Analysis of trace element levels in the nails in patients with colorectal cancer: Consider to the effects of chemotherapy or radiotherapy

Abstract Nails are considered as suitable biological materials for the diagnosis of diseases by measuring trace element levels. This study aimed to evaluate the role of trace elements in detecting the risk of colorectal cancer. Evaluating the effects of cancer treatment with chemotherapy or radiotherapy was also the aim of this study. The levels of trace elements in the nails of 104 patients with colorectal cancer and 112 healthy subjects were analyzed using the k0-standardization method of neutron activation analysis. The results showed that there were significant differences of the following elements, As, Fe, Hg, Sc, Se, and Zn between the control and the patient groups, while it was not the case for the elements Br, Co, and Cr. Furthermore, this study showed that there was no significant difference in the levels of the obtained trace elements in both colon and rectal cancer patient groups between untreated and treated subjects. We conclude that the levels of As, Hg, Fe, Se, and Zn in integrated samples of the fingernail and toenails may be used to evaluate the colorectal cancer risk, and they were not affected by chemotherapy or radiotherapy.

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Comparison of trace element levels after cardiopulmonary bypass between cyanotic and acyanotic patients

Cardiology in the Young ◽

10.1017/s1047951117001226 ◽

2018 ◽

Vol 28 (5) ◽

pp. 632-638 ◽

Cited By ~ 1

Author(s):

Firat H. Altin ◽

Bahar Ozturk Kurt ◽

Ibrahim C. Tanidir ◽

Mehmet Kaya ◽

Okan Yildiz ◽

...

Keyword(s):

Trace Elements ◽

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Trace Element ◽

Baseline Serum ◽

Significant Difference ◽

Postoperative Serum ◽

Patient Groups ◽

Trace Element Levels ◽

Zinc Levels

AbstractTrace elements are essential micronutrients for the human body. In this study, we evaluated the alterations in copper, chromium, manganese, selenium, magnesium, zinc, iron, arsenic, boron, and silicon levels in children with cyanotic and acyanotic CHD who underwent cardiac surgery with cardiopulmonary bypass. Participants were divided into the following three groups: patients acyanotic CHDs (n=34), patients with cyanotic CHDs (n=30), and healthy controls (n=30). Blood samples were collected before the surgery and 1 hour after the sternum was closed. Serum trace elements were determined by Inductively Coupled Plasma Optical Emission Spectrometer-ICAP 6000. The baseline serum arsenic, manganese, and zinc levels of both patient groups were lower compared with controls, but there was no significant difference between baseline serum trace element levels of cyanotic and acyanotic patients. In both the patient groups, there was a significant decrease in postoperative serum arsenic, boron, copper, and zinc levels, and a significant increase in postoperative serum iron and magnesium levels. Silicon levels increased in cyanotic patients. Alterations in trace element levels were in the same direction in cyanotic and acyanotic patients. Copper, zinc, and manganase replacement may be needed after on-pump cardiac surgery.

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Evaluation of Trace Element Levels and Antioxidant Metabolism in Cattle with Cutaneous Papillomatosis

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.82553 ◽

2018 ◽

Vol 46 (1) ◽

pp. 5

Author(s):

Handan Hilal Arslan ◽

Duygu Tarhan ◽

Sena Cenesiz ◽

Fatma Ates Alkan ◽

Umit Ozcan ◽

...

Keyword(s):

Trace Elements ◽

Trace Element ◽

Control Group ◽

Study Group ◽

Antioxidant Metabolism ◽

Essential Components ◽

Significant Difference ◽

Trace Element Levels ◽

Ruminant Metabolism ◽

And Control

Background: Cutaneous papillomas are benign proliferative neoplasms. The aetiology and pathogenesis of the disease are very complex. Papillomatosis lesions can be detected anywhere on the body, frequently appearing on the surface of the head, neck, teats, udder, external genital mucosa and upper part of the gastrointestinal tract. The disease is not life threatening but due to loss of productivity, owners often cull animals with papillomatosis. The relationships between trace elements, heavy metals and cancer are still researching. The aim of this study was the evaluation of the relationships between trace elements and antioxidant metabolism, and cutaneous papillomatosis, in cattle.Materials, Methods & Results: Eleven cattle with cutaneous papillomatosis and 10 healthy cattle constituted the study group and control group, respectively. Clinical examinations were performed on all animals. Blood samples were collected and Cr, Cu, Fe, Mg, Mn, Se, Zn, As, B, Ni, Si and Co levels were determined. The analyses were conducted with an inductively coupled plasma-optical emission spectrophotometer. In addition, catalase (CAT), glutathione (GSH), malondialdehyde (MDA) and ceruloplasmin (Cp) concentrations were measured. The Ni, Si and MDA levels of the study group were significantly higher than those of the control group (P < 0.05) but the Se levels of the study group were significantly lower than in the control group (P < 0.05). The normality of the data was determined with the Shapiro-Wilk Test and the Independent Samples t-Test or Mann-Whitney U test was used for statistical comparison of the groups.Discussion: Trace elements are essential components of biological systems. The levels of trace elements, such as Cu, Co, I, Se, Zn and Mn, which are affected by grazing activity, influence ruminants’ reproductive performance and other production parameters. The elements Al, As, Cr, Ni and Sn are also presumed to be essential for ruminant metabolism, although sufficient research data are not available. In the present study, Cr, Cu, Fe, Mg, Mn, Zn, As, B and Co levels were not significantly different between the papilloma and control groups. Se is an important trace element for skin health. This study revealed a mean serum Se level in animals with papillomatosis that was significantly lower than in the healthy group. Although the mode of anticancer activity of Se is not clear, some factors, such as antioxidant protection, improved immune system surveillance, carcinogen detoxification, modulation of cell proliferation and inhibition of tumour cell invasion and angiogenesis, are important. Ni is classified as a toxic heavy metal. In addition, it could be carcinogenic to humans. Ni level was two times higher in the papillomatosis group than in the healthy animals, in the present study. This result may indicate that Ni has a role in the genesis of papillomatosis in cattle. Si injection can cause inflammation, granulomas and cancer. There are few reports about Si levels in animals and the significant difference in the Si levels in cattle with cutaneous papillomatosis reported in this study may be a new indicator for the disease. The skin contains antioxidant molecules that include GSH, alpha-tocopherol or vitamin E, ascorbic acid or vitamin C, glutathione peroxidases, glutathione reductase, glutathione S-transferases (GSTs), superoxide dismutases (SODs), CAT and quinine reductase. There is strong interaction between ROS and/or their oxidant products and antioxidant molecules in the skin. In this study, although MDA levels were higher in the study group than in the control group, there was no significant difference between the groups in their CAT levels, and also in the GSH and CP levels. In conclusion, these results may evidence the systemic effects of papillomatosis on trace element levels and on oxidant metabolism in cattle.

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Correlation of Some Trace Elements Serum Levels with Prostate Cancer Progression in Saudi Patients

The Open Public Health Journal ◽

10.2174/1874944501912010212 ◽

2019 ◽

Vol 12 (1) ◽

pp. 212-218

Author(s):

Saleh A. K. Saleh ◽

Heba M. Adly ◽

Altaf A.Abdulkhaliq ◽

Anmar M. Nassir

Keyword(s):

Prostate Cancer ◽

Trace Elements ◽

Trace Element ◽

Cancer Patients ◽

Cancer Progression ◽

Specific Antigen ◽

Cancer Management ◽

Significant Difference ◽

Trace Element Levels ◽

Different Levels

Background:Trace elements, such as zinc, arsenic, cadmium and nickel are found naturally in the environment, and human exposure comes from a variety of sources, including air, drinking water, and food. Yet, there are a few studies of the association between trace element levels and prostate cancer in the country.Objective:This study aimed to investigate the changes in trace elements in prostate cancer patients with different levels of their prostate-specific antigen (PSA) values.Methods:The study included 58 patients with prostate cancer aged 70 years and older, divided into 3 different levels of PSA. Full history and clinical data were recorded for all subjects. Blood samples from all subjects and levels of Se, Zn, Cd and Cu were analyzed by inductively-coupled plasma mass spectrometry. The odds ratio of trace element levels was adjusted in accordance with socioeconomic data, family history and supplements intake.Results:Mean Se and Zn levels in serum were significantly low (p<0.05) in all prostate cancer patients. The levels of serum Se decreased by 56%, 67% and 70%, while the levels of serum Zn decreased by 35%, 41% and 47%, in subjects with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. Cu levels were increased significantly in prostate cancer patients, while Cd levels had no significant difference between control and prostate cancer groups.Conclusion:This study emphasizes the importance of minerals intake during prostate cancer management and follow-up period. This highlights the importance of trace elements Zn and Se intake as food supplements for prostate cancer patients.

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Vitamin Analysis, Trace Elements Content, and Their Extractabilities in Tetrapleura tetraptera

Journal of Chemistry ◽

10.1155/2020/1608341 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Prince Oteng ◽

John K. Otchere ◽

Stephen Adusei ◽

Richard Q. Mensah ◽

Emmanuel Tei-Mensah

Keyword(s):

Trace Elements ◽

Vitamin A ◽

Vitamin C ◽

Trace Element ◽

Trace Element Content ◽

Beta Carotene ◽

Flame Atomic Absorption ◽

Significant Difference ◽

Tetrapleura Tetraptera ◽

Vitamin Analysis

Tetrapleura tetraptera is widely cherished in African traditional homes because of its alleged therapeutic and nutritional properties. This present study aimed at determining the levels of vitamin A, C, E, and beta-carotene and trace element (Fe, Cu, Mn, Co, Se, and Zn) concentrations and their extractabilities in the pulp, seeds, and whole fruit (mixture of pulp and seeds) of T. tetraptera. The total trace element concentration of Fe, Cu, Co, Mn, and Zn and their extractabilities (%) were determined using flame atomic absorption spectrometer (FAAS), whereas UV-VIS spectrophotometer was used to determine selenium concentration. The trace element content (mg/kg) based on dry weight in the pulp, seeds, and whole fruit was Fe (162.00 ± 7.14, 115.00 ± 12.00, and 154.00 ± 25.20, respectively), Zn (31.60 ± 4.77, 43.40 ± 5.29, and 41.50 ± 8.97, respectively), Cu (16.10 ± 4.98, 11.90 ± 8.40, and 17.20 ± 14.50, respectively), Mn (55.30 ± 2.41, 156.00 ± 10.20, and 122.00 ± 5.29, respectively), Co (38.10 ± 6.40, 21.10 ± 7.15, and 44.00 ± 14.90, respectively), and Se (1.49 ± 0.17, 2.43 ± 0.28, and 2.97 ± 0.27 μg/g, respectively). The mineral extractabilities (%) in the pulp, seeds, and whole fruit of T. tetraptera were established to be in the order Co > Zn > Fe > Cu > Se > Mn. Also, the chromatographic method (HPLC) was used to evaluate vitamin E concentration, and vitamin C and concentration of beta-carotene were calculated from the obtained concentration of vitamin A using a conversion factor by the titrimetric method. From the results of vitamin analysis, a significant difference (p<0.05) was observed among the pulp, seeds, and whole fruit for vitamin C and E. However, no significant difference (p>0.05) was perceived among these plant parts for vitamin A and beta-carotene. This study has therefore revealed that the pulp, seeds, and whole fruit of T. tetraptera contain varying concentrations of vitamins and trace elements and has given many vital insights on which part of T. tetraptera to consume, as concentrations of these nutrients differ in the discrete parts of the fruit.

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Nfy-c expression in colorectal cancer

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e15086 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e15086-e15086

Author(s):

A. E. Kottorou ◽

A. G. Antonacopoulou ◽

L. Skarlas ◽

P. D. Grivas ◽

C. D. Scopa ◽

...

Keyword(s):

Colorectal Cancer ◽

Disease Recurrence ◽

Clinicopathological Parameters ◽

Mrna Levels ◽

Nuclear Factor ◽

Expression Levels ◽

Nuclear Factor Y ◽

Significant Difference ◽

Tissue Specimens

e15086 Background: Nuclear factor Y- C (NFY-C) gene encodes one of the three subunits of nuclear factor Y, a highly conserved transcription factor which binds to the promoters of a variety of genes, which are implicated in cell cycle progression, drug metabolism and antigen presentation. The purpose of the current study was to investigate the role of NFY-C in colorectal cancer by evaluating its mRNA expression in both malignant and normal colonic tissue from patients with colorectal carcinomas with and without disease relapse. Methods: Publicly available expression microarray data were analyzed to reveal elevated levels of NFY-C in patients with colorectal carcinoma who relapsed compared to patients who remained disease free. The mRNA levels of NFY-C were evaluated by quantitative RT-PCR in 81 neoplastic colorectal tissue specimens and 23 normal tissue specimens from patients with colorectal cancer who had undergone curative resections at the University Hospital of Patras, Greece, between 1995 and 2005. The mRNA levels were analysed in relation to clinicopathological parameters. Results: No significant difference was found in the expression levels of NFY-C between normal and malignant tissues. The expression levels of NFY-C were not related to age, gender, grade, stage or primary site of the disease. However, a statistically significant difference (p=0.02) was observed in NFY-C levels between patients with and without disease recurrence. More specifically, patients with low NFY-C levels relapsed more often than patients who overexpressed NFY-C. Nevertheless, the expression was not related to time to disease progression. Finally, patients with higher NFY-C expression levels seem to have improved survival, compared to patients with low NFY-C expression levels although the difference was not statistically significant. Conclusions: Expression levels of NFY-C seem to be associated with disease recurrence. The role of NFY-C in colorectal cancer warrants further investigation. No significant financial relationships to disclose.

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Association of antiepileptic drug usage, trace elements and thyroid hormone status

Acta Endocrinologica ◽

10.1530/eje-15-1081 ◽

2016 ◽

Vol 174 (4) ◽

pp. 425-432 ◽

Cited By ~ 7

Author(s):

Chantal Zevenbergen ◽

Tim I M Korevaar ◽

Andrea Schuette ◽

Robin P Peeters ◽

Marco Medici ◽

...

Keyword(s):

Trace Elements ◽

Thyroid Hormone ◽

Trace Element ◽

Clinical Importance ◽

Psychomotor Retardation ◽

Thyroid Stimulating Hormone ◽

Linear Regression Models ◽

Drug Usage ◽

Negatively Associated ◽

Trace Element Levels

BackgroundLevels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, we explored these interactions.MethodIn total 898 participants, from the Thyroid Origin of Psychomotor Retardation study designed to investigate thyroid parameters in subjects with intellectual disability (ID), had data available on serum Se, Cu, thyroid stimulating hormone (TSH), free thyroxine (FT4), tri-iodothyronine (T3), reverse T3, T4, and thyroxine-binding globulin (TBG); 401 subjects were on AED treatment. Differences in trace elements according to medication usage was investigated using ANOVA, and associations between trace elements and thyroid parameters were analysed using (non-) linear regression models.ResultsStudy participants were not deficient in any of the trace elements analyzed. AED (carbamazepine, valproate and phenytoin) usage was negatively associated with serum Se and showed compound-specific associations with Cu levels. After correction for drug usage, Se was positively associated with TSH levels, negatively associated with FT4levels, and positively with T3levels. Cu was positively associated with T4, T3, and rT3, which was largely dependent on TBG levels.ConclusionThe subjects with ID did not display profound deficiencies in trace element levels. AEDs were associated with serum Se and Cu levels, while serum Se and Cu were also associated with thyroid parameters. Further studies on the underlying mechanisms and potential clinical importance are warranted.

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Are serum levels of trace elements in children with auditory neuropathy within normal limits? – A pilot study

Clinical & Investigative Medicine ◽

10.25011/cim.v33i3.13720 ◽

2010 ◽

Vol 33 (3) ◽

pp. 155

Author(s):

Nuray Bayar Muluk ◽

Fulya Yalçınkaya ◽

Osman Kürşat Arikan ◽

Özden Çırpar ◽

Sedat Kaygusuz ◽

...

Keyword(s):

Trace Elements ◽

Trace Element ◽

Serum Levels ◽

Auditory Neuropathy ◽

Neural Function ◽

Mean Values ◽

Normal Limits ◽

High Zinc ◽

Serum Trace Element ◽

Trace Element Levels

Objectives: To determine whether trace elements that are essential for neural function play a role in the pathophsiology and etiology of auditory neuropathy (AN).. Materials and methods: Patients diagnosed with auditory neuropathy consisted of eight children (two male, six female). The blood tests including the measurement of sodium, potassium, chloride, calcium, phosphorus, iron, copper and magnesium were done in children with AN during their routine care. Results: Of the eight children with AN, many had serum levels outside the normal range: one had low sodium, two had low potassium, one had low chloride, two had high zinc and three had low zinc, two had low calcium and two had higher than normal phosphorus. Conclusion: Although some serum trace element levels in our patients were higher or lower than normal values, the mean values were within normal limits. Thus, we were unable to detect a relationship between serum trace element levels and AN-. In the future, larger studies should be conducted to confirm these findings.

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Trace Element Levels in Serum Are Potentially Valuable Diagnostic Markers in Dogs

Animals ◽

10.3390/ani10122316 ◽

2020 ◽

Vol 10 (12) ◽

pp. 2316

Author(s):

Yolanda Cedeño ◽

Marta Miranda ◽

Inmaculada Orjales ◽

Carlos Herrero-Latorre ◽

Maruska Suárez ◽

...

Keyword(s):

Trace Elements ◽

Trace Element ◽

Acute Phase ◽

Biochemical Parameters ◽

Indirect Measurement ◽

Serum Copper ◽

Serum Selenium ◽

Acute Phase Reactants ◽

Additional Tool

The objective of this study was to obtain information about the role of trace element imbalance in the pathogenesis of certain diseases in dogs and to evaluate the suitability of trace element profiling as an additional tool in the diagnosis. Serum trace element concentrations (copper, molybdenum, selenium and zinc) were measured in a cohort of healthy (control) dogs (n = 42) and dogs affected by hepatic (n = 25), gastrointestinal (n = 24), inflammatory/infection (n = 24), and renal (n = 22) diseases. These data were analyzed together with data on basic biochemical parameters (alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, albumin, globulin, and glucose) by using chemometric techniques. The chemometric analysis revealed distinctive association patterns between trace elements and biochemical parameters for each clinical disorders. The findings provide clear evidence for the important role of trace elements in disease, particularly in relation to acute phase reactions, with serum copper providing an indirect measurement of ceruloplasmin (positive acute-phase protein) and serum selenium and zinc acting as negative acute phase reactants. Molybdenum may also be a suitable marker of incipient renal disease. Thus, the analysis of trace element profiles, by multielement techniques, in a single serum sample would be a valuable additional tool for the diagnosis of certain diseases.

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Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients: A Review of the Literature

Anemia ◽

10.1155/2012/270923 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 42

Author(s):

Q. Shazia ◽

Z. H. Mohammad ◽

Taibur Rahman ◽

Hossain Uddin Shekhar

Keyword(s):

Oxidative Stress ◽

Trace Elements ◽

Antioxidant Enzymes ◽

Tissue Injury ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Beta Thalassemia Major ◽

Trace Element Levels ◽

Serum Trace Elements

Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. The aim of this review is to scrutinize the relationship between oxidative stress and serum trace elements, degree of damage caused by oxidative stress, and the role of antioxidant enzymes in beta thalassemia major patients. The findings indicate that oxidative stress in patients with beta thalassemia major is mainly caused by tissue injury due to over production of free radical by secondary iron overload, alteration in serum trace elements and antioxidant enzymes level. The role of trace elements like selenium, copper, iron, and zinc in beta thalassemia major patients reveals a significant change of these trace elements. Studies published on the status of antioxidant enzymes like catalase, superoxide dismutase, glutathione, and glutathione S-transferase in beta thalassemia patients also showed variable results. The administration of selective antioxidants along with essential trace elements and minerals to reduce the extent of oxidative damage and related complications in beta thalassemia major still need further evaluation.

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Obesity without diabetes: the role of hormonal regulation

Terapevticheskii arkhiv ◽

10.26442/00403660.2020.10.000750 ◽

2020 ◽

Vol 92 (10) ◽

pp. 15-22

Author(s):

E. A. Shestakova ◽

I. A. Sklyanik ◽

A. S. Panevina ◽

L. V. Nikankina ◽

M. V. Shestakova ◽

...

Keyword(s):

Hormonal Regulation ◽

Tolerance Test ◽

Insulinogenic Index ◽

Obese Patients ◽

Protective Mechanisms ◽

Significant Difference ◽

History Of ◽

Patient Groups

Aim.Obese patients without diabetes present an interesting phenotype to explore protective mechanisms against type 2 diabetes (T2D) development. In our study we looked for specific hormonal features of obese patients without T2D. Materials and methods.We included 6 groups of patients with different metabolic profiles (n=212): controls with BMI25 kg/m2, HbA1c6%, age 30 years; patients with 25BMI30 kg/m2and HbA1c6%; patients with 25BMI30 kg/m2and HbA1c6%; patients with BMI30 kg/m2and HbA1c6% (+ Obesity - T2D) obese patients without T2D or prediabetes; patients with BMI30 kg/m2and newly-diagnosed T2D/prediabetes, HbA1c6%; patients with known history of T2D on glucose-lowering drugs with BMI30 kg/m2. Insulin, GLP-1, GIP were measured during glucose-tolerance test at 0, 30 and 120 minutes; insulin resistance (IR) was assessed by HOMA-IR. Results.Waist circumference was bigger in patients with obesity despite their metabolic profile comparing to patients without obesity (p0.001). Waist-to-hip ratio was similar in patients with different metabolic status. According to IR + Obesity - T2D group had intermediate position: IR was higher in that group comparing to people without obesity, but was less that in patients with obesity and HbA1c6% (p0.001). + Obesity - T2D group had the most potent baseline insulin secretion, assessed by НОМА-%band the highest postprandial secretion, measured by insulinogenic index among all patient groups with obesity (p0.001). There was no significant difference in GLP-1 secretion; GIP secretion was higher in patients with BMI30 kg/m2comparing to people with BMI30 kg/m2(p0.01).

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