scholarly journals The Developmental Pathways of Preschool Children with Acute Lymphoblastic Leukemia: Communicative and Social Sequelae One Year after Treatment

2019 ◽  
Author(s):  
Marta Tremolada ◽  
Livia Taverna ◽  
Sabrina Bonichini ◽  
Marta Pillon ◽  
Alessandra Biffi
Keyword(s):  
Preschool Children ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Rapid Development ◽  
Developmental Pathways ◽  
Adaptive Behaviour ◽  
Control Group ◽  
Vineland Adaptive Behaviour Scales ◽  
One Year ◽  
Italian Norms

Early childhood is considered to be a period of rapid development, with the acquisition of abilities predicting future positive school competences. Motor, cognitive and social difficulties related to cancer therapies heavily impact the development of children with cancer. This study focused on two main aims: to assess the developmental pathways of preschool children with acute lymphoblastic leukaemia one year post-treatment and to compare these abilities both with those of a control group of healthy peers and with Italian norms. Forty-four children and their families, recruited through the Haematology-Oncologic Clinic of the Department of Child and Woman Health (University of Padua), agreed to participate to this study. The children’s mean age was 4.52 years (SD = 0.94, range = 2.5-6 years), equally distributed by gender, all diagnosed with Acute Lymphoblastic Leukaemia. Matched healthy peers were recruited through paediatricians’ ambulatories. Each family was interviewed adopting the Vineland Adaptive Behaviour Scales. Paired sample Wilcoxon tests revealed that children were reported to have significantly more developmental difficulties than their healthy peers. When compared with Italian norms they scored particularly low in verbal competence, social and coping skills. No significant association were found between treatment variables and developmental abilities. These findings suggest that the creation of specialized interventions both for parents and children may fill the possible delays in children’s development probably due to stress, lack of adequate stimulation or difficult adaptation.

scholarly journals The Developmental Pathways of Preschool Children with Acute Lymphoblastic Leukemia: Communicative and Social Sequelae One Year after Treatment

Children ◽  
2019 ◽  
Vol 6 (8) ◽  
pp. 92
Author(s):  
Marta Tremolada ◽  
Livia Taverna ◽  
Sabrina Bonichini ◽  
Marta Pillon ◽  
Alessandra Biffi
Keyword(s):  
Preschool Children ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Rapid Development ◽  
Developmental Pathways ◽  
Control Group ◽  
Cancer Therapies ◽  
Vineland Adaptive Behavior Scales ◽  
One Year ◽  
Italian Norms

Early childhood is considered to be a period of rapid development, with the acquisition of abilities predicting future positive school competences. Motor, cognitive, and social difficulties related to cancer therapies heavily impact the development of children with cancer. This study focused on two main aims: To assess the developmental pathways of preschool children with acute lymphoblastic leukemia one year post-treatment and to compare these abilities both with those of a control group of healthy peers and with Italian norms. Forty-four children and their families, recruited through the Hematology-Oncologic Clinic of the Department of Child and Woman Health (University of Padua), agreed to participate in this study. The children’s mean age was 4.52 years (SD = 0.94, range = 2.5–6 years), equally distributed by gender, all diagnosed with acute lymphoblastic leukemia. Matched healthy peers were recruited through pediatricians’ ambulatories. Each family was interviewed adopting the Vineland adaptive behavior scales. Paired sample Wilcoxon tests revealed that children were reported to have significantly more developmental difficulties than their healthy peers. When compared with Italian norms, they scored particularly low in verbal competence, social, and coping skills. No significant association was found between treatment variables and developmental abilities. These findings suggest that the creation of specialized interventions, both for parents and children, may fill the possible delays in children’s development probably due to stress, lack of adequate stimulation, or difficult adaptation.

scholarly journals Secondary Thymoma among Adult Treated For Acute Lymphoblastic Lymphoma/Leukemia: Report of a Case and Review of the Literature

2018 ◽  
Vol 6 (12) ◽  
pp. 2373-2375
Author(s):  
Mounia Bendari ◽  
Hanaa Bencharef ◽  
Nisrine Khoubila ◽  
Siham Cherkaoui ◽  
Mouna Lamchahab ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Mediastinal Mass ◽  
Histological Study ◽  
Anterior Mediastinal Mass ◽  
Review Of The Literature ◽  
Chemotherapy Treatment ◽  
Surgical Biopsy ◽  
One Year ◽  
Made In

BACKGROUND: Concomitant thymoma and T- lymphoblastic/leukaemia lymphoma is possible. Secondary thymoma after treatment for T-lymphoblastic/leukaemia lymphoma was also occasionally reported, although this is quite rare. CASE REPORT: We report a case of 44-year-old women with secondary thymoma after chemotherapy treatment for T Acute Lymphoblastic leukaemia/lymphoma. Diagnosis of lymphoblastic/leukaemia lymphoma was made in 2015 by morphological and histological study. The patient underwent Moroccan protocol for acute lymphoblastic leukaemia (MARALL) from 2015 to 2017 and achieved complete remission. One year later, the patient developed an anterior mediastinal mass, relapse was suspected, but the surgical biopsy was performed and histological, the mass showed thymoma. CONCLUSION: At the time of diagnosis of thymoma for a patient treated for T-lymphoblastic/leukaemia lymphoma it is necessary to eliminate a relapse because the distinction between thymoma and T-lymphoblastic/leukaemia lymphoma is sometimes difficult, and the association is possible.

scholarly journals Nutritional Assessment and Serum Zinc Level in Children with Acute Lymphoblastic Leukaemia

2017 ◽  
Vol 40 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Akma Morshed ◽  
Ikram Soma ◽  
TR Choudhury ◽  
Shahnoor Islam ◽  
Md Salim ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Z Score ◽  
Serum Zinc Level ◽  
The Mean ◽  
Height For Age

Background: Acute lymphoblastic leukaemia (ALL) is a common malignancy in children which may cause significant nutritional problem as well as micronutrient deficiency like zinc. These deficiencies ultimately affect the outcome of the patient.Objective: The present study was done to identify the relationship of height, weight and serum zinc with acute lymphocytic leukemia in pediatric patients.Methods: This observational study was carried out in the Department of Pediatric Haematology and Oncology, Dhaka Medical College Hospital, Dhaka over a period of one year from July 2013 to June 2014. All children ranging from 1-10 years with newly diagnosed acute lymphocytic leukaemia were enrolled as case. An equal number of healthy children of similar age and sex were also included as control. The outcome measures were weight for height (wasting) and height for age (stunting) in children 5 or below 5 years of age and BMI in children > 5 years of age. The serum zinc level was also studied as a measure of micronutrient status.Result: Majority (80%) of the cases and 60% of the controls were 5 or < 5 years old. The mean ages of the children of cases and controls were almost similar (4.2 ± 2.3 vs. 4.8 ± 1.8 years, p >0.05). The groups were significantly different in terms of sex with male children being more prone to develop leukaemia than the females (p <0.05). Anaemia was invariably present. Majority (83.3%) of the children in the case group was wasted (weight for height Z-score lie below -2SD) as opposed 22.2% in the control group (p < 0.001). About 37% the children in the case group were stunted (height for age Z-score lies -2SD) as opposed to 16.7% in the control group (p< 0.05). The mean BMI was significantly lower in the case group than that in the control group (8.8 ± 2.7 vs. 17.1 ± 1.8, p < 0.001). Serum zinc level was also significantly lower in the former group than that in the latter group (0.7 ± 0.1 vs. 1.5 ± 0.5 mg/dl, p< 0.05).Conclusion: A good number leukaemia patients present with wasting and stunting and low BMI. Serum zinc level is significantly reduced which, in turn, may hamper various enzymatic functions in the body thereby reducing growth.Bangladesh J Child Health 2016; VOL 40 (1) :12-16

The Genetic Variants of IKZF1 Gene Linked with the Growing Risk of Childhood Acute Lymphoblastic Leukaemia

2019 ◽  
Vol 19 (1) ◽  
pp. 32-39
Author(s):  
Safaa I. Tayel ◽  
Sally M. El-Hefnway ◽  
Wafaa Moustafa M. Abo El-fotoh ◽  
Rania S. El-Zayat
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Genetic Variants ◽  
Transferrin Saturation ◽  
Significant Risk ◽  
Control Group ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Group I ◽  
Egyptian Children ◽  
Significant Difference

Background: The zinc finger protein IKAROS (IKZF1) is an essential transcription factor in haematopoiesis that is involved primarily in lymphoid tissue differentiation. Many studies have indicated that IKZF1 alterations may be associated with acute lymphoblastic leukaemia, but the results remain controversial. Objective: We aimed to investigate the association of the rs4132601 T/G and rs10272724 T/C IKZF1 gene polymorphisms with the risk of childhood acute lymphoblastic leukaemia and to determine whether these genetic variants affect the clinical parameters and the iron profiles of these children cohort. Methods: This case control study was conducted on 170 Egyptian children comprising of two groups: group (I) included 90 children diagnosed with acute lymphoblastic leukaemia and group (II) comprised of 80 ages and sex-matched healthy control children. The studied polymorphisms were genotyped using PCR restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the mutant GG genotype and G allele of rs4132601 was found in the patient group than in the control group. The results also showed a significant difference among the rs10272724 genotypes, with a higher frequency of the mutant CC genotype and C allele in the patients than in controls. The mutant GG genotype of rs4132601 and the mutant CC genotype of rs10272724 were associated with a higher serum ferritin level and transferrin saturation and an older age at diagnosis of acute lymphoblastic leukaemia than the other genotypes. Conclusion: IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children.

Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia)1

2008 ◽  
Vol 28 (3) ◽  
pp. 117-124 ◽  
Author(s):  
Marilyn G. Rimando ◽  
Mary N. Chua ◽  
Ernesto d'J. Yuson ◽  
Gloria de Castro-Bernas ◽  
Takashi Okamoto
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Glutathione Transferase ◽  
The Philippines ◽  
Control Group ◽  
Childhood Leukaemia ◽  
Wild Type ◽  
Significant Difference ◽  
High Incidence ◽  
Filipino Children

In the present paper, we examined the incidence of polymorphic genes involved with the detoxification of exogenous chemicals, including carcinogens, namely GSTT1 (glutathione transferase θ1), GSTM1 (glutathione transferase μ1) and NQO1 (NAD(P)H:quinone oxidoreductase 1) in 60 Filipino children with ALL (acute lymphoblastic leukaemia). We found a significantly high incidence of the GSTM1 null genotype in ALL children (71.7%) compared with 51.7% in the control group of children (P<0.05). The GSTT1 null genotype was observed in 35.0% and 33.3% of the ALL cases and the control subjects respectively, with no significant difference. Screening for NQO1 (609C>T) mutant alleles showed a high incidence of the NQO1 C/C genotype (NQO1 homozygous wild-type allele genotype) in 60.0% of ALL cases and was significantly higher than in the control group (23.3%) (P<0.01). These GSTM1 null and NQO1 wild-type genotypes are independently associated with the risk of ALL in Filipino patients. When these two genotypes, GSTM1 null and NQO1 C/C, were combined, the hazard rate for childhood leukaemia was significantly increased (P<0.001). We also noticed that the incidences of GSTM1 null mutations and the NQO1 C/C genotype were significantly higher among Filipinos. These findings suggest a possible role of the GSTM1 null and NQO1 C/C genotypes in the susceptibility of paediatric ALL cases in the Philippines.

scholarly journals Breastfeeding and acute lymphoblastic leukaemia: potential leukemogenesis in children in developing countries

2020 ◽  
Author(s):  
Ameer Kakaje ◽  
Mohammad Marwan Alhalabi ◽  
Ayham Ghareeb ◽  
Bahjat Karam ◽  
Aya Hamid ◽  
...  
Keyword(s):  
Developing Countries ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Educational Level ◽  
Feeding Habits ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Carcinogenic Substances ◽  
And Control

Abstract Background:Breastfeeding (BF) in infancy is associated with a decreased risk of acute lymphoblastic leukaemia (ALL). However, most of the studies were conducted in developed countries, neglecting developing countries where mothers might be exposed to different carcinogenic substances which could be transferred through breastmilk.Methods: This is a case-control study which was conducted in the major paediatric cancer centre in Syria. Data of case and control groups were obtained from the hospital’s records. Only patients with no hereditary or chromosomal syndrome and aged 4 years and younger were included. The case group included ALL patients and control group contained hospital patients who visited its various clinics. The patients were categorised into 3 groups depending on their feeding habits before the age of 6 months. Results:Our sample contained 70 patients in the case group with 42 (60%) being males and 82 patients in the control group with 52 (55.3%) being males. Sixty (85.7%) cases and 59 (72%) controls were exclusively breastfed. We found a statistically significant difference when comparing cases and controls in BF patterns (P<0.05) as cases were exclusively breastfed more frequently. Exclusive breastfeeding was found more frequently in the case group compared to other patterns of infancy feeding P=0.04 (OR, 2.339; CI, 1.025 -5.336). In case group, parents of a low educational level breastfed their children more frequently (P<0.05). Number of siblings was not associated with ALL or any of its variables. Furthermore, infancy feeding pattern correlation with gender, being born with no complications, consanguinity, CD10, FAB classification, ALL-subtype, risk, and family history were insignificant. Conclusion:There are certain practices among the Syrian people, especially among parents of a low educational level that has possibly exposed their children to carcinogenic substances which were possibly transferred through BF, causing this association between ALL and BF. We speculate certain substances and behaviours being responsible. However, BF had minor effects on the prognosis and subtype of ALL, and number of siblings had no effect on ALL.

N-Terminal-ProB-Type Natriuretic Peptide as a Marker for Anthracycline Cardiotoxicity in Children with Acute Lymphoblastic Leukaemia

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3965-3965
Author(s):  
Teresa Jackowska ◽  
Malgorzata Golabek
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Natriuretic Peptide ◽  
Lymphoblastic Leukaemia ◽  
Left Ventricular ◽  
Control Group ◽  
Healthy Children ◽  
Anthracycline Cardiotoxicity ◽  
Average Value

Abstract Background: Anthracyclines (ANTR) are very effective agents in treatment of acute lymphoblastic leukaemia (ALL). However, a potential heart damage caused by ANTR in patients who have been cured of ALL may lessen the success of this cure. Plasma brain B-type natriuretic peptide (BNP) levels are highly sensitive biochemical markers for myocardial damage. Objectives of the study: Our purpose was to evaluate N-terminal proBNP (Nt-proBNP) as a screening test for detecting cardiac dysfunction in children with ALL. Subjects: 156 asymptomatic children (72 girls and 84 boys) who had received ANTR during treatment for ALL were evaluated. They had received ANTR doses of 180 to 480mg/m2 (according to the protocol treatment) at median age of 6.6 years at diagnosis. 47 healthy children constituted the control group. Methods: Concentration of plasma N-terminal proBNP was measured in 420 samples by enzyme immunoassay (Biomedica) before treatment, after 6 months, 2 and 4 years and longer than 5 years after ANTR therapy. 261 echocardiograms (ECHO) were performed in 128 children. Nt-proBNP was measured at the same time. Shortening fraction (%SF) and ejection fraction (%EF) were determined as systolic left ventricular function. Results: Mean Nt-proBNP plasma levels in children with ALL were higher in comparison with the control group (90.7 and 66.2pg/ml respectively) but the difference was not significant (p=0.2). The levels of Nt-proBNP before ALL treatment were significantly the lowest (51.5pg/ml). Later, they were respectively: 108.3pg/ml after 6 months, 97.4pg/ml after 2 years and 92.9pg/ml after 4 years (p=0.0019). The highest levels of NT-proBNP were observed in children with cumulative ANTR doses of 240, 330 and 480mg/m2 (98.8pg/ml, 102.8pg/ml, 86.1pg/ml respectively) (p=0.0008). The lowest levels were observed with the cumulative doses of 180mg/m2 and 300mg/m2 (60.7pg/ml and 58.8pg/ml respectively). The average value of %SF in children with ALL was 39.4% (26 to 52%) and the average value of %EF was 69.95% (51.1 do 83.4%). In children with %SF and %EF lower than the average in both study and control group Nt-proBNP was insignificantly higher than in children whose %SF and %EF were higher than the average in both groups (respectively for %SF: 107.1pg/ml and 97.3pg/ml and for %EF: 106.3pg/ml and 98.8pg/ml). Conclusion: Increased Nt-proBNP levels were observed more often in children who received higher doses of ANTR and in all children after the end of treatment. Independently of ECHO assessment of the left ventricular function, the Nt-proBNP is of value in the detection of subclinical left ventricular dysfunction in children with ALL who were treated with ANTR therapy.

Immature reticulocyte fraction as a predictor of bone marrow recovery in children with acute lymphoblastic leukaemia on remission induction phase

1970 ◽  
Vol 37 (2) ◽  
pp. 57-60 ◽  
Author(s):  
S Yesmin ◽  
T Sultana ◽  
CK Roy ◽  
MQ Rahman ◽  
ANN Ahmed
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Clinical Pathology ◽  
Remission Induction ◽  
Morphologic Change ◽  
Induction Phase ◽  
One Year ◽  
Medical University ◽  
Age Range

Immature reticulocyte fraction a new routine parameter in the hematology analyzer can give the idea of the earliest morphologic change of bone marrow recovery before other test become positive after chemotherapy. A prospective observational study was carried out in the Department of Clinical Pathology in collaboration with Paediatric Haematology and Oncology, Bangabandhu Sheikh Mujib Medical University during a period of one year starting from October 2009 to September 2010 to evaluate the bone marrow recovery in children with acute lymphoblastic leukaemia by automated reticulocyte analysis. Total fifty patients were enrolled in this study on remission induction phase. All patients were between 8 months to 15 years age range with a mean age of 5.5 ± 3.2. At the end of the study out of 50 cases, 52% patients showed early immature reticulocyte fraction recovery and concluded that the immature reticulocyte fraction parameter showed earlier haematopoietic recovery than the current practice of absolute neutrophil count recovery. DOI: http://dx.doi.org/10.3329/bmrcb.v37i2.8435 BMRCB 2011; 37(2): 57-60

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