scholarly journals A secondary data analysis of qualitative study of individualized treatment regimen for North Indians living with human immunodeficiency virus-1

2021 ◽  
Author(s):  
Sushanta Kumar Barik ◽  
Avi Kumar Bansal ◽  
Ashwini Yadav ◽  
Srikanth Prasad Tripathy ◽  
Tej Pal Singh ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Data Analysis ◽  
Secondary Data ◽  
First Line ◽  
Cd4 Counts ◽  
Viral Loads ◽  
Indian Patients ◽  
Resistance Patterns ◽  
Endpoint Data ◽  
The Individual

Abstract The follow-up of fifty-seven patients were conducted after a confirmation genotyping test. The secondary data analysis was done on the data available to observe the correlation between the CD4 counts and viral loads (One of the markers of clinical outcome) of the individual North Indian patients infected with HIV-1 Subtype C. The drug resistance mutations in individual patient were analysed through the drug resistance database, Stanford University, USA. The data of resistance associated with drugs, CD4 counts, viral loads of the individual patient was compiled and statistically analysed for drug resistance pattern profiles using Microsoft Excel 2016 and SPSS Version 22. The normality of data was checked by Shapiro-Wilk test (p<0.05). The study starting and endpoint data on CD4 counts, viral loads and drug resistance patterns associated with multiple first-line ART was available for 24 north Indian patients. The starting and study endpoint data on CD4 counts and drug resistance patterns associated with multiple first- line ART was available for 33 North Indian patients. The study indicative that the recommendation of policy to provide a tailor-made individualized regimen to each patient under AIDS control program.

scholarly journals A secondary data analysis of qualitative study of individualized treatment regimen for North Indians living with human immunodeficiency virus-1

2021 ◽  
Author(s):  
Sushanta Kumar Barik ◽  
Avi Kumar Bansal ◽  
Ashwini Yadav ◽  
Srikanth Prasad Tripathy ◽  
Tej Pal Singh ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Secondary Data ◽  
Resistance Pattern ◽  
First Line ◽  
Cd4 Counts ◽  
Viral Loads ◽  
Indian Patients ◽  
Drug Resistance Pattern ◽  
Point Data ◽  
Hiv 1

Abstract Background A correlation between the CD4 counts and viral loads of HIV-1 infected North Indian patients with first line ART was reported. The follow up of fifty-seven patients were conducted after a confirmation genotypic test. The secondary data analysis was done on the data available to observe the correlation between the CD4 counts and viral loads (markers of clinical outcome) of HIV-1 Subtype C infected North Indian patients. Methods After analysis of the drug resistance mutations in individual patients through the drug resistance database, Stanford University, the data of resistance associated drugs, CD4 counts, viral load of individuals were compiled and analysed using Microsoft Excel 2016 and SPSS Version 22. Normality of data was checked by Shapiro-Wilk test (p < 0.05). Results Starting and study end point data on CD4 count, viral load and drug resistance pattern associated with multiple first line ART was available for 24 North Indian patients. Starting and study end point data on CD4 count and drug resistance pattern associated with multiple first line ART was available for 33 North Indian patients. Conclusion Our findings are categorically indicative that policy recommendation to provide tailor-made individualized regimen based on molecular drug resistance testing to HIV patients under AIDS control program requires robust evidence before implementation.

scholarly journals Study protocol: Strengthening understanding of effective adherence strategies for first-line and second-line antiretroviral therapy (ART) in selected rural and urban communities in South Africa

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261107
Author(s):  
Siphamandla Bonga Gumede ◽  
John Benjamin Frank de Wit ◽  
Willem Daniel Francois Venter ◽  
Samanta Tresha Lalla-Edward
Keyword(s):  
Public Health ◽  
South Africa ◽  
Systematic Review ◽  
Data Analysis ◽  
Antiretroviral Therapy ◽  
Meta Analysis ◽  
Secondary Data ◽  
Limpopo Province ◽  
Second Line ◽  
First Line

Multiple factors make adherence to antiretroviral therapy (ART) a complex process. This study aims to describe the barriers and facilitators to adherence for patients receiving first-line and second-line ART, identify different adherence strategies utilized and make recommendations for an improved adherence strategy. This mixed method parallel convergent study will be conducted in seven high volume public health facilities in Gauteng and one in Limpopo province in South Africa. The study consists of four phases; a retrospective secondary data analysis of a large cohort of patients on ART (using TIER.Net, an ART patient and data management system for recording and monitoring patients on ART and tuberculosis (TB)) from seven Johannesburg inner-city public health facilities (Gauteng province); a secondary data analysis of the Intensified Treatment Monitoring Accumulation (ITREMA) trial (a randomized control trial which ran from June 2015 to January 2019) conducted at the Ndlovu Medical Center (Limpopo province); in-depth interviews with people living with Human Immunodeficiency Virus (PLHIV) who are taking ART (in both urban and rural settings); and a systematic review of the impact of treatment adherence interventions for chronic conditions in sub-Saharan Africa. Data will be collected on demographics, socio-economic status, treatment support, retention in care status, disclosure, stigma, clinical markers (CD4 count and viral load (VL)), self-reported adherence information, intrapersonal, and interpersonal factors, community networks, and policy level factors. The systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting and Population, Interventions, Comparisons and Outcomes (PICO) criteria. Analyses will involve tests of association (Chi-square and t-test), thematic analysis (deductive and inductive approaches) and network meta-analysis. Using an integrated multilevel socio-ecological framework this study will describe the factors associated with adherence for PLHIV who are taking first-line or second-line ART. Implementing evidence-based adherence approaches, when taken up, will improve patient’s overall health outcomes. Our study results will provide guidance regarding context-specific intervention strategies to improve ART adherence.

PENGARUH KARAKTERISTIK INDIVIDU DAN KOMPETENSI PEGAWAI TERHADAP KEPUASAN PELAYANAN PADA MASYARAKAT (STUDI KASUS PADA KANTOR URUSAN AGAMA KECAMATAN SUNGAI PENUH )

2020 ◽  
Author(s):  
Dwi Handayani
Keyword(s):  
Data Analysis ◽  
Community Service ◽  
Secondary Data ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Individual Characteristics ◽  
Service Satisfaction ◽  
Primary Data ◽  
Employee Competencies ◽  
The Individual

The research is proposed to test the influence of individual characteristics and employee competencies on community service satisfaction. The population in this study was the Sungai Penuh City community who had received the last 1 year service at the Kantor Urusan Agama Kecamatan Sungai Penuh, amounting to 150 people. Furthermore, by using the Slovin formula, a sample size of 110 people was chosen with a sampling technique based on Simple Random Sampling. This study uses primary data and secondary data. Data analysis techniques used are path analysis and hypothesis testing using t test with data analysis using SPSS version 20. The results of the study based on showing that partially the individual characteristics and competence of employees have a positive and significant effect on community service satisfaction. The results also show that employee competency variables act as intervening variables between individual characteristics and community service satisfaction.

scholarly journals First-line anti-tuberculosis drug resistance patterns and trends at the national TB referral center in Iran—eight years of surveillance

2009 ◽  
Vol 13 (5) ◽  
pp. e236-e240 ◽  
Author(s):  
Masoud Shamaei ◽  
Majid Marjani ◽  
Ehsan Chitsaz ◽  
Mehdi Kazempour ◽  
Mehdi Esmaeili ◽  
...  
Keyword(s):  
Drug Resistance ◽  
First Line ◽  
Referral Center ◽  
Resistance Patterns

scholarly journals Hubungan antara Pola Resistensi OAT Lini Pertama dan Gradasi Gambaran Foto Toraks Penderita TB Paru MDR

2019 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Pramanindyah Bekti Anjani ◽  
Soedarsono Soedarsono
Keyword(s):  
Drug Resistance ◽  
Chest Radiograph ◽  
Outpatient Clinic ◽  
Multi Drug Resistance ◽  
Resistance Pattern ◽  
First Line ◽  
X Ray ◽  
Resistance Patterns ◽  
Mdr Tb ◽  
Chest X Ray

Background: Tuberculosis (TB) is a disease which has long been known and is still a cause of death in the world. The emergece of the drug resistance in TB treatment, particularly Multi drug-Resistance Tuberculosis (MDR TB) become a significant public health problem in many countries. The diagnosis of MDR TB based on culture results. In some cases radiographic feature with severe abnormalities consideres as MDR TB. From this phenomenon, there is no research that connects the resistance pattern of first line ATD with chest x-ray feature in patients with MDR TB. Methods: The research design are analytical observational with cross-sectional study conducted in outpatient clinic of MDR TB in Dr. Soetomo hospital. Subjects were patients who are following a theraphy program in outpatient clinic of MDR TB in Dr. Soetomo hospital from 2012 to 2014 who meet the inclusion and exclusion criteria. A total of 65 patients. Result: the result of this study showed that of all patterns of resistance, most of the MDR TB patients were classified as having severe chest radiograph. 27 patients with RH resistance patterns, there were 14(51.9%) who had a chest radiograph are classified as severe. 5 patients with RHS resistance patterns, 2(60%) vwho had a chest radiograph are classified as severe. 13 patients RHES resistance patterns, 8(61.5%) who had a chest radiograph are classified as severe. 20 patients with RHE resistance patterns, 14(70%) who had a chest radiograph are classified as severe. Conclusion: There were no significant association between resistance pattern of first line ATD and chest x-ray feature in patient with MDR TB.

Strategi Bertahan Pedagang Konvensional di Tengah Perkembangan Pasar Online (Studi Kasus pada Pedagang Konvensional di Pasar Nagari Air Bangis Kecamatan Sungai Beremas Kabupaten Pasaman Barat)

Horizon ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 543-553
Author(s):  
Lifia - Fitriana ◽  
Rinel Fitlayeni ◽  
Waza Karia Akbar
Keyword(s):  
Data Analysis ◽  
Secondary Data ◽  
Research Problem ◽  
Survival Strategies ◽  
Research Approach ◽  
Data Presentation ◽  
Left Behind ◽  
The Individual ◽  
Depth Interviews ◽  
Collection Methods

This research is motivated by the existence of an online market. Which makes the conventional market to be left behind and the income of traders to decline. The same is true for conventional traders in the Nagari Air Bangis market, Sungai Beremas District, West Pasaman Regency. The formulation of the research problem is how to survive conventional traders in the midst of the development of the online market. The theory used in this study is the theory of rational choice proposed by Coleman. This research approach is a qualitative approach with a descriptive type of research. The types of research data are primary and secondary data. There were 14 informants. Data collection methods are observation, in-depth interviews and document studies. To achieve the validity of the data using triangulation techniques. Meanwhile, the unit of data analysis is the individual with data analysis by Miles and Huberman, namely data reduction, data presentation, data presentation and conclusion drawing. From the results of the study, it can be concluded that there are conventional traders' survival strategies in the Nagari Air Bangis market, namely following the trend of goods being sold, displaying new goods on the front, giving discounts (discounts), and increasing social networks with buyers..

First-line antituberculosis drug resistance prevalence and its pattern among HIV-infected patients in the national referral tuberculosis centre, Iran

2009 ◽  
Vol 20 (8) ◽  
pp. 566-570 ◽  
Author(s):  
P Tabarsi ◽  
E Chitsaz ◽  
A Moradi ◽  
P Baghaei ◽  
P Farnia ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistant ◽  
Resistance Rate ◽  
Antitubercular Agents ◽  
First Line ◽  
Hiv Patients ◽  
Tertiary Centre ◽  
Resistance Patterns ◽  
Culture Positive ◽  
Culture Negative

The objective of this study was to determine the drug resistance prevalence and its pattern among tuberculosis (TB)–HIV patients in Iran. In this retrospective study, all admitted TB/HIV patients presenting to our tertiary centre during 2005–2007 were considered. After confirmation for TB–HIV, first-line DST was performed for culture-positive patients. The drug resistance patterns and the treatment outcomes were analysed. Of the total 92 TB/HIV patients, 27 were culture negative, and DST were available in 65. Intravenous drug abuse was seen in 59 (90.8%). Thirty-seven (57%) were ‘sensitive’ cases and 28 (43%) were ‘any drug resistance’ cases. Twenty-one (32.3%) were mono-drug, three (4.6%) poly-drug and four (6.1%) were multidrug-resistant TB patients. Previous anti-TB medication was significantly associated with any drug resistance ( P = 0.041; 95% confidence interval =0.086–0.984); however, having any drug resistance did not affect the treatment outcome ( P = 0.56). Streptomycin showed the highest resistance rate (27%) followed by isoniazid (20%), pyrazinamide (9.8%), rifampin (9.2%) and ethambutol (3%). Drug resistance to antitubercular agents in TB–HIV co-infected patients in Iran is high compared with other reports. Drug resistance is higher among those who have had prior anti-TB medication.

scholarly journals First-line tuberculosis drug resistance patterns and associated risk factors in Germany, 2008-2017

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0217597 ◽  
Author(s):  
Saskia Glasauer ◽  
Doris Altmann ◽  
Barbara Hauer ◽  
Bonita Brodhun ◽  
Walter Haas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Resistance ◽  
First Line ◽  
Resistance Patterns ◽  
Associated Risk Factors

scholarly journals Unmet Needs of People With Parkinson's Disease and Their Caregivers During COVID-19-Related Confinement: An Explorative Secondary Data Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Anne-Marie Hanff ◽  
Claire Pauly ◽  
Laure Pauly ◽  
Valerie E. Schröder ◽  
Maxime Hansen ◽  
...  
Keyword(s):  
Data Analysis ◽  
Health Professionals ◽  
Unmet Needs ◽  
Secondary Data ◽  
Structured Interview ◽  
Support Network ◽  
Atypical Parkinsonism ◽  
Health Related ◽  
Directed Information ◽  
The Individual

Self-perceived unmet needs in people with typical and atypical parkinsonism (PwP) and their caregivers, support network, personalized ways to address self-perceived unmet needs during confinement, as well as the prevalence of self-reported COVID-19 related symptoms, confirmed SARS-CoV-2 infection, and self-reported COVID-19 related hospitalization in Luxembourg and the Greater Region were assessed. From 18th March to 10th April 2020, 679 PwP were contacted by phone. Data was collected in the form of a semi-structured interview. The thematic synthesis identified 25 themes where PwP need to be supported in order to cope with consequences of the pandemic, and to adapt their daily and health-related activities. The present work highlights that in the context of personalized medicine, depending on the individual needs of support of the patient the identified self-perceived unmet needs were addressed in various ways ranging from one-directed information over interaction up to proactive counseling and monitoring. Family and health professionals, but also other support systems were taking care of the unmet needs of PwP (e.g., shopping, picking-up medication, etc.) during the pandemic. 7/606 PwP (1.15%) reported COVID-19 related symptoms, 4/606 (0.66%) underwent a rRT-PCR-based diagnostic test and 2/606 (0.33%) were confirmed as SARS-CoV-2 positive. None of these PwP reported being hospitalized due to COVID-19. Our results will allow health professionals to expand their services in a meaningful way i.e., personalize their support in the identified themes and thus improve the healthcare of PwP in times of crisis.

scholarly journals FIRST LINE ANTI-TUBERCULOSIS DRUG RESISTANCE PATTERN IN MULTIDRUG-RESISTANT PULMONARY TUBERCULOSIS PATIENTS CORRELATE WITH ACID FAST BACILLI MICROSCOPY GRADING

2020 ◽  
Vol 8 (2) ◽  
pp. 83
Author(s):  
Soedarsono Soedarsono ◽  
Ni Made Mertaniasih ◽  
Titiek Sulistyowati
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Acquired Resistance ◽  
Multidrug Resistant ◽  
First Line ◽  
Pulmonary Tb ◽  
Acid Fast Bacilli ◽  
Drug Resistance Pattern ◽  
Resistance Patterns ◽  
Spearman Test

Multidrug-resistant tuberculosis (MDR-TB) is a global public health crisis. Acid-fast bacilli (AFB) gradation in sputum examination is an important component in Pulmonary Tuberculosis (PTB) diagnosis and treatment outcome monitoring. Previously treated pulmonary TB patients with a higher AFB smear gradation may have higher rates of acquired resistance. Patients with a higher AFB grade indicate a higher bacillary load and had higher rates of acquired resistance. This study aims to evaluate the correlation between AFB gradation and first-line anti-TB drug resistance patterns in MDR pulmonary TB patients. This was a retrospective study conducted from August 2009 to April 2018 in Dr. Soetomo Hospital. Sputum samples were taken from MDR PTB patients. Sputum smear examination was done using Ziehl–Neelsen staining and gradation was measured according to IUATLD criteria. Samples with positive smear were evaluated for resistance patterns based on culture and resistance tests using the MGIT 960 BACTEC System. There were 433 sputum samples with AFB positive collected from MDR PTB patients. Resistance to RHES was found in 22 (14%) AFB +1, 19 (15%) AFB +2, and 29 (20%) AFB +3. Resistance to RHS was found in 22 (14%) AFB +1, 12 (9%) AFB +2, and 13 (9%) AFB +3. Resistance to RHE was found in 39 (25%) AFB +1, 38 (29%) AFB +2, and 35 (24%) AFB +3. Resistance to RH was found in 74 (47%) AFB +1, 61 (47%) AFB +2, and 69 (47%) AFB +3. Statistic analysis by Spearman test showed that there was no significant correlation between AFB gradation and first-line anti-TB drug resistance patterns. Acquired resistance to RHES can also found in lower bacillary load AFB +1.

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