scholarly journals Ecological Aspects of microelements’ and Vitamins’ Salts Impact on Dairy Cows’ Productivity and Reproductive Function in Mountain Territories of KBR

2019 ◽  
Author(s):  
I K Taov ◽  
Ts B Kagermazov ◽  
A M Khuranov
Keyword(s):  
Vitamin A ◽  
Reproductive Function ◽  
Control Group ◽  
Mountainous Areas ◽  
Cattle Feeding ◽  
Ecological Aspects ◽  
Protein Change ◽  
Fat Soluble Vitamins ◽  
Biological Spectrum

The article examining the implication for the microelements’ salts – cobalt and copper – to milk production, vitamin A and trivitamin (vitamin A, D3, E) to the cows’ reproductive function in mountainous areas. The study is relevant due to the fact that when organizing cattle feeding, first of all, we care about the balance of rations for the main nutrients and only then for vitamins, minerals and micro minerals. That is why it becomes more important to provide the breeding stock with vitamins and increase the metabolism of the main substrate of life - protein, change its biological function. It is noteworthy that it is necessary to clarify the way that fat-soluble vitamins on cells act, so that their biological spectrum of action is wider than we realize. The purpose of this research is the further study of the biological role of trace elements and vitamins used in cattle breeding, considering the soil and climatic zones of mountainous areas. In our research, the mountainous farms cows’ feeding with microelements favorably affected their milk pr76nv hghhjhhnhghjuo9huyoduction. So, in animals from the second group, milk yield was higher compared to the control by 0.95 kg of milk, the third – by 1.28 kg and the fourth – by 1.45 kg. Calves from cows that received vitamin A and trivitamin developed better during the embryonic period and their birth weight was 2.8–3.0 kg more compared to the control group. Within 90 days after calving, 87.5–92 % of cows from the experimental groups became enceinte, while in the control group it was only 75 %.

Retinol, α-Tocopherol and Vitamin D3 in White MuscleDisease

2018 ◽  
Vol 74 (1) ◽  
pp. 6029-2018
Author(s):  
HANDAN MERT ◽  
SERKAN YİLDİRİM ◽  
IBRAHİM HAKKİ YORUK ◽  
KİVANC IRAK ◽  
BAHAT COMBA ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin D3 ◽  
White Muscle ◽  
Bone Structure ◽  
Early Stage ◽  
Vitamin A Deficiency ◽  
Muscle Disease ◽  
Control Group ◽  
White Muscle Disease ◽  
Fat Soluble Vitamins

Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White muscle disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, α-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum α-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p<0.001) and α-tocopherol (p<0.0011) level differences were statistically relevant. Macroscopically, Zenker’s necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker's necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of α tocopherol and retinol (p<0.001) compared to the sick lambs. .

The role of antioxidants in the complex therapy of patients with endometriosis-associated infertility

2020 ◽  
Vol 19 (6) ◽  
pp. 28-33
Author(s):  
M.G. Khatlamadzhiyan ◽  
◽  
E.V. Kharitonova ◽  
L.N. Shcherbakova ◽  
E.I. Kalenikova ◽  
...  
Keyword(s):  
Blood Flow ◽  
Reproductive Function ◽  
Control Group ◽  
Complex Therapy ◽  
Endometrium Receptivity ◽  
Infertile Patients ◽  
Subendometrial Blood Flow ◽  
Endometrial Blood Flow ◽  
Fertile Women

Objective. To study the role of antioxidants in the complex therapy of patients with endometriosis-associated infertility on the example of evaluating the effectiveness of ubidecarenone. Patients and methods. Forty-three patients with endometriosis-associated infertility and nineteen fertile women with complete reproductive function were examined. In order to improve the receptivity of endometrium and correct the antioxidant status in infertile patients with endometriosis after laparoscopy, therapy with Synergin® was administered at a dosage of 2 capsules per day for 3 months. After therapy, an assessment of endometrium and intrauterine perfusion was made. Results. There was a significant decrease in intrauterine perfusion in patients with endometriosis-associated infertility compared to the control group. However, after therapy with Synergin® within 3 months and correction of endothelial dysfunction in infertile patients with endometriosis, an improvement in intrauterine perfusion was revealed. Thus, prior to therapy, subendometrial blood flow was assessed in 13% of patients as satisfactory, in 77% – it was reduced, in 10% – it was absent; after therapy, 86% of patients showed satisfactory blood flow and 14% had decreased blood flow. Endometrial blood flow was reduced in 32% of patients and in 68% were absent prior to treatment, and after treatment, it was assessed as satisfactory in 45% and was reduced in 55%. Conclusion. Pathogenetic antioxidant therapy is necessary in the complex therapy of infertility in patients with external genital endometriosis after surgical treatment. Key words: α-Tocopherol, infertility, coenzyme Q10, endometrium receptivity, endometriosis

Antioxidant Role of Plasma Carotenoids in Bronchopulmonary Dysplasia in Preterm Infants

2009 ◽  
Vol 79 (56) ◽  
pp. 288-296 ◽  
Author(s):  
Annelies Vogelsang ◽  
Richard A. van Lingen ◽  
Janine Slootstra ◽  
Bert D. Dikkeschei ◽  
Boudewijn J. Kollen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Plasma Concentrations ◽  
Antioxidant Defenses ◽  
Control Group ◽  
Cholesterol Ratio ◽  
Β Carotene

Objectives: Oxidative stress is implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) and consequently, it might be theorized that sufficient antioxidant defenses are needed to prevent BPD. We hypothesized that, except for vitamins E and A, carotenoids may be important in this defense. Carotenoids are present in human milk; however, they are not added to parenteral nutrition, the main food source of preterm infants in the first week of life. Aim: To evaluate prospectively the role of carotenoids in BPD in a cohort of preterm infants. Methods: The plasma concentrations of F2α-isoprostane, α- and β-carotene, lycopene, lutein, vitamin A, and the vitamin E/cholesterol ratio were studied at days 1, 3, and 7 in a cohort of 109 preterm infants, of whom 19 had BPD. Results: When comparing the BPD and control group, infants in the BPD group were younger (p<0.001) and β-carotene (day 7, p<0.01) and vitamin A concentrations were lower (days 3 and 7, p<0.001). Lycopene, lutein, α-carotene, vitamin E, and F2α-isoprostane concentrations did not differ between groups. Conclusions: Plasma β-carotene and vitamin A concentrations are lower in BPD infants which may result in a reduction of their antioxidant protection.

scholarly journals Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective

2013 ◽  
Vol 2013 ◽  
pp. 1-26 ◽  
Author(s):  
Anthony R. Mawson
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Physiological Limits ◽  
Retinoid Metabolism ◽  
New Perspective ◽  
Fat Soluble Vitamins ◽  
Diabetes And Obesity

Reduced exposure to solar radiation, leading to a deficiency of vitamin D and hence impaired innate immunity, has been suggested as a trigger for influenza viral replication and as an explanation of seasonal influenza. Although this hypothesis accounts for many unexplained facts about the epidemiology of influenza, gaps remain in understanding the pathogenesis and manifestations of the disease. Several observations suggest a role for vitamin A compounds (retinoids) in the disease. This paper presents a new model of the etiopathogenesis of influenza, suggesting that host resistance and susceptibility depend importantly on the ratio of vitamin D to vitamin A activity. Retinoid concentrations within normal physiological limits appear to inhibit influenza pathogenesis whereas higher background concentrations (i.e., very low vitamin D : A ratios) increase the risk of severe complications of the disease. There is also evidence that influenza-induced or preexisting liver disease, diabetes, and obesity worsen the severity of infection, possibly via liver dysfunction and alterations in retinoid metabolism. The model could be tested by determining the presence of retinoids in the secretions of patients with influenza and by studies of retinoid profiles in patients and controls. Potential strategies for prevention and treatment are discussed.

scholarly journals THE ROLE OF VITAMIN D AS A NEW MARKER ON THE WOMEN INFERTILITY

2020 ◽  
Vol 17 (36) ◽  
pp. 1099-1109
Author(s):  
Najla Salim MOHAMMED ◽  
Zena Abdul Monim AL-JAWADI
Keyword(s):  
Vitamin D ◽  
Total Cholesterol ◽  
Inverse Correlation ◽  
Female Infertility ◽  
Control Group ◽  
Infertile Women ◽  
Healthy Women ◽  
Strong Positive Relationship ◽  
Fat Soluble Vitamins

Cholecalciferol (Vitamin D) is essential to the proper functioning of the human body. This vitamin belongs to fat-soluble vitamins, responsible for stimulating the intestinal absorption of calcium and phosphate. It has been recently observed that vitamin D may be related to cases of female infertility. This study aimed to examine the effect of vitamin D on female infertility by analyzing hormonal and biochemical parameters. Estrogen, progesterone, FSH, LH, total Cholesterol, Triglyceride, HDL, LDL, VLDL, vitamin D, and BMI were tested in 60 women with infertility and 40 fertile women as a control group. The results showed a highly significant elevation in LH concentration, Triglyceride, LDL, and BMI in infertile women, compared to the healthy women at a significant P = 0.025, P = 0.01, P = 0.05, and P = 0.001, respectively. Also, a significant low elevation in the concentration of estrogen, progesterone, FSH, HDL, and vitamin D in infertile women when compared to the healthy women at a significant level of P = 0.01, P = 0.039, P = 0.05, P = 0.05, and P = 0.001, respectively was observed. This vitamin had a strong positive relationship with progesterone, FSH, total cholesterol, HDL, and LDL. It was also proved a significant inverse correlation to LH, estrogen, TG, VLDL, and BMI. It could be concluded that there is a significant decrease in the level of vitamin D in infertile women compared with the group of healthy women, especially with high BMI. It could also be deduced that vitamin D can be a new marker of increasing infertility and miscarriage risk.

scholarly journals Retinol, α-tocopherol and vitamin D3 in White MuscleDisease

2018 ◽  
Vol 74 (1) ◽  
pp. 6027-2018
Author(s):  
HANDAN MERT ◽  
SERKAN YİLDİRİM ◽  
IBRAHİM HAKKİ YORUK ◽  
KİVANC IRAK ◽  
BAHAT COMBA ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin D3 ◽  
White Muscle ◽  
Bone Structure ◽  
Early Stage ◽  
Vitamin A Deficiency ◽  
Muscle Disease ◽  
Control Group ◽  
White Muscle Disease ◽  
Fat Soluble Vitamins

Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White muscle disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, α-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum α-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p<0.001) and α-tocopherol (p<0.0011) level differences were statistically relevant. Macroscopically, Zenker’s necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker's necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of α tocopherol and retinol (p<0.001) compared to the sick lambs. .

The Potential role of Eugenol and Ocimum sanctum extract on female rats: a focus on infertility efficacy

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Venkataramanaiah Poli ◽  
Motireddy Srinivasulu Reddy
Keyword(s):  
Estrogenic Activity ◽  
Reproductive Function ◽  
Female Rats ◽  
Ocimum Sanctum ◽  
Control Group ◽  
Albino Rats ◽  
Corpora Lutea ◽  
Healthy Female ◽  
Saline Vehicle

Objectives The aim of the present study was to evaluate the infertility effect of Eug and OS extract administrations in female albino rats. Methods Healthy female albino rats are provided with EUG (99% pure) with a dose of 0.4 ml/ day/ rat and OS Linn. Leaf extract with a dose of 500 mg/kg body weight/ day/ rat orally for 20 days. The control group received saline (vehicle). On day 20 of gestation, maternal and foetal, Antifertility and Antiimplantation, ovarian follicular kinetics and Estrogenic activity parameters. ANOVA Analysis One-way with Dunnett comparison tests used to analyze data. Ocimum Sanctum also gets an antifertility effect.   Results Oral administration of the extract from days 1 to 19 of gestation showed a reduction (p<0.05) in the number of corpora lutea of pregnancy and number of live fetuses. The foetal and placental weights were also significantly (P < 0.05) decreased in Eug and OS extract compared with the control. The results revealed that Antiimplantation activity were 87.17% and 79.48% in Eug and OS extract administration. Antifertility activity was 83.33 % in in Eug and OS extract administration. Conclusion The results of this study concluded the evidence for the antifertility activity of the administration of Eug and OS extract in female rats. Administration can induce the effects of inhibition on reproductive function in female albino rats.

scholarly journals The Role of Endothelial Dysfunction Markers in Pregnant Women with Chorion Detachment, Included in the Program of Auxiliary Reproductive Technologies

2017 ◽  
Vol 24 (3) ◽  
Author(s):  
Natalya Lytvyn
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Reproductive Function ◽  
Reproductive Technologies ◽  
The Body ◽  
Control Group ◽  
Vitro Fertilization ◽  
Endothelin 1

An urgent medical and social problem is the restoration of reproductive function of womenwho suffer from infertility, which became possible due to auxiliary reproductive technologies. Women with induced pregnancy make thegroup of a high-risk on miscarriage, due to interrelated processes –immunological disorders and endothelial dysfunction that occur in the body of pregnant women after the use of extracorporal fertilization programs, and can lead to the chorion detachment and the formation of subchorionic hematomas.The purpose of the study is to determine the role of endothelial dysfunction as one of the leading factors that determine the development of a local non-progressive chorion detachment in infertile patients included in the program of auxiliary reproductive technologies.Materials and methods. We have examined 130 pregnant women, who were divided into groups: the control group included 30 women, whose pregnancy occurred in the natural cycle and with uncomplicated gestational course; the main group – 50 patients with induced pregnancy and risk factors of the occurrence of chorion detachment, who wereperformed the proposed pre-gravidapreparation; the comparative group – 50 pregnant women who received a standard scheme of pregnancy management before and after in-vitro fertilization. A general clinical examination, ultrasound examination, homocysteine level determination, endothelin-1 and nitrogen oxide metabolites were performed.Results. In women included into the program of auxiliary reproductive technologies with local chorion detachment were recorded changes of vascular endothelial function with a possible increase in endothelin-1 production and a decrease of the nitric oxidesynthesis. During the induced pregnancy with the presence of subchorionic hematoma, an increase of the level of endothelium-damaging factor of homocysteine was noted.Conclusions.This study identifies the parameters that reflect the main links of endothelial dysfunction and can be used as markers of local chorion detachment.

INFLUENCE OF INTEGRATED FODDER ADDITIVE ON THE PRODUCTIVITY OF CATTLE IN THE MAGADAN REGION

2020 ◽  
Author(s):  
И.Ю. КУЗЬМИНА ◽  
Е.В. ГИНТЕР ◽  
А.М. КУЗЬМИН
Keyword(s):  
Milk Fat ◽  
Reproductive Function ◽  
Feed Additive ◽  
Control Group ◽  
Plant Resources ◽  
Magadan Region ◽  
Cattle Feeding ◽  
Service Period ◽  
Milk Protein Content ◽  
Daily Milk Yield

Проведены исследования по применению кормовой добавки (КД) из нетрадиционных региональных растительных ресурсов: лишайников Cladonia alpestris и Cetraria islandica, морских водорослей (ламинария Laminaria, фукус Fucus) и микроэлементов в рационах кормления коров за 2 мес перед и 2 мес после отела. Использование КД положительно влияло на молочную продуктивность. Наибольшая эффективность ее применения в рационе коров проявлялась в повышении среднесуточного удоя на 1,67 кг (11,4%), жирномолочности — на 0,25 абс.%, содержания белка в молоке — на 0,06 абс.% относительно контроля. Применение КД позволило оптимизировать воспроизводительные функции. У коров опытной группы сервис-период был короче на 24,8%, индекс осеменения меньше в 0,75 раза, чем в контроле. Оплодотворяемость от первого осеменения также была выше у опытных коров (62,5—87,5%). Животные, получавшие дополнительно к основному рациону КД, обладали повышенной воспроизводительной способностью по сравнению с аналогами, не получавшими ее, что позволило успешней использовать первых в процессе воспроизводства стада. Включение в рацион кормовой добавки способствует и повышению экономической эффективности производства. Снижение уровня убыточности в сравнении с применением хозяйственного рациона составило 16,2 п.п. Улучшение всех гематологических показателей сыворотки крови коров показывает, что использование КД оказывает положительное влияние на их организм. На основе результатов исследований разработана кормовая добавка для кормления крупного рогатого скота с использованием нетрадиционных источников кормов в условиях Магаданской области, получен патент на изобретение «Кормовая добавка для крупного рогатого скота с иммуномодулирующим действием». The studies have been carried out on use of feed additive of nontraditional regional  plant resources: lichens, seaweeds, and trace elements in diets for cow feeding for 2 months of dry period and 2 months after calving. Use of the feed additive (FA) influences positively on the milk productivity. The highest efficiency of use of the FA in cattle diet showed in increasing average daily milk yield by 1.67 kg (11.4%), milk fat content by 0.25 absolute percent, milk protein content by 0.06 absolute percent, relative to the control group. Use of the feed additive enables optimizing reproductive function of the cows. The cows in the 2 experimental group had a service period shorter by 24.8%, insemination index lover 0.75 times than those in the control group cows. Fertility from the first insemination was higher in experimental cows (62.5-87.5%). The cows fed the FA in addition to the basic diet have a heightened reproductive abilities as that did not feed it which makes it possible to use the former in the process of the herd reproduction. The inclusion of a feed additive in the diet also contributes to increasing the economic efficiency of production. The decrease in the level of unprofitability in comparison with the use of the ration was 16.2 percentage points. Data of haematological investigations showed that, according to studied  indices, the state of the cows in the experimental groups had improved in comparison wilh ones in the control group. On the basis of results of the studies, a feed additive for cattle feeding has been developed using the nontraditional feed resources in conditions of Magadan region and a patent has been taken out for an invention entitled «Feed additive for cattle possessed an immunomodulating effect».

The role of thrombophilia in the genesis of reproductive losses

2017 ◽  
Author(s):  
I.B. Manukhin , N.F. Kuneshko , G.M. Turgunova et all
Keyword(s):  
Pregnant Women ◽  
High Frequency ◽  
Molecular Genetic ◽  
Fetal Loss ◽  
Reproductive Function ◽  
Molecular Genetic Analysis ◽  
Control Group ◽  
Reproductive Losses ◽  
Genetically Determined

Objective. Defining the role and frequency of acquired and genetic thrombophilia in the genesis of fetal loss syndrome. Methods. 49 pregnant women with a syndrome of reproductive losses and 27 pregnant women with normal reproductive function were examined. The identification of genetic forms of thrombophilia was performed by the method of molecular genetic analysis in 3 phases. Results. In 31 pregnant women of the main group (63,3 %) and 9 pregnant women in the control group (33,3 %) were the presence of acquired, genetically determined or multigeneration. Conclusion. Our analysis of clinical material showed a high frequency of complications and outcomes of pregnancy in women with thrombophilia and fetal loss syndrome and a possibility to avoid the above complications and poor pregnancy outcomes.

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