scholarly journals Taste disorders in children with hemoblastosis and malignant CNS tumors after treatment

Author(s):  
A. Yu. Vashura ◽  
T. A. Kovtun ◽  
S. S. Lukina

Despite significant achievements in oncopediatrics there is an increasing amount of children with remote consequences of anticancer treatment. Nutritional disorders are one of the key consequences, the main factors of which are taste disorders. Despite the interest in this issue, an increase in the number of studies, the exact genesis and causal relationships of these violations have not yet been established.Objective. To study the characteristics of taste perception in children with hemoblastosis and CNS tumors after treatment. Material and methods. The authors carried out a cross-sectional study, which included 110 children with hematological malignancies (42 patients) and CNS tumors (68 patients) aged from 10 to 17 years. The after – treatment period was 2–5 years. They analyzed the nutritional screening data (body mass index and survey data). A test for the identification of four tastes (sour, bitter, salty, sweet) was carried out with the solutions in a regulated concentration according to the standard GOST ISO 3972-2014.Results. The majority of children had violations of taste: to bitter taste – 64,6%, sweet – 40%, sour – 43,7%, salty – 33,6%. Children with hemoblastosis had more disorders.Parageusia was more common in children with CNS tumors. Obese children have a greater proportion of these disorders compared to children with malnutrition and normal nutritional status. There is no relationship with the frequency of food intake, its regularity andappetite.Conclusion. The authors have confirmed the presence of nutritional disorders and problems with taste perception that persist for a long time after the end of treatment. Apparently, a significant part of them has a peripheral genesis.

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110012
Author(s):  
Mariane C.F. Barbosa ◽  
Caio L.B. Reis ◽  
Célia M.C.F. Lopes ◽  
Isabela R. Madalena ◽  
Erika C. Küchler ◽  
...  

Objective. To evaluate if nutritional status is associated with caries and gingivitis in Brazilian schoolchildren. Material and methods. Children of both genders, age ranging from 8 to 11 years old, were included in this study. Caries was diagnosed using ICDAS (International System for Detection and Assessment of Carious Lesions) and gingivitis was diagnosed using the Community Periodontal Index. The nutritional status of each child was defined by BMI Z-score calculation. Data on oral health behavior and dietary habit were collected through parent’s questionnaires. Parametric analyzes were performed to compare the groups. The established alpha was 5%. Results. The sample consisted of 353 schoolchildren: 16 underweight children, 247 eutrophic children, 64 overweight children, and 26 were obese children. Overweight, Obese and Overweight + Obese children presented less cavitated caries lesion than Eutrophic children ( P < .05). Gingivitis was not associated with nutritional status ( P > .05). Conclusion. Caries was associated with overweight and obesity in Brazilian schoolchildren.


2021 ◽  
Vol 10 (13) ◽  
pp. 2812
Author(s):  
Cristina Bellarosa ◽  
Giorgio Bedogni ◽  
Annalisa Bianco ◽  
Sabrina Cicolini ◽  
Diana Caroli ◽  
...  

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.


2013 ◽  
Vol 16 (3) ◽  
pp. 644-657 ◽  
Author(s):  
Inês Gullich ◽  
Andrews Barcellos Ramos ◽  
Tiago Rafael Anschau Zan ◽  
Cíntia Scherer ◽  
Raúl Andrés Mendoza-Sassi

Objective: To identify the prevalence of anxiety in adults hospitalized in the clinical ward of a university hospital and to analyze the possible associated factors. Method: A cross-sectional study was performed in a university hospital. All interviewees answered a specific questionnaire and the Hospital Anxiety and Depression Scale. A Poisson regression was used to calculate prevalence ratios with 95% confidence intervals. Results: 282 patients were enrolled. The prevalence of anxiety was 33.7% (95%CI 28.2 - 39.3). Characteristics associated with the outcome were female gender (RP 2.44), age ≥ 60 years (PR 0.65), consultation in primary health care (PR 2.37), estimated time of contact between patient and student > 30 min (RP 1.36), high blood pressure (PR 1.57), diabetes mellitus (PR 1.43), and obesity (RP 1.43). Conclusion: This study found prevalence of high anxiety. It may be associated with certain characteristics of the patients (gender, age, chronic diseases); the medical appointment in primary care and time (estimated by the patient) that the student remained with this patient. The need for a focused approach to mental health care within the hospital has been discussed for a long time. The particularity of this study refers to the environment of a university hospital and to what extent the environment and the patient's relationship with the student are associated with higher prevalence of anxiety.


2019 ◽  
Vol 41 (2) ◽  
pp. 193-199
Author(s):  
Luciana Satiko Sawamura ◽  
Gabrielle Gomes de Souza ◽  
Juliana Dias Gonçalves dos Santos ◽  
Fabíola Isabel Suano-Souza ◽  
Anelise Del Vecchio Gessullo ◽  
...  

Abstract Objective: To describe the frequency of albuminuria in overweight and obese children and adolescents and to relate it to the severity of obesity, pubertal staging, associated morbidities and the glomerular filtration rate. Method: Cross-sectional study including 64 overweight and obese children and adolescents between 5 and 19 years of age. Data collected: weight, height, waist circumference and systemic arterial pressure. Laboratory tests: lipid profile; glycemia and insulin, used to calculate the Homeostasis Model Assessment (HOMA-IR); C-reactive protein; glutamic-pyruvic transaminase and albuminuria in an isolated urine sample (cutoff <30 mg/g). Creatinine was used to calculate the estimated glomerular filtration rate (eGFR, mL/min/1.73 m2). Results: The mean age was 11.6 ± 3.4 years, 32 (50%) and 29 (45.3%) were male and prepubertal. Forty-six (71.9%) had severe obesity. The frequency and median (min/max) of the observed values for albuminuria (> 30 mg/g) were 14 (21.9%) and 9.4 mg/g (0.70, -300.7 mg/g). The mean eGFR was 122.9 ± 24.7 mL/min/1.73 m2. There was no significant correlation between body mass index, pubertal staging, insulin and HOMA-IR with albuminuria values and neither with eGFR. Children with albuminuria tended to have higher values of diastolic blood pressure (75.0 ± 12.2 vs. 68.1 ± 12.4, p = 0.071). Conclusion: Albuminuria, although frequent in children and adolescents with obesity, was not associated with other morbidities and the glomerular filtration rate in these patients.


2020 ◽  
Vol 13 (1) ◽  
pp. 82
Author(s):  
Aidah Juliaty ◽  
Putri Lestari Gabrilasari ◽  
Dasril Daud ◽  
Johan Setyawan Lisal

INTRODUCTION: Obesity represents the major risk factor for development of insulin resistance during childhood and adolescents. In obesity, adipose tissue release free fatty acids, various hormones, and cytokines, resulting in insulin resistance. This study aimed to establish the correlation between vitamin D deficiency and the incidence of insulin resistance in obese children. DESIGN AND METHOD: This analytical cross-sectional study was arranged from December 2019 - February 2020 included 96 students aged 11 - 17 years old from junior and senior high school who met the criteria for obesity in Makassar. The study subjects were parted into two groups, obese children with vitamin D deficiency (levels of 25-hydroxyvitamin D &le; 20 ng/ml) and obese children without vitamin D deficiency group (levels of 25-hydroxyvitamin D &gt; 20 ng/ml). Data were analyzed using univariate and bivariate analysis. RESULTS: The frequency of insulin resistance in obese children with vitamin D deficiency was 28 (54.9%), while obese children without vitamin D deficiency was 10 (22.2%). Based on statistical analysis, the frequency of the occurrence of insulin resistance in vitamin D deficiency obese children was higher than in obese children without vitamin D deficiency with OR = 4.261 (95% CI 1.744 &ndash; 10.411), p = 0.001. CONCLUSION: The risk of insulin resistance in obese children with vitamin D deficiency is 4.261 times higher than obese children without vitamin D deficiency.


Author(s):  
Laxmi Gautam ◽  
Durga Khadka Mishra ◽  
Gobind Prasad Pant ◽  
Rabina Khadka ◽  
Prakash Datt Chataut ◽  
...  

Background: People who are suffering from PTSD have disturbing feelings and thoughts which is related to their experience even after a long time of such traumatic events happened. This study highlight the characteristics and prevalence of PTSD among the earthquake survivors.Methods: Cross sectional study was carried out using standard PCL-5 PTSD questionnaire. Interview was taken among 376 survivors of earthquake after 4 years of earthquake in Sindhupalchok. Descriptive statistics, Chi-square test and multiple logistic regression were used to describe data and test association.Results: The mean age of the respondents was 39.47±16.18 years. Almost 2/5th of the respondents were either buried, injured or physically or mentally disabled during earthquake. Majority of the survivors had loss their loved one while most of them loss their property. Among the respondents who were buried 28.6% had develop PTSD which was 22.2% among physical or mental disable during earthquake. PTSD showed significant association with age, loss of known person and loss of property however didn’t show with gender, caste, experience of earthquake and so on. The prevalence of PTSD was 71 (21.5%) out of 331 respondents. Female (63.4%) were more prone to PTSD than male (36.6%).Conclusions: PTSD is prevalent among 21.5% of survivors even after 4 years of earthquake which showed an urgent need to address PTSD among the respondents and immediate intervention to prevent and treat such problems in case of future disasters. 


2018 ◽  
Vol 21 (2) ◽  
pp. 179-184 ◽  
Author(s):  
M. Rodriguez-Ayllon ◽  
C. Cadenas-Sanchez ◽  
I. Esteban-Cornejo ◽  
J.H. Migueles ◽  
J. Mora-Gonzalez ◽  
...  

2013 ◽  
Vol 39 (4) ◽  
pp. 476-483 ◽  
Author(s):  
Silvana Gomes Nunes Piva ◽  
Maria da Conceicao Nascimento Costa ◽  
Florisneide Rodrigues Barreto ◽  
Susan Martins Pereira

OBJECTIVE: To determine the prevalence of nutritional deficiency among patients with pulmonary tuberculosis. METHODS: This was a cross-sectional study using data obtained from the Brazilian Case Registry Database and from the medical records of patients diagnosed with pulmonary tuberculosis (15-59 years of age) residing in one of the municipalities that make up the 16th Regional Health District of the state of Bahia. We calculated the incidence, lethality, and mortality rates, as well as the prevalence of nutritional deficiency, as evaluated by body mass index. Demographic, social, clinical, and epidemiological data were collected. RESULTS: Of the 72 confirmed cases of tuberculosis, 59 (81.9%) were in males, and 21 (29.2%) of the patients were in the 40-49 year age bracket. The majority (85.3%) described themselves as Mulatto or Black; 55.2% reported using alcohol; and approximately 90% were treated as outpatients. In the district and age bracket studied, the incidence of pulmonary tuberculosis was 30.6/100,000 population. Among the 72 patients, data regarding nutritional status was available for 34. Of those, 50% and 25%, respectively, presented nutritional deficiency at the beginning and at the end of treatment. No statistically significant differences were found between normal-weight and malnourished patients regarding the characteristics studied. CONCLUSIONS: The prevalence of nutritional deficiency was high among our sample of patients with pulmonary tuberculosis. This underscores the importance of nutritional follow-up for the assessment of tuberculosis treatment in the decision-making process regarding therapeutic interventions.


2019 ◽  
Vol 18 (1) ◽  
pp. 51-58
Author(s):  
Nirju Ranjit ◽  
Bidur Adhikari ◽  
Rajani Shrestha ◽  
Anusuya Shrestha ◽  
Rosha Bhandari ◽  
...  

Introduction: Palm creases have been studied for a long time and have been recently found to be helpful in tracking underlying medical and genetic conditions. Scientific study and typing of palm prints have been found to be lacking in the Nepalese population Methods: A cross sectional study was done on 252 subjects, 153 male and 99 females, from Kathmandu, Nepal. Subjects were selected by purposive sampling from different age groups. Demographic profile including age, sex, and handedness was collected. Palm print pattern was recorded by digital photography. Each photograph was analysed visually by single observer and pattern of palm crease was noted. Variation of each crease was also noted. Results: On the basis of relation between radial longitudinal crease and proximal transverse crease, 17.3% subjects had open type of palm crease which was significantly more in females while 76.6% subjects had closed type crease which was significantly more in males. Meeting type of palm crease was found in 5.7% of subjects. On the basis of relation between proximal and distal transverse crease, normal crease type was found in 90.1% of subjects, Simian type was found in 7.7% subjects and Sydney type was found in 1.4% of subjects. The concordance of this pattern in left and right palms was found statistically significant. Conclusions: This study presented data from 252 seemingly normal healthy subjects and found that most of them had the normal with no branching, that is normal 1 and closed crease types. Most of the individual major creases were seen to be branched type.  


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