scholarly journals Growth rate and acid-base balance in turkeys fed a silage-containing diet modified by different dietary cation-anion difference

2017 ◽  
Vol 73 (12) ◽  
pp. 786-791
Author(s):  
Kamil Gruszczyński ◽  
Wacław Strobel ◽  
Marta Wójcik ◽  
Urszula Kosior-Korzecka ◽  
Joanna Wessely-Szponder ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Diet Group ◽  
Control Group ◽  
Standard Diet ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Group B ◽  
Group D

The aim of the study was to find the responses of acid-base parameters and performance parameters of turkeys to a corn silage (CS) diet with different values of the dietary cation-anion difference (DCAD). The turkeys were fed as follows: group A (control) – standard diet (SD) (60%) plus CS (40%); group B – SD (60%), CS (40%) plus 240 g of CaCl2 per100 kg of diet; group C – SD (60%), CS (40%) plus 480 g of CaCl2 per 100 kg of diet; group D – SD (60%), CS (40%) plus 240 g of NaHCO3 per 100 kg of diet; group E – SD (60%), CS (40%) plus 480 g NaHCO3 per 100 kg of diet. The addition of the smaller amount of CaCl2 reduced DCAD, which ranged between 49.75 ± 6.29 mEq/kg DM and 93.56 ± 3.34 mEq/kg DM. An increased content of CaCl2 led to high, negative values of DCAD. NaHCO3 supplemented in both doses resulted in a significant elevation of DCAD. The addition of CS to the SD led to a lower body weight in comparison to that in the B, C, D and E groups. Forage acidification and alkalization improves body weight gain (BWG) at every stage of feeding. Compared to the control group, the anion gap was insignificantly lower in birds exposed to the acidic diet, and was comparable to the decrease in HCO3 –. Conversely, the addition of NaHCO3 to the diet led to a marked elevation in HCO3 – to 29.63 ± 0.4 mEq/L in group D and to 30.3 ± 0.69 mEq/l in group E. In conclusion, a change in DCAD during the feeding of forage containing CS exerts stimulatory effects on productive parameters of turkeys....

scholarly journals Effects of Allium siculum in ethylene glycol induced kidney stone in male albino rats

2021 ◽  
Vol 48 (3) ◽  
Author(s):  
Sarbast A. Mahmud ◽  
◽  
Aveen R. Khdhr ◽  
Abdulsamih M. Taha, Hero A. Qadir, Payam M. Abdulla ◽  
Kurdo B. Chato ◽  
...  
Keyword(s):  
Body Weight ◽  
Uric Acid ◽  
Ethylene Glycol ◽  
Serum Uric Acid ◽  
Kidney Stone ◽  
Body Weight Gain ◽  
Control Group ◽  
Albino Rats ◽  
Standard Diet ◽  
Group B

This study attempts to find out the curative effects of Allium siculum (A. siculum) on ethylene glycol (EG) induced kidney stone in male albino rats. Throughout this study, twenty-two male albino rats were taken and divided into four experimental groups. Group A is a control group, while the rest of the groups, namely group B, C, and D animals, received 1% EG in water for 14 days, then from day 15 to day 28, the treatment of EG stopped and group C and D animals from day 15 to day 28 received A. siculum (5g of dried powder in 100 ml water and 950 g standard diet) and cystone (2.5 tablets in water and standard diet) respectively. Serum uric acid, creatinine, urea, lipid profile measurements, and glucose were evaluated besides the kidneys' weight and body weight gain. Allium siculum and cystone treatments indicated a significant reduction in serum uric acid, creatinine, urea, glucose, very low-density lipoprotein, and triglyceride compared to EG-treated rats. The kidneys' weight and body weight gains significantly increased in group B compared with A, C, and D. In conclusion: A. siculum has curative effects on ethylene glycol induced kidney stone which resembled the cystone drug.

scholarly journals Role of Oyster Mushroom (Pleurotus ostreatus) Against Cecal Coccidiosis in Cobb 500 Broiler Chicken

2012 ◽  
Vol 5 (1) ◽  
pp. 185-193
Author(s):  
S. Akter ◽  
M. Z. Hossain ◽  
A. H. N. A. Khan ◽  
M. M. Ashraf ◽  
M. K. Islam
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Pleurotus Ostreatus ◽  
Body Weight Gain ◽  
Morbidity And Mortality ◽  
Oyster Mushroom ◽  
Control Group ◽  
Group A ◽  
Group B ◽  
Group D

A total of 25 day old Cobb 500 broiler chicks were purchased and randomly divided into five groups (A, B, C, D and E). Group A served as noninfected, non-supplemented control. Group B were infected and non-supplemented while chicks of group C, D and E were supplemented oyster mushroom (Pleurotus ostreatus) @ 50, 100 and 150 mg/kg body weight respectively with feed from 2-28 day of age. The chicks of group B, C, D and E were challenged orally with 1 x 104 sporulated oocysts of Eimeria tenella on 10th day. The anticoccidial efficacy of oyster mushroom was evaluated based on oocysts counts per gram (OPG) of feces, weight gain, morbidity and mortality, necropsy findings and histopathology. Concerning the mean OPG count, body weight gain (p<0.01), morbidity and mortality the highest performance (p<0.01) was detected in group D and E on day 28 among the supplemented groups whereas group B showed the lowest performance. Group D and E showed the best results in regards of body weight, OPG counts, morbidity, mortality and post mortem findings as compared to healthy control (group A). So it could be concluded that supplementation of 100-150 mg oyster mushroom/kg body weight reduces the development of cecal coccidiosis in chicken.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.12229        J. Sci. Res. 5 (1), 185-193 (2013)

scholarly journals Status Asthmaticus

2017 ◽  
Vol 15 (9-10) ◽  
pp. 269
Author(s):  
J.S Partana
Keyword(s):  
Body Weight ◽  
Status Asthmaticus ◽  
Fluid Administration ◽  
Acid Base Balance ◽  
Acid Base ◽  
Extreme Caution ◽  
Electrolyte Disturbances ◽  
Oxygen Administration ◽  
Base Balance ◽  
Normal Acid

The therapy of status asthmaticus must be rational. Thus it is important to evaluate: 1. the severity and duration of an asthmatic attack. 2. the degree of dehydration. 3. whether infection plays a role. 4. all medication previously administered. 5. any possible complication.Treatment is as follows :Fluid and electrolyte therapy is important not only for the correction of dehydration and electrolyte disturbances but also for preventing inspissation of mucus in the bronchi. The best route of fluid administration is intravenous.Potassium iodide orally administered may be helpful as an expectorant.After hydration and normal acid-base balance have been established, epinephrine may be of benefit.Aminophylline is effective when administered intravenously. It should be used with extreme caution: the dose should not exceed 3 mg per kg of body weight, it should be given slowly and should not be given more frequently than every 8 hours.Corticosteroids should be administered, especially in cases who have received suppressive doses previously.Humidified oxygen administration is of the utmost importance.Antibiotics are recommended when infection is suspected.Management of complications.

scholarly journals Effects of aqueous leaf extract of Corchorus olitorius on the testis and blood testosterone level of adult Wistar rats

2021 ◽  
Vol 10 (2) ◽  
pp. 024-030
Author(s):  
Godwin Chinedu Uloneme ◽  
Demian Nnabuihe Ezejindu ◽  
Darlington Cyprian Akukwu ◽  
Amadi Chibundu Chiekezie
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Day Treatment ◽  
Control Group ◽  
Corchorus Olitorius ◽  
Group A ◽  
Normal Rat ◽  
Group B ◽  
Calcium Iron ◽  
Group D

Background: The extract of Corchorus olitorius has a reasonable content of vitamins A and C, calcium, iron and fibre, and therefore enjoys a universal application in the treatment of some disease conditions, even as the whole leaf is a very important component of food in so many cultures. Purpose: The study was designed to investigate the effect of Corchorus olitorius extracts on the testis of adult Wistar rats. Method: A total number of thirty two adult Wistar rats weighing between 180 and 200 grammes separated into four groups labeled A,B,C and D respectively were used for the study. Animals in group A which served as the control group were fed with the normal rat chow and water only. The group B rats were administered 100mg/kg body weight of aqueous extract of Corchorus olitorus; while those in group C were administered 500mg/kg body weight of the extract. The group D rats received 1000mg/kg body weight of the extract. For a period of four weeks, the different experimental animal groups received the respective aforementioned treatments once daily, around nine- o’clock in the morning through oral intubation. At the end of the 28 day treatment, the animals were sacrificed and the testes harvested for histological, investigation, and through cardiac puncture, blood samples for some hormonal studies was also collected and investigated using standard laboratory standards. Results: Observations made showed that the extract produced no histological distortions, degenerative or defective effects on the testicular tissues. The testosterone levels of group B, C, and D rats were observed to be significantly higher (P<0.005) than that of the group A (control group).ound: The extract of Corchorus olitorius has a reasonable content of vitamins A and C, calcium, iron and fibre, and therefore enjoys a universal application in the treatment of some disease conditions, even as the whole leaf is a very important component of food in so many cultures. Purpose: The study was designed to investigate the effect of Corchorus olitorius extracts on the testis of adult Wistar rats. Method: A total number of thirty two adult Wistar rats weighing between 180 and 200 grammes separated into four groups labeled A,B,C and D respectively were used for the study. Animals in group A which served as the control group were fed with the normal rat chow and water only. The group B rats were administered 100mg/kg body weight of aqueous extract of Corchorus olitorus; while those in group C were administered 500mg/kg body weight of the extract. The group D rats received 1000mg/kg body weight of the extract. For a period of four weeks, the different experimental animal groups received the respective aforementioned treatments once daily, around nine- o’clock in the morning through oral intubation. At the end of the 28 day treatment, the animals were sacrificed and the testes harvested for histological, investigation, and through cardiac puncture, blood samples for some hormonal studies was also collected and investigated using standard laboratory standards. Results: Observations made showed that the extract produced no histological distortions, degenerative or defective effects on the testicular tissues. The testosterone levels of group B, C, and D rats were observed to be significantly higher (P<0.005) than that of the group A (control group).

scholarly journals Effects of Neem and Nishyinda leaves supplementation on growth performance and gut biosis in broiler

2020 ◽  
Vol 6 (2) ◽  
pp. 168-175
Author(s):  
Atikur Rahaman ◽  
Md Bazlar Rashid ◽  
Md Mahmudul Hasan ◽  
Rakibul Islam ◽  
Fahima Binthe Aziz ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth Performance ◽  
Body Weight Gain ◽  
Health Hazard ◽  
Feed Consumption ◽  
Control Group ◽  
Broiler Chicks ◽  
Neem Leaves ◽  
Group D

This study was conducted under the Department of Physiology and Pharmacology to determine the effects of Neem and Nishyinda leaves supplementation on growth performance and GUT biosis in broilers. A total of 40 day old broiler chicks were divided into four groups A, B, C and D. Group A was considered as control, fed only with commercial broiler ration. Group B supplemented with formulation of 2 gm grinded Neem leaves, Group C with 2 gm grinded Nishyinda leaves and Group D with 1 gm grinded Neem leaves plus 1 gm grinded Nishyinda leaves per liter of water respectively. Observations were recorded for live body weight, weight gain, feed consumption, feed efficiency, hemato-biochemical parameters and GUT biosis specially the parasite of birds in six weeks. Body weights were increased significantly (p<0.05) in all treated groups in respect to the control and highest was recorded in combine Neem plus Nishyinda supplemented groups (Group D). No significant (p>0.05) differences were observed among the groups for PCV and TEC values. Hb content increased and ESR decreased significantly (p<0.05) with combine Neem plus Nishyinda supplemented group (Group D). The serum SGOT and SGPT levels were also decreased with the same kind of supplementation. In treatment group there was significantly decreased of parasitic eggs, but in case of control group no decrease of parasitic eggs. There was no significant pathological change in any internal organs of the broiler of treated groups. Best result was found in the group D. The present study reveals that combine supplementation of Neem plus Nishyinda gives better result over other groups in respect to body weight gain, feed conversion ratio, hemato-biochemical parameter and profitability without making any health hazard of the broilers. Asian J. Med. Biol. Res. June 2020, 6(2): 168-175

Changes in blood acid-base balance parameters and coagulation profile during diarrhea in calves

2013 ◽  
Vol 16 (3) ◽  
pp. 543-549 ◽  
Author(s):  
P. Sobiech ◽  
W. Rękawek ◽  
M. Ali ◽  
R. Targoński ◽  
K. Żarczyńska ◽  
...  
Keyword(s):  
Control Group ◽  
Thrombin Time ◽  
Acid Base Balance ◽  
Acid Base ◽  
Blood Samples ◽  
Coagulation Profile ◽  
At Iii ◽  
Base Balance ◽  
Diarrheic Calves ◽  
D Dimer

Abstract The purpose of this study was to investigate possible alterations in acid-base balance parameters and the coagulation profile in neonatal diarrheic calves. Twenty neonatal diarrheic and 20 clinically healthy neonatal calves aged between 1 week to 10 days were used. All blood samples were taken on the third day from the onset of diarrhea symptom. Venous blood samples were collected from each animal to determine platelet numbers, pH, pCO2, pO2, HCO3-, BE, O2SAT, ctCO2 and electrolytes (K+, Na+ and Cl-). Plasma samples were collected from each animal for the measurement of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), the concentrations of fibrinogen, D-dimer and the activity of antithrombin III (AT III). Blood pH (7.19), BE (-10.6 mmol/l), HCO3 - (25.15 mmol/l), pO2 (3.33 kPa), O2SAT (24.12 %) were significantly lower and serum concentration of K+ (6.55 mmol/l) was significantly higher in diarrheic calves. These changes indicate the state of uncompensated metabolic acidosis with accompanying hyperkalemia. TT (32.05s) and APTT (39.9s) values were more prolonged in calves with diarrhea than in the control group. D-dimer (587.25 μg/l) concentrations were significantly increased while a visible drop in AT III (103.75%) activity and platelets counts (598 x109/l) were observed in diarrheic group of calves. The results suggest that a consumptive type of disseminated intravascular coagulation (DIC) developed in diarrheic calves.

scholarly journals DYNAMICS OF THE VENOUS BLOOD ACID-BASE BALANCE AND RELATIONSHIP BLOOD PH VS TUMOR IN LARYNGEAL CANCER PATIENTS

2020 ◽  
Vol 44 (1) ◽  
Author(s):  
V. A. Kashirin ◽  
O. V. Khorolets ◽  
S. I. Andreev ◽  
A. A. Mikheev
Keyword(s):  
Laryngeal Cancer ◽  
Venous Blood ◽  
Combined Treatment ◽  
Control Group ◽  
Acid Base Balance ◽  
Acid Base ◽  
Tumor Ph ◽  
Blood Ph ◽  
Base Balance ◽  
Group 2

Abstract The characteristic for most solid tumors cells is the intracellular alkalinization and acidification of the extracellular milieu and this pH gradient inversion (pHe < pHi) is associated with tumor proliferation, invasion, metastasis, aggressiveness, and treatment resistance. However is there tumor pH (pHi and/or pHe) changes affect on venous blood plasma pH? Purpose of the study. The venous blood acid-base balance before and after the combined treatment, correlation of the venous blood pH indicators (pHb), relationship neoplasm and blood pH in patients with laryngeal cancer was study. Material and methods. Studies were performed in patients with laryngeal cancer categories T2–3 N0 M0 before and after the combined treatment. The patients were divided into four groups: Group 1 – 25 patients before the start of treatment; Group 2 – 21 patients (from Group 1) after completion of the combined treatment; Group 3 – 14 patients from Group 2 with positive results of treatment and Group 4 – 7 patients from Group 2 with a negative result of treatment (recurrence and/or metastasis of the neoplasm). The control group consisted of 15 practically healthy people (Group C). Examination of venous blood acid-base balance of patients, tumor pH and tumor cells pHi and pHe was carried. Results and discussion. The increase in pCO2 and HCO – concentration will result in decrease in the pH, but if these indicators have a clear correlation in the control group, then in patients groups there was a correlation for pHb & pCO2 and pO2 only. Besides, we marked increase in pCO2, HCO –, K+, while pO decreased in pHb after the combined treatment. It is necessary to point out the differences between some benchmarks and indicators of acid-base balance in the plasma of venous blood in primary patients and patients with recurrent laryngeal cancer. So, if pHb, pO2, and Cl– patients have statistically significant differences from control data, then differences with control pCO2 values are characteristic only for patients of Groups 1 and 3. On the contrary, differences in the HCO – indices are characteristic only for patients of Group 4. There are statistically significant differences from the control indicators K+, Na+, Ca2+, Glu, Lac, mOsm in patients of the first group and Cl– and Lac of patients in the third group. Among the indicators in the third and fourth groups of patients, statistically significant differences were noted in the values of pHb, HCO – and Glu.In patients of groups 1 and 4, the determination of pHt and the calculation of pHi, pHe revealed decrease in pHt and pHe with increasing pHi in patients with recurrence of the neoplasm.The final stage of the study was to determine the relationship (and not correlation) of blood pH and laryngeal tumors and the relationship was noted in the «pHb-tumor» system in primary patients, but in patients in 3 and 4 Groups, that «pHb-tumor» connection is rather contradictory. Conclusion. Acid-base balance indicators obviously cannot be considered as unconditional markers of carcinogenesis, but their monitoring and, in particular, venous blood pH, of patients after special treatment, can help determine the risk group of patients who may develop of a malignant neoplasm recurrence. Keywords: acid-base balance, laryngeal cancer, se, prognosis.

scholarly journals Anti-hyperglycemic Effects of Diacerein in Alloxan-Induced Diabetes Mellitus in Wistar Albino Rats

2020 ◽  
pp. 107-113
Author(s):  
Arsalan Uqaili ◽  
Samia Siddiqui ◽  
Roomi Aijaz ◽  
Yar Muhammad Nizammani ◽  
Navaid Kazi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Treated Group ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Group B ◽  
Group D

Objective: To determine the anti-hyperglycemic effects of interleukin-1 inhibitor (diacerein) in alloxan induced diabetic albino wistar rats. This experimental study was performed at the Department of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tando Jam within 6 months from April 2016 to September 2016. Total of 160 adult Albino Wistar Rats having an average of 200 to 300 grams body weights were selected. Animals were categorized into 4 groups as; Group A (n=15): Control rats – receive 0.9% normal saline as placebo Experimental Groups Group B (n=15): Experimental Control (Diabetic rats) - Alloxan50 mg/kg body weight intraperitoneal. Group C (n=15): Diabetic rats + Diacerein (30 mg/kg/day) orally daily. Group D (n=15): Diabetic rats + Diacerein (50 mg/kg/day) orally daily. Animals were kept and treated as per the NIH Guideline for Use and Care of Laboratory Animals. Diabetes mellitus was induced via a single intraperitoneal injection of 50 milligram/kg alloxan monohydrated dissolved in aseptic 0.9% saline. After 72 hours, blood specimens were taken from the caudal vein of the rats and glucose level>200 mg/dL was taken as diabetes. Experimental rats were given diacerein approximately 30 and 50 mg orally for 6 weeks. At the completion of experiment the body weight was measured of each animal by electronic measuring balance and blood sample was taken from each animal of all groups to assess the blood glucose level and HbA1c level. Data were recorded via self-made proforma and analysis was done by using SPSS version 20. Results: Average body weight of Diabetic control (Group B) was 193.33±22.50 grams, which was lower in contrast to Diacerein treated group C 202.47±25.70 grams and significantly lower as compared to Diacerein treated group D as  212.6±23.43 grams. A significant increase in blood glucose levels 182.07±10.63 mg/dl was noted in the Diabetic control (Group B) compared to Diacerein treated group C (110.13± 8.54 mg/dl) and group D (85.87±8.41 mg/dl) (P=0.001). HbA1c was markedly raised in the Group B- diabetic controls, while diacerein treated diabetic rats (groups C and D) showed a significant decrease in HbA1c (P=0.001). Conclusion: It was concluded that Diacerein achieves the Euglycemic state by reducing the levels of blood glucose and glycated hemoglobin (HbA1c) in Alloxan-Induced diabetes mellitus in Wistar Albino Rats.

scholarly journals Physiological Panel of Some Feed Additives for Turkey Toms

2017 ◽  
Vol 9 (12) ◽  
pp. 335
Author(s):  
Sohair Y. Saleh ◽  
N. S. El-Toukhy ◽  
H. I. Abass ◽  
S. I. El-Samannoudy ◽  
M. A. Tony ◽  
...  
Keyword(s):  
Body Weight Gain ◽  
Basal Diet ◽  
Tolerance Test ◽  
Diet Group ◽  
Feed Additives ◽  
Control Group ◽  
Feed Conversion ◽  
Sod Activity ◽  
Antioxidant Parameters ◽  
Group B

A tolerance test was conducted with total 48 male turkeys (strain, Big 6, of three months old) over a period of 70 days, to find the effect of basil and thyme (medicinal plants) and some enzymes (kemzyme and zymogen) as feed additives on turkey toms’ performances. Forty-eight male turkeys (3 months old) were randomly divided into eight groups (6 toms/each). The control group (C) was fed a basal diet without feed supplementation. Group (B) was supplemented with basil (3 g basil/kg diet) group (T) was fed thyme (2 g thyme/kg diet), group (TB) was fed a mixture of basil and thyme (3 g basil + 2 g thyme kg diet), group (Z) was fed zymogen (1 ml/4 liter water); and group (K) was supplemented with kemzyme (0.5 g/kg diet), group (BTK) was fed a mixture of basil, thyme and kemzyme, the last group was fed with diet supplemented with basil, thyme and zymogen. Body weight gain, feed conversion ratio was measured at the end of 10th week of experiment. Blood samples were taken to measure some biochemical parameters, at the same time some tissues for morphological and molecular studies were prepared. Toms fed with either basil, thyme or kemzyme (BT) had significantly (p < 0.05) heaviest body gain than the control, (Z) or (BTZ). Significant increase occurred of the dressing percent (DP%) in group (B) and (BT) compared to the groups (T, Z, BTK and BTZ).Supplementation with (K) significantly decreases the serum total lipids than the (C) group and all supplemented groups at P < 0.05. Serum cholesterol levels of the groups (T), (BT) and (Z) recorded a significant increase than those of groups (C), (K), (BTK) and (BTZ). Meanwhile; triglyceride levels revealed significant decrease in control group at (p < 0.05) than all other groups. All experimental groups recorded no differences in both serum protein and albumin. Although there were an increased levels of serum AST of groups (T) and (Z) compared to control and other groups, meanwhile; (T) and (Z) groups revealed the lowest level of serum ALT.Concerning the antioxidant parameters, results reviewed that (T), (BT), (BTK) and (BTZ) had a higher level of MDA activity than the (B), (K) and (Z) supplemented groups illustrate no difference versus the serum (MDA) activity of the (C) group. Serum SOD activity revealed no differences within all groups. Serum TAC recorded significant increase in all supplemented groups compared to their level in control group.Studies of intestinal integrity; morphometry studies indicated that the villous height increased in groups (T), (Z) and (BTK) with a higher villous to crypt ratio and goblet cell numbers of group supplemented with (BTK). Moreover, the villous width revealed a significant increase in the (C) and (Z) groups. The measurement of total DNA of duodenal tissues which reflect the cell mitosis was higher in (T), (Z) and (BTK), (BTZ) at P < 0.05; the recorded results of DNA/protein of the same segment of the duodenal tissues revealed higher ratio (higher ribosomal activity) of (T), (Z), and (BTK) groups. Cell size of the duodenal tissues as indicated by (protein/DNA) was increased by (K) and decrease by (T) and (Z) supplementation at P < 0.05.

Effects of Ganoderma Lucidum and Krestin on Subset T-cell in Spleen of γ-irradiated Mice

1995 ◽  
Vol 23 (03n04) ◽  
pp. 289-298 ◽  
Author(s):  
Wang-Chi Chen ◽  
Dou-Mong Hau ◽  
Chih-Chung Wang ◽  
I-Hsin Lin ◽  
Shiuh-Sheng Lee
Keyword(s):  
Body Weight ◽  
Ganoderma Lucidum ◽  
Radiation Treatment ◽  
Whole Body ◽  
Control Group ◽  
Γ Irradiation ◽  
Group A ◽  
Group B ◽  
Group D ◽  
Better Than

Effects of Ganoderma lucidum (Gl) and Krestin (PSK) extracts on spleen, thymus and splenocytes in γ-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A was the normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gy γ-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in groups D and E were higher than group C on day 28 after γ-irradiation. Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damage of subset T-cells in the spleen of γ-irradiated mice.

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