An Insight into Unani Hypoglycemic Drugs and Their Mechanism of Action.

2020 ◽  
Vol 23 ◽  
Author(s):  
Mohammad Fazil ◽  
Sadia Nikhat ◽  
Imran Ali
Keyword(s):  
Critical Evaluation ◽  
Complete Information ◽  
Convincing Evidence ◽  
Significant Activity ◽  
Type Ii ◽  
Major Health Problem ◽  
Major Health ◽  
Diabetes Mellitus Type Ii ◽  
Unani Medicine ◽  
Insight Into

Background: Diabetes mellitus type-II is a major health problem characterized by hypo-insulinemia and insulin resistance; leading to hyperglycemia and its complications. In Unani medicine, it is known as ziyābetus. Several drugs are prescribed in Unani medicine as single and compound formulations for this disease. Most of these drugs have been studied on scientific parameters and shown significant activity in reducing the symptoms and complications of diabetes. Objectives: Critical evaluation of Unani medicines for treating diabetes patients. To provide complete information on this subject with the action of the mechanism so that proper treatment should be done with prospective research. Methods: Unani literature was reviewed extensively via various search engines for the herbs, shrubs used for diabetes treatment. Ten drugs were selected for the present review. Results and Conclusion: There is convincing evidence to suggest that the selected drugs have promising actions against diabetes and its complications. Also, none of the studies has reported any adverse effects with the drugs. Also, there is evidence to suggest that the method of usage described in Unani medicine may reduce or eliminate adverse events if any. Further, there is a great need to do more research on making medicine more effective. Besides, the review article is useful for treating patients effectively by advancing the research.

An Insight Into Unani Hypoglycemic Drugs And Their Mechanism of Action

2019 ◽  
Vol 05 ◽  
Author(s):  
Sadia Nikhat ◽  
Mohd. Fazil
Keyword(s):  
Adverse Events ◽  
Scientific Evidence ◽  
Public Health Problem ◽  
Convincing Evidence ◽  
Major Public Health Problem ◽  
Significant Activity ◽  
Preparation Methods ◽  
Diabetes Mellitus Type Ii ◽  
Unani Medicine ◽  
Action Mechanisms

Background: Diabetes mellitus type-II is a major public health problem characterized by hypo-insulinemia and insulin resistance leading to hyperglycemia and its complications. In Unani medicine, it is known as ziyābetus. Several drugs are prescribed in Unani medicine as single and compound formulations for various abnormalities caused by the disease. Most of these drugs have been studied on scientific parameters and have shown significant activity in reducing the symptoms and complications of diabetes. Objectives: The literature research was planned with the objective to find out the action mechanisms of certain selected herbal drugs of Unani medicine, with evidence of their efficacy. Methods: Unani literature was first reviewed extensively and the most frequently-prescribed and easily available drugs for diabetes were selected, followed by a search on major internet search engines for scientific evidence of their efficacy alongwith information of their active ingredient and dosage. Ten drugs were selected for the present review. Results and Conclusion: There is convincing evidence to suggest that the selected drugs have a promising action against diabetes and its complications. Also, there are largely no adverse events reported and some of the preparation methods described in Unani medicine have been proven to reduce or eliminate the adverse events, if any.

Management of Prameha with Mustadi Kwatha - A Case Study

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Akshay H. Malshikare ◽  
Dr. Sharada Chikurte
Keyword(s):  
Type Ii Diabetes ◽  
Single Case ◽  
Type Ii Diabetes Mellitus ◽  
Ayurvedic Medicine ◽  
Type Ii ◽  
Single Case Study ◽  
Major Health Problem ◽  
Major Health ◽  
Uncontrolled Diabetes

Diabetes is a major health problem in whole world. In spite of many drugs available, uncontrolled diabetes remains a challenge. Moreover, some anti-diabetic drugs are on the verge of withdrawal due to its adverse effects. So, there is an acute need for a new effective and safe drug. So in this case study we used Ayurvedic medicine ‘Mustadi Kwatha’ mentioned in Bhaishajya Ratnawali in Prameha Chikitsa. A single case study was done on use of Mustadi Kwatha on Type II Diabetes Mellitus. Significant reduction was seen in blood sugar level fasting and post-prandial.

scholarly journals Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

2019 ◽  
Vol 20 (24) ◽  
pp. 6284 ◽  
Author(s):  
Dae Yun Seo ◽  
Jeong Rim Ko ◽  
Jung Eun Jang ◽  
Tae Nyun Kim ◽  
Jae Boum Youm ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Protective Effects ◽  
Potential Therapeutic Target ◽  
Major Health Problem ◽  
Major Health ◽  
Positive Effects ◽  
Underlying Mechanisms ◽  
Microvascular Diseases ◽  
Insight Into

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

scholarly journals Innate Immune Recognition ofMycobacterium tuberculosis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Johanneke Kleinnijenhuis ◽  
Marije Oosting ◽  
Leo A. B. Joosten ◽  
Mihai G. Netea ◽  
Reinout Van Crevel
Keyword(s):  
Mannose Receptor ◽  
Epidemiological Studies ◽  
Innate Immune ◽  
Immune Recognition ◽  
Major Health Problem ◽  
Lectin Receptors ◽  
Major Health ◽  
Downstream Signaling ◽  
Genes Encoding ◽  
Insight Into

Tuberculosis (TB), caused byMycobacterium tuberculosis(MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense againstM. tuberculosis, and the first step in this process is recognition of MTB by cells of the innate immune system. Several classes of pattern recognition receptors (PPRs) are involved in the recognition ofM. tuberculosis, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs). Among the TLR family, TLR2, TLR4, and TLR9 and their adaptor molecule MyD88 play the most prominent roles in the initiation of the immune response against tuberculosis. In addition to TLRs, other PRRs such as NOD2, Dectin-1, Mannose receptor, and DC-SIGN are also involved in the recognition ofM. tuberculosis. Human epidemiological studies revealed that genetic variation in genes encoding for PRRs and downstream signaling products influence disease susceptibility, severity, and outcome. More insight into PRRs and the recognition of mycobacteria, combined with immunogenetic studies in TB patients, does not only lead to a better understanding of the pathogenesis of tuberculosis but also may contribute to the design of novel immunotherapeutic strategies.

scholarly journals Natural Phyto-Active Antihyperglycemic Moieties as Preventive Therapeutics for Diabetes Type II

2019 ◽  
Vol 6 (sp1) ◽  
Author(s):  
Priyanka Agnihotri ◽  
Harsha Kashyap ◽  
Sarika Gupta
Keyword(s):  
Health Concern ◽  
Type Ii ◽  
Plant Metabolites ◽  
Promising Candidate ◽  
Major Health ◽  
Diabetes Mellitus Type Ii ◽  
Diabetes Type Ii ◽  
Natural Remedy ◽  
Impaired Insulin ◽  
Lifestyle Diseases

Diabetes mellitus type-II (DM II) is a state characterized by hyperglycemia as fallout of endocrine dysfunction. This condition comes under the category of lifestyle diseases. The impaired insulin secretion, resistance or a combination of both results in the dysregulation of carbohydrate, protein and lipid metabolism. The extremities of this state are associated with other detrimental complications such as cardiomyopathy, retinopathy, nephropathy, hepatopathy and neuropathy etc. DM II has now become a growing epidemic and a major health concern globally. Naturopathy deals with the development of promising therapeutics using herbal origin to ensure minimal or no other side effects with best efficacy of the drug as a promising candidate against a diseased condition. Therefore the review aims to find out a range of medicinal plants that can be used as a natural remedy for the management of DM II, through isolation of active plant moieties (specifically proteins) with antihyperglycemic properties. The active plant metabolites, with antidiabetic potential based on the available pharmacological reports are used as herbal cure against DM II. These isolated active plant moieties, possessing antihyperglycemic properties, might play a significant role in the development of a formulation of plant protein moieties (as a preventive therapeutic) to reduce the prevalence of DM II and to serve the mankind.

scholarly journals Gradings of periodontitis in relation with systemic disease

2021 ◽  
Vol 8 (7) ◽  
pp. 3671
Author(s):  
Abdulhameed G. Albeshr ◽  
Yazeed A. Alhabdan ◽  
Raef Mohamad Aljasem ◽  
Maha Assad Munshi ◽  
Ahmed Mohammadhassan Bagasi ◽  
...  
Keyword(s):  
Respiratory Tract Infections ◽  
Systemic Disease ◽  
Systemic Diseases ◽  
Major Health Problem ◽  
Major Health ◽  
Proper Management ◽  
Key Factor ◽  
Artery Disease ◽  
Tract Infections ◽  
Insight Into

With the increasing prevalence rates of periodontitis cases, it has a great impact on human health, especially elderly patients. It constitutes a major health problem that can cause significant burdens. Infections are the main pathology that have been previously reported among studies in the literature because it has a strong correlation. There are common mechanisms that can cause systemic diseases: induction of systemic inflammation, inflammatory markers, the release of toxins, and translocation into other organs through the bloodstream. Proving the correlation between the potential presence of the involved pathogen and systemic diseases might be a significant key factor in predicting these systemic events. In addition, it will assist to have proper management in early intervention. The aim of the study was to provide more insight into the effect of correlation between periodontitis and other systemic diseases according to studies in the literature. Multiple organisms that can cause periodontitis have been significantly correlated with the development of many systemic diseases, such as atherosclerosis, coronary artery disease (CAD), pneumonia, respiratory tract infections, oral and colorectal cancers, diabetes and Alzheimer’s disease. Moreover, Porphyromonas gingivalis has been commonly reported with the variously discussed systemic diseases which should draw more attention towards the proper management and prevent this organism and other microbes within the literature to enhance the outcomes.

scholarly journals Management of Madhumeha with Vallipanchmool Churna – A Case Study.

2021 ◽  
Vol 5 (04) ◽  
Author(s):  
Payal Thakur Payal
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Single Case ◽  
Type Ii Diabetes Mellitus ◽  
Ayurvedic Medicine ◽  
Type Ii ◽  
Major Health Problem ◽  
Major Health ◽  
Modern System

Diabetes Mellitus is a major health problem in the whole world. In spite of tremendous advancements of the modern system of medicine as OAD (oral anti-diabetic drug) and insulin therapy, to date, an ideal drug that can control hyperglycemia is still a distant dream. It has been a challenge for Ayurveda to search for additional effective solutions resulting in the better management of the disease. There is a need for effective, safe and potent medicine which can control hyperglycemia related to type II diabetes and has no side effects.  In this case study, we used Ayurvedic medicine ‘Vallipanchmoolchurna’ mentioned in Sushruta Samhita in a single case study which was done on the use of  Vallipanchmool churna on type II Diabetes Mellitus. A significant reduction was seen in blood sugar level fasting and post-meal.

scholarly journals Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

2019 ◽  
Author(s):  
Dae Yun Seo ◽  
Jeong Rim Ko ◽  
Jung Eun Jang ◽  
Tae Nyun Kim ◽  
Jae Boum Youm ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Protective Effects ◽  
Potential Therapeutic Target ◽  
Major Health Problem ◽  
Major Health ◽  
Positive Effects ◽  
Underlying Mechanisms ◽  
Microvascular Diseases ◽  
Insight Into

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising from diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include the prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function, and calcium regulation. The present review summarizes the recent findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

Prevention and Treatment of Early Childhood Caries (ECC)

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Jeffrey .
Keyword(s):  
Early Childhood ◽  
Health Problem ◽  
Early Childhood Caries ◽  
Health Providers ◽  
Missing Teeth ◽  
Optimal Basis ◽  
Major Health Problem ◽  
Major Health ◽  
Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

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