Adrenergic and Cholinergic Uterine Innervation and the Impact on Reproduction in Aged Women

2020 ◽  
Vol 26 (3) ◽  
pp. 358-362 ◽  
Author(s):  
Ioannis P. Kosmas ◽  
Antonio Malvasi ◽  
Daniele Vergara ◽  
Ospan A. Mynbaev ◽  
Radmila Sparic ◽  
...  
Keyword(s):  
Negative Impact ◽  
Smooth Muscles ◽  
Nerve Fibers ◽  
The Body ◽  
Autonomous Nervous System ◽  
Childbearing Age ◽  
Assisted Reproductive Technique ◽  
Aged Patients ◽  
Post Menopause ◽  
The Impact

: In recent years, the development of Assisted Reproductive Technique, the egg and embryo donation changed substantially the role of the uterus in recent years. It provided a higher chance for a pregnancy even in women over 45 years or post-menopause. In fact, the number of aged patients and in peri/post-menopause in pregnancy is nowadays increasing, but it increases obstetrical and neonatal related problems. The human uterus is richly innervated and modified especially during pregnancy and labor, and it is endowed with different sensory, parasympathetic, sympathetic and peptidergic neurofibers. They are differently distributed in uterine fundus, body and cervix, and they are mainly observed in the stroma and around arterial vessel walls in the myometrial and endometrial layers. Many neurotransmitters playing important roles in reproductive physiology are released after stimulation by adrenergic or cholinergic nerve fibers (the so called sympathetic/parasympathetic co-transmission). Immunohistochemical study demonstrated the localization and quantitative distribution of neurofibers in the fundus, the body and cervix of young women of childbearing age. : Adrenergic and cholinergic effects of the autonomous nervous system are the most implicated in the uterine functionality. In such aged women, the Adrenergic and AChE neurofibers distribution in the fundus, body and cervix is progressively reduced by increasing age. Adrenergic and AChE neurotransmitters were closely associated with the uterine arteries and myometrial smooth muscles, and they reduced markedly by ageing. The Adrenergic and AChE neurofibers decreasing has a dramatical and negative impact on uterine physiology, as the reduction of pregnancy chance and uterine growth, and the increase of abortion risk and prematurity.

scholarly journals Hyaluronan and the Fascial Frontier

2021 ◽  
Vol 22 (13) ◽  
pp. 6845
Author(s):  
Rebecca L. Pratt
Keyword(s):  
Nerve Fibers ◽  
The Body ◽  
Water Volume ◽  
Cell Behavior ◽  
Connective Tissues ◽  
Wide Range ◽  
The World ◽  
Extracellular Microenvironment ◽  
The Impact ◽  
The Relationship

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body’s fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.

scholarly journals Quality of Life in Patients with Psoriasis Seen in the Department of Dermatology, Antananarivo, Madagascar

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Fandresena Arilala Sendrasoa ◽  
Naina Harinjara Razanakoto ◽  
Volatantely Ratovonjanahary ◽  
Onivola Raharolahy ◽  
Irina Mamisoa Ranaivo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Young Patients ◽  
The Body ◽  
University Hospital ◽  
Medical Decision ◽  
Cross Sectional ◽  
The Difference ◽  
The Impact

Background. Psoriasis is a chronic, inflammatory, and multifactorial dermatosis that impairs quality of life (QoL). Health-related QoL has become an important element in medical decision-making along with the effectiveness and the harmlessness of the treatments. Objective. To assess the impact of psoriasis in the QoL of patients with psoriasis by using the DLQI scales. Methods. A cross-sectional study from January to June 2018 was conducted in the Department of Dermatology of the University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar, including patients more than 18 years old with mild to severe psoriasis. The severity of psoriasis was assessed using the “Psoriasis Area and Severity Index (PASI)”. QoL of patients with psoriasis was evaluated by using the DLQI scales. Results. 80 patients were included, their mean age was 36.5 years, and the male to female was 1.5 : 1. The mean DLQI score was 13.8. Symptoms, feelings, and psychic were the most altered dimensions. QoL was impaired in young patients, single, having medium level education. Even though patients with disease duration more than 5 years had higher DLQI score than other patients, the difference was not statistically significant (p=0.36). Furthermore, the clinical presentation of psoriasis did not influence the patient’s QoL (p=0.73). Patients with nail involvement had QoL impaired but the difference with another localization was not statistically significant (p=0.2). The quality of life was influenced by body area involved. The higher the body surface area involved, the more QoL is impaired (p=0.002). Furthermore, the higher the PASI, the more QoL is altered (p=0.002). Conclusion. Psoriasis has a negative impact in the quality of life in Malagasy patients with psoriasis, especially in younger and single patients. Worse quality of life is correlated to severity of psoriasis.

Predation pressure, density-induced stress and tail regeneration: a casual-nexus situation or a bunch of independent factors?

2009 ◽  
Vol 30 (4) ◽  
pp. 471-482 ◽  
Author(s):  
Gerasimia Tsasi ◽  
Efstratios Valakos ◽  
Chrysi Simou ◽  
Panayiotis Pafilis
Keyword(s):  
Negative Impact ◽  
Predation Pressure ◽  
The Body ◽  
Defensive Strategy ◽  
Tail Regeneration ◽  
Regeneration Rate ◽  
Island Populations ◽  
Induced Stress ◽  
Significant Difference ◽  
The Impact

AbstractCaudal autotomy, the self-induced tail shedding from the body, is a common defensive strategy in lizards. Tail loss is followed rapidly by regeneration, revealing the importance of a fully functional tail. Predation pressure has been traditionally correlated with autotomy performance. However there is a lack of evidence regarding the impact of predation regime on tail regeneration. Another important factor that has been neglected is the population density. Though it is well established that crowding alters various life-history traits, the impact of density on caudal regeneration remains understudied. In this paper we compared three island populations of the Aegean Wall Lizard (Podarcis erhardii) that have evolved under different levels of predation pressure: whereas the Naxos population is exposed to numerous predators the Kopries and Daskalio islet populations experience low predation pressure. To evaluate the effect of density-induced stress on caudal regeneration, lizards were treated under two conditions of housing, in single and crowded (six individuals) terraria. Tail sheding occurred prior to this treatment following a standardised method. The length of regenerated tail was recorded weekly. Regeneration rate was higher in single terraria when compared to crowded, reflecting the negative impact of crowding. However we failed to detect any statistically significant difference between single and crowded terraria in the case of Naxos. We believe that the underlying reason must be the heavy predation pressure under which rapid tail regeneration, even under unfavourable conditions, is crucial for survival. It seems that the imperious need for regeneration counteracts density-induced stress.

scholarly journals Pet Ownership and Quality of Life: A Systematic Review of the Literature

2021 ◽  
Vol 8 (12) ◽  
pp. 332
Author(s):  
Kristel J. Scoresby ◽  
Elizabeth B. Strand ◽  
Zenithson Ng ◽  
Kathleen C. Brown ◽  
Charles Robert Stilz ◽  
...  
Keyword(s):  
Mental Health ◽  
Negative Impact ◽  
Positive Impact ◽  
Adult Population ◽  
The Body ◽  
Future Research ◽  
Pet Ownership ◽  
Physical And Mental Health ◽  
Prospective Longitudinal ◽  
The Impact

Pet ownership is the most common form of human–animal interaction, and anecdotally, pet ownership can lead to improved physical and mental health for owners. However, scant research is available validating these claims. This study aimed to review the recent peer reviewed literature to better describe the body of knowledge surrounding the relationship between pet ownership and mental health. A literature search was conducted in May 2020 using two databases to identify articles that met inclusion/exclusion criteria. After title review, abstract review, and then full article review, 54 articles were included in the final analysis. Of the 54 studies, 18 were conducted in the general population, 15 were conducted in an older adult population, eight were conducted in children and adolescents, nine focused on people with chronic disease, and four examined a specific unique population. Forty-one of the studies were cross-sectional, 11 were prospective longitudinal cohorts, and two were other study designs. For each of the articles, the impact of pet ownership on the mental health of owners was divided into four categories: positive impact (n = 17), mixed impact (n = 19), no impact (n = 13), and negative impact (n = 5). Among the reviewed articles, there was much variation in population studied and study design, and these differences make direct comparison challenging. However, when focusing on the impact of pet ownership on mental health, the results were variable and not wholly supportive of the benefit of pets on mental health. Future research should use more consistent methods across broader populations and the development of a pet-ownership survey module for use in broad, population surveys would afford a better description of the true relationship of pet ownership and mental health.

scholarly journals Analisis Dampak Sosial Akibat Pabrik Kertas Di Desa Parmaksian Tobasa Menggunakan Paradigma Ekofeminis

2021 ◽  
Vol 19 (1) ◽  
pp. 53-70
Author(s):  
Ayu Indira Hasugian
Keyword(s):  
Social Impact ◽  
Negative Impact ◽  
Paper Industry ◽  
Paper Mill ◽  
Social Impacts ◽  
The Body ◽  
The Social ◽  
The World ◽  
The Impact

AbstrakDesa Siruar Parmaksian Tobasa di salah satu desa yang berada di daerah Toba mengalami perubahan sosial akibat dampak negatif berdirinya PT TPL. Dampak yang diberikan mengarah kepada kaum perempuan/ibu sehingga mengakibatkan aktivitas sehari-hari perempuan/ibu menjadi terkendala. Dampak ini terjadi di setiap harinya, sehingga akan sangat berdampak buruk bagi hubungan antara perempuan dan alam. Melihat kasus tersebut peneliti ingin melakukan penelitian terhadap kondisi  yang dialami kaum perempuan/ibu tersebut. Tujuan penelitian ini untuk menganalisa dampak sosial akibat pabrik kertas di Desa Siruar Parmaksian Tobasa kepada para perempuan dengan menggunakan paradigma Ekofeminis yang di tawarkan oleh McFague dan Warren, dan dikaji dalam bentuk studi kasus. Metode penelitian yang peneliti pakai adalah Metode Studi Kasus dari Teori E.P Gintings. Ada beberapa isu yang muncul dari kasus atau masalah ini, diantaranya : dampak sosial, dampak kerusakan alam terhadap kehidupan para perempuan, dan paradigma baru relasi perempuan dan alam atau rekonstruksi paradigma. Hal ini dilakukan untuk mengetahui Bagaimana dampak sosial akibat pabrik kertas terhadap masyarakat yang berada di lingkungan  Industri Kertas di Desa Siruar Parmaksian Tobasa yang mengarah kepada perempuan yang terdampak dan Bagaimana upaya-upaya yang dilakukan kaum perempuan/ibu di desa siruar untuk mempertahankan tanah/wilayahnya yang telah di rusak oleh perusahaan tersebut?. Hasil Analisis menunjukkan bahwa  paradigma Ekofeminis sudah menerapkan paradigma dengan istilah “Konstruksionisme”, yang disebut dengan istilah metafora dunia sebagai tubuh Allah, artinya dunia harus dipahami sebagai satu kesatuan organik, tubuh Tuhan dan bisa menanamkan sikap yang menghargai dunia.Kata Kunci: dampak sosial, paradigma ekofeminis AbstractThe village of Siruar Parm testimony Tobasa in a village in the Toba area experienced social changes due to the negative impact of the establishment of PT TPL. The impact that is given is directed at women / mothers so that it causes the daily activities of women / mothers to be constrained. This impact occurs every day, so it will have a very bad impact on the relationship between women and nature. Seeing this case, the researchers wanted to conduct research on the conditions experienced by these women / mothers. The purpose of this study is to analyze the social impacts of the paper mill in Siruar Parm testimony Tobasa on women using the Ecofemist paradigm offered by McFague and Warren, and study it in the form of a case study. The research method that researchers use is the Case Study Method of E.P Gintings Theory. There are several issues that arise from this case or problem, including: social impacts, the impact of natural destruction on women's lives, and a new paradigm of relations between women and nature or paradigm reconstruction. This is done to find out how the social impact of the paper mill on the community living in the Paper Industry in Siruar Parm testimony Tobasa Village which leads to affected women and how the efforts made by women / mothers in Siruar Village to defend their has been damaged by the company ?. The results of the analysis show that the Ecofemist paradigm has applied a paradigm with the term "Constructionism", which is called the metaphor of the world as the body of God, meaning that the world must be understood as an organic unit, the body of God and can instill an attitude of respect for the world. Keywords: social impact, eco-feminist paradigm

scholarly journals Inflationary Rate in Nigeria: Impact of Foreign Capital Inflows

2021 ◽  
Vol 7 (1) ◽  
pp. 44-54
Author(s):  
Olabode Eric Olabisi
Keyword(s):  
Foreign Capital ◽  
Negative Impact ◽  
Forecast Error ◽  
Daily Basis ◽  
The Body ◽  
Capital Inflows ◽  
Parameter Estimates ◽  
Long Run ◽  
Foreign Capital Inflows ◽  
The Impact

As the prices of daily needs are aggravating in Nigeria, the value of the country’s currency (naira) is less appreciated on a daily basis, and this pose a threat to a good standard of living in Nigeria. Therefore, this study investigated the impact of foreign capital inflows on the persistent increase in inflation in Nigeria over the period of 1985 to 2019. The Autoregressive Distributed Lags was used to obtain the parameter estimates of the long run relationship between foreign capital inflows and inflation. By using the Forecast Error Variance Decomposition techniques, the cause-effect analysis of foreign capital inflows and inflation was determined. Results provide evidence of a long run relationship between the series. Results further indicate that inflation is sensitive to foreign capital inflows variables such as net official development assistance received and remittance inflows in Nigeria. Policies that reduce the negative impact on inflation are recommended in the body of the paper.

scholarly journals The Impact of Behavioural Biases on Stock Volatility: Evidence From Pakistan Stock Exchange

2021 ◽  
Vol 5 (1) ◽  
pp. 215-225
Author(s):  
IRFAN ULLAH ◽  
DR. MUHAMMAD ZAHID ◽  
ZAIN ULLAH
Keyword(s):  
Quantitative Methods ◽  
Negative Impact ◽  
Positive Impact ◽  
Stock Exchange ◽  
Secondary Data ◽  
Efficient Market Hypothesis ◽  
The Body ◽  
Stock Volatility ◽  
Trading Volumes ◽  
The Impact

The main purpose of the current study is to investigate the impact of behavioural biases such as confidence, optimism, and pessimism on stock volatility evidence from Pakistan Stock Exchange (PSX). Prospect theory and overconfidence theory formed the foundation of this study. The methodology composed of positivist philosophical stance, deductive approach and quantitative methods with secondary data. Data analysis involved the use of descriptive statistics, correlation and regression. The study consists ofa 10-years analysis from June 2008 to June 2018 and includes daily trading volumes KSE-100 index in PSX. Results reveal that behavioral biases such as confidence have a positive impact on stock volatility. Similarly, optimism bias has also a positive impact on stock volatility. While pessimism bias has recorded a negative impact on stock volatility. Therefore, it is concluded that behavioural biases have an impact on stock volatility. The current study has a contribution to the body of knowledge on the ground that it attempts to change the traditional notion of society who believes in the efficient market hypothesis. The study has implications for different stakeholders of stock markets.

scholarly journals EVALUATION OF CYTOKINES AND HEAT SHOCK PROTEIN IN VIBRATION DISEASE

2018 ◽  
Vol 20 (6) ◽  
pp. 895-898 ◽  
Author(s):  
G. M. Bodienkova ◽  
S. I. Kurchevenko
Keyword(s):  
Heat Shock ◽  
Defense Mechanism ◽  
Vascular System ◽  
Negative Impact ◽  
Cell Damage ◽  
Statistical Processing ◽  
The Body ◽  
Immunological Study ◽  
Local Vibration ◽  
The Impact

The prolonged impact of industrial vibration on workers leads to the development of a vibrational disease (VB), which occupies a leading position in the structure of occupational pathology. VB from the impact of local vibration is a chronic occupational disease characterized by a predominant lesion of the nervous, vascular system and musculoskeletal system of the upper and lower extremities. One of the real ways to reduce the incidence is the early detection of the negative impact of vibration on the body of workers. In this regard, cytokines and heat shock proteins (HSP70) can be early and sensitive indicators that reflect the severity of health disorders from exposure to vibration. The aim of the study was to study changes in the content of pro- and antiinflammatory cytokines, extracellular HSP70 and their relationship in patients with VB. In the immunological study included 43 male patients with a diagnosis of VB. The criteria for inclusion in this group were: a verified diagnosis, written informed consent to participate in the study, the harmful effects of local vibration in the workplace. According to the data of hygienic control, the working conditions of workers in dangerous occupations by vibration belong to the 4 (dangerous) class due to intensive local vibration. The content of cytokines: IL-1β, IL-8, IL-10, TNFα and HSP70 in the serum of patients was determined by enzyme immunoassay. The blood sampling for the study was taken from patients only once on admission to the hospital before the treatment. Statistical processing of data was carried out with the help of packages of application programs Statistica for Windows 6.0 and Microsoft Excel. It was established that the development of VB disease is accompanied by imbalance of the cytokine profile, characterized by a decrease in the levels of IL-1β, IL-10 and an increase in IL-8. The inhibition of production of IL-1β and IL-10 is a consequence of the chronic process that has developed in the body of the patients examined. And the revealed decrease in extracellular concentration of HSP70 in comparison with practically healthy people can be caused by the accumulation of it inside the cell or on its surface. Correlation analysis revealed the relationship between a decrease in HSP70 and an increase in IL-1β, and a decrease in IL-10 levels. Synthesis of HSP is an intracellular defense mechanism that prevents cell damage by activating the synthesis and secretion of pro-inflammatory cytokines. The obtained relationships between cytokines and HSP70 testify to the involvement of HSP70 in immunoinflammatory processes in VB. The revealed changes contribute to the chronic inflammatory process and justify the progressive course of the VB.

scholarly journals Influence of stress factors on the personality of employees of the Russian penal system in the course of professional activity

2021 ◽  
Vol 228 (5) ◽  
pp. 35-46
Author(s):  
YULIYA A. SOKOLOVA ◽  
Keyword(s):  
Negative Impact ◽  
Emotional Health ◽  
The Body ◽  
Stress Factors ◽  
Professional Activity ◽  
Penal System ◽  
Structural Method ◽  
Factors Affecting ◽  
Professional Stress ◽  
The Impact

Abstract. The article examines the issues related to the influence of stress factors on the personality of penal system employees, analyzes the concept of stress, the symptoms of its manifestation, as well as the causes of stress. The article is devoted to the results of psycho-diagnostic research and scientific literature on the topic of the work. The research is aimed at studying stress factors affecting the personality of the penal system employees, confirming the statement that the professional activity of the penal system employees takes place in tense, conflict, extreme conditions, it is associated with the presence of permanent stress factors, which leads to the development of professional stress, has a negative impact on the mental and emotional state of the individual, affects the success of the performance of official duties. The methodological basis of the research includes methods of analysis and synthesis, statistical and system- structural method. As a result of this work, the concept of stress as a response of the body to the impact of the external environment has been studied, its symptoms have been identified. The stress factors of professional activity are analyzed, their negative impact on the personality of the penal system employees is investigated, professionally important qualities that prevent the negative impact of stress on the personality are highlighted. It has been established that the intensity of the stress factors’ impact on the personality of penal system employees depends on the length of service in the penal system, age, and the level of professionalism. Conclusions are drawn about the importance of preventing stressful conditions for maintaining and strengthening the mental and emotional health of employees, for reducing the risk of development of negative personality changes, for developing skills of overcoming and regulating stressful conditions, for the successful fulfillment of professional duties. Key words: professional stress, stress factors, professional activity, penal system employees, penal system.

scholarly journals RELATIONSHIP OF ADOLESCENTS BEHAVIOR TO CONSUMPTION OF SOFT DRINKS IN SMPN 5 PEKANBARU YEAR 2016

1930 ◽  
Vol 7 (02) ◽  
pp. 53-60
Author(s):  
Alhidayati ◽  
Nurhapipa ◽  
Rahma Putri
Keyword(s):  
Negative Impact ◽  
Calcium Deficiency ◽  
Soft Drinks ◽  
The Body ◽  
P Value ◽  
Negative Effects ◽  
Chi Square ◽  
Cross Sectional ◽  
The Impact

Behavior consumption of soft drinks are the actions or deeds regarding how often consume soft drinks per week is calculated. Carbonated drinks consumption habits will have a negative impact when it accumulates in the long term. Have been many studies that explain the negative effects of soft drinks, including carcinogenic benzene in soft drinks is very high, high phosphate content of vital minerals in the body that can trigger heart disease (magnesiumdeficiency), osteoporosis (calcium deficiency) and more. Based on the survey results of the sale of soft drinks in the cafeteria, 5 schools with the highest sales level, is SMP N 5 Pekanbaru selling 6-7 boxes per month. This type of research is quantitative with cross sectional design which was held on 16-18 May 2016 in SMP N 5 Pekanbaru. The population of this research is all student grades 7 and 8 SMP N 5 Pekanbaru which amounted to 541 people, with a sample size of 115 people. Data collected technique by stratified random sampling use questionnaire measuring instrument. Univariate data analysis and use your bivariate chi-square test. The results showed that there was a relationship between the knowledge obtained value (p value = 0.001 value POR = 2.14), Effect of friends (p value = 0.006 value POR = 3.45), Access (p value = 0.029 value POR = 2.70), And advertisement (p value = 0:01 value POR = 3.20) with the consumption of soft drinks. Suggested to the relevant instance, that is SMP N 5 Pekanbaru to provide education and information to as many students on the impact of consuming soft drinks for health when consumed in the long term and excessive, and form healthy canteen, or supervise the beverage products , to minimize the beverage products are bad for health.

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