scholarly journals Hygienic assessment of the skin-resorptive effect of xenobiotics (literature review)

2021 ◽  
Vol 100 (9) ◽  
pp. 980-984
Author(s):  
Irina V. Bereznyak ◽  
Leonora I. Lipkina ◽  
Nataliya E. Fedorova ◽  
Natalia G. Zavolokina ◽  
Natalia I. Nikolayeva
Keyword(s):  
Literature Review ◽  
Evidence Base ◽  
Dermal Absorption ◽  
The Body ◽  
Protective Function ◽  
Virtual Database ◽  
Physico Chemical ◽  
Skin Contamination ◽  
Permissible Levels ◽  
The Russian Federation

The basis of safety for working with chemicals, including pesticides, is to minimize contact with them and prevent them from entering the body by inhalation and dermal route, sometimes in actual production conditions, the skin pathway can be more dangerous. The most studied inhalation route of harmful substances entering the body of a working person is confirmed by an extensive evidence base, the presence of regulatory and methodological documents, experimentally established and approved MPC in the air of the occupational area for 2484 substances, and 601 substances included in SanPiN 1.2.3685-211. The maximum permissible levels (MPL) on the skin are presented for only 26 substances in the same document. Identification and evaluation of the skin-resorptive effect of xenobiotics have methodological features due to the properties of the skin, which performs a barrier-protective function, and the physico-chemical, toxic properties of substances. The main stages of development in the domestic hygienic science and practice of research on the study and assessment of the skin-resorptive effect of xenobiotics in industrial contact with them are presented. The continuity of research on the study and evaluation of the skin-resorptive impact of chemicals used in various industries and agriculture is shown, making it possible to develop methodological approaches to the identification and risk assessment of dermal absorption of xenobiotics, including pesticides, within the organisms of workers. Evaluating the risk of skin contamination is the main argument for the development of measures for the primary prevention of skin resorptive action. Establishing the priority of the dermal route of toxicant intake is an evidence-based justification for making decisions about the possibility of using, for example, pesticides on the territory of the Russian Federation. The literature review is based on open sources hosted on virtual database platforms: Scopus, Web of Science, MedLine, Global Health, e-LIBRARY, Electronic Fund of Legal and Regulatory Documents, etc.

Development of a functional product for the prevention of iodine deficiency

2020 ◽  
Vol 82 (3) ◽  
pp. 45-49
Author(s):  
L. V. Antipova ◽  
A. O. Daryin
Keyword(s):  
Iodine Deficiency ◽  
Food Systems ◽  
The Body ◽  
Biologically Active ◽  
Modern World ◽  
Physico Chemical ◽  
Functional Product ◽  
The Russian Federation ◽  
Vegetable Milk ◽  
Inorganic Iodine

Iodine belongs to the most important elements that are responsible for the full working condition of the body. Iodine deficiency is a very acute problem, its elimination is an important task of the world communities, reflected in the Doctrine of Food security of the Russian Federation, regional target programs of Russia. In the modern world, the proposed measure for the prevention of iodine deficiency is the consumption of iodized salt and some foods containing an inorganic form of iodine, or the use of a variety of biologically active additives. However, according to the observed statistics of diseases that are associated with a lack of iodine, the presented measures are not very effective. The article presents studies of the process of bioconversion of inorganic iodine into organic – bioavailable, capable of reaching the target organ, for example, during the germination of lentil grains in the appropriate nutrient medium. The possibility of obtaining an organic form of iodine from sprouted lentils in an iodized medium with subsequent production of food products, such as vegetable milk, is proved. The organoleptic, physico-chemical parameters of the milk obtained, as well as vitamin and amino acid compositions that increase the nutritional and biological value of the product were studied, the safety indicators were analyzed and meet the requirements for use in food systems. In the course of the work carried out, we obtained a product with a balanced composition of nutrients for the human body. These developments open up prospects for the creation of functional products for functional purposes with a bioavailable form of iodine.

High Heels sebagai Agensi bagi Tubuh Wanita

2020 ◽  
Vol 5 (2) ◽  
pp. 196
Author(s):  
Sunandar Macpal ◽  
Fathianabilla Azhar
Keyword(s):  
Body Image ◽  
Literature Review ◽  
The Body ◽  
The Other ◽  
Body Image Disturbance ◽  
Other Hand ◽  
High Heels ◽  
Experience Pain ◽  
Woman's Body

The aims of this paper is to explain the use of high heels as an agency for a woman's body. Agency context refers to pain in the body but pain is perceived as something positive. In this paper, the method used is a literature review by reviewing writings related to the use of high heels. The findings in this paper that women experience body image disturbance or anxiety because they feel themselves are not beautiful or not attractive. The use of high heels, makes women more attractive and more confident, on the other hand the use of high heels actually makes women feel pain and discomfort. However, for the achievement of beauty standards, women voluntarily allow their bodies to experience pain. However, the agency's willingness to beauty standards here is meaningless without filtering and directly accepted. Instead women keep negotiating with themselves so as to make a decision why use high heels.

QUALIDADE DAS ÁGUAS E NÍVEL TRÓFICO DA BACIA DO RIO PACIÊNCIA NA ILHA DO MARANHÃO, BRASIL

2019 ◽  
Vol 21 (2) ◽  
pp. 437-453
Author(s):  
Elna Lucilia Santos Corrêa ◽  
Karina Suzana Feitosa Pinheiro ◽  
Cláudio José Da Silva de Sousa ◽  
Luiz Jorge Bezerra da Silva Dias
Keyword(s):  
Water Quality ◽  
Trophic Status ◽  
The Body ◽  
Chemical Parameters ◽  
Public Supply ◽  
Physico Chemical ◽  
Great Availability ◽  
Del Rio ◽  
Fluvial Environments

O Brasil apresenta grande disponibilidade de água doce em seus mananciais. Fazendo parte desse recurso encontra-se, o rio Paciência, localizado na Ilha do Maranhão destacado pela sua importância local, principalmente por contribuir com suas águas para recarga dos mananciais subterrâneos, fonte de abastecimento público de vários bairros de São Luís, capital do estado. No entanto, este rio vem sofrendo comprometimento da qualidade de suas águas, consequência do processo de uso e ocupação dos espaços em sua bacia. Destacando-se como um dos principais problemas relacionados a qualidade de ambientes fluviais,  a eutrofização, que consiste no processo em que o corpo d’água adquire elevados níveis de nutrientes (fosfatos e nitratos), é um indicador determinante da qualidade da água. Neste sentido, o objetivo deste trabalho foi caracterizar a qualidade da água e do estado trófico na bacia hidrográfica do rio Paciência atráves dos parâmetros fisico-químico evidenciando os trechos mais comprometidos conforme os valores alcançados nas análises. Os resultados das análises foram comparados com a CONAMA No. 357/05 que indicaram uma situação preocupante quanto à qualidade da água no local de estudo.Palavras-chave: Qualidade de água; Eutrofização; Ilha do Maranhão. ABSTRACTThe Brazil has great availability of fresh water in its springs. Within these contexts, the Paciência River, located on the Island of Maranhão stands out for its local importance, mainly for contributing its waters to the recharge of the underground springs, source of public supply of several districts of São Luís, capital of the state. However, this river has been compromising the quality of its waters, a consequence of the process of use and occupation of the spaces in its basin. Highlighting as one of the main problems related to the quality of fluvial environments, eutrophication, which consists of the process in which the body of water acquires high levels of nutrients (phosphates and nitrates), is a determinant indicator of water quality. In this sense, the objective of this work was to characterize the water quality and trophic status in the Paciência river basin through the physico-chemical parameters, showing the most compromised stretches according to the values reached in the analyzes. The results of the analyzes were compared with CONAMA No. 357/05 which indicated a worrying situation regarding the quality of the water at the place of study.Keywords: Water quality; Eutrophication; Island of Maranhão. RESUMENBrasil tiene gran disponibilidad de agua dulce en sus manantiales. Parte de este recurso es el río Paciencia, ubicado en la isla de Maranhão, que destaca por su importancia local, principalmente porque contribuye con sus aguas a recargar las fuentes subterráneas, fuente de suministro público de varios barrios de São Luís, capital del estado. Sin embargo, este río se ha visto afectado por la calidad de sus aguas, como consecuencia del proceso de uso y ocupación de los espacios en su cuenca. Destacando como uno de los principales problemas relacionados con la calidad de los ambientes fluviales, la eutrofización, que consiste en el proceso en el que el cuerpo de agua adquiere altos niveles de nutrientes (fosfatos y nitratos), es un indicador determinante de la calidad del agua. En este sentido, el objetivo de este trabajo fue caracterizar la calidad del agua y el estado trófico en la cuenca del río Paciência a través de los parámetros fisicoquímicos, mostrando las secciones más comprometidas de acuerdo con los valores alcanzados en los análisis. Los resultados de los análisis se compararon con CONAMA N°. 357/05, que indicó una situación preocupante con respecto a la calidad del agua en el sitio de estudio.Palabras clave: Calidad del agua; Eutrofización, Isla Maranhão.

scholarly journals How to express the antioxidant properties of substances properly?

2021 ◽  
Author(s):  
Małgorzata Olszowy-Tomczyk
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Literature Review ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Reactive Oxygen ◽  
The Body ◽  
Universal Method ◽  
Oxygen Species ◽  
Good Tool

AbstractOxidative stress, associated with an imbalance between the oxidants (reactive oxygen species) and the antioxidants in the body, contributes to the development of many diseases. The body’s fight against reactive oxygen species is supported by antioxidants. Nowadays, there are too many analytical methods, but there is no one universal technique for assessing antioxidant properties. Moreover, the applied different ways of expressing the results lead to their incompatibility and unreasonable interpretation. The paper is a literature review concerning the most frequent ways of antioxidant activities expression and for an easy and universal method of the obtained results discussion. This paper is an attempt to point out their disadvantages and advantages. The manuscript can support the searching interpretation of the obtained results which will be a good tool for the development of a number of fields, especially medicine what can help in the future detection and treatment of many serious diseases. Graphic abstract

scholarly journals Children’s Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study

2021 ◽  
Vol 18 (14) ◽  
pp. 7429
Author(s):  
Kyung-Shin Lee ◽  
Yoon-Jung Choi ◽  
Jin-Woo Cho ◽  
Sung-Ji Moon ◽  
Youn-Hee Lim ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cohort Study ◽  
Literature Review ◽  
Cognitive Ability ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Association Studies ◽  
The Body ◽  
Genome Wide Association Studies ◽  
Regulatory Pathways

Epigenetics is known to be involved in regulatory pathways through which greenness exposure influences child development and health. We aimed to investigate the associations between residential surrounding greenness and DNA methylation changes in children, and further assessed the association between DNA methylation and children’s intelligence quotient (IQ) in a prospective cohort study. We identified cytosine-guanine dinucleotide sites (CpGs) associated with cognitive abilities from epigenome- and genome-wide association studies through a systematic literature review for candidate gene analysis. We estimated the residential surrounding greenness at age 2 using a geographic information system. DNA methylation was analyzed from whole blood using the HumanMethylationEPIC array in 59 children at age 2. We analyzed the association between greenness exposure and DNA methylation at age 2 at the selected CpGs using multivariable linear regression. We further investigated the relationship between DNA methylation and children’s IQ. We identified 8743 CpGs associated with cognitive ability based on the literature review. Among these CpGs, we found that 25 CpGs were significantly associated with greenness exposure at age 2, including cg26269038 (Bonferroni-corrected p ≤ 0.05) located in the body of SLC6A3, which encodes a dopamine transporter. DNA methylation at cg26269038 at age 2 was significantly associated with children’s performance IQ at age 6. Exposure to surrounding greenness was associated with cognitive ability-related DNA methylation changes, which was also associated with children’s IQ. Further studies are warranted to clarify the epigenetic pathways linking greenness exposure and neurocognitive function.

TAMI-01. BRAIN METASTASES: CURRENT LITERATURE REVIEW

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi198-vi198
Author(s):  
Ruchi Raval ◽  
Aadi Pandya ◽  
Jaspreet Behl ◽  
Sumul Raval
Keyword(s):  
Literature Review ◽  
Brain Metastases ◽  
Current Literature ◽  
Anticoagulation Therapy ◽  
Signs And Symptoms ◽  
The Body ◽  
Definitive Treatment ◽  
Cognitive Changes ◽  
Cancer Breast ◽  
The Brain

Abstract PURPOSE As more information is gathered about brain metastases, it still remains that the current prognosis of brain metastases is very poor. Due to this, it is imperative that physicians are aware of the most important components regarding brain metastases. This literature review will encompass the most current literature in order to highlight the most crucial information. METHODS All mentioned studies and literature reviews cited in the paper were obtained through various sites, and were published between 1996 and 2017. The main components that were required from the papers reviewed included where in the body the brain metastases originated from, where in the brain they tended to spread to, what the signs and symptoms typical of patients with brain metastases are, and what the options are in terms of treatment. RESULTS Using the results from a variety of studies performed within the past three decades, it is apparent that brain metastases most commonly originate from, in order of increasing frequency, lung cancer, breast cancer, melanoma, and colorectal cancer. In addition, it is reaffirmed that the magnetic resonance imaging (MRI) is the best diagnostic tool to be used when dealing with brain metastases. The most frequent signs and symptoms of a brain metastases include cognitive changes, headaches, weakness, and seizures. Finally, supportive treatment includes use of corticosteroids, antiepileptic drugs (AEDs), and anticoagulation therapy. Definitive treatment for brain metastases varies based on size, location, and prevalence in the brain, but the most effective options include chemotherapy, radiation therapy, and surgery. CONCLUSIONS The study’s results confirm the need for more research to be done regarding brain metastases, and better options to increase the survival of patients.

Ocular Tuberculosis: Clinics, Diagnosis and Treatment (Literature Review)

The Eye ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 41-45
Author(s):  
O. E. Russkikh ◽  
N. Y. Nikolenko
Keyword(s):  
Literature Review ◽  
Diagnostic Methods ◽  
Diagnosis And Treatment ◽  
Ocular Tuberculosis ◽  
Treatment Regimens ◽  
The Russian Federation ◽  
Serious Disease ◽  
Suggested Classification

Ocular tuberculosis is a serious disease with a long recurrent course, often leading to a significant decrease in the visual functions and quality of life of patients as well as disability. In recent years, the incidence rate of the ocular tuberculosis in the Russian Federation has been declining: in 2016, according to a number of authors, its incidence amounted to 5.2%.Purpose. To systematize literature data on the topic of ocular tuberculosis.Materials and methods. We reviewed literature available on elibrary.ru, cyberleninka.ru websites and in “Clinical Ophthalmology” journal. Results. We suggested classification of the ocular tuberculosis lesions, analyzed modern diagnostic methods and treatment regimens and evaluated their effectiveness.Conclusions. Literature review revealed that in order to improve the quality of detection, diagnosis and treatment of ocular tuberculosis, joint efforts of ophthalmologists and phthisiologists as well as use of modern methods of tuberculinodiagnosis are essential.

Morphometric and genetic studies of the mechanisms of damage to the cardiovascular system in Kuzbass miners with dust lung pathology

2021 ◽  
Vol 61 (9) ◽  
pp. 611-619
Author(s):  
Anastasiya S. Kazitskaya ◽  
Oleg I. Bondarev ◽  
Maria S. Bugaeva ◽  
Anna G. Zhukova ◽  
Tatyana K. Yadykina
Keyword(s):  
Russian Federation ◽  
Work Experience ◽  
The Body ◽  
Lung Pathology ◽  
Federal Law ◽  
Autopsy Material ◽  
Ministry Of Health ◽  
Genetic Studies ◽  
The Russian Federation ◽  
Medical Examinations

Introduction. The combined impact of unfavorable factors of the production environment in miners leads to the development of associated pathology of the bronchopulmonary and cardiovascular systems, the predisposition to which depends on the individual susceptibility of the body. In this regard, it is important to comprehensively study the pathogenetic mechanisms underlying the formation and course of occupational and work-related diseases for a personalized approach to the diagnosis, prevention and therapy of this pathology. The purpose of this study was to study the mechanisms of damage to the cardiovascular system in miners with dust lung pathology on the basis of morphological and genetic studies. Materials and methods. For genetic studies, venous blood drawing was conducted in 190 Kuzbass miners. The main group included 126 miners of the main professions with the previously proven diagnosis "dust lung pathology", the comparison group consisted of 64 workers without a proven diagnosis working in similar sanitary and hygienic conditions. Morphometric studies were carried out using autopsy material obtained during 80 forensic medical examinations of miners in the Kemerovo region. All the miners were divided into 4 groups depending on their underground work experience. The control group was formed from 20 cases of forensic medical examinations of men who died in road accidents and did not have organ pathology according to the results of autopsies. Results. The study of the autopsy material revealed the presence of morphostructural changes in the vascular walls of the miners’ hearts in the form of hypertrophy of the smooth muscle cells of the medial layers, thickening of the endothelial lining, and the development of fibroplastic changes in the perivascular zones. These changes began to form from the first years of work in the underground conditions and progressed with increasing work experience contributing to the "recalibration" of the heart vessels with the formation of the lumen "obstruction". One of the mechanisms of endothelial damage in miners was a change in the expression of the EDN1 gene, which regulates the synthesis of endothelin-1. The risk and resistance genotypes of the development of dust lung pathology for the rs5370 polymorphism of the EDN1 gene were identified. Morphostructural rearrangement of the endothelium in the combination with its pathological activation contributed to the occurrence of endothelial dysfunction in miners. Conclusions. The conducted studies of the parameters of the vascular endothelium indicate its key role in the pathogenesis of bronchopulmonary and cardiovascular pathology in miners of the main professions. Getting into the body of workers, particles of coal-rock dust lead to morphostructural rearrangement of the cells of the endothelial layer and its pathological activation. The contribution of molecular and genetic mechanisms to the development of occupational lung pathology and associated diseases of the circulatory system in miners is revealed. Ethics. The studies were carried out in compliance with the ethical standards of the Bioethical Committee of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, elaborated on the basis of the Helsinki Declaration of the World Medical Association "Ethical Principles for Conducting Human Scientific Medical Research" as amended in 2013 and the "Rules of Clinical Practice in the Russian Federation" approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated 19.06.2003. All workers were informed about their participation in the molecular-genetic study and gave written consent to carry it out. The research of the dead miners was based on the secondary examination of blocks and ready-made histological micro-preparations of the material of the Bureau for Forensic Medical Expert Examination of the cities of Novokuznetsk, Osinniki, and Prokopyevsk. The study of pathomorphological material was carried out in accordance with the Federal Law of 21.11.2011, No. 323-FZ "On the Fundamentals of Health Protection of Citizens in the Russian Federation", in particular, with Article 67 "Carrying out pathological and anatomical autopsies", Federal Law of 12.01.1996, No. 8-FZ "On burial and funeral business" (Article 5, paragraphs 1, 2), as well as on the basis of the Order of the Ministry of Health of April 29, 1994, No. 82 "On the procedure for conducting pathological and anatomical autopsy" (Annex to the Order of the Ministry of Health and Medical Industry of 29.04.1994 No. 82), the Order of the Ministry of Health of Russia of 24.03.2016. No. 179n "On the rules for conducting pathological and anatomical examinations".

Increased severity of labor is the most important risk factor of occupational diseases at enterprises in the Arctic

2020 ◽  
pp. 26-34
Author(s):  
S.A. Syurin
Keyword(s):  
Occupational Diseases ◽  
Cumulative Effect ◽  
Occupational Exposures ◽  
The Arctic ◽  
Physical Factors ◽  
Mining Operations ◽  
Production Factors ◽  
Permissible Levels ◽  
The Russian Federation ◽  
Total Structure

In Russia, in the structure of harmful production factors that cause the development of occupational pathology, the severity of labor takes the second place. The aim of the study was to investigate the effect of increased labor severity on the occurrence, prevalence and structure of occupational diseases in workers at enterprises in the Arctic. The analysis included results of the monitoring study “Working conditions and occupational morbidity” of the population of the Arctic zone of Russia in 2008 – 2018. It was found that in 2008-2018 there was a significant increase in the etiological significance of increased labor severity in the development of occupational pathology: the share of the factor in the total structure of harmful occupational exposures increased from 7.4% to 8.9% (p <0.001), and that of occupational diseases caused by increased labor severity - from 18.6% to 46.9% (p <0.001). Two thirds of occupational diseases caused by the increased severity of labor occur in miners, and diseases of the musculoskeletal system dominate in their structure (80.1%). The risk of developing this group of occupational health disorders in 2018 was higher than in 2008: RR=3,95; CI 3,13-4,99; χ2 =155,9; р<0,001. In contrast to the Russian Federation as a whole, where the increased severity of labor ranks second among the occupational pathology causing factors (24.7%), in the Russian Arctic it came out on top in 2018 (46.9%), exceeding the cumulative effect of all physical factors (44.0%). When carrying out recreational activities and prevention of occupational pathology at enterprises in the Arctic, special attention should be paid to achieving permissible levels of labor severity among workers engaged in mining operations.

scholarly journals A Left-Sided Prevalence of Lentigo Maligna: A UK Based Observational Study and Review of the Evidence

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mark Gorman ◽  
Andrew Hart ◽  
Bipin Mathew
Keyword(s):  
Risk Factor ◽  
Uv Light ◽  
Light Exposure ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Evidence Base ◽  
The Body ◽  
Cumulative Exposure ◽  
Lentigo Maligna ◽  
Recent Trends

Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous melanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and automobile driving patterns. Though left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on, more recent trends indicate a consistent left-sided bias. To clarify reasons for changing trends, a review of the evidence base and LM’s laterality in a UK cohort (99 cases 2000–2011) was conducted for the first time. The strong correlation of left-sided excess, found in both genders (ratios 1.381–1.5,P<0.05  X20.841), is congruent with more recent findings. Though evidence indicates that driving position is no longer a risk factor for LM, due most likely to improved car window UV protection, it remains the most commonly attributed cause. Understanding phenomena such as UV lights “scatter effect” or that cumulative exposure may not be a significant risk factor helps rationalize older conclusions that would otherwise appear contradictory. The reasons for left-sided excess remain unclear but may be due to factors requiring further research such as the body’s anatomical/embryological asymmetry.

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