scholarly journals Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

2019 ◽  
Author(s):  
Dae Yun Seo ◽  
Jeong Rim Ko ◽  
Jung Eun Jang ◽  
Tae Nyun Kim ◽  
Jae Boum Youm ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Protective Effects ◽  
Potential Therapeutic Target ◽  
Major Health Problem ◽  
Major Health ◽  
Positive Effects ◽  
Underlying Mechanisms ◽  
Microvascular Diseases ◽  
Insight Into

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising from diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include the prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function, and calcium regulation. The present review summarizes the recent findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

scholarly journals Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

2019 ◽  
Vol 20 (24) ◽  
pp. 6284 ◽  
Author(s):  
Dae Yun Seo ◽  
Jeong Rim Ko ◽  
Jung Eun Jang ◽  
Tae Nyun Kim ◽  
Jae Boum Youm ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Protective Effects ◽  
Potential Therapeutic Target ◽  
Major Health Problem ◽  
Major Health ◽  
Positive Effects ◽  
Underlying Mechanisms ◽  
Microvascular Diseases ◽  
Insight Into

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

Wogonin Alleviates Hyperglycemia Through Increased Glucose Entry into Cells Via AKT/GLUT4 Pathway

2019 ◽  
Vol 25 (23) ◽  
pp. 2602-2606 ◽  
Author(s):  
Shahzad Khan ◽  
Mohammad A. Kamal
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Modern World ◽  
Major Health Problem ◽  
Major Health ◽  
Chronic Hyperglycemia ◽  
Main Factor

: Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health problem in the modern world. Many drugs have been tested to control hyperglycemia which is believed to be the main factor behind many of the diabetes-related late-term complications. Wogonin is a famous herbal medicine which has been shown to be effective in controlling diabetes and its complications. In our previous work, we showed that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we mainly explained wogonin anti-hyperglycemic property through AKT/GLUT4 pathway. Here we briefly discussed that wogonin increases Glut4 trafficking to plasma membrane which allows increased entry of glucose and thus alleviates hyperglycemia. Conclusion: Wogonin can be used as an anti-diabetic and anti-hyperglycemic drug and works via AKT/GLUT4 pathway.

scholarly journals Effect of Maternal Gestational Diabetes on Infant Feeding and Growth

Proceedings ◽  
2019 ◽  
Vol 37 (1) ◽  
pp. 26
Author(s):  
Manerkar ◽  
Harding ◽  
Conlon ◽  
McKinlay
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Infant Feeding ◽  
Health Problem ◽  
Major Health Problem ◽  
Major Health ◽  
Obesity And Diabetes ◽  
In Pregnancy

Gestational diabetes mellitus (GDM) is a major health problem not only in pregnancy but alsofor lifelong health, with increased risks of obesity and diabetes in offspring [...]

The positive effects and underlying mechanisms of Undaria pinnatifida polysaccharides on type 2 diabetes mellitus in rats

2021 ◽  
Author(s):  
Zhao-Rong Li ◽  
Rui-Bo Jia ◽  
Luo Donghui ◽  
Lianzhu Lin ◽  
Zheng Qianwen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Rat Model ◽  
Undaria Pinnatifida ◽  
Current Work ◽  
Loading Test ◽  
Positive Effects ◽  
Underlying Mechanisms

The aim of current work was to investigate the anti-diabetic effects and underlying mechanisms of Undaria pinnatifida polysaccharides (UPP) based on T2DM rat model. The starch loading test showed that...

An Insight into Unani Hypoglycemic Drugs and Their Mechanism of Action.

2020 ◽  
Vol 23 ◽  
Author(s):  
Mohammad Fazil ◽  
Sadia Nikhat ◽  
Imran Ali
Keyword(s):  
Critical Evaluation ◽  
Complete Information ◽  
Convincing Evidence ◽  
Significant Activity ◽  
Type Ii ◽  
Major Health Problem ◽  
Major Health ◽  
Diabetes Mellitus Type Ii ◽  
Unani Medicine ◽  
Insight Into

Background: Diabetes mellitus type-II is a major health problem characterized by hypo-insulinemia and insulin resistance; leading to hyperglycemia and its complications. In Unani medicine, it is known as ziyābetus. Several drugs are prescribed in Unani medicine as single and compound formulations for this disease. Most of these drugs have been studied on scientific parameters and shown significant activity in reducing the symptoms and complications of diabetes. Objectives: Critical evaluation of Unani medicines for treating diabetes patients. To provide complete information on this subject with the action of the mechanism so that proper treatment should be done with prospective research. Methods: Unani literature was reviewed extensively via various search engines for the herbs, shrubs used for diabetes treatment. Ten drugs were selected for the present review. Results and Conclusion: There is convincing evidence to suggest that the selected drugs have promising actions against diabetes and its complications. Also, none of the studies has reported any adverse effects with the drugs. Also, there is evidence to suggest that the method of usage described in Unani medicine may reduce or eliminate adverse events if any. Further, there is a great need to do more research on making medicine more effective. Besides, the review article is useful for treating patients effectively by advancing the research.

scholarly journals Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wenjie Lv ◽  
Lei Wang ◽  
Jianhua Lu ◽  
Jiasheng Mu ◽  
Yingbin Liu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Gallbladder Cancer ◽  
Noncoding Rna ◽  
Poor Prognosis ◽  
Noncoding Rnas ◽  
Migration And Invasion ◽  
Potential Therapeutic Target ◽  
Cell Migration And Invasion ◽  
Underlying Mechanisms ◽  
Insight Into

Gallbladder cancer (GBC) is one of the mostly aggressive diseases with poor prognosis due to the lack of severe symptoms. To date, little is known about the potential roles and underlying mechanisms of long noncoding RNAs (lncRNAs) in GBC initiation and progression. Thus, it provides us with a novel insight into the contribution of lncRNAs to GBC development. Remarkably, we found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials. Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system. Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression. Moreover, the expression ofβ-Catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. Thus, our findings suggested that KIAA0125 promoted the migration and invasion of GBC cells and could serve as a potential therapeutic target in advanced GBC.

scholarly journals Hyperglycemic memory in diabetic cardiomyopathy

2021 ◽  
Author(s):  
Jiabing Zhan ◽  
Chen Chen ◽  
Dao Wen Wang ◽  
Huaping Li
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Blood Glucose ◽  
Cardiovascular Diseases ◽  
Glycemic Control ◽  
Diabetic Cardiomyopathy ◽  
Cardiovascular Complication ◽  
Diabetes Therapy ◽  
Patients With Diabetes ◽  
Underlying Mechanisms

AbstractCardiovascular diseases account for approximately 80% of deaths among individuals with diabetes mellitus, with diabetic cardiomyopathy as the major diabetic cardiovascular complication. Hyperglycemia is a symptom that abnormally activates multiple downstream pathways and contributes to cardiac hypertrophy, fibrosis, apoptosis, and other pathophysiological changes. Although glycemic control has long been at the center of diabetes therapy, multicenter randomized clinical studies have revealed that intensive glycemic control fails to reduce heart failure-associated hospitalization and mortality in patients with diabetes. This finding indicates that hyperglycemic stress persists in the cardiovascular system of patients with diabetes even if blood glucose level is tightly controlled to the normal level. This process is now referred to as hyperglycemic memory (HGM) phenomenon. We briefly reviewed herein the current advances that have been achieved in research on the underlying mechanisms of HGM in diabetic cardiomyopathy.

scholarly journals Innate Immune Recognition ofMycobacterium tuberculosis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Johanneke Kleinnijenhuis ◽  
Marije Oosting ◽  
Leo A. B. Joosten ◽  
Mihai G. Netea ◽  
Reinout Van Crevel
Keyword(s):  
Mannose Receptor ◽  
Epidemiological Studies ◽  
Innate Immune ◽  
Immune Recognition ◽  
Major Health Problem ◽  
Lectin Receptors ◽  
Major Health ◽  
Downstream Signaling ◽  
Genes Encoding ◽  
Insight Into

Tuberculosis (TB), caused byMycobacterium tuberculosis(MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense againstM. tuberculosis, and the first step in this process is recognition of MTB by cells of the innate immune system. Several classes of pattern recognition receptors (PPRs) are involved in the recognition ofM. tuberculosis, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs). Among the TLR family, TLR2, TLR4, and TLR9 and their adaptor molecule MyD88 play the most prominent roles in the initiation of the immune response against tuberculosis. In addition to TLRs, other PRRs such as NOD2, Dectin-1, Mannose receptor, and DC-SIGN are also involved in the recognition ofM. tuberculosis. Human epidemiological studies revealed that genetic variation in genes encoding for PRRs and downstream signaling products influence disease susceptibility, severity, and outcome. More insight into PRRs and the recognition of mycobacteria, combined with immunogenetic studies in TB patients, does not only lead to a better understanding of the pathogenesis of tuberculosis but also may contribute to the design of novel immunotherapeutic strategies.

scholarly journals Gradings of periodontitis in relation with systemic disease

2021 ◽  
Vol 8 (7) ◽  
pp. 3671
Author(s):  
Abdulhameed G. Albeshr ◽  
Yazeed A. Alhabdan ◽  
Raef Mohamad Aljasem ◽  
Maha Assad Munshi ◽  
Ahmed Mohammadhassan Bagasi ◽  
...  
Keyword(s):  
Respiratory Tract Infections ◽  
Systemic Disease ◽  
Systemic Diseases ◽  
Major Health Problem ◽  
Major Health ◽  
Proper Management ◽  
Key Factor ◽  
Artery Disease ◽  
Tract Infections ◽  
Insight Into

With the increasing prevalence rates of periodontitis cases, it has a great impact on human health, especially elderly patients. It constitutes a major health problem that can cause significant burdens. Infections are the main pathology that have been previously reported among studies in the literature because it has a strong correlation. There are common mechanisms that can cause systemic diseases: induction of systemic inflammation, inflammatory markers, the release of toxins, and translocation into other organs through the bloodstream. Proving the correlation between the potential presence of the involved pathogen and systemic diseases might be a significant key factor in predicting these systemic events. In addition, it will assist to have proper management in early intervention. The aim of the study was to provide more insight into the effect of correlation between periodontitis and other systemic diseases according to studies in the literature. Multiple organisms that can cause periodontitis have been significantly correlated with the development of many systemic diseases, such as atherosclerosis, coronary artery disease (CAD), pneumonia, respiratory tract infections, oral and colorectal cancers, diabetes and Alzheimer’s disease. Moreover, Porphyromonas gingivalis has been commonly reported with the variously discussed systemic diseases which should draw more attention towards the proper management and prevent this organism and other microbes within the literature to enhance the outcomes.

scholarly journals Management of Madhumeha with Vallipanchmool Churna – A Case Study.

2021 ◽  
Vol 5 (04) ◽  
Author(s):  
Payal Thakur Payal
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Single Case ◽  
Type Ii Diabetes Mellitus ◽  
Ayurvedic Medicine ◽  
Type Ii ◽  
Major Health Problem ◽  
Major Health ◽  
Modern System

Diabetes Mellitus is a major health problem in the whole world. In spite of tremendous advancements of the modern system of medicine as OAD (oral anti-diabetic drug) and insulin therapy, to date, an ideal drug that can control hyperglycemia is still a distant dream. It has been a challenge for Ayurveda to search for additional effective solutions resulting in the better management of the disease. There is a need for effective, safe and potent medicine which can control hyperglycemia related to type II diabetes and has no side effects.  In this case study, we used Ayurvedic medicine ‘Vallipanchmoolchurna’ mentioned in Sushruta Samhita in a single case study which was done on the use of  Vallipanchmool churna on type II Diabetes Mellitus. A significant reduction was seen in blood sugar level fasting and post-meal.

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