Curcumin and Zinc Co-Supplementation Along With a Loss-Weight Diet Can Improve Lipid Profiles in Subjects with Pre-Diabetes: A Multi-Arm, Parallel-Group, Randomized, Double-Blind Placebo-Controlled Phase 2 Clinical Trial

Abstract Background: Diabetes is one of the major public health concerns. Pre-diabetes can increase the risk of developing some non-communicable diseases such as type 2 diabetes. Given the increasing trend of pre-diabetes, it is critical to control it and prevent its complications. Curcumin is a major bioactive component of turmeric. Zinc is an antioxidant nutrient. The present trial aimed to evaluate the effect of curcumin and zinc co-supplementation along with a loss-weight diet on serum lipid profiles in overweight or obese patients with pre-diabetes.Methods: Eighty-four participants were randomized to four groups (curcumin (500 mg/day), zinc (30 mg/day), “curcumin & zinc”, and placebo) for 90 days. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), non-HDL, HDL/LDL ratio, weight, BMI, waist circumstance (WC), hip circumstance (HC), physical activity (PA) and dietary intake were determined pre and post-intervention. This study will be conducted at Yazd Diabetes Research Clinic, Shahid Sadoughi University of Medical Sciences.Results: Totally, 82 participants were included in the final analysis. After the adjusted PA effect, changes in serum TG (adjusted p = 0.001), LDL (adjusted p = 0.035), non-HDL (adjusted p =0.003), HDL/LDL ratio (adjusted p =0.002), and HDL (adjusted p < 0.0001) revealed a significant difference between the groups. However, the changes in weight (adjusted p = 0.004) and BMI (adjusted p = 0.006) were significant but the changes in dietary intake, PA, WC, and HC were non-significant (adjusted p ≥ 0.05). Despite that there was a significant difference for post-intervention HDL levels (adjusted p = 0.016), other lipid profiles showed no significant difference (adjusted p ≥ 0.05).Conclusion: The beneficial effects of “curcumin & zinc” co-supplementation was reported for the changes of some lipid profiles (TG, LDL, HDL, non-HDL, and HDL to LDL ratio), BMI, and weight with no positive effects on TC, dietary intake, PA, WC, and HC. Therefore, it may play a potential role in the prevention of macro and microvascular complications.Trial registration: The project is a registered clinical trial (Registration number: IRCT20190902044671N1, Iranian Registry of Clinical Trials (IRCT), registered October 11, 2019.

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Ayurveda Body–Mind Constitutional Types and Role of Yoga Intervention Among Type 2 Diabetes Mellitus Population of Chandigarh and Panchkula Regions

Annals of Neurosciences ◽

10.1177/09727531211000040 ◽

2021 ◽

pp. 097275312110000

Author(s):

Madhava Sai Sivapuram ◽

Vinod Srivastava ◽

Navneet Kaur ◽

Akshay Anand ◽

Raghuram Nagarathna ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lipid Profiles ◽

Control Groups ◽

Yoga Intervention ◽

Positive Effects ◽

Study Results ◽

Significant Difference ◽

And Control

Background: Type 2 diabetes needs a better understanding of etiological factors and management strategies based on lifestyle and constitutional factors, given its high association rate with many cardiovascular, neurological disorders, and COVID-19 infection. Purpose: The present study was undertaken to investigate the effect of Diabetes-specific integrated Yoga lifestyle Protocol (DYP) on glycemic control and lipid profiles of diabetic adults. Along with the DYP intervention, the individuals residing in Chandigarh and Panchkula union territories in the northern part of India were assessed for Ayurveda-based body–mind constitutional type. Ayurveda describes body–mind constitution as “ prakriti,” which has been discussed from two angles, namely physiological and psychological as body and mind are correlated. Methods: Cluster sampling of waitlist control study subjects was used as the sampling method for the study. A total of 1,215 registered subjects (81 diabetic) responded in randomly selected clusters in Chandigarh and Panchkula. Ayurveda physicians did Ayurveda body–mind constitutional assessment called prakriti assessment (physiological body–mind constitution assessment) in 35 participants (23 diabetic, 12 prediabetic) as a part of the study. Results: A group of 50 subjects was randomly selected for yoga intervention out of 81 diabetes mellitus adults, and 31 subjects were enrolled as waitlist controls. A significant decrease in the glycosylated hemoglobin levels from 8.49 ± 1.94% to 7.97 ± 2.20% in the intervention group was noticed. The lipid profiles of the DYP intervention and control groups were monitored. Three-month follow-up results of lipid profile diagnostic tests in intervention and control groups showed a significant difference between the two groups ( P < 0.05). Most diabetic and prediabetic individuals were found to have pitta dosha ( pitta controls all heat, metabolism, and transformation in the mind and body) as dominant constitution type. Conclusion: The study results demonstrated significant positive effects of yoga in diabetic individuals. This study has indicated the evidence for the safety and efficacy of the validated DYP for community-level interventions to prevent maladies like brain damage and stroke.

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The Effect of Urtica Dioica Extract on Blood Lipids Profile in Patients with Type 2 Diabetes: A Randomized Double-blinded Clinical Trial

Journal of Nutrition and Food Security ◽

10.18502/jnfs.v6i4.7615 ◽

2021 ◽

Author(s):

Roya Khajeh Mehrizi ◽

Hassan Mozaffari-Khosravi ◽

Parisa Aboee

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Clinical Trial ◽

Total Cholesterol ◽

Density Lipoprotein ◽

Urtica Dioica ◽

Significant Difference ◽

The Mean ◽

Double Blinded

Background: Diabetes is an endocrine disorder that is strongly associated with cardiovascular disease. The use of alternative therapy has recently increased and medicinal plants are one of the alternative therapies for diabetic patients. This study aimed to evaluate the protective effect of Urtica dioica (Nettle) on lipid profile in patients with type 2 diabetes (T2D). Method: This parallel randomized double-blinded clinical trial was conducted on 60 men and women with T2D for an 8-week period. The participants were randomly assigned to received 100mg/kg/day extract of Urtica Dioica (UG) and the placebo group (PG). Blood triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLc) and high density lipoprotein cholesterol (HDLc) were measured at baseline and end of the study. The data were analyzed using SPSS 16.0 and P < 0.05 was considered significant. Results: The mean difference of total cholesterol showed no significant difference in the UG compared to the PG which were -10.56±40.5 and -19.5± 35.9 (P = 0.14), respectively. The study also showed no significant difference between TG and LDLc in the UG compared to the PG (-39.8±171.5 vs. -23.37±72.3 (P = 0.68) and -3.16±33.4 vs. -11.2±35.6 (P = 0.15), respectively). The mean difference of HDLc in the UG and PG were -2.68±8.11 and 2.62±10.6 (P = 0.05), respectively, indicating a significant increase in the UG compared to the PG. Conclusion: The results demonstrated that consumption of 100mg/kg/day extract of UD for 8 weeks by increasing HDL concentration can decrease the risk of cardiovascular disease in patients with T2D.

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IMPACTS OF AEROBIC EXERCISE ON HDL LEVEL OF ADULTS; IT’S SOCIAL IMPLICATIONS IN EDUCATIONAL INSTITUTES

Humanities & Social Sciences Reviews ◽

10.18510/hssr.2021.9410 ◽

2021 ◽

Vol 9 (4) ◽

pp. 65-68

Author(s):

Noor Muhammad Marwat ◽

Shah Khalid ◽

Pir Muhammad Abdul Aziz Shah ◽

Fayaz ul Hasnain ◽

Rashid Naeem Khan

Keyword(s):

High Density Lipoprotein ◽

Aerobic Exercise ◽

Heart Valves ◽

Density Lipoprotein ◽

High Density ◽

Social Implications ◽

Exercise Protocol ◽

Post Intervention ◽

The Social ◽

Significant Difference

Purpose: The purpose of this study to find out the impacts of a 6-weeks supervised aerobic exercise protocol on High-Density Lipoprotein among adults aged between 25-35 years was evaluated. Methodology: Researchers through a non-probability sampling procedure selected thirty (30) volunteers ranging from 25-35 untrained adults from Lakki Marwat. Researchers used a six-week aerobic exercise protocol to collect relevant information from the targeted dependent variables. The CHOD PAP method was used to measure the High-Density Lipoprotein (HDL) of adults. All the data collected from pre-and post- (HDL) tests were recorded in numerical form and analyzed by using a t-test. Main Findings: The results of the study indicate that the six-week aerobic exercise protocol program had no significant difference on pre-and post-intervention quantities of HDL of Experimental Group which is (P>0.05). The implication of the Study: The aerobic exercise programs used for this particular study may help adults to improve and maintain their health status, proper social stature, and lipid profile. An increase in the HLD is ideal as this increase in the HDL helps to prevent cardiovascular diseases particularly the heart valves from stroke and cardiac arrest and academic achievements of the participants. Novelty: So far, no particular research has been conducted on the social implications of exercise effects on adults. Future researchers may work on the social habits of physically fit adults and their input to society.

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Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial

Lipids in Health and Disease ◽

10.1186/s12944-020-01399-0 ◽

2020 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Mahsa Maroofi ◽

Javad Nasrollahzadeh

Keyword(s):

Body Weight ◽

Calorie Restriction ◽

Density Lipoprotein ◽

The Body ◽

Trial Registration ◽

Lipoprotein Cholesterol ◽

Short Term ◽

Significant Difference ◽

The Impact ◽

Overweight Or Obesity

Abstract Background Intermittent calorie restriction (ICR) is a novel method of dietary restriction for body weight control with the potential to improve obesity-related cardiometabolic markers, but the impact of this diet on subjects with hypertriglyceridemia (HTG) remains unknown. Methods Eighty-eight subjects with overweight or obesity and mild-to-moderate HTG were randomized to the continuous calorie restriction (CCR) group, or ICR group (a very low-calorie diet during 3 days of the week) for 8 weeks (44 patients in each group). Body composition, plasma lipids, glucose, insulin, adiponectin, and liver enzymes were measured at baseline and after 8 weeks. An intention-to-treat analysis was performed. Results The body weight decreased in both groups (4.07 ± 1.83 kg in the CCR group and 4.57 ± 2.21 kg in the ICR group) with no significant difference between the groups. There was no significant difference between the two groups in the reduced amount of fat mass, fat-free mass, and waist circumference. Both groups achieved a significant reduction in plasma triglycerides after 8 weeks (by 15.6 and 6.3% in ICR and CCR groups, respectively) with no difference between treatment groups. HOMA-IR improved significantly in ICR compared to the CCR group (P = 0.03). Plasma glucose, insulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, liver enzyme, and adiponectin were not different between the two groups. Conclusions The results of this short-term study suggest that three-days a week of the ICR is comparable to a CCR diet for the reduction of triglycerides level in patients with HTG and in the short-term it appears to be more effective than continuous dieting in improving insulin resistance. However, longer-term studies are needed to confirm these findings. Trial registration Trial registration number:NCT04143971.

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Comparison of the effect of three therapies on liver enzymes and lipid profiles in hypercholesterolemic rats

Journal of Birjand University of Medical Sciences ◽

10.32592/jbirjandunivmedsci.2021.28.1.105 ◽

2020 ◽

pp. 51-60

Keyword(s):

Statistical Analysis ◽

Liver Enzymes ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Exercise Group ◽

Lipid Profiles ◽

Control Group ◽

Low Density ◽

Biochemical Tests ◽

Positive Effects

Background and Aims: The present study aimed to compare the effects of three therapeutic methods (including herbal, atorvastatin, and exercise) on liver enzymes and lipid profiles in hypercholesterolemic rats. Materials and Methods: A number of 32 male Wistar rats were randomly assigned to four groups (n=8), including hypercholesterolemia (Hc) control group, anvil extract at a dose of 100 mg/kg, (Ext), exercise (E), and atorvastatin (AT) at a dose 10 mg/kg. Endurance training, anvil extract, and atorvastatin were performed three sessions per week for 8 weeks. Thereafter, liver biochemical tests, including alkaline phosphatase (ALT), aspartate aminotransferase (AST), and lipid profiles were performed using a biochemical autoanalyzer (Ra-2000 made in USA) and the kits provided by Pars Azmun company. The data were analyzed in SPSS software using analysis of variance (ANOVA) and Tukeychr('39')s test were used for data analysis. Results: The results of statistical analysis indicated that all variables (e.g., Alanine transaminase, Triglyceride, High-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL), except for ALT, AST, and cholesterol, were significant in all groups. The results of the statistical analysis demonstrated that triglycerides and VLDL significantly reduced in the atorvastatin and exercise groups, compared to the hypercholesterolemic control group. Furthermore, HDL had a significant increase in the exercise group, compared to the atorvastatin, extract, and control groups. In addition, LDL significantly decreased in the exercise group, compared to the atorvastatin group. Conclusion: The results of the current study pointed to the similar effects of medication and exercise on the improvement of some lipid profiles. Nonetheless, exercise is advantageous over the use of medicine and herbal extracts due to the positive effects of exercise on the reduction of blood lipids and the absence of any side effects.

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Evaluation of the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, and inflammatory and antioxidant biomarkers in overweight or obese prediabetic patients: a study protocol for a randomized double-blind placebo-controlled phase 2 clinical trial

Trials ◽

10.1186/s13063-020-04923-w ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Majid Karandish ◽

Hassan Mozaffari-khosravi ◽

Seyed Mohammad Mohammadi ◽

Maryam Azhdari ◽

Bahman Cheraghian

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Clinical Trial ◽

Type 2 Diabetes Mellitus ◽

Serum Zinc ◽

Lipid Profiles ◽

Diabetes Research ◽

Double Blind ◽

Double Blind Placebo

Abstract Background The prevalence of prediabetes is increasing worldwide. Unfortunately, prediabetes is related to non-communicable diseases. A high risk of developing type 2 diabetes mellitus (T2DM) is reported in people with prediabetes. Curcumin, a polyphenol, might lead to its therapeutic role in obesity and some obesity-related metabolic diseases. Zinc is a trace element that plays a key role in the synthesis and action of insulin, carbohydrate metabolism, and decreasing inflammation. There has been no clinical trial of zinc and curcumin co-supplementation in patients with prediabetes. In previous studies, the single administration of zinc or curcumin has not been conducted on many of the studied markers in prediabetic patients. Methods The purpose of this randomized double-blind placebo-controlled clinical trial is to investigate the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, and inflammatory and antioxidant biomarkers among 84 prediabetic patients with body mass index (BMI) between 25 and 35. Also, liver enzyme, serum zinc, urine zinc, blood pressure, anthropometric parameters, quality of life, adherence to co-supplementation, the side effects of co-supplementation, physical activity, and dietary intake will be assessed. Women or men (18–50 years old for men and 18 years to before menopause for women) will be followed for 3 months (90 days). This study will be conducted at Yazd Diabetes Research Clinic, Shahid Sadoughi University of Medical Sciences. Discussion A diet rich in antioxidants, polyphenols, and phytochemicals has been shown to have a beneficial role in prediabetes. According to the beneficial properties of curcumin or zinc and inadequate evidence, RCTs are needed to assess the effect of curcumin and zinc co-supplementation in native prediabetes patients. We hope the results of the present trial, negative or positive, fill this gap in the literature and facilitate the approach for a much larger, multi-center clinical trial. In conclusion, a synergic effect of co-supplementation along with a weight-loss diet may delay the progression to type 2 diabetes mellitus. Trial registration Iranian Registry of Clinical Trials (IRCT) IRCT20190902044671N1. Registered on 11 October 2019

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Effect of Origanum dubium, Origanum vulgare subsp. hirtum, and Lavandula angustifolia essential oils on lipid profiles and liver biomarkers in athletes

Zeitschrift für Naturforschung C ◽

10.1515/znc-2021-0142 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Hasan Maral ◽

Süleyman Ulupınar ◽

Ayşegül Türk Baydır ◽

Serhat Özbay ◽

Konca Altınkaynak ◽

...

Keyword(s):

Essential Oils ◽

Density Lipoprotein ◽

Lipid Profiles ◽

Analysis Of Covariance ◽

Lipoprotein Cholesterol ◽

Mass Spectrometry Analysis ◽

Control Group ◽

Origanum Vulgare ◽

Lavandula Angustifolia ◽

Significant Difference

Abstract This study aims to determine the effects of essential oils of Origanum dubium (DUB), Origanum vulgare subsp. hirtum (HIR), and Lavandula angustifolia (LAV) on lipid profiles and liver biomarkers in athletes. Thirty-four trained athletes were randomly assigned to one of three experimental groups or the control group (CON). The concentrations of serum lipids and liver biomarkers were assessed before and after the 14-day essential oil intervention. Gas chromatography-mass spectrometry analysis showed 68.0 and 82.1% carvacrol in DUB and HIR, respectively, and 34.50% linalyl acetate and 33.68% linalool in LAV essential oils. One-way analysis of covariance (ANCOVA) indicated a significant difference (p = 0.001) among the groups for high-density lipoprotein cholesterol (HDL-C) when the associated preintervention values were used as a covariate. The related pairwise comparisons revealed that DUB (p = 0.001) and HIR (p = 0.024) had greater HDL-C values than CON. From the two-way ANOVA, an interaction between time (before vs. after) and the groups (DUB vs. HIR vs. LAV vs. CON) was found for HDL-C (p = 0.030). Findings indicated a significant increase in DUB (p = 0.0001) and HIR (p = 0.010) for HDL-C, and there was a significant decrease in DUB (p = 0.023) for low-density lipoprotein cholesterol. However, there was no difference in total cholesterol, triglycerides, and all liver biomarkers.

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Effects of different exercise loads on the thyroid hormone levels and serum lipid profile in swimmers

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2018-0025 ◽

2018 ◽

Vol 38 (1) ◽

Cited By ~ 1

Author(s):

Sayad Kocahan ◽

Aykut Dundar

Keyword(s):

Thyroid Hormone ◽

Lipid Profile ◽

Serum Lipid ◽

Positive Impact ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Thyroid Stimulating Hormone ◽

Lipid Profiles ◽

Serum Lipid Profile ◽

Significant Difference

Abstract Background The aim of this study was to investigate the effects of different exercise loads (short, medium and long swimming distances) on the thyroid hormone (THs) levels and serum lipid profiles of male professional swimmers. Materials and methods The participants in this study were 20 healthy male professional swimmers aged 18–22 years, who all competed at an elite level. The THs levels [thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4)] and serum lipid profile were also obtained. Results It was determined that the TSH and T4 values increased after exercise (p < 0.05). When compared to the pretest values, the increase in the TSH and T4 values following the L400 tests was statistically significant (p < 0.001 and p < 0.05). It was also determined that the changes in the cholesterol, high-density lipoprotein (HDL) and total glucose (TG) values were significant after exercise (p < 0.001). There was no significant difference between the groups in terms of the low-density lipoprotein (LDL) values (p = 0.07). According to the results, the cholesterol counts for the M200 and L400 groups were lower than the pretest counts (p < 0.001). When compared to the pretest values, the decrease in the HDL counts for the M200 and L400 groups was higher than the pretest HDL counts (p < 0.001 and p < 0.05, respectively). Further, the triglycerides counts for the M200 and L400 groups were higher than the pretest counts (p < 0.001). Conclusions Different exercise loads can have a positive impact on the physical health of swimmers via their lipid profiles and THs. Additionally, swimming exercise could be considered an efficient protective strategy against metabolic disorders, as it serves to balance the serum lipid levels.

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Effects of summer shield supplementation on growth performance, nutrient utilisation, and plasma lipid profiles in broiler chickens

Veterinární Medicína ◽

10.17221/7818-vetmed ◽

2014 ◽

Vol 59 (No. 11) ◽

pp. 536-542 ◽

Cited By ~ 11

Author(s):

AA Saleh ◽

D. Ijiri ◽

A. Ohtsuka

Keyword(s):

Growth Performance ◽

Broiler Chickens ◽

Plasma Lipid ◽

Density Lipoprotein ◽

Basal Diet ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Dry Matter Content ◽

Positive Effects ◽

Nutrient Utilisation

This study was conducted to evaluate the effects of herb mixture (summer shield) supplementation on growth performance, nutrient utilisation, and plasma lipid profiles in broiler chickens. Thirty-six male chicks at 15 days of age were divided into three groups with three replicates of four birds. The control group of chicks was fed a basal diet and the remaining two groups of chicks were fed the basal diet supplemented with summer shield at a concentration of 1 g/kg or 2 g/kg, respectively, until 37 days of age. Although feed intake was not different among the three groups, both body weight gain and breast muscle weight were increased in chicks fed a summer shield-supplemented diet. Summer shield supplementation decreased abdominal fat weight and consequently feed efficiency was improved. Both protein and fat utilisation was improved in chickens fed a summer shield-supplemented diet although dry matter content was not influenced. In addition, summer shield supplementation improved plasma lipid profiles, i.e., total cholesterol, triglyceride, and low-density lipoprotein cholesterol were decreased, whereas high-density lipoprotein cholesterol was increased. Furthermore, summer shield supplementation increased total protein, albumin, and globulin levels in plasma, while neither glutamate oxaloacetate transaminase nor glutamate pyruvate transaminase were affected. These results suggest that summer shield supplementation has positive effects on growth performance, nutrient utilisation, and plasma lipid profiles in broiler chickens.

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Oatmeal induced gut microbiota alteration and its relationship with improved lipid profiles: a secondary analysis of a randomized clinical trial

Nutrition & Metabolism ◽

10.1186/s12986-020-00505-4 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Mengyao Ye ◽

Jianqin Sun ◽

Yanqiu Chen ◽

Qian Ren ◽

Zhen Li ◽

...

Keyword(s):

Clinical Trial ◽

Gut Microbiota ◽

Positive Response ◽

Secondary Analysis ◽

Lipid Profiles ◽

Procrustes Analysis ◽

Fecal Samples ◽

Linear Discriminant ◽

Significant Difference ◽

Firmicutes Phylum

Abstract Background In vitro and animal experiments reported a microbiota-regulating ability of oatmeal, however, related in vivo evidences remained limited. Thus, we conducted this study aiming to investigate the oatmeal-induced alteration of gut microbiota and its potential relationship with the improvements of lipid profiles. Methods and study design Data of anthropometric measurements and biochemical parameters were extracted from a randomized, controlled clinical trial, in which 62 hypercholesterolemic men and women (18–65 years old) were provided with either treatment of 80 g/day oatmeal or 80 g/day refined white rice for 45 days. Fasting blood samples and fecal samples were collected both at baseline and endpoint of the study for lipid profiling and microbiota 16S rRNA amplicon sequencing, respectively. Results Totally 28 participants (56 fecal samples) qualified with the new criteria and were thus included in this secondary analysis. The results of microbiota analysis showed that no significant difference was observed in the alteration of its overall α or β diversity between two groups throughout the study. Nor did any notable between-group difference was found in the relative abundance changes of microorganism at different taxonomies. However, results from linear discriminant analysis effect size in the oatmeal group indicated a significant positive response of Firmicutes phylum following oatmeal consumption. Further Procrustes analysis suggested a concordance trend between microorganism alteration and alleviation of hypercholesterolemia phenotypes throughout the study (P = 0.05). The results of within-group comparison from Spearman’s correlation in the oatmeal group demonstrated a significant association between the enrichment of Blautia genus and the reduction of serum total cholesterol (P < 0.05), low-density lipoprotein cholesterol (P < 0.01), and apolipoprotein B (P < 0.05). Conclusions Positive response of Firmicutes phylum might be a critical characteristic of oatmeal-induced alteration of microbiota, whereas, one of the underlying cholesterol-lowering mechanism of oatmeal consumption might be its microbiota-manipulating ability, in which the enrichment of Blautia genus played a potentially significant role. Current results should be taken cautiously and more studies were needed for further verification. Trial registration: ChiCTR, ChiCTR180001864. Registered 30 September 2018, http://www.chictr.org.cn/showproj.aspx?proj=31469.

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