Perspectives for gallotannins neuroprotective potential - current experimental evidences

10.20883/172 ◽  
2016 ◽  
Vol 85 (4) ◽  
pp. 317 ◽  
Author(s):  
Radosław Kujawski ◽  
Małgorzata Kujawska ◽  
Marcin Ożarowski ◽  
Justyna Baraniak ◽  
Halina Laskowska ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Experimental Studies ◽  
Heme Oxygenase 1 ◽  
Neurocognitive Performance ◽  
Active Metabolites ◽  
Hydrolyzable Tannins ◽  
Sugar Moiety ◽  
Age Related

Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin‑rich plant preparations might be effective at reversing neurodegenerative pathology and age‑related declines in neurocognitive performance. This mini‑review summarizes, based on experimental studies, current knowledge about diverse neuroprotective abilities of gallotannins, mostly via antioxidant properties and some mechanisms of the effect are proposed including blocking accumulation of nitrites, inhibiting expression and activity of heme oxygenase 1(HO-1), and decreasing degradation of poly(ADP‑ribose) glycohydrolase (PARP).

scholarly journals Perspectives for gallotannins neuroprotective potential - current experimental evidences

2016 ◽  
Vol 85 (4) ◽  
pp. 317-322
Author(s):  
Radosław Kujawski ◽  
Małgorzata Kujawska ◽  
Marcin Ożarowski ◽  
Justyna Baraniak ◽  
Halina Laskowska ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Experimental Studies ◽  
Heme Oxygenase 1 ◽  
Neurocognitive Performance ◽  
Active Metabolites ◽  
Hydrolyzable Tannins ◽  
Sugar Moiety ◽  
Age Related

Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin-rich plant preparations might be effective at reversing neurodegenerative pathology and age-related declines in neurocognitive performance. This mini-review summarizes, based on experimental studies, current knowledge about diverse neuroprotective abilities of gallotannins, mostly via antioxidant properties and some mechanisms of the effect are proposed including blocking accumulation of nitrites, inhibiting expression and activity of heme oxygenase 1(HO-1), and decreasing degradation of poly(ADP-ribose) glycohydrolase (PARP).

scholarly journals Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Maria D. Pinazo-Durán ◽  
Francisco Gómez-Ulla ◽  
Luis Arias ◽  
Javier Araiz ◽  
Ricardo Casaroli-Marano ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Scientific Evidence ◽  
Experimental Studies ◽  
Beta Carotene ◽  
Dietary Intakes ◽  
Omega 3 ◽  
Age Related ◽  
Disease Study

Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (ω-3) supplements in AMD prevention.Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX andω-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain).Results. High dietary intakes ofω-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence.Conclusion. Research has proved that elder people with poor diets, especially with low AOX andω-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.

Saffron and retina: Neuroprotection and pharmacokinetics

2014 ◽  
Vol 31 (4-5) ◽  
pp. 355-361 ◽  
Author(s):  
SILVIA BISTI ◽  
RITA MACCARONE ◽  
BENEDETTO FALSINI
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Clinical Trial ◽  
Neuroprotective Effect ◽  
Experimental Studies ◽  
Dietary Supplementation ◽  
Complex Interaction ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
And Function

AbstractAge-related macular degeneration (AMD) is a retinal neurodegenerative disease whose development and progression are the results of a complex interaction between genetic and environmental risk factors. Both oxidative stress and chronic inflammation play a significant role in the pathogenesis of AMD. Experimental studies in rats with light-induced photoreceptors degeneration demonstrated that saffron may protect photoreceptor from retinal stress, preserving both morphology and function and probably acting as a regulator of programmed cell death, in addition to its antioxidant and anti-inflammatory properties. Recently, a randomized clinical trial showed that in patients with early AMD, dietary supplementation with saffron was able to improve significantly the retinal flicker sensitivity suggesting neuroprotective effect of the compound. Here, we examine the progress of saffron dietary supplementation both in animal model and AMD patients, and discuss the potential and safety for using dietary saffron to treat retinal degeneration.

scholarly journals Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 467
Author(s):  
Iveta Bernatova ◽  
Silvia Liskova
Keyword(s):  
Cardiovascular System ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Antioxidant Properties ◽  
Experimental Studies ◽  
Biological Action ◽  
Preclinical Studies ◽  
Physiological Processes ◽  
Lower Blood ◽  
Treatment Of Hypertension

Various studies have shown that certain flavonoids, flavonoid-containing plant extracts, and foods can improve human health. Experimental studies showed that flavonoids have the capacity to alter physiological processes as well as cellular and molecular mechanisms associated with their antioxidant properties. An important function of flavonoids was determined in the cardiovascular system, namely their capacity to lower blood pressure and to improve endothelial function. (−)-Epicatechin and taxifolin are two flavonoids with notable antihypertensive effects and multiple beneficial actions in the cardiovascular system, but they also possess antiviral effects, which may be of particular importance in the ongoing pandemic situation. Thus, this review is focused on the current knowledge of (−)-epicatechin as well as (+)-taxifolin and/or (−)-taxifolin-modified biological action and underlining molecular mechanisms determined in preclinical studies, which are relevant not only to the treatment of hypertension per se but may provide additional antiviral benefits that could be relevant to the treatment of hypertensive subjects with SARS-CoV-2 infection.

scholarly journals Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
W. Rungratanawanich ◽  
G. Abate ◽  
M. M. Serafini ◽  
M. Guarienti ◽  
M. Catanzaro ◽  
...  
Keyword(s):  
Nuclear Translocation ◽  
Antioxidant Properties ◽  
Quinone Reductase ◽  
Glutathione Synthetase ◽  
Heme Oxygenase 1 ◽  
Hek 293 ◽  
Human Embryonic Kidney Cells ◽  
Nrf2 Pathway ◽  
Protein Levels ◽  
Age Related

γ-Oryzanol (ORY) is well known for its antioxidant potential. However, the mechanism by which ORY exerts its antioxidant effect is still unclear. In this paper, the antioxidant properties of ORY were investigated for its potential effects as a reactive oxygen and nitrogen species (ROS/RNS) scavenger and in activating antioxidant-promoting intracellular pathways utilizing the human embryonic kidney cells (HEK-293). The 24 h ORY exposure significantly prevented hydrogen peroxide- (H2O2-) induced ROS/RNS production at 3 h, and this effect was sustained for at least 24 h. ORY pretreatment also enhanced the activity of antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPX). Interestingly, ORY induced the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation and upregulation of Nrf2-dependent defensive genes such as NAD(P)H quinone reductase (NQO1), heme oxygenase-1 (HO-1), and glutathione synthetase (GSS) at mRNA and protein levels in both basal condition and after H2O2 insult. Thus, this study suggested an intriguing effect of ORY in modulating the Nrf2 pathway, which is also involved in regulating longevity as well as age-related diseases.

scholarly journals Bioisosteric Analogues of Cinnamic Acid as Effective Neuroprotectors

2018 ◽  
Vol 1 (3) ◽  
pp. e00052
Author(s):  
M.E. Neganova ◽  
V. Semenov ◽  
M. Semenova ◽  
O.M. Redkozubova ◽  
Yu.R. Aleksandrova ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Cinnamic Acid ◽  
Biological Activities ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Neuroprotective Activity ◽  
Age Related ◽  
Mitochondrial Functions ◽  
Wide Range ◽  
The Creation

Compounds that act on mitochondrial functions are considered as promising drugs for the treatment of neurodegenerative diseases and age-related dementias. As a basis for the creation of such potential drugs, bioisosteric cinnamic acid analogs and polymethoxybenzene derivatives were selected. Derivatives of cinnamic acid have a wide range of biological activities, which can be important for drugs aimed at the treatment of neurodegenerative diseases, in particular Alzheimer′s disease. In this work, the neuroprotective activity of bioisosteric cinnamic acid analogs and polymethoxybenzene derivatives was studied. Among the compounds studied, lead substances 3, 4, and 7 have been identified. These compounds show no intrinsic toxicity and have a neuroprotective effect on the cellular model of neurodegeneration associated with calcium stress. The mechanism of their cytoprotective activity is probably due to the influence on mitochondrial functions, because these compounds effectively suppress the calcium-induced process of mitochondrial permeability jump. In addition, one of the substances investigated (7) has antioxidant properties, showing the ability to inhibit lipid peroxidation (LPO) of rat brain homogenate, which may be an additional mechanism of neuroprotective effect. The data obtained make it possible to recommend the investigated substances as a basis for the creation of effective neuroprotective drugs capable of influencing early stages of the development of neurodegenerative diseases.

Internet Navigation Skills for Financial Management: Associations with Age, Neurocognitive Performance, and Functional Capacity

2020 ◽  
Author(s):  
Samina Rahman ◽  
Victoria Kordovski ◽  
Savanna Tierney ◽  
Steven Paul Woods
Keyword(s):  
Older Adults ◽  
Functional Capacity ◽  
Financial Management ◽  
Internet Banking ◽  
Online Banking ◽  
Neurocognitive Performance ◽  
Younger Adults ◽  
Neurocognitive Functions ◽  
Age Related ◽  
Use Factors

Objective: Online banking is becoming increasingly common among older adults, whomay experience difficulties effectively navigating this instrumental technology. Thisstudy examined age effects on a performance-based Internet banking task and itsassociation with neurocognitive ability and functional capacity in older and youngeradults. Method: Thirty-five older adults and 50 younger adults completed anexperimenter-controlled online banking measure in which they independentlyperformed a series of naturalistic financial tasks (e.g., account transfers, bill paying).Participants also completed a standardized battery of neuropsychological tests andmeasures of functional capacity. Results: Older adults were markedly slower and lessaccurate in completing the Internet-based banking task, which was not confounded byother demographic, mood, or computer use factors. Higher scores on measures ofneurocognition and financial functional capacity were both strongly associated withhigher Internet-based banking task accuracy scores and quicker completion times inthe older, but not the younger adults. Conclusions: Findings suggest that older adultsexperience difficultly quickly and accurately navigating online banking platforms, whichmay be partly related to age-related declines in neurocognitive functions and basicfinancial capacity. Future studies might examine whether neurocognitive approaches toremediation and compensation can be used to improve online banking capacity inolder adults.

Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A Comprehensive Review on Diversity, Therapeutic Uses, and Valorization of Bioactive Constituents

2019 ◽  
Vol 20 (5) ◽  
pp. 376-389 ◽  
Author(s):  
Sonali Mishra ◽  
Nupur Srivastava ◽  
Velusamy Sundaresan ◽  
Karuna Shanker
Keyword(s):  
Secondary Metabolite ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Critical Discussion ◽  
Future Research ◽  
Bioactive Constituents ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
Therapeutic Uses ◽  
Decalepis Arayalpathra

Background: Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter is used primarily for nutrition besides its therapeutic values. Traditional preparations/formulations from its tuber are used as a vitalizer and blood purifier drink. The folklore medicinal uses cover inflammation, cough, wound healing, antipyretic, and digestive system management. A comprehensive review of the current understanding of the plant is required due to emerging concerns over its safety and efficacy. Objective: The systematic collection of the authentic information from different sources with the critical discussion is summarised in order to address various issues related to botanical identity, therapeutic medicine, nutritional usage, phytochemical, and pharmacological potentials of the D. arayalpathra. Current use of traditional systems of medicine can be used to expand future research opportunities. Materials and Methods: Available scripted information was collected manually, from peered review research papers and international databases viz. Science Direct, Google Scholar, SciFinder, Scopus, etc. The unpublished resources which were not available in database were collected through the classical books of ‘Ayurveda’ and ‘Siddha’ published in regional languages. The information from books, Ph.D. and MSc dissertations, conference papers and government reports were also collected. We thoroughly screened the scripted information of classical books, titles, abstracts, reports, and full-texts of the journals to establish the reliability of the content. Results: Tuber bearing vanilla like signature flavor is due to the presence of 2-hydroxy-4-methoxybenzaldehyde (HMB). Among five other species, Decalepis arayalpathra (DA) has come under the ‘critically endangered’ category, due to over-exploitation for traditional, therapeutic and cool drink use. The experimental studies proved that it possesses gastro-protective, anti-tumor, and antiinflammatory activities. Some efforts were also made to develop better therapeutics by logical modifications in 2-Hydroxy-4-methoxy-benzaldehyde, which is a major secondary metabolite of D. arayalpathra. ‘Amruthapala’ offers the enormous opportunity to develop herbal drink with health benefits like gastro-protective, anti-oxidant and anti-inflammatory actions. Results: The plant has the potential to generate the investigational new lead (IND) based on its major secondary metabolite i.e. 2-Hydroxy-4-methoxy-benzaldehyde. The present mini-review summarizes the current knowledge on Decalepis arayalpathra, covering its phytochemical diversity, biological potentials, strategies for its conservation, and intellectual property rights (IPR) status. Chemical Compounds: 2-hydroxy-4-methoxybenzaldehyde (Pubchem CID: 69600), α-amyrin acetate (Pubchem CID: 293754), Magnificol (Pubchem CID: 44575983), β-sitosterol (Pubchem CID: 222284), 3-hydroxy-p-anisaldehyde (Pubchem CID: 12127), Naringenin (Pubchem CID: 932), Kaempferol (Pubchem CID: 5280863), Aromadendrin (Pubchem CID: 122850), 3-methoxy-1,2-cyclopentanedione (Pubchem CID: 61209), p-anisaldehyde (Pubchem CID: 31244), Menthyl acetate (Pubchem CID: 27867), Benzaldehyde (Pubchem CID: 240), p-cymene (Pubchem CID: 7463), Salicylaldehyde (Pubchem CID: 6998), 10-epi-γ-eudesmol (Pubchem CID: 6430754), α -amyrin (Pubchem CID: 225688), 3-hydroxy-4-methoxy benzaldehyde (Pubchem CID: 12127).

HIV-Associated Neurocognitive Disorders

2019 ◽  
pp. 27-60
Author(s):  
Jennifer E.  Iudicello ◽  
Erin E. Morgan ◽  
Mariam A. Hussain ◽  
Caitlin Wei-Ming Watson ◽  
Robert K. Heaton
Keyword(s):  
Differential Diagnosis ◽  
Neurocognitive Impairment ◽  
Hiv Treatment ◽  
People Living With Hiv ◽  
Neurocognitive Disorder ◽  
Diagnostic Systems ◽  
Neurocognitive Performance ◽  
Everyday Functioning ◽  
Asymptomatic Neurocognitive Impairment ◽  
Age Related

Human immunodeficiency virus enters the central nervous system (CNS) early after systemic infection, and may cause neural injury and associated neurocognitive impairment through multiple direct and indirect mechanisms. An international conference of multidisciplinary neuroAIDS experts convened in 2005 to propose operationalized research criteria for HIV-related cognitive and everyday functioning impairments. The resulting classification system, known as the Frascati criteria, defined three types of HIV-associated neurocognitive disorder (HAND): asymptomatic neurocognitive impairment, mild neurocognitive disorder, and HIV-associated dementia (HAD). Consideration of comorbid conditions that can influence neurocognitive performance, such as developmental disabilities, non-HIV forms of CNS compromise (neurological and systemic), severe psychiatric conditions, and substance use disorders, is essential to differential diagnosis. Since the introduction of combination antiretroviral therapy (ART), rates of severe HAND (i.e., HAD) have greatly declined, although the milder forms of HAND remain quite prevalent, even in virally suppressed people living with HIV (PLWH). Beyond ART, clinical management of HAND includes behavioral interventions focused on neurocognitive and functional improvements. This chapter covers a range of HAND-related topics, such as the neuropathological mechanisms of HIV-related CNS injury, assessment and diagnostic systems for neurocognitive and everyday functioning impairment in HIV, treatment and protective factors, aging with HIV, HAND in international settings, and ongoing challenges and controversies in the field. Future needs for progress with HAND include advances in early detection of mild cognitive deficits and associated functional impairment in PLWH; biomarkers that may be sensitive to its underlying pathogenesis; and differential diagnosis of HAND versus age-related, non-HIV-associated disorders.

scholarly journals The Potential Effects of Phytoestrogens: The Role in Neuroprotection

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2954
Author(s):  
Justyna Gorzkiewicz ◽  
Grzegorz Bartosz ◽  
Izabela Sadowska-Bartosz
Keyword(s):  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Estrogen Therapy ◽  
Neuroprotective Effects ◽  
Potential Health ◽  
Naturally Occurring ◽  
Epigenetic Effects ◽  
Estrogen Synthesis ◽  
Health Promoting ◽  
The Brain

Phytoestrogens are naturally occurring non-steroidal phenolic plant compounds. Their structure is similar to 17-β-estradiol, the main female sex hormone. This review offers a concise summary of the current literature on several potential health benefits of phytoestrogens, mainly their neuroprotective effect. Phytoestrogens lower the risk of menopausal symptoms and osteoporosis, as well as cardiovascular disease. They also reduce the risk of brain disease. The effects of phytoestrogens and their derivatives on cancer are mainly due to the inhibition of estrogen synthesis and metabolism, leading to antiangiogenic, antimetastatic, and epigenetic effects. The brain controls the secretion of estrogen (hypothalamus-pituitary-gonads axis). However, it has not been unequivocally established whether estrogen therapy has a neuroprotective effect on brain function. The neuroprotective effects of phytoestrogens seem to be related to both their antioxidant properties and interaction with the estrogen receptor. The possible effects of phytoestrogens on the thyroid cause some concern; nevertheless, generally, no serious side effects have been reported, and these compounds can be recommended as health-promoting food components or supplements.

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