scholarly journals Bioactive Food Compounds As Epigenetic Regulators

2021 ◽  
Author(s):  
Iván Enrique Naranjo Logroño ◽  
Anthony Alfonso Naranjo Coronel ◽  
Ashley Carolina Cuzco Macías ◽  
Alison Tamara Ruiz Chico
Keyword(s):  
Disease Prevention ◽  
Bioactive Compounds ◽  
Scientific Evidence ◽  
Relevant Information ◽  
New Drugs ◽  
Palabras Clave ◽  
Continuous Progress ◽  
Epigenetic Regulators ◽  
Prevention Methods ◽  
The Impact

Introduction: Nutrigenomics explores and defines the rapidly evolving field of interactions in the diet and genome, through the use of nutrition, proteomics, physiology, biochemistry and epigenomics to seek and explain the mutual interactions between genes and nutrients from a molecular approach. Objective: To summarize the evidence of the impact that bioactive compounds of food exerts on epigenetic events aimed primarily at disease prevention. Methods: A literature review was carried out on the main bioactive compounds of food as epigenetic regulators, in the following search engines: COCHRANE, PUBMED, MEDLINE, LILACS, SCIELO, CINAHL, EBSCO and SCOPUS. The synthetic analytical method was used. Results: 40 bibliographic sources were found, of which 33 scientific articles were used that provided relevant information on the subject and seven articles were excluded. Discussion: There is scientific evidence about various bioactive compounds that experience efficacy in disease prevention through epigenetic regulation. Conclusion: With the continuous progress of changes in lifestyle, it is necessary to study new molecules, which can potentially be used for disease prevention and find new drugs that can be crucial in the treatment of different diseases. Keywords: bioactive, food, regulators, epigenetics. RESUMEN Introducción: La nutrigenómica explora y define el campo en rápida evolución de las interacciones en la dieta y el genoma, mediante el uso de la nutrición, proteómica, fisiología, bioquímica y epigenómica para buscar y explicar las mutuas interacciones existentes entre genes y nutrientes desde un enfoque molecular. Objetivo: Resumir la evidencia del impacto que ejercen los compuestos bioactivos de los alimentos sobre los eventos epigenéticos dirigido principalmente en la prevención de enfermedades. Métodos: Se realizó una revisión bibliográfica acerca de los principales compuestos bioactivos de los alimentos como reguladores epigenéticos, en los siguientes buscadores: COCHRANE, PUBMED, MEDLINE, LILACS, SCIELO, CINAHL, EBSCO y SCOPUS. Se empleó el método analítico sintético. Resultados: Se encontraron 40 fuentes bibliográficas, de los cuales se utilizaron 33 artículos científicos que aportaron información relevante del tema y se excluyeron siete artículos. Discusión: Existe evidencia científica acerca de diversos compuestos bioactivos que demuestran eficacia en la prevención de enfermedades mediante la regulación epigenética. Conclusiones: Con el avance continuo de los cambios en el estilo de vida, es necesario estudiar nuevas moléculas, que pueden usarse potencialmente para la prevención de enfermedades y encontrar nuevos medicamentos que pueden ser cruciales en el tratamiento de distintas enfermedades. Palabras clave: bioactivos, alimentos, reguladores, epigenética.

scholarly journals Fútbol para personas con amputaciones: Revisión sistemática exploratoria (Football for people with amputations: Exploratory systematic review)

Retos ◽  
2021 ◽  
Vol 42 ◽  
pp. 145-153
Author(s):  
José Martín Gamonales Puerto ◽  
Maykel Durán-Vaca ◽  
Luisa Gámez-Calvo ◽  
Víctor Hernández-Beltrán ◽  
Jesús Muñoz-Jiménez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Scientific Evidence ◽  
Relevant Information ◽  
Social Aspects ◽  
Inclusion Criteria ◽  
Palabras Clave ◽  
Revisión Sistemática ◽  
The Subject ◽  
Part Deal

  El trabajo tiene por objetivo revisar la evidencia científica relacionada con el fútbol para personas amputadas. Para la búsqueda de referencia, se utilizó como descriptores las siguientes palabras clave: “Football” y “Amputee”. Los términos fueron introducidos en inglés en las siguientes bases de datos informatizadas: SPORTDiscus, PUBMED, Web Of Science y SCOPUS, considerando todos los documentos publicados hasta septiembre del 2020. Para limitar la búsqueda, se introdujeron cuatro criterios de inclusión: 1) Seleccionar documentos disponibles a texto completo o con resumen, 2) Contar con suficiente información relevante sobre el fútbol para personas con amputaciones (Mínimo 50 palabras), 3) Aportar información relacionada con la condición física, entrenamiento, lesiones y/o aspectos sociales de los jugadores de fútbol para personas con amputaciones, y 4) Estar escrito en español, inglés o portugués. La revisión sistemática exploratoria contó con diez documentos relacionados con el fútbol para personas con amputaciones. Los documentos existentes relacionados con la temática son escasos como consecuencia de la falta de evolución de esta modalidad. Estos manuscritos, en su mayoría, tratan aspectos como la fuerza y la resistencia. Además, un sólo documento habla de la utilización de dispositivos inerciales en sus mediciones. Por tanto, surge la necesidad de realizar nuevas investigaciones en el ámbito de fútbol para personas con amputaciones. Abstract. The study aims to review the scientific evidence related to football for amputees. For the reference search, the following keywords were used as descriptors: “Football” and “Amputee”. The terms were entered in English in the following computerized databases: SPORTDiscus, PUBMED, Web of Science and SCOPUS, considering all the documents published up to September 2020. To limit the search, four inclusion criteria were introduced: 1) Select documents available in full text or with abstract, 2) Have enough relevant information about soccer for amputees (Minimum 50 words), 3) Provide information related to the physical condition, training, injuries and / or social aspects of the players of soccer for people with amputations, and 4) Be written in Spanish, English or Portuguese. The exploratory systematic review featured ten football related documents for amputees. The existing documents related to the subject are scarce as a consequence of the lack of evolution of this modality. These manuscripts, for the most part, deal with aspects such as strength and endurance. Furthermore, only one document talks about the use of inertial devices in their measurements. Therefore, there is a need for further research in the field of football for amputees.

scholarly journals Development of alien and invasive taxa lists for regulation of biological invasions in South Africa

Bothalia ◽  
2019 ◽  
Vol 49 (1) ◽  
Author(s):  
Moleseng C. Moshobane ◽  
Mukundi Mukundamago ◽  
Samuel Adu-Acheampong ◽  
Ross Shackleton
Keyword(s):  
Biological Invasions ◽  
Scientific Evidence ◽  
Relevant Information ◽  
Additional Species ◽  
Public Comment ◽  
The Status ◽  
The Government ◽  
Invasive Taxa ◽  
Scoring Tool ◽  
The Impact

Background: Lists are fundamental for guiding policy and management of biological invasions. The process of developing regulatory lists of alien and invasive taxa should be based on scientific evidence through an objective, transparent and consistent process.Objectives: In this study, we review the development of the lists for the alien and invasive species regulations in terms of section 97(1) of the National Environmental Management: Biodiversity Act, 2004 (NEM:BA) (Act No. 10 of 2004).Method: Lists published in the National Government Gazette were compared and assessed for changes in the taxa listed and their status between 2009 and 2016. Minutes from expert workshops convened to inform the listing were reviewed. Relevant information such as the criteria for listing taxa was extracted from minutes of the workshops.Results: Three draft versions were produced and published in the Government Gazette for public comment before the final list was published in August 2014 and promulgated in October 2014. The list is to be reviewed regularly and additional species can be added, and the status of species can be changed as additional evidence of threat levels is available – and was even amended in May 2015. The various stakeholders involved in the listing process were academics, conservation experts, managers and the general public through an inclusive process which included participation workshops or through public comment. A scoring tool based on the likelihood of invasion versus the impact of invasion was recommended for evaluating the risk of a species, but was rarely used. A number of issues relating to conflicts and approaches for listing were faced during development of lists.Conclusion: We conclude with some recommendations for future refinements in the listing process, including improving transparency and participation as well as developing standardised approaches for listing.

Modelling the cost of ill health in Health&WealthMOD (Version II): lost labour force participation, income and taxation, and the impact of disease prevention

2010 ◽  
Vol 4 (3) ◽  
pp. 32-36 ◽  
Author(s):  
Deborah Schofield ◽  
Rupendra Shrestha ◽  
Emily Callander ◽  
Richard Pervical ◽  
Simon Kelly ◽  
...  
Keyword(s):  
Disease Prevention ◽  
Labour Force ◽  
Labour Force Participation ◽  
The Cost ◽  
The Impact

Role of Nutraceuticals in Health Promotion and Disease Prevention: A Review in the Indian Context

2020 ◽  
Vol 19 (2) ◽  
pp. 139-145
Author(s):  
Sheena Chhabra ◽  
Apurva Bakshi ◽  
Ravineet Kaur
Keyword(s):  
Health Promotion ◽  
Disease Prevention ◽  
Human Health ◽  
Health Issues ◽  
Scholarly Literature ◽  
Indian Context ◽  
The Impact ◽  
Immense Potential ◽  
Specific Health

Nutraceuticals have been around for quite some time. As the nomenclature suggests, they are placed somewhere between food (nutra-) and medicine (-ceuticals) in terms of their impact on human health. Researches have focused on the impact of various types of nutraceuticals on health, their efficacy in health promotion and disease prevention, and often on suitable uses of certain categories of nutraceuticals for specific health issues. However, we are still far from utilizing the immense potential of nutraceuticals for benefiting human health in a substantial manner. We review the available scholarly literature regarding the role of nutraceuticals in health promotion, their efficacy in disease prevention and the perception of nutraceuticals' health benefits by consumers. Thereafter we analyze the need for regulation of nutraceuticals and various provisions regarding the same.

The Impact of Plant Bioactive Compounds on Aging and Fertility of Diverse Organisms: A Review

2020 ◽  
Vol 20 (13) ◽  
pp. 1287-1299
Author(s):  
Muhammad Akram Mohd Noordin ◽  
Mahanem Mat Noor ◽  
Wan Mohd Aizat
Keyword(s):  
Clinical Trial ◽  
Bioactive Compounds ◽  
Defense Mechanisms ◽  
Healthy Aging ◽  
Antioxidant Defense ◽  
Senior Citizens ◽  
Aging Population ◽  
Human Clinical Trial ◽  
Fertility Reduction ◽  
The Impact

It is expected that in 2050, there will be more than 20% of senior citizens aged over 60 years worldwide. Such alarming statistics require immediate attention to improve the health of the aging population. Since aging is closely related to the loss of antioxidant defense mechanisms, this situation eventually leads to numerous health problems, including fertility reduction. Furthermore, plant extracts have been used in traditional medicine as potent antioxidant sources. Although many experiments had reported the impact of various bioactive compounds on aging or fertility, there is a lack of review papers that combine both subjects. In this review, we have collected and discussed various bioactive compounds from 26 different plant species known to affect both longevity and fertility. These compounds, including phenolics and terpenes, are mostly involved in the antioxidant defense mechanisms of diverse organisms such as rats, mites, fruit flies, roundworms, and even roosters. A human clinical trial should be considered in the future to measure the effects of these bioactive compounds on human health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements or potential medical drugs to ensure a healthy aging population.

scholarly journals How Risky Is That Risk Sharing Agreement? Mean-Variance Tradeoffs and Unintended Consequences of Six Common Risk Sharing Agreements

2021 ◽  
Vol 6 (1) ◽  
pp. 238146832199040
Author(s):  
Gregory S. Zaric
Keyword(s):  
Risk Sharing ◽  
Financial Risk ◽  
Unintended Consequences ◽  
Drug Costs ◽  
New Drugs ◽  
Total Drug ◽  
Number Of Patients ◽  
Clinical Benefits ◽  
The Impact ◽  
Mean Variance

Background. Pharmaceutical risk sharing agreements (RSAs) are commonly used to manage uncertainties in costs and/or clinical benefits when new drugs are added to a formulary. However, existing mathematical models of RSAs ignore the impact of RSAs on clinical and financial risk. Methods. We develop a model in which the number of patients, total drug consumption per patient, and incremental health benefits per patient are uncertain at the time of the introduction of a new drug. We use the model to evaluate the impact of six common RSAs on total drug costs and total net monetary benefit (NMB). Results. We show that, relative to not having an RSA in place, each RSA reduces expected total drug costs and increases expected total NMB. Each RSA also improves two measures of risk by reducing the probability that total drug costs exceed any threshold and reducing the probability of obtaining negative NMB. However, the effects on variance in both NMB and total drug costs are mixed. In some cases, relative to not having an RSA in place, implementing an RSA can increase variability in total drug costs or total NMB. We also show that, for some RSAs, when their parameters are adjusted so that they have the same impact on expected total drug cost, they can be rank-ordered in terms of their impact on variance in drug costs. Conclusions. Although all RSAs reduce expected total drug costs and increase expected total NMB, some RSAs may actually have the undesirable effect of increasing risk. Payers and formulary managers should be aware of these mean-variance tradeoffs and the potentially unintended results of RSAs when designing and negotiating RSAs.

scholarly journals Exploitation of Marine-Derived Robust Biological Molecules to Manage Inflammatory Bowel Disease

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 196
Author(s):  
Muhammad Bilal ◽  
Leonardo Vieira Nunes ◽  
Marco Thúlio Saviatto Duarte ◽  
Luiz Fernando Romanholo Ferreira ◽  
Renato Nery Soriano ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bioactive Compounds ◽  
Bowel Disease ◽  
Clinical Translation ◽  
Biologically Active ◽  
Naturally Occurring ◽  
Inflammatory Bowel ◽  
Functional Features ◽  
Biological Entities ◽  
The Impact

Naturally occurring biological entities with extractable and tunable structural and functional characteristics, along with therapeutic attributes, are of supreme interest for strengthening the twenty-first-century biomedical settings. Irrespective of ongoing technological and clinical advancement, traditional medicinal practices to address and manage inflammatory bowel disease (IBD) are inefficient and the effect of the administered therapeutic cues is limited. The reasonable immune response or invasion should also be circumvented for successful clinical translation of engineered cues as highly efficient and robust bioactive entities. In this context, research is underway worldwide, and researchers have redirected or regained their interests in valorizing the naturally occurring biological entities/resources, for example, algal biome so-called “treasure of untouched or underexploited sources”. Algal biome from the marine environment is an immense source of excellence that has also been demonstrated as a source of bioactive compounds with unique chemical, structural, and functional features. Moreover, the molecular modeling and synthesis of new drugs based on marine-derived therapeutic and biological cues can show greater efficacy and specificity for the therapeutics. Herein, an effort has been made to cover the existing literature gap on the exploitation of naturally occurring biological entities/resources to address and efficiently manage IBD. Following a brief background study, a focus was given to design characteristics, performance evaluation of engineered cues, and point-of-care IBD therapeutics of diverse bioactive compounds from the algal biome. Noteworthy potentialities of marine-derived biologically active compounds have also been spotlighted to underlying the impact role of bio-active elements with the related pathways. The current review is also focused on the applied standpoint and clinical translation of marine-derived bioactive compounds. Furthermore, a detailed overview of clinical applications and future perspectives are also given in this review.

scholarly journals A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract

2021 ◽  
Vol 14 (5) ◽  
pp. 467
Author(s):  
Ana Henriques Mota ◽  
Inês Prazeres ◽  
Henrique Mestre ◽  
Andreia Bento-Silva ◽  
Maria João Rodrigues ◽  
...  
Keyword(s):  
Biological Activities ◽  
Scientific Evidence ◽  
Release Profile ◽  
Health Claims ◽  
Topical Formulation ◽  
Sambucus Nigra ◽  
Western Asia ◽  
Wide Range ◽  
The Impact ◽  
Over Time

Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time.

scholarly journals Effects of the Marine Biotoxins Okadaic Acid and Dinophysistoxins on Fish

2021 ◽  
Vol 9 (3) ◽  
pp. 293
Author(s):  
Mauro Corriere ◽  
Lucía Soliño ◽  
Pedro Reis Costa
Keyword(s):  
Okadaic Acid ◽  
Harmful Algal Blooms ◽  
Algal Blooms ◽  
Current Knowledge ◽  
Global Climate ◽  
Scientific Evidence ◽  
Shellfish Poisoning ◽  
Morphological Alterations ◽  
The Impact ◽  
Dsp Toxins

Natural high proliferations of toxin-producing microorganisms in marine and freshwater environments result in dreadful consequences at the socioeconomically and environmental level due to water and seafood contamination. Monitoring programs and scientific evidence point to harmful algal blooms (HABs) increasing in frequency and intensity as a result of global climate alterations. Among marine toxins, the okadaic acid (OA) and the related dinophysistoxins (DTX) are the most frequently reported in EU waters, mainly in shellfish species. These toxins are responsible for human syndrome diarrhetic shellfish poisoning (DSP). Fish, like other marine species, are also exposed to HABs and their toxins. However, reduced attention has been given to exposure, accumulation, and effects on fish of DSP toxins, such as OA. The present review intends to summarize the current knowledge of the impact of DSP toxins and to identify the main issues needing further research. From data reviewed in this work, it is clear that exposure of fish to DSP toxins causes a range of negative effects, from behavioral and morphological alterations to death. However, there is still much to be investigated about the ecological and food safety risks related to contamination of fish with DSP toxins.

scholarly journals Personality and Dementia: an Approach to Differential Profile of the Caregiver

2011 ◽  
Vol 1 (3) ◽  
pp. 85-94
Author(s):  
Elena de Andrés-Jiménez ◽  
Rosa Mª Limiñana-Gras ◽  
Encarna Fernández-Ros
Keyword(s):  
Relevant Information ◽  
Personality Profile ◽  
Family Carers ◽  
Psychological Variables ◽  
People With Dementia ◽  
The Family ◽  
Study Population ◽  
The One ◽  
The Impact

The aim of this study is to determine the existence of a characteristic personality profile of family carers of people with dementia. The correct knowledge and use of psychological variables which affect the carer, helps to promote appropriate actions to mitigate the impact of care and improve the carer’s quality of life and likewise the one of the person cared for. The study population consists of 69 family carers of people with dementia, members of various associations and care centers. The results allow us to identify a characteristic personality profile for these carers and it reveals a specific psychological working in this sample, although we cannot directly relate it with the tasks of caring for people with this disease, this profile gives us very relevant information to pay more attention to the needs of this group. Moreover, the analysis of personality styles depends on the sex of the family carer, showing, once again, that the woman is in a situation of most vulnerability.

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