An Evaluation of the Antioxidant and Anticancer Properties of Complex Compounds of Copper (II), Platinum (II), Palladium (II) and Ruthenium (III) for Use in Cancer Therapy

Background: Essential oils are complex mixtures of low molecular weight compounds extracted from plants. Their main constituents are terpenes and phenylpropanoids, which are responsible for their biological and pharmaceutical properties, such as insecticidal, parasiticidal, antimicrobial, antioxidant, anti-inflammatory, analgesic, antinociceptive, anticarcinogenic, and antitumor properties. Cancer is a complex genetic disease considered as a serious public health problem worldwide, accounting for more than 8 million deaths annually. Objective: The activities of prevention and treatment of different types of cancer and the medicinal potential of essential oils are addressed in this review. Conclusion: Several studies have demonstrated anti-carcinogenic and antitumor activity for many essential oils obtained from various plant species. They may be used as a substitution to or in addition to conventional anti-cancer therapy. Although many studies report possible mechanisms of action for essential oils compounds, more studies are necessary in order to apply them safely and appropriately in cancer therapy.

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Alkaloids of Peganum harmala; anticancer biomarkers with promising outcomes

Current Pharmaceutical Design ◽

10.2174/1381612826666201125103941 ◽

2020 ◽

Vol 26 ◽

Cited By ~ 1

Author(s):

Atefeh Jalali ◽

Farid Dabaghian ◽

Mohammad M. Zarshenas

Keyword(s):

Cell Proliferation ◽

Cancer Therapy ◽

Cancer Treatment ◽

Peganum Harmala ◽

Anticancer Properties ◽

Cancer Management ◽

Global Health Issue ◽

Cancerous Cells ◽

Abnormal Cell Proliferation ◽

Normal Cell Cycle

Background: Cancer is a serious and growing global health issue worldwide. In the cancerous cells, the normal cell cycle has been disrupted via the series of irreversible changes. Recently, the investigations on herbal medicine and clarifying the phytochemicals potential in treat cancer has been increased. The combination of phytochemicals with conventional approaches in cancer treatment can improve outcomes via advancing cell death, restraining cell proliferation and invasion, sensitizing cancerous cells, and promoting the immune system. Therefore, phytochemicals can be introduced as relevant complementary medicaments in cancer therapy. Peganum harmala L. (Zygophyllaceae) as a valuable medicinal herb, possesses various alkaloid ingredient. Objective: Pointing to the importance of new avenues for cancer management and of P. harmala convincing effect in this field, this review strived to collect a frame to epitome possible scopes for the development of novel medicines in cancer treatment. Methods: Keywords "Peganum harmala" and cancer, or chemotherapy, or anti-neoplasm were searched through the "Scopus", database up to the 29th of February 2020. Papers linking to agriculture, chemistry, environmental, and genetics sciences were omitted and, papers centered on cancer were selected. Result and Discussion: In the current study, 42 related papers to cancer treatment and 22 papers on alkaloid bioactive components are collected from 72 papers. The β-carboline alkaloids derived from P. harmala, especially harmine, demonstrate notable anticancer properties by targeting apoptosis, autophagy, abnormal cell proliferation, angiogenesis, metastasis, and cytotoxicity. Based on the collected information, P. harmala holds significant anticancer activity. Considering the mechanism of the various anticancer drugs and their acting similarity to P. harmala, the alkaloids derived from this herb, particularly harmine, can introduce as a novel anticancer medicine solely or in adjuvant cancer therapy.

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Repurposing of Metformin for Cancer Therapy: Updated Patent and Literature Review

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892816666210615163417 ◽

2021 ◽

Vol 16 ◽

Author(s):

Zainab Sabry Othman Ahmed ◽

Matthew Golovoy ◽

Yassen Abdullah ◽

Reda Saber Ibrahim Ahmed ◽

Q. Ping Dou

Keyword(s):

Clinical Trials ◽

Cancer Therapy ◽

Late Phase ◽

Drug Dosage ◽

Great Promise ◽

Cancer Therapies ◽

Anticancer Properties ◽

Anticancer Effects ◽

Pubmed Database ◽

Early Phase Clinical Trials

Background: Over recent years, there has been an increasing focus on the repurposing of existing, well-known medications for new, novel usage. One such drug is metformin, typically utilized in the management of diabetes, which demonstrates a positive relationship between its administration and lower cancer morbidity and mortality. Based on this finding, numerous studies and clinical trials have been conducted to examine the potential usage of metformin as an anticancer agent. Objective: This article aims to summarize metformin’s anticancer effects through reviewing its literature and patents, with a focus on its potential to be repurposed for cancer therapy. Methods: Various databases were examined using keywords, ‘Metformin’ and ‘Cancer’. Research articles were collected through the PubMed database, clinical trials were obtained from the Clinical Trials database, and patents were collected through the Google Patents database. Results: Metformin shows antineoplastic activity in various models. These anticancer properties appear to synergize with existing chemotherapeutics, which allows for a reduction in drug dosage without losing potency while minimizing adverse effects. Numerous patents on metformin have been filed which claim various combination therapies, delivery methods, and uses for cancer therapy, displaying an increasing interest in metformin’s anticancer potential. Conclusion: Preclinical studies, along with early phase clinical trials, have examined antitumor properties of metformin on a variety of cancers. Metformin’s anticancer effects are well documented, demonstrating a great promise in improving current cancer therapies. However, there is a significant lack of late phase clinical trials, specifically those involving non-diabetic cancer patients, and therefore further research in this area is required.

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TIMP-3 as a therapeutic target for cancer

Therapeutic Advances in Medical Oncology ◽

10.1177/1758835919864247 ◽

2019 ◽

Vol 11 ◽

pp. 175883591986424 ◽

Cited By ~ 5

Author(s):

Chun-Wen Su ◽

Chiao-Wen Lin ◽

Wei-En Yang ◽

Shun-Fa Yang

Keyword(s):

Cancer Therapy ◽

Cancer Progression ◽

Drug Target ◽

Review Article ◽

Tissue Inhibitor Of Metalloproteinase ◽

Apoptosis Induction ◽

Anticancer Properties ◽

Current State ◽

Proteinase Inhibition ◽

Inhibition Ability

Tissue inhibitor of metalloproteinase-3 (TIMP-3), a secreted glycoprotein, plays an important role in carcinogenesis. It can bind to many proteinases to suppress their activity and thus protect the extracellular matrix from degradation. TIMP-3 may have many anticancer properties, including apoptosis induction and antiproliferative, antiangiogenic, and antimetastatic activities. This review summarizes the structure, proteinase inhibition ability, genetic and epigenetic regulation, cancer therapy potential, and contribution to cancer development of TIMP-3. Furthermore, in this review we discuss its potential as a biomarker for predicting cancer progression and the current state of drugs that target TIMP-3, either alone or in combination with clinical treatment. In conclusion, TIMP-3 can be a biomarker of cancer and a potential target for cancer therapy. This review article can serve as a basis to understand how to modulate TIMP-3 levels as a drug target of cancers.

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Insights on magnetic spinel ferrites for targeted drug delivery and hyperthermia applications

Nanotechnology Reviews ◽

10.1515/ntrev-2022-0027 ◽

2022 ◽

Vol 11 (1) ◽

pp. 372-413

Author(s):

Mohamed Ibrahim Ahmed Abdel Maksoud ◽

Mohamed Mohamady Ghobashy ◽

Ahmad S. Kodous ◽

Ramy Amer Fahim ◽

Ahmed I. Osman ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Spinel Ferrite ◽

Spinel Ferrites ◽

Cancer Cell Proliferation ◽

Anticancer Properties ◽

Targeted Drug ◽

Induced Apoptosis ◽

Scientific Attention

Abstract Magnetic spinel ferrite nanoparticles (SFNPs) attract high scientific attention from researchers due to their broad area for biomedicine applications, comprising cancer magnetic hyperthermia and targeted drug delivery. Uniquely, its excellent performance, namely, tuning size and surface morphology, excellent magnetism, extraordinary magnetically heat induction, promising biocompatibility, and specific targeting capacity, is essential for their effective utilization in clinical diagnosis and therapeutics of diseases. This review emphasizes the anticancer properties of nanoparticles of spinel ferrites with extra focus on the most recent literature. A critical review is provided on the latest applications of SFNPs in cancer therapy. Based on the results obtained from this review, SFNPs have the indefinite ability in cancer therapy through two mechanisms: (1) hyperthermia, where SFNPs, used as a hyperthermia mediator, elevated the tumor cells heat post-exposure to an external magnetic field and radiosensitizer during cancer radiotherapy; and (2) targeted drug delivery of cytotoxic drugs in tumor treatment. SFNPs induced apoptosis and cell death of cancer cells and prevented cancer cell proliferation.

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Use of Plant Species and Sponges on Cancer Therapy

10.31219/osf.io/29ezu ◽

2018 ◽

Author(s):

Wafa Asad

Keyword(s):

Cancer Therapy ◽

Anticancer Drugs ◽

Plant Species ◽

Chemical Compounds ◽

Anticancer Properties

This paper will discuss the use of plant species and sponges on cancer therapy under species with anticancer properties, plant anticancer chemical compounds and anticancer drugs derived from plants.

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Development of Marine-Derived Compounds for Cancer Therapy

Marine Drugs ◽

10.3390/md19060342 ◽

2021 ◽

Vol 19 (6) ◽

pp. 342

Author(s):

Weimin Zuo ◽

Hang Fai Kwok

Keyword(s):

Cancer Therapy ◽

Anticancer Drugs ◽

Mortality Rates ◽

High Morbidity ◽

Anticancer Properties ◽

Treatment Side Effects ◽

Cycle Arrest ◽

Bioactive Properties ◽

Induction Of Apoptosis ◽

Shed Light

Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.

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Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy

International Journal of Molecular Sciences ◽

10.3390/ijms21239273 ◽

2020 ◽

Vol 21 (23) ◽

pp. 9273

Author(s):

Sarah Méresse ◽

Mostefa Fodil ◽

Fabrice Fleury ◽

Benoît Chénais

Keyword(s):

Cancer Therapy ◽

Tumor Cells ◽

Epithelial Mesenchymal Transition ◽

Current Knowledge ◽

Bioactive Compound ◽

Cell Growth Arrest ◽

Brown Seaweeds ◽

Mesenchymal Transition ◽

Anticancer Properties ◽

Anticancer Effects

Fucoxanthin is a well-known carotenoid of the xanthophyll family, mainly produced by marine organisms such as the macroalgae of the fucus genus or microalgae such as Phaeodactylum tricornutum. Fucoxanthin has antioxidant and anti-inflammatory properties but also several anticancer effects. Fucoxanthin induces cell growth arrest, apoptosis, and/or autophagy in several cancer cell lines as well as in animal models of cancer. Fucoxanthin treatment leads to the inhibition of metastasis-related migration, invasion, epithelial–mesenchymal transition, and angiogenesis. Fucoxanthin also affects the DNA repair pathways, which could be involved in the resistance phenotype of tumor cells. Moreover, combined treatments of fucoxanthin, or its metabolite fucoxanthinol, with usual anticancer treatments can support conventional therapeutic strategies by reducing drug resistance. This review focuses on the current knowledge of fucoxanthin with its potential anticancer properties, showing that fucoxanthin could be a promising compound for cancer therapy by acting on most of the classical hallmarks of tumor cells.

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Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

Biomolecules ◽

10.3390/biom10091268 ◽

2020 ◽

Vol 10 (9) ◽

pp. 1268

Author(s):

Malgorzata Dobrzynska ◽

Marta Napierala ◽

Ewa Florek

Keyword(s):

Cancer Therapy ◽

Anticancer Activity ◽

Cancer Cells ◽

Anticancer Agents ◽

English Language ◽

Science Data ◽

Anticancer Properties ◽

Toxicity Of Drugs ◽

Low Solubility ◽

Anti Tumour Effect

Flavonoids, a ubiquitous group of naturally occurring polyphenolic compounds, have recently gained importance as anticancer agents. Unfortunately, due to low solubility, absorption, and rapid metabolism of dietary flavonoids, their anticancer potential is not sufficient. Nanocarriers can improve the bioavailability of flavonoids. In this review we aimed to evaluate studies on the anticancer activity of flavonoid nanoparticles. A review of English language articles published until 30 June 2020 was conducted, using PubMed (including MEDLINE), CINAHL Plus, Cochrane, and Web of Science data. Most studies determining the anticancer properties of flavonoid nanoparticles are preclinical. The potential anticancer activity focuses mainly on MCF-7 breast cancer cells, A549 lung cancer cells, HepG2 liver cancer cells, and melanoma cells. The flavonoid nanoparticles can also support the anti-tumour effect of drugs used in cancer therapy by enhancing the anti-tumour effect or reducing the systemic toxicity of drugs.

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Presence of phytochemicals in fruits and leaves of guava (Psidium guajava Linn.) for cancer prevention: A mini review

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i4-s.3290 ◽

2019 ◽

Vol 9 (4-s) ◽

pp. 726-729

Author(s):

Sudipta Biswas ◽

Partha Talukdar ◽

Dr. Soumendra Nath Talapatra

Keyword(s):

Experimental Study ◽

Solvent Extraction ◽

Cancer Therapy ◽

Drug Design ◽

Bioactive Compounds ◽

Psidium Guajava ◽

Anticancer Properties ◽

Future Experimental Study

The present review deals with the bioactive compounds (phytochemicals) in the fruits and leaves of guava (Psidium guajava Linn.). In the present study, an attempt was done to survey of literatures for exact solvent extraction to know exact phytocompound and characterization by using instruments along with anticancer properties of these phytochemicals present in fruits and leaves of guava. The compilation of available literatures of last 10 years can be suitable ready references for future experimental study as in vitro and in vivo as well as new drug design as phytomedicines for cancer therapy. Keywords: Bioactive compounds, Psidium guajava, Guava fruits and leaves, Cancer therapy, Phytomedicines

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