scholarly journals The Correlation between Maternal Age and Fetal Sex Chromosome Aneuploidies: A 8-year Single Institution Experience in China

2020 ◽  
Author(s):  
Li Hongge ◽  
Jinglei Jin
Keyword(s):  
Odds Ratio ◽  
Maternal Age ◽  
Sex Chromosome ◽  
Age Groups ◽  
University Teaching ◽  
Advanced Age ◽  
Chi Square ◽  
Fetal Sex ◽  
Chi Square Test ◽  
Sex Chromosome Aneuploidies

Abstract Background: Although a few studies have investigated the association between maternal age and fetal sex chromosome aneuploidies (SCAs), most of these studies were limited to advanced age women and the results were conflicting. This study aimed to investigate maternal age-specific rates for common fetal SCAs (including 45,X, 47,XXY, 47,XXX and 47,XYY) in pregnant women of different ages that not only limited to advanced age women. We retrospectively investigated a 8-year experience of prenatal diagnosis for fetal chromosome aberrations by second-trimester amniocentesis at a university teaching hospital in China. 20,409 amniotic fluid specimens collected at 19–22+6 gestational weeks were included in this study. The women were categorized into five age groups (≤23, 24-28, 29-33, 34-38, 39+ years) based on maternal age at the time of amniocentesis and entered as a categorical variable in all samples. The correlation between fetal SCAs and maternal age was determined using the logistic regression analysis. A chi-square test was performed to compare the incidence of fetal SCAs among age groups. Results: A total of 179 cases of fetal SCAs were detected, and the incidence was 8.77‰ (about 1/114). The incidence of all SCAs increased significantly with advancing maternal age (SE, 0.014; odds ratio, 1.044; P=0.002), from 5.81 per 1,000 fetuses at the 24-28 years to 10.92 per 1,000 at the 39+ years. The incidence of all SCAs was also significantly different among age groups (χ2=10.197, P=0.037<0.05). Specifically, the incidence of 45,X (SE, 0.037; odds ratio, 0.916; P=0.017) and 47,XXY (SE, 0.024; odds ratio, 1.127; P=0.000) had significant correlation with maternal age, while the incidence of 47,XXX and 47,XYY had no correlation with maternal age (P=0.473; P=0.272, respectively). Conclusions: Maternal age was ascertained to be a strong risk factor for fetal SCAs.

scholarly journals The Correlation Between Maternal Age and Fetal Sex Chromosome Aneuploidies: A 8-Year Single Institution Experience in China

2020 ◽  
Author(s):  
Hong-Ge Li
Keyword(s):  
Odds Ratio ◽  
Maternal Age ◽  
Sex Chromosome ◽  
Age Groups ◽  
University Teaching ◽  
Chi Square ◽  
Fetal Sex ◽  
Conventional Cytogenetic Analysis ◽  
Chi Square Test ◽  
Sex Chromosome Aneuploidies

Abstract Background: To date, it has been widely accepted that the risk of autosomal aneuploidies (including T21, T18 and T13) is directly related to the increase in maternal age. However, up to now, the relationship between maternal age and fetal sex chromosome aneuploidies (SCAs) was still unclear. This study aimed to investigate maternal age-specific rates for common SCAs (including 45,X, 47,XXY, 47,XXX and 47,XYY) in fetuses. Methods: We retrospectively investigated a 8-year experience of prenatal diagnosis for fetal chromosome aberrations by second-trimester amniocentesis at a university teaching hospital in China. 20,409 amniotic fluid specimens collected at 19–22+6 gestational weeks were included in this study. Conventional cytogenetic analysis was performed on all samples. Maternal age was as the only indication for the statistical analysis. The women were categorized into five age groups (≤23, 24-28, 29-33, 34-38, ≥39 years) based on maternal age at the time of amniocentesis and entered as a categorical variable in all samples. The correlation between fetal SCAs and maternal age was determined using the logistic regression analysis. A chi-square test was performed to compare the incidence of fetal SCAs among age groups. Results: A total of 179 cases of fetal SCAs were detected, and the incidence was 8.77‰ (about 1/114), far higher than the earlier publication of 1/500. The incidence of all SCAs increased significantly with advancing maternal age (SE, 0.014; odds ratio, 1.044; P=0.002), from 5.81 per 1,000 fetuses at the 24-28 years to 10.92 per 1,000 at the ≥39 years. The incidence of all SCAs was also significantly different among age groups (χ2=10.197, P=0.037<0.05). Specifically, the incidence of 45,X (SE, 0.037; odds ratio, 0.916; P=0.017) and 47,XXY (SE, 0.024; odds ratio, 1.127; P=0.000) had significant correlation with maternal age, while the incidence of 47,XXX and 47,XYY had no correlation with maternal age (P=0.473; P=0.272, respectively). Conclusions: Maternal age was ascertained to be a strong risk factor for fetal SCAs. The incidence of 45,X and 47,XXY was significantly correlated with maternal age, while the incidence of 47,XXX and 47,XYY was not.

The Influence of Age and Gender on Mandibular Indices among the Libyan Population

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Negative Correlation ◽  
Bone Mineralization ◽  
Age Groups ◽  
T Test ◽  
Chi Square ◽  
Age And Gender ◽  
Significant Difference ◽  
Chi Square Test ◽  
And Gender ◽  
Libyan Population

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization. Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population. Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender

scholarly journals Changes in Six-Month Prevalence of Circulatory System Diseases among People Aged 20 Years and Older between 2013 and 2018 in Hunan, China

2021 ◽  
Vol 18 (5) ◽  
pp. 2599
Author(s):  
Zhenzhen Rao ◽  
Junjie Hua ◽  
Ruotong Li ◽  
Yanhong Fu ◽  
Jie Li ◽  
...  
Keyword(s):  
Age Groups ◽  
Circulatory System ◽  
Population Based ◽  
Hunan Province ◽  
Rural Residents ◽  
Chi Square ◽  
Circulatory System Diseases ◽  
Chi Square Test ◽  
Urban Rural ◽  
Socio Demographic Factors

Recent changes in population-based prevalence for circulatory system diseases (CSDs) remain unreported either nationally or locally for China. Data were from the two-round health service household interview survey of Hunan Province, China, in 2013 and 2018. A Rao–Scott chi-square test was performed to examine prevalence differences across socio-demographic variables. The overall age-standardized prevalence of CSDs increased substantially between 2013 and 2018 for inhabitants aged 20 years and older (14.25% vs. 21.25%; adjusted odds ratio (OR) = 1.59, 95% CI: 1.24–2.04). Hypertensive disease was the most prevalent type of CSD, accounting for 87.24% and 83.83% of all CSDs in 2013 and in 2018, respectively. After controlling for other socio-demographic factors, the prevalence of CSDs was significantly higher in 2018 (adjusted OR = 1.40), urban residents (adjusted OR = 1.43), females (adjusted OR = 1.12) and older age groups (adjusted OR = 5.36 for 50–59 years, 9.51 for 60–69 years, 15.19 for 70–79 years, and 12.90 for 80 years and older) than in 2013, rural residents, males and the youngest age group (20–49 years). The recent increase in the overall age-standardized CSD prevalence and the large prevalence disparities across urban/rural residents, sex and age groups merit the attention of policymakers and researchers. Further prevention efforts are needed to curb the increasing tendency and to reduce the prevalence of disparities across socio-demographic groups.

scholarly journals Prevalence and risk factors of apical periodontitis in endodontically treated teeth in a selected population of Brazilian adults

2008 ◽  
Vol 19 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Carlos Estrela ◽  
Cláudio Rodrigues Leles ◽  
Augusto César Braz Hollanda ◽  
Marcelo Sampaio Moura ◽  
Jesus Djalma Pécora
Keyword(s):  
Risk Factors ◽  
Confidence Intervals ◽  
Odds Ratio ◽  
Apical Periodontitis ◽  
Endodontic Treatment ◽  
Technical Quality ◽  
Endodontically Treated Teeth ◽  
Chi Square ◽  
Chi Square Test

The aim of this study was to assess the prevalence and risk factors of apical periodontitis in endodontically treated teeth in a selected population of Brazilian adults. A total of 1,372 periapical radiographs of endodontically treated teeth were analyzed based on the quality of root filling, status of coronal restoration and presence of posts associated with apical periodontitis (AP). Data were analyzed statistically using odds ratio, confidence intervals and chi-square test. The prevalence of AP with adequate endodontic treatment was low (16.5%). This percentage dropped to 12.1% in cases with adequate root filling and adequate coronal restoration. Teeth with adequate endodontic treatment and poor coronal restoration had an AP prevalence of 27.9%. AP increased to 71.7% in teeth with poor endodontic treatment associated with poor coronal restoration. When poor endodontic treatment was combined with adequate coronal restoration, AP prevalence was 61.8%. The prevalence of AP was low when associated with high technical quality of root canal treatment. Poor coronal restoration increased the risk of AP even when endodontic treatment was adequate (OR=2.80; 95%CI=1.87-4.22). The presence of intracanal posts had no influence on AP prevalence.

Vicinity of Schools, But Not of Residences, Seems to Regulate Physical and Sports Activities of 13-Year-Old Teenagers in a South European Setting

2017 ◽  
Vol 14 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Alexandre Magalhães ◽  
Elisabete Ramos ◽  
Maria Fátima Pina
Keyword(s):  
Physical Activity ◽  
Odds Ratio ◽  
Parental Education ◽  
Sports Participation ◽  
Green Spaces ◽  
Chi Square ◽  
Physically Active ◽  
Urban Green Spaces ◽  
Chi Square Test ◽  
Sports Activities

Background:Proximity to urban green spaces (UGS) and open sports spaces (OSS) benefits health, promotes physical activity (PA) and sports practice (SP).Objective:Analyze the association between PA or SP according to distances between UGS or OSS and teenagers’ residences or schools.Methods:We evaluated 1333 (53.9% girls) teenagers (13 years old) living and studying in Porto, Portugal (EPITeen cohort). PA was classified as light or moderate/vigorous. Distances were the shortest routes from residences or schools to UGS/OSS, and classified in ≤250 m; >250 m to ≤500 m; >500 m to ≤750 m; >750 m. Chi-square test and chi-square for trends were used to compare proportions; associations were measured using logistic regression, through odds ratio and 95% confidence intervals, adjusting to BMI and parental education.Results:Regarding vicinity’ of schools, the prevalence of moderate/vigorous PA among boys, decreases as distances to OSS increases. For girls, the prevalence of sports decreases as distances to UGS increase. For boys, we found an association between moderate/vigorous PA and proximity to OSS in the vicinity of schools: considering ≤250 m as reference, the odds of moderate/vigorous PA is 0.20 (0.06–0.63) for >250 m to ≤500 m; 0.21 (0.07–0.61) for >500 m to ≤750 m and 0.19 (0.06–0.58) for >750 m.Conclusion:Vicinities of schools seem to influence teenagers to be more physically active and increase sports participation.

The influence of varying maxillary central incisor vertical dimension on perceived smile aesthetics

2019 ◽  
Vol 46 (2) ◽  
pp. 137-142
Author(s):  
Elis Janaina Lira dos Santos ◽  
Alana Moura Xavier Dantas ◽  
Raíssa Marçal Vilela ◽  
Karina Jerônimo Rodrigues Santiago de Lima ◽  
Rejane Targino Soares Beltrão
Keyword(s):  
Age Groups ◽  
Educational Background ◽  
Cross Sectional Study ◽  
Central Incisor ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Maxillary Central Incisor ◽  
Significant Difference ◽  
Chi Square Test

Objective: To evaluate patient perception of the smile focused on analysis of the upper incisors. Design: Cross-sectional study. Setting: Department of Clinical and Social Dentistry at Federal University of Paraíba, João Pessoa, Brazil. Participants: The sample consisted of 135 individuals (73 women and 62 men). Methods: Images with different characteristics associated with the incisal edges were shown at random and analysed using a Likert scale. Data were analysed using the Chi-square test or Fisher’s exact test with a statistically significant difference ( P < 0.05). Results: Smile I (difference of 1.5 mm in relation to the central incisor and lateral) was considered the most aesthetic, while Smile III (no difference in height between the central and lateral incisors) was the least aesthetic. A significant difference was found between perception of smile II (difference of 1 mm in relation to the central incisor and lateral) and age groups ( P < 0.005), with 31% (n = 13) of individuals aged 45–64 years considering smile II as not pleasant, 4.4% (n = 2) aged 15–24 years and 8.3% (n=4) aged 25–44 years and 4.4% (n = 2) aged 15–24 years considering the same. A significant difference was also found in relation to educational background of the assessor and smile perception, with smile III ( P = 0.0441) and smile IV ( P = 0.0053) considered the most aesthetic ( P = 0.0116). Conclusion: The smile considered most attractive among the sample was that with 1.5 mm steepness between the central and lateral incisors, while a flat smile arc was considered least attractive.

scholarly journals Faktor Usia Ibu dan Paritas Meningkatkan Kejadian Mioma Uteri

2018 ◽  
Vol 11 (1) ◽  
pp. 21
Author(s):  
Army Novitasari ◽  
Gangsar Indah Lestari ◽  
Martini Fairus
Keyword(s):  
Maternal Age ◽  
Uterine Myoma ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Reproductive Disease ◽  
Independent Variable ◽  
Cross Sectional Design ◽  
The Relationship

<p><strong><em>Background:</em></strong><strong><em> </em></strong><em>The most common reproductive disease among Indonesian women is uterine myoma. The number of occurrences of this disease in Indonesia ranks second after cervical cancer. </em><strong><em>Purpose:</em></strong><em> </em><em>This study aims to determine the relationship between maternal age and parity with the incidence of uterine myoma at Mardi Waluyo Metro Hospital in 2016.</em><em> </em><strong><em>Methods:</em></strong><em> </em><em>This study uses a cross sectional design. The study sample was 141 respondents. The independent variable of the study was maternal age and parity, while the dependent variable was uterine myoma. Data analysis using univariate and bivariate analysis. Bivariate analysis using chi square test.</em><em> </em><strong><em>Results:</em></strong><em> </em><em>The results showed that there was a relationship between maternal age (p = 0,000) and parity (p = 0,000) with the incidence of uterine myoma at Mardi Waluyo Metro Hospital.</em><em> </em><strong><em>Conclusion:</em></strong><em> </em><em>The conclusions of this study are maternal age and parity are factors that increase the incidence of uterine myoma. Prevention efforts and reducing the incidence of uterine myoma need to be improved by early detection of women with age and risky parity.</em><em></em></p>

scholarly journals Clinical Spectrum of Angiomatous Granuloma and Inflammatory Fibrous Hyperplasia- A Retrospective Study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 159-162
Author(s):  
Rithanya P ◽  
Archana Santhanam ◽  
Subhashree R
Keyword(s):  
Age Groups ◽  
Hospital Setting ◽  
Clinical Spectrum ◽  
Complete Analysis ◽  
P Value ◽  
Chi Square ◽  
Female Population ◽  
Gingival Enlargement ◽  
Gingival Diseases ◽  
Chi Square Test

Angiomatous granuloma is a reactive tumour-like lesion commonly seen in the oral cavity. It generally occurs due to proliferation of capillary blood vessels. Whereas, inflammatory fibrous hyperplasia (IFH) refers to gingival enlargement, which is the current terminology for an increase in the size of the gingiva and is a common feature of gingival diseases. Therefore, the aim of the current study is to analyse the clinical spectrum of angiomatous granuloma/ IFH in a private dental hospital. This study was carried out in a hospital setting (single centred study). The data of the study subjects was collected after a complete analysis of data of 86000 patients between June 2019 and March 2020. The data of the patients, including age, gender clinical diagnosis and histopathological reports, were collected and analysed using the Chi-square test to find the association between the clinical and histopathological reports in the study. In the present study, angiomatous granuloma(55%) had a higher prevalence compared to IFH (40%) with higher gender predilection among the female population (61.5%) and generally in the age group ranging from 20 to 40 years. (57.5%) [p value= 0.329] statistically not significant. Similarly, IFH was also found to be higher in the female population of about (38.4%), in the age groups between 20 to 50 years (41.3%). The knowledge of various clinical presentations and histopathological characteristics the lesion is necessary for proper identification and treatment planning.

scholarly journals Association of cleft lip and palate on mother-to-infant bonding: a cross-sectional study in the Japan Environment and Children’s Study (JECS)

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shinobu Tsuchiya ◽  
◽  
Masahiro Tsuchiya ◽  
Haruki Momma ◽  
Takeyoshi Koseki ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Maternal Depression ◽  
Odds Ratio ◽  
Maternal Age ◽  
Cleft Lip ◽  
Cross Sectional Study ◽  
Advanced Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Abstract Background Cleft lip and/or palate is among the most prevalent congenital birth defects, and negatively affects maternal psychological status and may consequently result in higher prevalence of child maltreatment. However, the association of childbirths of infants with cleft lip and/or palate with maternal emotional involvement still remains unclear. We examined the association between childbirths of infants with cleft lip and/or palate and mother-to-infant bonding, using data from the Japan Environment and Children’s Study, a nationwide birth cohort study. Methods A cross-sectional study using the jecs-an-20,180,131 dataset was performed. A total 104,065 fetuses in 15 regional centres in Japan were enrolled after obtaining informed written consent. The Mother-to-Infant Bonding Scale, a self-report scale consisting of 10 items, was used to evaluate maternal bonding at one year after childbirth. Finally, the participants consisted of 79,140 mother-infant pairs, of which 211 mothers of infants with cleft lip and/or palate were included in our analyses. Multivariable logistic regression analysis using multiple imputation for missing data was performed to calculate the odds ratio and 95% confidence interval in the estimation of the association between bonding disorders and childbirths with cleft lip and/or palate. Results No increased risk of bonding disorders was observed among all the mothers of infants with cleft lip and/or palate (odds ratio [95% confidence interval]; 0.97 [0.63–1.48], p = 0.880), however, advanced maternal age or multiple parity may adversely affect the associations between bonding disorders and cleft lip and/or palate, respectively. After stratification with a combination of maternal age and parity, a significant association of cleft lip and/or palate with bonding disorders was found only among advanced-age multiparae (odds ratio [95% confidence interval] = 2.51 [1.17–5.37], p = 0.018), but it was weakened after additional adjustment for maternal depression. Conclusions Childbirths of infants with cleft lip and/or palate may increase the risk of bonding disorders among advanced-age multiparae, possibly through maternal depression. This finding provides valuable information for the provision of multidisciplinary cleft care.

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