Dose ◽  
Fetal Outcome ◽  
Control Group ◽  
Average Weight ◽  
Indian Women ◽  
Mortality And Morbidity ◽  
Labour Room ◽  
And Control

Background: Eclampsia is one of the most common causes of maternal and perinatal mortality and morbidity in India. Amongst the principles of management of eclampsia, the first is the control of convulsions. Magnesium sulphate is the main stay of treatment in eclampsia and imminent eclampsia. Average weight of Indian women is less than the western women due to which lower dose of magnesium sulphate can be used.  The aim of the study was to compare the efficacy of low dose magnesium sulphate regimen with standard Pritchard regimen in control of eclampsia.Methods: The study was carried out at emergency labour room, GMERS Sola Civil Hospital Ahmedabad. 120 patients of eclampsia were divided randomly into study group (n=60) receiving low dose MgSO4 and control group (n=60) receiving Pritchard regimen. The recurrence of convulsion, toxicity of MgSO4 and maternal and fetal outcome was studied.Results: It was observed that with low dose MgSO4 regime, convulsions were controlled in 91.7% of the cases. With standard Pritchard’s regime convulsions were controlled in 95% of patients. The maternal and perinatal mortality and morbidity were comparable in both groups.Conclusions: Low dose magnesium sulphate therapy is as effective as Pritchard’s regime for controlling convulsions in eclampsia and can be safely given in Indian women. 

A low dose ('Dhaka') magnesium sulphate regime for eclampsia: Clinical findings and serum magnesium levels

2001 ◽  
Vol 80 (11) ◽  
pp. 998-1002 ◽  
Author(s):  
Rashida Begum ◽  
Anowara Begum ◽  
Richard Johanson ◽  
Mohammad Nawsher Ali ◽  
Syeba Akhter
Keyword(s):  
Magnesium Sulphate ◽  
Low Dose ◽  
Serum Magnesium ◽  
Clinical Findings

scholarly journals Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

2019 ◽  
Vol 37 (1) ◽  
pp. 329-341 ◽  
Author(s):  
Martin Kallab ◽  
Stephan Szegedi ◽  
Nikolaus Hommer ◽  
Hannes Stegmann ◽  
Semira Kaya ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dry Eye ◽  
Low Dose ◽  
Signs And Symptoms ◽  
Preservative Free

Assessment Framework for Recognizing Clinical Deterioration in Patients With ACS Undergoing PCI

2021 ◽  
Vol 41 (4) ◽  
pp. 18-28
Author(s):  
Kevin White ◽  
Judy Currey ◽  
Julie Considine
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndrome ◽  
Signs And Symptoms ◽  
Coronary Artery Occlusion ◽  
Coronary Intervention ◽  
Clinical Deterioration ◽  
Access Site ◽  
Mortality And Morbidity ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

Topic Patients with acute coronary syndrome undergoing primary percutaneous coronary intervention are at risk of clinical deterioration that results in similar general signs and symptoms regardless of its cause. However, specific causes and forms of clinical deterioration are associated with key differences in assessment findings. Focused clinical assessments using a modified primary survey enable nurses to rapidly identify the cause and form of clinical deterioration, facilitating targeted treatment. Clinical Relevance Clinical deterioration during percutaneous coronary intervention is associated with increased mortality and morbidity. Previous studies identified nursing inconsistencies when recognizing clinical deterioration, with inconsistent collection of cues and prioritization of cues related to cardiac performance over more sensitive indicators of clinical deterioration. Purpose of Paper To describe a framework to help nurses optimize physiological cue collection to improve recognition of clinical deterioration during periprocedural care of patients undergoing percutaneous coronary intervention for unstable acute coronary syndrome. Content Covered Literature analysis revealed 7 forms of clinical deterioration in patients undergoing percutaneous coronary intervention: coronary artery occlusion, stroke, ventricular rupture, valvular insufficiency, lethal cardiac arrhythmias, access-site and non–access-site bleeding, and anaphylaxis. Evidence for the pathophysiology, incidence, severity, and clinical features of each form of clinical deterioration is identified. A framework is proposed to help nurses conduct highly focused patient assessments, enabling prompt recognition of and response to the specific forms of clinical deterioration that occur in patients undergoing percutaneous coronary intervention.

scholarly journals The Role of Anemia in Pregnancy in the Incidence of Post Partum Hemorrhage in Maternal Maternity at the Hospital in Sidoarjo, Indonesia

2019 ◽  
Vol 2 ◽  
Author(s):  
Mukarromatul Khoiroh ◽  
Nurul Azizah
Keyword(s):  
Postpartum Hemorrhage ◽  
Post Partum ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Chi Square ◽  
Chi Square Test ◽  
Anemia In Pregnancy ◽  
Relationship Of ◽  
The Relationship ◽  
In Pregnancy

Postpartum hemorrhage is bleeding that occurs after the birth of the baby, placenta, and 2 hours after the placenta is born. One of the causes is anemia. Research in 2015, 60% of 100 mothers giving birth at RSIA Kirana Taman Sidoarjo experienced postpartum hemorrhage. The aim of the study was to determine the relationship of anemia in pregnancy with the incidence of postpartum hemorrhage in labor mothers. The study design used an analytical survey with a retrospective method. The population of 206 maternity mothers was taken with simple random sampling technique as many as 136 samples in August 2017. Data were analyzed by Chi Square statistical test with 0.05. The results showed that postpartum hemorrhage was more experienced by mothers with anemia (66.7%) than  those without anemia (26.2%). While those who did not experience postpartum hemorrhage were more experienced by mothers who were not anemic (73.8%) than those who were anemic (33.3%). Chi square test results  (p=0.000  <0.05),  which means there is a relationship  of anemia in pregnancy with the incidence of postpartum hemorrhage in labor mothers. Conclusions of the study were the relationship of anemia in pregnancy with the  incidence  of postpartum hemorrhage in labor mothers. It is expected that midwives and doctors conduct early detection of anemia so that appropriate care can be carried out.

scholarly journals Adverse Maternal and Fetal Outcome in Patients with Eclampsia

2019 ◽  
Vol 16 (41) ◽  
pp. 425-427
Author(s):  
Tarun Pradhan ◽  
Pappu Rijal ◽  
Rubina Rai ◽  
Rabindra Dev Bhatta ◽  
Baburam Dixit Thapa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Maternal Mortality ◽  
Magnesium Sulphate ◽  
Post Partum ◽  
Mode Of Delivery ◽  
Fetal Outcome ◽  
Adverse Outcomes ◽  
Time Interval ◽  
Maternal Condition ◽  
Emergency Cesarean

Background: Eclampsia is a multisystem disorder that may lead to deterioration of maternal condition, hypoxia and acidosis of fetus. Objective was to evaluate the risk factors associated with adverse maternal and fetal outcome in patients with eclampsia. Methods: All patients with eclampsia were enrolled after informed consent from February 2013 to February 2014. Questions as per per-forma were asked to the patients and attendants about antenatal visits, parity, number of episodes of seizures, duration from onset of seizure to magnesium sulfate, then the patients were followed as per the hospital protocol, the mode of delivery, outcome of baby, post partum maternal condition and mortality were then noted. Results: Fifty-two patients with eclampsia were admitted in the study period. Thirty-one patients required mechanical ventilator support. Twenty-five (48.07%) patients were delivered by emergency cesarean section and 30(57.6%) babies were low birth weight and there were 11(21.1%) stillbirths. There was one maternal mortality and 45(86.5%) patients were discharged with improvement but 6(11.5%) patients had neurological impairment. Mortality was significantly related with number of seizure episodes and time interval between seizure onset and administration of magnesium sulphate. Conclusions: Early detection of hypertension and management with magnesium sulphate for eclampsia can help to minimize the maternal and fetal adverse outcomes. Keywords: Eclampsia; maternal mortality; risk factors.

scholarly journals KOGNITIF BIDAN TERHADAP PEMERIKSAAN DIASTASIS RECTI PADA IBU NIFAS

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Nurun Ayati Khasanah ◽  
Ferilia Adiesti ◽  
Citra Adityarini Safitri
Keyword(s):  
Random Sampling ◽  
Post Partum ◽  
Simple Random Sampling ◽  
Rectus Abdominis ◽  
Cross Sectional ◽  
Exact Test ◽  
Fisher's Exact Test ◽  
Diastasis Recti ◽  
Fisher’S Exact Test

Diastasis rectus abdominis dapat terjadi kapanpun pada ibu hamil trimester dua, dampaknya pada ibu post partum yang mengalami diastasis rectus abdominis adalah melemahnya dinding abdomen, mengurangi kontraksi kekuatan otot abdomen dan kestabilan pelvis. Risiko seorang perempuan mengalami diastasis recti  ini jauh lebih besar jika ukuran tubuhnya tergolong kecil, mengandung janin kembar, hamil pada usia 35 tahun ke atas, serta berat janin yang besar.Tujuan penelitian ini untuk mengetahui Hubungan kognitif terhadap pemeriksaan diastasis recti pada ibu nifas .Penelitian ini menggunakan pendekatan cross sectional . Populasi pada penelitian ini adalah seluruh tenaga kesehatan ( bidan ) di wilayah kerja  UPT Puskesmas Bangsal Kabupaten Mojokerto. Sampel penelitian ini adalah   sebagian tenaga kesehatan ( bidan ) yang ada  di wilayah kerja UPT Puskesmas Bangsal Kabupaten Mojokerto, jumlah sampel 23 orang . pengambilan sampel pada penelitian adalah simple random sampling dilkasanakan pada bulan Agustus – November 2020. Instrumen  pada penelitian menggunakan kuisioner , kemudian dianalisis secara univariat dan bivariat . untuk mengetahui hubungan menggunakan Analisis statistik  Fisher’s Exact Test. Berdasarkan hasil penelitian bahwa sebagian besar responden memiliki kognitif yang baik  sebanyak 13 ( 56.53 %)dan sebagian besar melakukan pemeriksaan diastasis recti  sebanyak 17 ( 73.92%) responden .Berdasarkan uji Analisis Fisher's Exact Test dengan tingkat kemaknaan ( α< 0.05) didapatkan nilai (α = 0,022)  menunjukkan  bahwa ada hubungan kognitif  dengan  pemeriksaan diastasis recti pada ibu nifas .Pengetahuan didapat dari informasi sepanjang hidup seseorang. Pengetahuan tenaga kesehatan ( bidan ) tentang pemeriksaan diastasis recti yang mempengaruhi tenaga  kesehatan ( bidan ) tersebut untuk melakukan pemeriksaan diastasis recti. Sebagai tenaga kesehatan seyogyanya selalu  melakukan pemeriksaan diastasis recti pada ibu nifas yang datang kepelayanan baik di Rumah Sakit , Puskesmas maupun PMB

scholarly journals SERUM MAGNESIUM LEVEL

2010 ◽  
Vol 17 (02) ◽  
pp. 279-285
Author(s):  
SADIA ZAFAR ◽  
HINA AYESHA ◽  
ASGHAR BUTT ◽  
Bushra Abdul Malik
Keyword(s):  
Serum Albumin Level ◽  
Serum Magnesium ◽  
Simple Random Sampling ◽  
Albumin Level ◽  
Magnesium Level ◽  
Healthy Children ◽  
Persistent Diarrhea ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Study Setting

Objectives: To evaluate serum magnesium level in children with 3rd degree malnutrition and to compare these values with healthy children. Study Design: Cross sectional comparative study. Setting and Duration: Pediatric Department of Allied Hospital Faisalabad from Oct. 2003 to Nov. 2004. Subjects: Cases: 60 children of age six month to five year having weight < 60% of that for age. Control: 60 healthy children of age six month to five year having weight > 80% of that for age. Methods: Both cases & controls were selected from indoor & outdoor through simple random sampling. Detailed history & examination was done and S/Mg level were measured by atomic absorption spectrophotometer. Data was analyzed with the help of SPSS by applying T test and was presented by frequency tables. Results: The cases showed decreased S/Mg level (1.11+/- 0.24 mg/dl) as compared to controls (2.01+/- 0.78mg/dl).S/Mg levels were also decreased in cases with height < 80 % of that for age (0.98+/-0.5mg/dl) as compared to controls having height > 90 % of that for age. S/Mg levels were markedly low in cases who had low albumin level (0.98+/- 0.05 mg/dl) and those children who presented with persistent diarrhea (0.96+/-0.12mg/dl) Conclusion: S/Mg levels were decreased in children with PEM as compared to those with age and sex matched control. This decrease in S/Mglevels was marked in those cases who had decrease serum albumin level and persistent diarrhea.

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