scholarly journals Efficacy of homologous fibrin sealant in the surgery for pneumothorax

2020 ◽  
Vol 8 (6) ◽  
pp. 2228
Author(s):  
Murat Saricam
Keyword(s):  
Hospital Stay ◽  
Fibrin Sealant ◽  
Air Leakage ◽  
Age And Gender ◽  
Mean Values ◽  
Patient Groups ◽  
And Gender ◽  
The Cost ◽  
Homologous Fibrin ◽  
Mini Thoracotomy

Background: Prolonged air leakage following pneumothorax surgery is a significant issue causing increased hospital stay and morbidity. This study aimed to investigate the cost and efficacy of homologous fibrin sealant in preventing the air leakages.Methods: Among the patients who had undergone bullectomy and subtotal parietal pleurectomy for recurrent primary spontaneous pneumothorax via transaxillary mini thoracotomy between 2010 and 2018, two groups each including 35 cases were conducted as to whether fibrin sealent had been applied. These two patient groups were compared in terms of age, gender, duration of air leakage and cost.Results: Mean age of whole group of patients including 59 males and 11 females was 21.5 years. Mean values of air leakage duration and cost of hospital stay was calculated as 1.94 days and 2777 TL for sealant applied group and 2.97 days and 1200 TL for sealent unapplied group, respectively. The patient groups did not indicate a statistically difference in terms of age and gender whereas duration of air leakage was shorter but cost was higher in the group for whom fibrin sealant had been administered (p<0.001). None of the patients developed mortality but recurrence was present in 4 (5.7%) patients.Conclusions: Although homologous fibrin sealant applied in pneumothorax surgery results in cost increase, it contributes to surgical outcomes by preventing possible additional complications in consideration of shortened duration of air leakage.

scholarly journals Cephalometric comparison of cesarean and normal births

2016 ◽  
Vol 10 (02) ◽  
pp. 199-202 ◽  
Author(s):  
Merve Goymen ◽  
Tolga Topcuoglu ◽  
Ali Murat Aktan ◽  
Ozlem Isman
Keyword(s):  
Considerable Effect ◽  
Plane Angle ◽  
Negative Effects ◽  
Age And Gender ◽  
Vertical Relationships ◽  
Mandibular Plane ◽  
Kolmogorov Smirnov ◽  
Patient Groups ◽  
And Gender ◽  
Student’S T

ABSTRACT Objective: The aim of this study was to compare cephalometric variables of subjects with normal and cesarean births. Materials and Methods: Ninety age- and gender-matched patients, who were treated in Gaziantep University, Faculty of Dentistry Orthodontics Department were equally divided into normal and cesarean groups according to the birth methods reported by their mothers. To eliminate the negative effects of being different in terms of age and gender among parameters, control, and patient groups were matched in the present study. Pretreatment cephalometrics radiographs were used. Six measurements representing sagittal and vertical relationships were evaluated from pretreatment cephalograms using Dolphin Imaging Orthodontics Software was used in this issue by an orthodontist. Kolmogorov–Smirnov test, Student's t-test, and Mann–Whitney U-test were used for statistical comparisons. Results: A point-nasion-B point angle (ANB) and Wits values were higher in the normal group, while sella-nasion-A point angle, sella-nasion-B point angle, Frankfort horizontal-mandibular plane angle, and gonion-gnathion-SN plane angle values were higher in the cesarean group. However, the groups showed no significant differences (P > 0.05). ANB angle and Wits values showed high correlation. Conclusions: Within the study limitations, the results suggest that the birth method may not have a considerable effect on the development of the craniofacial skeletal system.

scholarly journals Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients

Rheumatology ◽  
2019 ◽  
Vol 59 (8) ◽  
pp. 2085-2089
Author(s):  
Gabriel Miltenberger-Miltenyi ◽  
Ana Rita Cruz-Machado ◽  
Jennifer Saville ◽  
Vasco A Conceição ◽  
Ângelo Calado ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Arthritis ◽  
Classification Criteria ◽  
Control Group ◽  
Established Rheumatoid Arthritis ◽  
Regression Analyses ◽  
Lipid Levels ◽  
Age And Gender ◽  
Patient Groups ◽  
And Gender

Abstract Objectives To identify serum sphingolipids that could act as candidate biomarkers in RA. Methods We performed lipidomic analyses in the serum of 82 participants: 19 established RA patients, 18 untreated early RA patients, 13 untreated early arthritis patients not fulfilling the classification criteria for RA, 12 established SpA patients and 20 controls. We compared the lipid levels from the different patient groups with the control group through multiple-regression analyses controlling for age at diagnosis, gender and medication (cDMARDs and corticoids). Results Established RA patients had significantly increased levels of sphingosine, monohexosylceramide and ceramide compared with controls, when controlling for age and gender. Monohexosylceramide levels remained significantly increased when additionally controlling for medication. On the contrary, SpA patients had significantly decreased levels of ceramide, in both analyses. Conclusion We observed a detectable increase in the levels of certain sphingolipids in the serum of established RA patients when compared with controls, in line with previous observations in the synovial fluid. Such findings provide further evidence that sphingolipids may play a key role in the pathophysiology of RA.

scholarly journals Articular Eminence Inclination, Height, and Condyle Morphology on Cone Beam Computed Tomography

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Dilhan İlgüy ◽  
Mehmet İlgüy ◽  
Erdoğan Fişekçioğlu ◽  
Semanur Dölekoğlu ◽  
Nilüfer Ersan
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Mean Value ◽  
Cone Beam ◽  
Articular Eminence ◽  
Age And Gender ◽  
Mean Values ◽  
The Mean ◽  
And Gender ◽  
The Relationship

Aim. The aim of the present study was to examine the relationship between articular eminence inclination, height, and thickness of the roof of the glenoid fossa (RGF) according to age and gender and to assess condyle morphology including incidental findings of osseous characteristics associated with osteoarthritis (OA) of the temporomandibular joint (TMJ) using cone beam computed tomography (CBCT).Materials and Methods. CBCT images of 105 patients were evaluated retrospectively. For articular eminence inclination and height, axial views on which the condylar processes were seen with their widest mediolateral extent being used as a reference view for secondary reconstruction. Condyle morphology was categorized both in the sagittal and coronal plane.Results. The mean values of eminence inclination and height of males were higher than those of females (P<0.05). There were significant differences in the RGF thickness in relation to sagittal condyle morphology. Among the group of OA, the mean value of the RGF thickness for “OA-osteophyte” group was the highest (1.59 mm), whereas the lowest RGF values were seen in the “OA-flattening.”Conclusion. The sagittal osteoarthritic changes may have an effect on RGF thickness by mechanical stimulation and changed stress distribution. Gender has a significant effect on eminence height (Eh) and inclination.

scholarly journals The Utility of the Callosal/Supratentorial-Supracallosal Area Ratio to Evaluate Corpus Callosum Morphometry in Children

2020 ◽  
Author(s):  
Mehmet Öztürk ◽  
Emine Uysal ◽  
Halil İbrahim Duran ◽  
Zuhal İnce Bayramoğlu ◽  
Abidin Kılınçer
Keyword(s):  
Corpus Callosum ◽  
Sagittal Plane ◽  
Pediatric Population ◽  
Age Group ◽  
Age And Gender ◽  
Mean Values ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
Group 1

Objective: To perform morphometric analysis of corpus callosum (CC) by using callosal area (CA), supratentorial-supracallosal area (SSA) and CA/SSA parameters in a healthy pediatric population and to investigate changes according to age and gender. Method: Method: This retrospective study included a total of 313 children (154 boys, 159 girls) aged between 3-17 years. The cases were divided into three groups according to age: 3-6 years (Group 1) (pre-school), 7-12 years (Group 2) (preadolescent) and 13-17 years (Group 3) (adolescent). CA and SSA were measured on the mid-sagittal plane on T1-weighted images. CA/ SSA index was calculated. Differences in age, CA, SSA, and ratio parameters among the gender groups were compared using the Mann-Whitney U or the t-test. Results: Median values of CA (p= 0.002), mean values of SSA (p=0.001) and CA/SSA ratios (p= 0.04) were significantly higher in boys compared to girls. The median CA and mean CA/SSA ratios in Group 3 were significantly higher than Groups 1 and 2 (p= 0.001). Mean CA/SSA ratio values of boys and girls in Age Group 3 were significantly higher than Group 1 (p= 0.001) and significantly higher than Age Group 2 in girls. There were highly significant positive correlations of age with CA (p=0.001, r=0.47), SSA (p=0.028, r=0.12) and CA/SSA ratio (p=0.001, r=042). There was a highly significant and positive correlation between CA and SSA (p=0.001, r=0.25) and CA/SSA ratio (p=0.001, r=0.87). Conclusion: CA, SSA, and CA/ SSA ratio values in children are affected by age and gender. These parameters can be used as reference values for the diagnosis of congenital and acquired pathologies affecting the corpus callosum.

scholarly journals Patient flow dynamics in hospital systems during times of COVID-19: Cox proportional hazard regression analysis.

2020 ◽  
Author(s):  
Sudhir Bhandari ◽  
Amit Tak ◽  
Sanjay Singhal ◽  
Jyotsna Shukla ◽  
Bhoopendra Patel ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Survival Rate ◽  
Hospital Stay ◽  
Cox Model ◽  
Patient Flow ◽  
Proportional Hazard ◽  
Age And Gender ◽  
Cox Proportional Hazard ◽  
And Gender ◽  
Cox Proportional Hazard Regression

Abstract Objectives: The present study is aimed at estimating patient flow dynamical parameters and requirement of hospital beds. Secondly, the effects of age and gender on parameters were evaluated. Patients and Methods: In this retrospective cohort study, 987 COVID-19 patients were enrolled from SMS Medical College, Jaipur (Rajasthan, India). The survival analysis was carried out from 29 Feb to 19 May 2020 for two hazards – ‘Hazard 1’ was hospital discharge and ‘Hazard 2’ was hospital death. The starting point for survival analysis of the two hazards was considered to be hospital admission . The survival curves were estimated and additional effects of age and gender were evaluated using Cox proportional hazard regression analysis. Results: The Kaplan Meier estimates of lengths of hospital stay (Median =10 days, IQR =10 days) and median survival rate ( more than 60 days due to large amount of censored data) were obtained. The Cox Model for ‘Hazard 1’ showed no significant effect of age and gender on duration of hospital stay. Similarly, the Cox Model 2 showed no significant difference of gender on survival rate. The case fatality rate 8.1 % , recovery rate 78.8% , mortality rate 0.10 per 100 person--days and hospital admission rate 0.35 per 105 person-days were estimated.Conclusion : The study estimates hospital bed requirement based on patient flow dynamic parameters. Furthermore, study concludes that average length of hospital stay were similar for patients of both genders and all age groups.

scholarly journals Mining Cancer-Specific Disease Comorbidities from a Large Observational Health Database

2014 ◽  
Vol 13s1 ◽  
pp. CIN.S13893 ◽  
Author(s):  
Yang Chen ◽  
Rong Xu
Keyword(s):  
Metabolic Syndrome ◽  
Adverse Event Reporting System ◽  
Adverse Event Reporting ◽  
Age And Gender ◽  
Genetic Mechanisms ◽  
Patient Groups ◽  
The Common ◽  
Health Database ◽  
And Gender ◽  
Metabolic Syndrome Components

Cancer comorbidities often reflect the complex pathogenesis of cancers and provide valuable clues to discover the underlying genetic mechanisms of cancers. In this study, we systematically mine and analyze cancer-specific comorbidity from the FDA Adverse Event Reporting System. We stratified 3,354,043 patients based on age and gender, and developed a network-based approach to extract comorbidity patterns from each patient group. We compared the comorbidity patterns among different patient groups and investigated the effect of age and gender on cancer comorbidity patterns. The results demonstrated that the comorbidity relationships between cancers and non-cancer diseases largely depend on age and gender. A few exceptions are depression, anxiety, and metabolic syndrome, whose comorbidity relationships with cancers are relatively stable among all patients. Literature evidences demonstrate that these stable cancer comorbidities reflect the pathogenesis of cancers. We applied our comorbidity mining approach on colorectal cancer and detected its comorbid associations with metabolic syndrome components, diabetes, and osteoporosis. Our results not only confirmed known cancer comorbidities but also generated novel hypotheses, which can illuminate the common pathophysiology between cancers and their co-occurring diseases.

scholarly journals CORRELATION STUDY BETWEEN THREE DIFFERENT GENES EXPRESSION AND CHRONIC MYELOID LEUKEMIA IN IRAQ

2021 ◽  
Vol 52 (3) ◽  
pp. 611-619
Author(s):  
Aljoubory & Altaee
Keyword(s):  
Gene Expression ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Correlation Study ◽  
Control Group ◽  
Age And Gender ◽  
Patient Groups ◽  
The Difference ◽  
And Gender ◽  
And Control

The following study was conducted to investigate the correlation between the expression of three different genes (NOB1, DDX47, CD101 (with the occurrence and development of chronic myeloid leukemia (CML) in Iraq. The difference in the expression of these genes between patients and healthy controls was studied. Moreover the correlation of age and gender with CML occurrence and comparing with control was also examined. Results showed significant increases in mean of gene expression level (ΔCt) of patient groups for all genes compared to the corresponding ΔCt means in control group, also the gene expression folding (2-∆∆Ct) reflect significant differences in the expression of these genes and CD101, mRNA showed the highest level in CML patients which reached to (3.44), while NOB1 and DDX47 recorded (2.90 and 1.08) respectively. On the other hand no significant differences were recorded according to age and gender between CML patients and control, CML disease could affect any age and both male and female.

D-dimer levels for Risk Stratification in Patients with Suspected COVID-19 – A Prospective Observational Study

2021 ◽  
Vol 20 (3) ◽  
pp. 193-203
Author(s):  
AS Jauslin ◽  
◽  
J Kellett ◽  
M Brabrand ◽  
NR Simon ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Prospective Observational Study ◽  
Observational Cohort Study ◽  
Control Group ◽  
Age And Gender ◽  
Group Methods ◽  
Observational Cohort ◽  
Patient Groups ◽  
And Gender ◽  
D Dimer

Background: Elevated D-dimer levels have been observed in COVID-19 and are of prognostic value, but have not been compared to an appropriate control group. Methods: Observational cohort study including emergency patients with suspected or confirmed COVID-19. Logistic regression defined the association of D-dimer levels, COVID-19 positivity, age, and gender with 30-day-mortality. Results: 953 consecutive patients (median age 58, 43% women) presented with suspected COVID-19: 12 (7.4%) patients with confirmed SARS-CoV-2-infection died, compared with 28 (3.5%) patients without SARS-CoV-2-infection. Overall, most (56%) patients had elevated D-dimer levels (≥0.5mg/l). Age (OR 1.07, CI 1.05-1.10), D-dimer levels ≥0.5mg/l (OR 2.44, CI 0.98-7.39), and COVID-19 (OR 2.79, CI 1.28-5.80) were associated with 30-day-mortality. Conclusion: D-dimer levels are effective prognosticators in both patient groups.

Comparison Between Lercanidipine and Amlodipine for Efficacy and Tolerability in Patients with Hypertension

2021 ◽  
Vol 15 (9) ◽  
pp. 3017-3019
Author(s):  
Amjad Abrar ◽  
Mahboob ur Rehman ◽  
Anwar Ali ◽  
Farhan Faisal ◽  
Malik Ali Raza ◽  
...  
Keyword(s):  
Medical Emergency ◽  
Age Group ◽  
Key Words Hypertension ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Age And Gender ◽  
Mean Values ◽  
The Mean ◽  
Pedal Edema ◽  
And Gender

Introduction: Hypertension has been perceived as a worldwide health worry for non-industrial nations and is hardly depicted in a considerable lot of these nations. Objectives: The main objective of the study is to find the Comparison between lercanidipine and amlodipine for efficacy and tolerability in patients with hypertension. Material and methods: This cross sectional, comparative study was conducted in PIMS during January 2021 to June 2021. After permission from hospital ethical committee, total 120 patients meeting the inclusion and exclusion criteria will be enrolled in the study from Medical Emergency and admitted in PIMS. Detailed history, physical examination and necessary investigations will be done to meet the inclusion and exclusion criteria. Informed consent will be obtained. Results: The data was collected from 120 patients of both male and female. Table 01 shows the mean values of systolic and diastolic BP according to age and gender. The mean systolic and diastolic BP of all the study subjects were 124.2 ± 15.0 mmHg and 83.4 ± 9.5 mmHg, respectively. In men, the highest mean systolic BP and mean diastolic BP were among the eldest age group and preceding eldest age group. Conclusion: It is concluded that lercanidipine is associated with considerably lower incidence of vasodilation related side effects than amlodipine, especially pedal edema. Key words: Hypertension, Efficacy, Drugs, Therapy

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