Pathogenesis of COVID-19, Disease outbreak: A Review

2021 ◽  
Vol 22 ◽  
Author(s):  
Himanshu Sharma ◽  
Sonia Singh ◽  
Shilpi Pathak
Keyword(s):  
Specific Treatment ◽  
Host Cells ◽  
World Health ◽  
Respiratory Disorder ◽  
Epidemic Disease ◽  
Major Health Problem ◽  
The World ◽  
Health Organization ◽  
Collective Information ◽  
Death Cases

: Coronavirus-19 causing a severe acute respiratory disorder in humans and becoming a major health problem. Its expansion takes place very rapidly throughout the world since it has been first identified in Wuhan, China (December 2019). The causative virus is known as severe acute respiratory syndrome coronavirus 2. And the World Health Organization has named this respiratory syndrome as a new epidemic disease called COVID-19. The incidence of COVID-19 continues to increase with three million confirmed infected cases and with 244,000 death cases worldwide. Still, now there is no specific treatment or vaccine available against COVID- 19. The collective information about the different aspects of COVID-19 viral infection has gathered from renowned journals, and electronic databases including Science Direct, Web of Science, Scopus and PubMed from 1990 to 2020 The current manuscript has highlighted transmission and symptoms. Therefore, the current manuscript also included says how the SARS-CoV 2 can facilitate the debut of the virus into targeted host cells.

scholarly journals The Pathogenesis of Coronavirus Disease 2019 (COVID-19): Evaluation and Prevention

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Hayat Ouassou ◽  
Loubna Kharchoufa ◽  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hamada Imtara ◽  
...  
Keyword(s):  
Specific Treatment ◽  
Respiratory Illness ◽  
World Health ◽  
Epidemic Disease ◽  
Major Health Problem ◽  
Major Health ◽  
Hygienic Measures ◽  
Health Organization ◽  
Pharmaceutical Interventions ◽  
Severe Acute Respiratory Illness

Coronavirus Disease 2019 (COVID-19) has become a major health problem causing severe acute respiratory illness in humans. It has spread rapidly around the globe since its first identification in Wuhan, China, in December 2019. The causative virus is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the World Health Organization (WHO) named the new epidemic disease Coronavirus Disease (COVID-19). The incidence of COVID-19 continues to increase with more than three million confirmed cases and over 244,000 deaths worldwide. There is currently no specific treatment or vaccine against COVID-19. Therefore, in the absence of pharmaceutical interventions, the implementation of precautions and hygienic measures will be essential to control and to minimize human transmission of the virus. In this review, we highlight the epidemiology, transmission, symptoms, and treatment of this disease, as well as future strategies to manage the spread of this fatal coronavirus.

Repurposing Drugs for the Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19)

2020 ◽  
Vol 26 ◽  
Author(s):  
Evellyn Claudia Wietzikoski Lovato ◽  
Lorena Neris Barboza ◽  
Samantha Wietzikoski ◽  
Amanda Nascimento Vasques de Souza ◽  
Pablo Alvarez Auth ◽  
...  
Keyword(s):  
Palliative Treatment ◽  
Specific Treatment ◽  
Clinical Severity ◽  
Host Cells ◽  
World Health ◽  
Specific Drug ◽  
Interferon Β ◽  
Therapeutic Value ◽  
The World ◽  
Health Organization

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19) by the World Health Organization, is a newly emerging zoonotic agent that emerged in China in December 2019. No specific treatment for COVID-19 is currently available. Usual palliative treatment includes maintaining hydration and nutrition and controlling fever and cough. The clinical severity and extent of transmission need to be determined, and therapeutic options need to be developed and optimized. Methods: The present review discusses the recent repurposing of drugs for COVID-19 treatment. Results: Several compounds, including remdesivir, lopinavir, ritonavir, interferon-β, ribavirin, chloroquine/hydroxychloroquine, azithromycin, tocilizumab, and ivermectin, have emerged as promising alternatives. They block the virus from entering host cells, prevent viral replication, and attenuate exacerbation of the host's immune response. Conclusion: Although some evidence indicates the positive actions of different classes of compounds for the treatment of COVID-19, few clinical assays have been established to definitively demonstrate their therapeutic value in humans. Multicenter clinical studies are urgently needed to validate and standardize therapeutic regimens that involve these agents. Although science has not yet presented us with a specific drug against COVID-19, the repurposing of drugs appears to be promising in our fight against this devastating disease.

ARIMA model for forecasting COVID-19 Death cases in India (Preprint)

2020 ◽  
Author(s):  
Jeya Sutha M
Keyword(s):  
Arima Model ◽  
Public Health Emergency ◽  
World Health ◽  
The People ◽  
The World ◽  
The Status ◽  
The Government ◽  
Health Organization ◽  
Spread Of Infection ◽  
Death Cases

UNSTRUCTURED COVID-19, the disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly contagious disease. On January 30, 2020 the World Health Organization declared the outbreak as a Public Health Emergency of International Concern. As of July 25, 2020; 15,947,292 laboratory-confirmed and 642,814 deaths have been reported globally. India has reported 1,338,928 confirmed cases and 31,412 deaths till date. This paper presents different aspects of COVID-19, visualization of the spread of infection and presents the ARIMA model for forecasting the status of COVID-19 death cases in the next 50 days in order to take necessary precaution by the Government to save the people.

scholarly journals Correlation Between Temperature and COVID-19 (Suspected, Confirmed and Death) Cases based on Machine Learning Analysis

2020 ◽  
Vol 14 (suppl 1) ◽  
pp. 1017-1024 ◽  
Author(s):  
Mohammad Khubeb Siddiqui ◽  
Ruben Morales-Menendez ◽  
Pradeep Kumar Gupta ◽  
Hafiz M.N. Iqbal ◽  
Fida Hussain ◽  
...  
Keyword(s):  
Machine Learning ◽  
World Health ◽  
Effect Of Temperature ◽  
Machine Learning Method ◽  
Contributing Factors ◽  
Data Set ◽  
The World ◽  
Health Organization ◽  
Death Cases ◽  
Learning Analysis

Currently, the whole world is struggling with the biggest health problem COVID-19 name coined by the World Health Organization (WHO). This was raised from China in December 2019. This pandemic is going to change the world. Due to its communicable nature, it is contagious to both medically and economically. Though different contributing factors are not known yet. Herein, an effort has been made to find the correlation between temperature and different cases situation (suspected, confirmed, and death cases). For a said purpose, k-means clustering-based machine learning method has been employed on the data set from different regions of China, which has been obtained from the WHO. The novelty of this work is that we have included the temperature field in the original WHO data set and further explore the trends. The trends show the effect of temperature on each region in three different perspectives of COVID-19 – suspected, confirmed and death.

scholarly journals RNA Editing and Modifications in Mood Disorders

Genes ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 872 ◽  
Author(s):  
Alessandro Barbon ◽  
Chiara Magri
Keyword(s):  
Gene Expression ◽  
Rna Editing ◽  
Well Being ◽  
World Health ◽  
Rna Modifications ◽  
Major Health Problem ◽  
Rna Molecules ◽  
The World ◽  
Health Organization

Major depressive disorder (MDD) is a major health problem with significant limitations in functioning and well-being. The World Health Organization (WHO) evaluates MDD as one of the most disabling disorders in the world and with very high social cost. Great attention has been given to the study of the molecular mechanism underpinning MDD at the genetic, epigenetic and proteomic level. However, the importance of RNA modifications has attracted little attention until now in this field. RNA molecules are extensively and dynamically altered by a variety of mechanisms. Similar to “epigenomic” changes, which modify DNA structure or histones, RNA alterations are now termed “epitranscriptomic” changes and have been predicted to have profound consequences for gene expression and cellular functionality. Two of these modifications, adenosine to inosine (A-to-I) RNA editing and m6A methylations, have fascinated researchers over the last years, showing a new level of complexity in gene expression. In this review, we will summary the studies that focus on the role of RNA editing and m6A methylation in MDD, trying to underline their potential breakthroughs and pitfalls.

Safe Use of Sodium Dodecyl Sulfate (SDS) to Deactivate SARS-CoV-2: An Evidence-Based Systematic Review

Coronaviruses ◽  
2021 ◽  
Vol 01 ◽  
Author(s):  
Ashok Kumar ◽  
Waseem Ahmad Ansari ◽  
Tanveer Ahamad ◽  
Mohammad Saquib ◽  
Mohammad Faheem Khan
Keyword(s):  
Sodium Dodecyl Sulfate ◽  
Sodium Dodecyl ◽  
Virus Transmission ◽  
Specific Treatment ◽  
World Health ◽  
The World ◽  
Dodecyl Sulfate ◽  
Chemical Disinfectant ◽  
Health Organization ◽  
Simplex Virus

Background: Coronavirus disease (COVID-19) has now morphed into the most serious healthcare challenge that the world has faced in a century. The coronavirus disease (COVID-19) was declared as a public health emergency of international concern (PHEIC) on January 30, 2020, and a pandemic on March 11 by the World Health Organization (WHO). The number of cases and the death toll are rapidly increasing day by day because of its fast transmission from human to human through droplets, contaminated hands or body, and inanimate surfaces. Objective: SDS has been found to exhibit broad-spectrum and effective microbicidal and viral inactivation agents through the denaturation of both envelope and non-envelop proteins. Method: Viable SARS-COV-2 particles may also be found on contaminated sites such as steel surfaces, plastic surfaces, stainless steel, cardboard, and glass surfaces that can serve as a source of virus transmission. We reviewed the available literature about the SARS-CoV-2 persistence on inanimate surfaces as well as the decontamination strategies of corona and other viruses by using Sodium dodecyl sulfate (SDS) as well as other cleaning chemicals and disinfectants. Result: The efficacy of SDS has been amply demonstrated in several studies involving human immunodeficiency virus (HIV), human papillomavirus (HPV) and herpes simplex virus (HSV). SDS has also been found as deactivator of SARSCoV-2. In toxic profile, up to 1% concentration of SDS is safe for humans and showed no toxic effect if ingested. Conclusion: Since no specific treatment is available as yet so containment and prevention continue to be important strategies against COVID-19. In this context, SDS can be an effective chemical disinfectant to slow and stop the further transmissions and spread of COVID-19.

scholarly journals Update on the SARS-CoV-2 (COVID-19) Outbreak: A Global Pandemic Challenge

2020 ◽  
Author(s):  
Abhishek Kumar Soni
Keyword(s):  
World Health ◽  
Global Public Health ◽  
Global Challenge ◽  
Global Pandemic ◽  
Therapeutic Algorithms ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control ◽  
Death Cases

The 2019 novel coronavirus (previously 2019-nCoV) or coronavirus infectious disease 2019 (COVID-19) outbreak has been summarized as on March 29, 2020. COVID-19 is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SERS-CoV-2). The disease was first seen during an outbreak in Wuhan, China and continuous spreading from human to human around the sphere. The disease is uncontrolled and increasing the death toll through. The world is facing a global challenge to protect human lives caused by coronavirus outbreak. The number of infected patients is increasing day by day due to COVID-19 as a pandemic. The world health organization (WHO) has declared global public health emergency on January 30, 2020. The disease has been spread around 201 countries with total confirmed cases 634835 and death cases 29891 as on March 29, 2020. The goal of this review to summaries and update the clinical/medical features and suggestions for diagnosis of the COVID-19 as a pandemic. The discussion of the various therapeutic algorithms, risk, prevention and control based on the latest reports has been provided.

scholarly journals The Infection of COVID-19 among Health Care Workers in Dharmais Cancer Hospital

2021 ◽  
Vol 15 (1) ◽  
pp. 1
Author(s):  
Mutiara Adelina ◽  
Fifi Dwijayanti
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
World Health ◽  
Care Workers ◽  
The World ◽  
Risk Condition ◽  
Contact Transmission ◽  
Health Organization ◽  
And Control ◽  
Death Cases

Infectious diseases are one of the biggest threats to humans. Currently, the world is in the outbreak condition causes of the COVID-19 virus which is started from Wuhan, China in December 2019. This disease was spread out rapidly throughout the World and was announced as a pandemic by the World Health Organization (WHO) on March 11, 2020(1). The infected number of SARS-CoV-2 was over 84 million people and caused over 1 million death cases in the worldwide. Indonesia had more than 800.000 infectious cases and 23.000 of death cases with the highest cases in Jakarta (2). This virus can be transmitted by two ways, such as direct contact (cough, sneeze, and droplet inhalation) and contact transmission (contact with oral, nasal, and eye mucous membranes) of person with COVID-19 (3). The current COVID-19 pandemic makes various challenges in prevention and control of infections in hospitals. Health care workers (HCWs) have been providing care to suspected, probable or confirmed COVID-19 patients that make them in high-risk condition. Several study indicated that many HCWs have been infected with SARS-CoV-2 in many hospitals worldwide (4)(5)(6).

scholarly journals Recent Discovery and Development on SARS-CoV-2: A Review of Current Literature

2020 ◽  
Author(s):  
V Deepak Bamola ◽  
Rama Chaudhry
Keyword(s):  
Specific Treatment ◽  
Central China ◽  
World Health ◽  
Diagnostic Tools ◽  
Future Research ◽  
Wuhan City ◽  
Global Challenge ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Origin and spread of current novel coronavirus raised serious concerns among stakeholders around the globe. Different speculations which may unfold the mystery in the future are taking roots, but now there is no globally acceptable opinion about the origin and spread of this novel coronavirus. It is reported that Wuhan city of Hubei Province of central China was the epicenter of this outbreak of novel coronavirus. However, initial inadequate preventive measures allowed the infection to cross the borders of China and that pull the world into a drastic public health and economic crisis. This novel coronavirus disease now named as COVID-19 by World Health Organization (WHO) and the responsible coronavirus is named as ‘severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)’. The spread of SARS-CoV-2 is alarming even after five months of inception and WHO further warns the world to be prepared for more intense spread of COVID-19. Different diagnostic tools to detect SARS-CoV-2 are being used around the globe, but the identification of asymptomatic carriers of the disease is a serious challenge in countering the COVID-19 pandemic. There is no specific treatment available, only preventive, symptomatic and supportive treatments are being used for clinical management of COVID-19. The available knowledge is limited therefore any escalation of information on the disease will help to combat with this global challenge of COVID-19. In this review, we have discussed and summarized the available multi-factorial information and recent updates on the SARS-CoV-2 which can support future research and may help in the strategic management of currentCOVID-19 pandemic. The articles available online before 30 April 2020 on bioRxiv, medRxiv, ChemRxiv, Google scholar and PubMed have been assessed for compilation of this review. Information on the official portal of WHO, CDC, ICMR etc were also assessed and used with due credit.

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