Imidazole Scaffold based Compounds in the Development of Therapeutic Drugs
Keyword(s):
: Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with various enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial and anti-viral properties. Herein, we review and discuss the recent developments occurred in using imidazole derivatives along with their special pharmacological activities for various diseases treatment.