scholarly journals Effectiveness Of Watery Extract And Ethanolic Extract Of Garlic Bulbs (Allium sativum L.) For Second Degree Burns Healing On Mice (Mus musculus)

2017 ◽  
Vol 2 (02) ◽  
pp. 90
Author(s):  
Noni Zakiah
Keyword(s):  
Water Extract ◽  
Ethanolic Extract ◽  
P Value ◽  
Test Results ◽  
Treatment Groups ◽  
Randomized Design ◽  
Degree Burn ◽  
The Mean ◽  
One Way Anova ◽  
Second Degree

Bulbs of garlic has been known to contain a compound that is potentially as alternative medicine for burns. This study aimed to determine the effectiveness of the water extract and ethanolic extract of garlic bulbs on second degree burn healing in mice. The test was conducted on 12 male mices divided using a completely randomized design (CRD) into 4 treatment groups consisting of P-1 without any treatment, P-2 by administering Bioplacenton®, P-3 with ethanolic extract and P-4 with watery extract. Lab studies have shown the average percentages of recovery for 18 days for P-2, P-3 and P-4, were 48%, 60% and 63% respectively. One way ANOVA test results obtained p value = 0.011 (p <0.05), it means there were differences in the healing duration of burns in four treatment groups. LSD test results showed that the group which had significant relationship were P-1 and P-4 wherein the Mean Difference was 0.90000. Thus it can be concluded that the group P-4 which is a water extract group was the most effective for the second degree burns healing.

scholarly journals Comparison of Letrozole versus Danazol for the Pain Management of Females Presented with Endometriosis

2018 ◽  
Vol 23 (4) ◽  
pp. 514-518
Author(s):  
Sadaf Ghulam Rasul ◽  
Uzma Yaqub ◽  
Maida Manzoor ◽  
Hafsa Mubasshar
Keyword(s):  
Pain Management ◽  
Pain Score ◽  
Pelvic Pain ◽  
P Value ◽  
Test Results ◽  
Treatment Groups ◽  
Estrogen Production ◽  
Group A ◽  
The Mean ◽  
Group B

Endometriosis is an estrogen-regulated disease, and is signified by the existence of a particular endometrial tissue exterior to the uterus. It is a principal cause of long lasting morbidity, mostly from serious pelvic pain(1). Endometriotic tissue has the potential for aromatase gene expression that leads to aromataseand estrogen production. Danazol is a synthetic androgen whereas Letrozole is aromatase inhibitor. This study was conducted to compare the mean decrease in visual analogue scale (VAS) pain score with Danazol versus Letrozole for the pain management of endometriosis in females. A total of 140 females fulfillinginclusion criteria were registered and an non-probability purposive technique of sampling was used. Diagnostic laparoscopy was conducted to make a diagnosis of endometriosis. Females were divided into two groups. Females in group A received treatment with Letrozole tablets (2.5 mg/day) and in group B receivedDanazol tablets (600 mg/day) for 3 months. Pelvic pain was assessed using VAS score and the mean decrease in pain score was assessed between two groups using independent sample student t-test. Results of this study demonstrate that the mean age of the patients was 29.99±5.80 and the mean pain score before treatment in Letrozole group was 3.04±1.01 while in Danazol group was 5.05±1.02. Post-three months of treatments, mean pain score was 2.01±0.95 and 2.78±0.99 in Letrozole and Danazol groups, respectively. The mean decrease in pain score in Letrozole group was 1.02±1.09 (p-value=0.00) while in Danazol group; it was 3.06±1.23 (p-value=0.00). This difference in pain score was considerably different in both treatment groups. A higher decrease in pain score was observed in Danazol compared to Letrozole treated groups.

The Effectiveness of Young Coconut Water and Watermelon Juice in Reducing Blood Pressure

2021 ◽  
Vol 15 (5) ◽  
pp. 1313-1322
Author(s):  
S. Fadlilah ◽  
A. Sucipto
Keyword(s):  
Blood Pressure ◽  
Nursing Students ◽  
Coconut Water ◽  
Control Group ◽  
P Value ◽  
Test Results ◽  
Watermelon Juice ◽  
Post Test ◽  
The Mean ◽  
Pressure Analysis

Background: Blood pressure is influenced by psychosocial (stress), genetic, age, gender, nutritional status, and lifestyle (diet, lack of fiber consumption, smoking, lack of physical activity). 30 ml of young coconut water contains 61 mg of potassium, 5.45 mg of sodium, and 1.3 mg of sugar, affecting blood pressure changes. Coconut water contains K minerals and is useful for lowering blood pressure. Whereaswatermelon contains anti-hypertensive content, namely sodium, beta carotene, and potassium. Watermelon is rich in water, amino acids, L-arginine, which can maintain healthy blood pressure. Aim: This study aims to determine the effect of young coconut water and watermelon juice on blood pressure in the 2013 nursing students of Respati University Yogyakarta. Methods: This type of research is a quasi-experimental design with a nonequivalent control group pre and post-test. The sample was taken by simple random sampling, namely the control group (18 respondents), the young coconut water group (18 respondents), and papaya juice (18 respondents). Data pre-posttest of each group was tested using Paired T-test. The comparison control-treatment group was tested using an independent-test. Results: The mean differences of systole and diastole pre-posttest blood pressure in the control group were -1.8 mmHg and -1.0 mmHg. The mean difference in systole blood pressure and the pre-posttest diastole of young coconut water groups were -3.1mmHg and -2.4 mmHg. The mean systole and diastole blood pressure in the pre-posttest watermelon juice group were -2.9 mmHg and -1.5 mmHg. The pre-posttest results of systole and diastole blood pressure analysis in the p-value control group were 0.100 and 0.450. The pre-post test results of systole and diastole blood pressure analysis of young coconut water groups gained p-value of 0.030 and 0.194. The pre-post test results of the juice watermelon group's systole and diastole blood pressure analysis gained p-value of 0.032 and 0.181. The posttest results of systole and diastole blood pressure analysis in the control group and young coconut water gained p-value of 0.014 and 0.157. The post-test results of the systole and diastole blood pressure analysis control group and juice watermelon gained p-value of 0.013 and 0.420. Conclusion: Consumption of young coconut water and watermelon juice affects systole blood pressure, but it does not affect diastole blood pressure in nursing students in 2013 in Respati University Yogyakarta. Keyword: Blood pressure, Coconut Water, Watermelon Juice

scholarly journals Efektifitas Puerperal Gymnastic dan Kegel Exercises terhadap Involusi Uterus pada Ibu Postpartum Hari 1 - 3

2021 ◽  
Vol 8 (2) ◽  
pp. 92-99
Author(s):  
Kholisotin Kholisotin ◽  
Kholifatun Naziro ◽  
Zainal Munir ◽  
Ahmad Kholid
Keyword(s):  
Sampling Technique ◽  
T Test ◽  
P Value ◽  
Test Results ◽  
Paired Sample ◽  
Uterine Involution ◽  
Kegel Exercises ◽  
Significant Difference ◽  
The Mean ◽  
Postpartum Mothers

During labor, women experience many reproductive changes, one of which is uterine involution. If the uterine involution is late to return to normal, it will cause subinvolution, puerperal gymnastic techniques and kegel exercises are the easiest techniques to use and are very effective. The purpose of this study was to determine the effectiveness of puerperal gymnastic and kegel exercises on uterine involution in postpartum mothers day 1-3 at BPM Hj. Nengah Mardani Tenggarang Bondowoso. This type of research uses a pre-experimental research methodology using a two-group interpretation-posttest design, with a sample of 30 respondents. The sampling technique in this study used total sampling. Data analysis used paired sample t test and independent t test. The independent t test results showed that there was no significant difference between puerperal gymnastic and kegel exercises in overcoming uterine involution in postpartum mothers with a p value of 0.039 (p value> α 0.05). Of the two techniques, Kegel exercises were more effective in reducing involution. uterus with a mean difference of 6.7333> than the mean puerperal gymnastic of 5.8000.

scholarly journals The Impact of the COVID-19 Pandemic on Medical Imaging Case Volumes in Aseer Region: A Retrospective Study

Medicines ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 70
Author(s):  
Magbool Alelyani ◽  
Ali Alghamdi ◽  
Nasser Shubayr ◽  
Yazeed Alashban ◽  
Hajar Almater ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Emergency Departments ◽  
Imaging Modality ◽  
Significant Decline ◽  
P Value ◽  
Test Results ◽  
Outpatient Departments ◽  
The Mean ◽  
Substantial Decline ◽  
The Impact

COVID-19 has had a significant impact on global health systems. The aim of this study was to evaluate how imaging volumes and imaging types in radiology departments have been affected by the COVID-19 pandemic across different locations. Methods: Imaging volumes in the Aseer region (in the south of Saudi Arabia) across main hospitals were reviewed retrospectively including all cases referred from different locations (outpatient, inpatient and emergency departments). Data for years 2019 and 2020 were compared. The mean monthly cases were compared using a t-test. Results: The total imaging volumes in 2019 were 205,805 compared to 159,107 in 2020 with a 22.7% overall reduction. A substantial decline was observed in both the April to June and the July to September periods of approximately 42.9% and 44.4%, respectively. With respect to location, between April and June, the greatest decline was observed in outpatient departments (76% decline), followed by emergency departments (25% decline), and the least impact was observed in inpatient departments, with only 6.8% decline over the same period. According to modality type, the greatest decreases were reported in nuclear medicine, ultrasound, MRI, and mammography, by 100%, 76%, 74%, and 66%, respectively. Our results show a statistically significant (p-value ≤ 0.05) decrease of cases in 2020 compared to 2019, except for mammography procedures. Conclusion: There has been a significant decline in radiology volumes due to COVID-19. The overall reduction in radiology volumes was dependent on the stage/period of lockdown, location, and imaging modality.

scholarly journals The Protective Effect of Artemisia spicigera Ethanolic Extract against Cryptosporidium parvum Infection in Immunosuppressed Mice

2021 ◽  
Author(s):  
Parisa Shahbazi ◽  
Ahmad Nematollahi ◽  
Sanaz Arshadi ◽  
Hosein Hashemzadeh Farhang ◽  
Amir Ali Shahbazfar
Keyword(s):  
Weight Gain ◽  
Cryptosporidium Parvum ◽  
Specific Treatment ◽  
Ethanolic Extract ◽  
Histopathological Analysis ◽  
Treatment Groups ◽  
Significant Difference ◽  
The Mean ◽  
Gain Loss ◽  
Immunosuppressed Mice

Background: A specific treatment has not yet developed for cryptosporidiosis, and some of the used drugs had side effects in immunodeficient patients. The goal of an appropriate remedy is to remove symptoms and improve immune responses in hosts. The current study was designed to evaluate the therapeutic efficacy of Artemisia spicigera ethanolic extract in experimentally infected immunosuppressed mice. Methods: Thirty six NMRI mice, 4-6 wk old, were randomly divided into six equal groups. C1: uninfected, treated control; C2: infected, untreated control; T1, T2, T3, and P: infected, treated with 0.2, 2, and 20 mg/ml extract, and 5mg/ml paromomycin, respectively. Mice were experimentally infected by oral administration of 104 oocysts/animal of Cryptosporidium parvum and treated orally for eight days per 12h, starting 12h before experimental infection. The presence of oocyst shedding, weight gain/loss, and the histopathology of ileum sections were examined. Results: Results revealed that oocyst shedding was significantly (P<0.05) reduced in treatment groups. There was no significant difference between the mean of weight gain/loss in the infected control and treated groups. Histopathological analysis of ileum sections further supported the parasitological findings. Conclusion: Artemisia spicigera had acceptable efficacy as a therapeutic agent for cryptosporidiosis.

scholarly journals Influence of Ethanolic extract of Aspilia Africana leaf on the performance and egg qualities of Japanese quails

2018 ◽  
Vol 24 (2) ◽  
pp. 135-140
Author(s):  
O.O.K Oko ◽  
P.O Ozung ◽  
F.B Abang
Keyword(s):  
Ethanolic Extract ◽  
Feed Conversion ◽  
Final Body Weight ◽  
Randomized Design ◽  
Old Japanese ◽  
Egg Composition ◽  
Growth Promoting ◽  
Completely Randomized Design ◽  
The One ◽  
One Way Anova

A 16-week trial evaluated the effects of ethanolic extract of Aspiliaafricana leaf (EeAaL) on the growth performance, carcass and egg characteristics of growing and laying quails. One hundred and eighty (180), one-week old Japanese quail chicks were assigned to six experimental diets (0, 2.5, 5, 7.5, 10% EeAaL or 0.02% oxytetracycline). Each treatment had 30 birdswhich were further subdivided into three replicates of 10 birds. Each replicate was housed in a pen under the deep litter system; feed and water were provided ad libitum.Growth performance and egg characteristics(egg quantity and quality) indices were subjected to the one-way ANOVA in a completely randomized design (CRD). No significant (P>0.05) effect of EeAaL was observed between treatments on the final body weight and daily weight gains of quails. Feed conversion ratio (4.95 – 5.28) was significantly (P<0.05) improved in quails fed 2.5 – 7.5% EeAaL diets. Zero mortality was observed in quails fed 5 – 10% EeAaL diets compared to other treatments. EeAaL supplementation reduced (P<0.05) the amount of fat deposition in quail carcass, thus improving the carcass quality. The efficacy ofEeAaL was more pronounced in laying than growing quails where significant (P<0.05) differences were observed on some external and internal egg characteristics, whereas egg composition did not differ (P>0.05) between treatments. Egg number, hen day production, albumen weight,yolk weight, shell thickness and yolk colour were significantly improved following dietary EeAaL  upplementation, indicative of strong growth promoting and stimulatory effects.Therefore, for improved carcass and egg performances up to 7.5% EeAaL shoud be supplemented intoquail diets.Keywords: Leaf extract, growth rate, egg characteristics, bush marigold, quails 

scholarly journals The potency of Andrographis paniculata Nees extract to increase the viability of monocytes following exposure to Porphyromonas gingivalis

2019 ◽  
Vol 52 (4) ◽  
pp. 219
Author(s):  
Yani Corvianindya Rahayu ◽  
Didin Erma Indahyani ◽  
Sheila Dian Pradipta ◽  
Anis Irmawati
Keyword(s):  
Porphyromonas Gingivalis ◽  
Trypan Blue ◽  
Age Groups ◽  
Andrographis Paniculata ◽  
Blue Staining ◽  
Test Results ◽  
Treatment Groups ◽  
Inverted Microscope ◽  
Global Population ◽  
One Way Anova

Background: Periodontitis is a chronic infectious disease affecting the global population. In Indonesia, the prevalence of periodontal disease has reached 57.6% across all age groups. The bacterium considered as the orginator factor of periodontitis is Porphyromonas gingivalis (P. gingivalis). Herbal ingredients are currently being promoted as a form of treatment because of the minimal side effects they induce. Andrographis paniculata Nees (ApN) extract produces pharmacological effects, including ones immunomodulatory in character, rendering possible its application as a preparation for treating periodontitis. Purpose: The purpose of the study was to prove the potency of Andrographis paniculata Nees extract in increasing the viability of monocytes following exposure to P. gingivalis. Methods: The sample was divided into four groups, namely; Control negative (C-): monocytes in the medium, not exposed to P. gingivalis; Control positive (C+): monocytes in the medium, exposed to P. gingivalis; Treatment I (AP25): monocytes with 25% ApN extract, exposed to P. gingivalis; Treatment II (AP50): monocytes with 50% ApN extract, exposed with P. gingivalis. The monocytes were exposed to 100 uL P. gingivalis for 4.5 hours and stained with trypan blue. Observations were conducted using an inverted microscope at 200x magnification. The percentage of viable monocytes was calculated based on the ratio of the number of the cells which absorbed trypan blue staining to that which did not. Data was tested using a one-way ANOVA followed by an LSD test. Results: There were significant differences between the treatment groups in the number of viable monocytes (p=0.001) they contained. Monocyte viability was higher in the 25% ApN extract group than that exposed to 50% P. gingivalis. Conclusion: Andrographis paniculata Nees extract demonstrates the potency to increase monocyte viability following exposure to P. gingivalis.

scholarly journals Effect extract of Ipomoea pes-caprae leaf as anti-inflammatory non immunological in rat Rattus norvegicus

2019 ◽  
Vol 4 (1) ◽  
pp. 11-17
Author(s):  
Safrida Safrida ◽  
Hasanuddin Hasanuddin ◽  
Nurul A. Agusdinianti
Keyword(s):  
Diclofenac Sodium ◽  
Control Variable ◽  
Positive Control ◽  
Negative Control ◽  
Test Results ◽  
Anova Test ◽  
Drug Candidates ◽  
Randomized Design ◽  
Anti Inflammatory ◽  
One Way Anova

Ipomoea pes-caprae is one of the plants in Indonesia that has the potential as a traditional herbal medicine to treat inflammation. Hence, the objective of this study was to evaluate the effect of I. pes-capraeleaf extract as anti-inflammatory in edema rats induced by 5% egg white solution. The experimental design used was a Completely Randomized Design (CRD) consisted of 5 treatments, each consisted of 5 rats.The treatment consisted of KN = negative control, KP = positive control, giving  of 25 mg diclofenac sodium, K 100 = giving 100 mg kg-1body weight (BW) of I. pes-capraeleaf extract , K300 = 300 mg kg-1BW of I. pes-capraeleaf extract, and K500 = 500 mg kg-1BW of I. pes-capraeleaf extract. The anti-inflammatory data obtained were tested statistically with a one-way ANOVA test at  99% confidence level and followed by Duncan's test. The ANOVA test results showed that the giving ofI. pes-capraeleaf extract had a very significant effect (p 0.01) on the percentage of inflammatory, obtained Fcount Ftable, 21.46 4.79 at the level of α = 0.01. The treatment of I. pes-capraeleaf extract of 500 mg kg-1BW had the effect of decreasing the volume of edema with the positive control variable using diclofenac sodium 25 mg. It is concluded that I. pes-capraeleaf extract can be used as an anti-inflammatory by decreasing rat feet edema volume. I. pes-capraeleaf extract has a prospect for non-immunological inflammatory natural drug candidates.

scholarly journals Face burns: A four-year experience

2021 ◽  
Author(s):  
Stephanie A Rasmussen ◽  
Kathleen S Romanowski ◽  
Soman Sen ◽  
Tina L Palmieri ◽  
David G Greenhalgh
Keyword(s):  
Total Body Surface Area ◽  
Adult Patients ◽  
P Value ◽  
Chi Square ◽  
Lengths Of Stay ◽  
Degree Burn ◽  
The Face ◽  
The Mean ◽  
Total Body ◽  
Student’S T

Abstract Introduction Burns on the face pose unique management challenges because they are in a place that is constantly visible, so scars are hard to hide. The goal of this study was to review our experience of adult patients who had face burns. Methods We performed a retrospective review of adult patients (≥ 18 years old) who were admitted to a regional burn center from July 2015 – June 2019 with face burns. Sex, age, ethnicity, burn etiology, burn size, and discharge status were collected from electronic medical records of the patients who met study criteria. Descriptive statistics, student’s t-tests, and chi-square tests were performed in Stata/SE 16.1. Significance was defined as a p-value &lt;0.05. Results In four years, 595/1705 patients (~35% of admissions) were admitted with face burns. The mean age was 44.9 ± 17.0 (mean ± SD) years, with the majority being men (475, 80%). The mean burn size was 19.8 ± 20.9% total body surface area (TBSA) with 10.1 ± 19.8% TBSA being third degree. The mean head burn size for any face burn was 2.8 ± 1.8% TBSA. The majority of burns were due to flames (478, 80%) and of those 122 (21%) were from accelerant use and 43 (7%) resulted from propane or butane use. Scalds caused 53 (9%), electric 25 (4%), hot tar 5 (1%), and chemical 5 (1%). Overall, 208 (35%) patients had grafting of some portion of their body, but only 31 patients (5.2%) had face grafting. The mean age of those with face grafting compared to patients who did not need grafting was 45.9 ± 13.8 and 44.9 ± 17.2 years, respectively. Patients who needed grafting had a mean third degree burn size of 31.7 ± 25.4% TBSA and a mean head (including face) burn size of 4.7 ± 2.0% TBSA, whereas patients who did not need grafting had a mean third degree burn size of 8.9 ± 18.7% TBSA and a mean head burn size of 2.7 ± 1.8% head TBSA. Patients requiring face grafts had longer lengths of stay, intensive unit stays, ventilator days, and mortality than those whose face burns healed spontaneously. Discussion Overall, head burns in adults were common within the four-year time span we studied, but only a small fraction (5%) had face grafts. The patients who needed grafting for their head burns had significantly larger total body and face burns, and had a 2.4-fold higher mortality rate compared to patients who did not need grafting. Most face burns were caused by flame, especially the use of accelerants or flammable gases. Prevention efforts should focus on avoiding the use of accelerants and being careful with flammable gases.

scholarly journals Pemanfaatan Arang Aktif Ampas Kopi Sebagai Adsorben Kadmium Pada Air Sumur (The Usage of Coffee Waste Actived Charcoal as Adsorbent of Cadmium in Well Water)

2019 ◽  
Vol 7 (1) ◽  
pp. 011
Author(s):  
Anita Dewi Moelyaningrum
Keyword(s):  
Research Method ◽  
Active Charcoal ◽  
Well Water ◽  
Test Results ◽  
Coffee Waste ◽  
Normality Test ◽  
Randomized Design ◽  
Coffee Ground ◽  
Completely Randomized Design ◽  
One Way Anova

Logam berat masih banyak ditemukan mencemari lingkungan. Cadmium adalah logam berat yang bisa ditemukan didalam air disekitar tempat pembuangan sampah. Penelitian ini bertujuan untuk menganalisis arang aktif ampas kopi dalam menurunkan kadar Cd dalam air. Metode penelitian ini adalah true eksperimental dengan desain Rancangan Acak Lengkap. Tahap pertama adalah pembuatan arang kemudian diaktivasi dengan HCl. Hasil Uji kualitas arang aktif ampas kopi meliputi rendemen (98,5%), kadar air (7%), kadar abu (4%) dan daya serap idoin (687,96 mg/g). Terdapat empat kelompok yaitu tanpa perlakuan 0 gr/l (P0), perlakuan dengan 5 gr/ l (P1), 8 gr/l (P2) dan 10g/l (P3),  dimana masing-masing kelompok terdiri dari 6 replikasi. Kelompok yang diberi perlakuan dikontakkan dengan arang aktif ampas kopi selama 2 jam. Selanjutnya dilakukan analisa kadar Cd dalam air dengan metode Spektrofotometri Serapan Atom. Hasil penelitian dilakukan uji normalitas kemudian dilakukan uji one way anova menggunakan SPSS. Hasil menunjukkan terdapat perbedaan secara signifikan sebesar 0,000 dengan interval kepercayaan 95% antara kelompok kontrol dan perlakuan. Arang aktif ampas kopi  secara significant dapat mengikat kadar cadmium dalam air. Heavy metal cadmium (Cd) is still polluted the environment. It can be found in the wells around the landfill. This study aimed to analyze the active charcoal coffee ground to adsorb the cadmium in the water. This research method is the true experimental design with Completely Randomized Design. The first stage is making charcoal and then activated with HCl. There are four groups 0 gram/littre (P0), perlakuan dengan 5 gram/littre (P1), 8 gram/littre (P2) dan 10 gram/littre (P3) with each group consisting of 6 replication. Treatement group contacted with active charcoal coffee around 2 hours. Results of research normality test later conducted ANOVA test. The test results informed that there is 0,000 difference significanly with 95% confidence intervals. The active charcoal coffee had significant to adsorb cadmium in the water.

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