scholarly journals Chemical Composition and Microhardness of Human Enamel Treated with Fluoridated Whintening Agents. A Study in Situ

2017 ◽  
Vol 11 (1) ◽  
pp. 34-40
Author(s):  
Thais de Mendonça Petta ◽  
Yasmin do Socorro Batista de Lima Gomes ◽  
Renata Antunes Esteves ◽  
Kelson do Carmo Freitas Faial ◽  
Roberta Souza D`Almeida Couto ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Morphological Changes ◽  
Dental Enamel ◽  
Hardness Test ◽  
Knoop Hardness ◽  
Control Group ◽  
High Concentration ◽  
Significance Level ◽  
Before And After

Background: Dental whitening has been increasingly sought out to improve dental aesthetics, but may cause chemical and morphological changes in dental enamel surfaces. Objective: Assess in situ the effects of high-concentration hydrogen peroxide with and without fluoride on human dental enamel using the ion chromatography test (IC) and the Knoop hardness test (KHN). Material and Methods: Nineteen enamel specimens were prepared using third human molars. These specimens were fixed on molars of volunteers and were divided into groups: OP38-Opalescence Boost PF38%, PO37-Pola Office 37.5% and CO-Control group. For chemical analysis (n= 3), the dentin layer was removed, keeping only the enamel, which was subjected to acidic digestion by microwave radiation. It was necessary to perform sample dilutions for the elements fluorine (F), calcium (Ca) and phosphorus (P) for quantification using the IC test. The KHN (n= 5) was performed before and after the treatments. Five indentations were made, separated by 100 µm, for each specimen using a load of 25 gf for 5 seconds in the microdurometer. The data were analyzed using ANOVA with a 5% significance level. Results: The OP38 group had the largest concentrations of F, Ca and P ions. The PO37 group showed the lowest concentrations of F and Ca ions. The average KHN was not significantly different between the OP38 and PO37 groups. Conclusion: Enamel whitened with hydrogen peroxide containing fluoride had greater concentrations of F, Ca and P ions. The presence of fluoride in the whitening agent did not influence the enamel microhardness.

scholarly journals Influence of Fluoride Concentration and pH Value of 35% Hydrogen Peroxide on the Hardness, Roughness and Morphology of Bovine Enamel

2014 ◽  
Vol 15 (4) ◽  
pp. 392-398 ◽  
Author(s):  
Wilcilene Costa Nascimento ◽  
Yasmin do Socorro Batista de Lima Gomes ◽  
Larissa Dias Alexandrino ◽  
Hilton Tulio Costi ◽  
José Otávio Carrera Silva ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Ph Value ◽  
Morphological Changes ◽  
Fluoride Concentration ◽  
Knoop Hardness ◽  
Scanning Electron Micrographs ◽  
High Concentration ◽  
Acidic Group ◽  
Bovine Enamel

ABSTRACT Aim The aim of this in vitro study was to evaluate the effects of different sodium fluoride (NaF) concentrations and pH values on the Knoop hardness (KHN), surface roughness (SR), and morphology of bovine incisors bleached with 35% hydrogen peroxide (HP). Materials and methods Sixty-five bovine incisors were fragmented (5 mm2 × 2 mm) and distributed in 5 groups: Control (unbleached), Low NaF/Acidic (35% HP + 1.3% NaF, pH 5.5), Low NaF/Neutral (35% HP + 1.3% NaF, pH 7.0), High NaF/ Acidic (35% HP + 2% NaF, pH 5.5), and High NaF/Neutral (35% HP + 2% NaF, pH 7.0). KHN analysis was performed with a microhardness tester under a load of 25 gf for 5 seconds. The average SR was obtained with a rugosimeter. KHN and SR were analyzed before and after treatments. For morphological analysis, specimens were dehydrated and gold-sputtered, and scanning electron micrographs were obtained and analyzed by 3 examiners with a double-blinded technique. KHN and SR results were analyzed by one-way ANOVA and Tukey's test (p < 0.05). Results Only the Low NaF/Acidic and Low NaF/Neutral groups showed significant differences between the initial and final KHN values. All bleached groups presented significant differences between the initial and final SR values. Among the bleached groups, the least and most morphological changes were shown by the High NaF/Neutral and the Low NaF/Acidic group, respectively. Conclusion Treatment with 35% HP and 2% NaF at pH 7.0 promoted the least changes in morphology, hardness and roughness among the bleached groups. Clinical significance In-office bleaching with high-concentration HP and 2% NaF at neutral pH promoted the least changes in enamel hardness, SR, and morphology compared to other treatments. How to cite this article Nascimento WC, Gomes YSBL, Alexandrino LD, Costi HT, Silva JOC Jr, Silva CM. Influence of Fluoride Concentration and pH Value of 35% Hydrogen Peroxide on the Hardness, Roughness and Morphology of Bovine Enamel. J Contemp Dent Pract 2014;15(4):392-398.

scholarly journals In situ Effect of Nanohydroxyapatite Paste in Enamel Teeth Bleaching

2017 ◽  
Vol 18 (11) ◽  
pp. 996-1003 ◽  
Author(s):  
Cecy Martins Silva ◽  
Yasmin SB de Lima Gomes ◽  
Larissa D Alexandrino ◽  
Cristiane de M Alencar ◽  
Eliane B Alves ◽  
...  
Keyword(s):  
Negative Control Group ◽  
Positive Control ◽  
Knoop Hardness ◽  
Negative Control ◽  
Control Group ◽  
Tristimulus Colorimetry ◽  
Before And After ◽  
The Mean ◽  
Bleaching Treatment

ABSTRACT Aim Evaluate in situ the effect of nanohydroxyapatite paste (nano-HAP) before bleaching with hydrogen peroxide 35% (HP35%) by ion chromatography (IC) Knoop hardness number (KHN) and tristimulus colorimetry (TC). Materials and methods A total of 60 fragments were obtained from third molars included (3 mm × 3 mm × 3 mm) and the specimens were divided into three groups (n = 20): Gas chromatography (CG) (negative control group) = no bleaching; HP35% (positive control group) = HP35% whitening (whiteness HP35%); nano-HAP = application for 10 minutes before bleaching treatment + HP35%. The specimens were fixed to the volunteers’ molars. The KHN and TC were measured before and after bleaching. For IC, the dentin layer was removed, leaving the enamel that was crushed, and autoclaved for chemical quantification (calcium, fluorine, and phosphorus). The results of KHN and TC were analyzed statistically by analysis of variance (ANOVA) followed by Tukey test (p < 0.05). Results The HP35% group showed reduction of the Ca, F, and P ions. The initial and final KHN mean of the CG and nano-HAP did not differ statistically; however, the group of HP35% did differ statistically. The mean ∆E of the HP35% and nano-HAP groups did not differ statistically from each other. However, they differed from the CG. Conclusion The nano-HAP paste preserved the KHN, promoted the lower loss of Ca and P ions and an increase of F ions when compared with the CG, but did not influence the effectiveness of the bleaching treatment. Clinical significance Nano-HA is a biomaterial that has shown positive results in the prevention of deleterious effects on the enamel by the action of the office bleaching treatment. How to cite this article Gomes YSBL, Alexandrino LD, Alencar CDM, Alves EB, Faial KCF, Silva CM. In situ Effect of Nanohydroxyapatite Paste in Enamel Teeth Bleaching. J Contemp Dent Pract 2017;18(11):996-1003.

Antimicrobial Effect of 940 nm Diode Laser based on Photolysis of Hydrogen Peroxide in the Treatment of Periodontal Disease

2018 ◽  
Vol 69 (8) ◽  
pp. 2081-2088 ◽  
Author(s):  
Alin Alexandru Odor ◽  
Edwin Sever Bechir ◽  
Deborah Violant ◽  
Victoria Badea
Keyword(s):  
Hydrogen Peroxide ◽  
Laser Therapy ◽  
Diode Laser ◽  
Antimicrobial Effect ◽  
The Other ◽  
Control Group ◽  
Group 4 ◽  
Periodontal Bacteria ◽  
Severe Periodontitis ◽  
Before And After

Moderate and severe periodontitis represents a challenge in the non-surgical periodontal therapy. Due to the lack of evidence regarding the antimicrobial effectiveness of 940 nm diode laser in periodontal treatment, this study aimed to evaluate the antimicrobial effect of hydrogen peroxide (H2O2) photolysis performed with 940 nm diode laser in the treatment of moderate and severe periodontitis. Twenty-five patients with 100 teeth were selected for this pilot study. The test teeth were randomly assigned to one of the four treatment groups: Group 1: scaling and root planning (SRP) (control group); and the following experimental groups: Group 2: H2O2; Group 3: 940 nm diode laser therapy; Group 4: 940 nm diode laser therapy and H2O2. Clinical examinations, like probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were performed before and after the treatment. The microbiological evaluation, effectuated before and after the treatment, included nine periodontal bacteria species and investigated by means of real-time PCR assay. The clinical and bacterial differences in the tested groups, was assessed between control group and the other three experimental groups, as well as between the experimental groups. The total bacteria load was reduced for all four studied groups. Group 4 (diode laser + H2O2) showed significant bacterial reduction of the major periodontal bacteria like Pg., Tf., Td., Pi., Pm., Fn (p[0.001) than the other 3 groups (p]0.001). Also the periodontal clinical parameters, like PD, CAL and BOP showed a significant reduction after the photolysis of H2O2 with the 940 nm diode laser (p[0.001). Differences between tested groups showed a significant beneficial results in regard to Group 4.It is suggested that the photoactivation of H2O2 with the 940 nm diode laser can be used successfully in adjunctive to the non-surgical periodontal treatment as a bactericidal tool.

scholarly journals A Comparative Evaluation of Nanohydroxyapatite-Enriched Hydrogen Peroxide Home Bleaching System on Color, Hardness and Microstructure of Dental Enamel

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3072
Author(s):  
Riccardo Monterubbianesi ◽  
Vincenzo Tosco ◽  
Tiziano Bellezze ◽  
Giampaolo Giuliani ◽  
Mutlu Özcan ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Particle Diameter ◽  
Dental Enamel ◽  
Sem Analysis ◽  
Control Group ◽  
Average Particle ◽  
Color Analysis ◽  
Enamel Microstructure ◽  
Prismatic Structure ◽  
20 Nm

This study aimed to evaluate two hydrogen peroxide (HP)-based at-home bleaching systems in order to analyze whether nano-hydroxyapatite (nHA) addition may represent a reliable and safe solution for tooth whitening without altering dental microstructure and hardness. Human third molars (N = 15) were treated with two bleaching agents, one containing 6%HP (6HP) and the other 6% HP nHA-enriched (6HP-nHA) with average particle diameter ranging from 5–20 nm. Their effects on enamel were assessed using a spectrophotometer, Vickers microhardness (VMH) test and Scanning Electron Microscopy (SEM), comparing the treated groups with the non-treated control group (CTR). Color analysis revealed improvement in whiteness in both groups compared to CTR. VMH test results showed no differences among the groups. SEM analysis highlighted no evident changes in the enamel microstructure of tested groups compared to CTR. At high magnification, in 6HP group, a slight increase in irregularities of enamel surface morphology was observed, while 6HP-nHA group displayed removal of the aprismatic layer but preservation of the intact prismatic structure. These results suggest that the 6HP-nHA agent may be recommended to provide reliable whitening treatment, without damaging the enamel micromorphology and hardness.

Bleaching Effects on Color, Chemical, and Mechanical Properties of White Spot Lesions

2016 ◽  
Vol 41 (3) ◽  
pp. 318-326 ◽  
Author(s):  
Y Kim ◽  
HH Son ◽  
K Yi ◽  
JS Ahn ◽  
J Chang
Keyword(s):  
Mechanical Properties ◽  
Hardness Test ◽  
Knoop Hardness ◽  
White Spot ◽  
Control Group ◽  
White Spot Lesions ◽  
Lesion Area ◽  
Experimental Conditions ◽  
Cross Sectional ◽  
The Cross

SUMMARY Objective: The purpose of the study was to evaluate the effect of bleaching on teeth with white spot lesions. Methods and Materials: Carious lesions with standardized whiteness were produced on the buccal and lingual surfaces of human premolars by pH cycling. Specimens were subjected to four experimental conditions (n=20/group) as follows: group 1, control; group 2, caries formation followed by remineralization using fluoride-containing casein phosphopeptide–amorphous calcium phosphate (CPP-ACP; Tooth Mousse Plus, GC, Tokyo, Japan); group 3, caries formation followed by bleaching using 10% carbamide peroxide; and group 4, caries formation followed by both bleaching and remineralization. The CIE L*a*b* color values were measured with a spectroradiometer, the mineral content was measured with electron probe microanalysis (EPMA) on the cross-sectional surface of each specimen, and the Knoop hardness test was carried out along the EPMA scan line. Two-way analysis of variance was performed with Tukey post hoc comparison. Results: The change in the CIE color values was not significantly different between the caries-formed (ΔE*=7.03) and the bleached enamel (ΔE*=7.60). Bleaching of the carious enamel extended the whiteness (ΔE*=3.38) without additional mineral loss (p&lt;0.05). The remineralization treatment significantly increased the calcium (Ca), phosphate (P), and fluoride content of the subsurface lesion area (p&lt;0.05). The cross-sectional microhardness values correlated well with the Ca and P content (R&gt;0.80). Conclusions: Bleaching reduced the color disparities between sound and carious enamel without deteriorating the chemical and mechanical properties. The application of CPP-ACP paste enhanced mineral deposition in the subsurface lesion area of carious enamel.

scholarly journals PENGARUH METODE PEMBELAJARAN BERBASIS PROYEK TERHADAP KEMAMPUAN KERJASAMA PADA ANAK KELOMPOK B TAMAN KANAK-KANAK

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Ni Wayan Eka Praba Dewi . ◽  
Dr. I Ketut Gading,M.Psi . ◽  
Dr. Putu Aditya Antara, S.Pd., M.Pd. .
Keyword(s):  
Project Based Learning ◽  
Control Group ◽  
Learning Method ◽  
Significance Level ◽  
Group Data ◽  
Before And After ◽  
Quasi Experimental ◽  
Observation Method ◽  
Group B ◽  
Academic Year

Penelitian ini bertujuan untuk mengetahui pengaruh metode pembelajaran berbasis proyek (project based learning) terhadap kemampuan kerjasama anak Taman Kanak-kanak. Penelitian ini termasuk penelitian eksperimen semu yang menggunakan desain nonequevalent pretest-posttest control group desaign. Populasi dalam penelitian ini adalah seluruh anak kelompok B Taman Kanak-kanak Gugus III Kecamatan Buleleng Tahun Ajaran 2017/2018. Sampel dalam penelitian ini adalah kelompok B2 Taman Kanak-kanak Widya Kumara Banjar Jawa yang berjumlah 21 anak sebagai kelompok eksperimen dan kelompok B Taman Kanak-kanak Dana Punia yang berjumlah 26 anak sebagai kelompok kontrol. Metode pengumpulan data yang digunakan dalam penelitian ini adalah metode observasi yang digunakan untuk mengumpulkan data tentang kemampuan kerjasama sebelum dan sesudah perlakuan. Dari hasil uji normalitas dan homogenitas varians, diketahui bahwa sampel bersistribusi normal dan varians populasinya homogen, maka untuk menguji hipotesis digunakan uji-t dengan taraf signifikansi 5%. Hasil penelitian menunjukkan bahwa ada pengaruh metode pembelajaran berbasis proyek (project based learning) terhadap kemampuan kerjasama anak (t= 21,551, sig= 0.000).Kata Kunci : Kerjasama, metode pembelajaran berbasis proyek. This study aimed at determining the effect of project based learning method on the cooperation ability of children at Kindergarten. This study was quasi-experimental research using a nonequevalent pretest-posttest control group desaign. Population in this research were all children of group B Kindergarten in Cluster III of Buleleng Subdistrict in Academic Year 2017/2018. The sample in this research were group B2 Kindergarten Widya Kumara Banjar Jawa which amounted to 21 children as experiment group and group B Kindergarten of Dana Punia which amounted to 26 children as control group. Data collection method used in this research was observation method used to collect data about the cooperation ability before and after treatment. From the test of normality and homogeneity variance, it was known that the sample were normally distributed and the variance was homogeneous, so to test the hypothesis t-test was used with 5% significance level. The result of the research showed that there was an effect of project based learning method on the cooperation ability of children (t = 21,551, sig = 0.000). keyword : Cooperation, project-based learning method.

scholarly journals An in situ evaluation of Bioactives on the morphology of bleached Enamel

2016 ◽  
Vol 17 (3) ◽  
pp. 192-197
Author(s):  
Yasmin do Socorro Batista de Lima Gomes ◽  
Larissa Dias Alexandrino ◽  
Cecy Martins Silva ◽  
Thiago da Rosa Nogueira ◽  
Cristiane de Melo Alencar ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Hydrogen Peroxide ◽  
Scanning Electron Microscopy ◽  
Third Molars ◽  
Double Blind ◽  
Human Morphology ◽  
Before And After ◽  
Post Hoc ◽  
Scanning Electron

ABSTRACT Aim The aim of this study was to use surface rugosity analysis (Ra) and scanning electron microscopy (SEM) comparing effects of nano-hydroxyapatite (NANO), casein phosphopeptideamorphous calcium phosphate (CPP-ACP), and NovaMin (NOVA) on enamel's human morphology bleached with 37.5% hydrogen peroxide. Materials and methods Forty specimens (3 × 3 × 3 mm) were obtained from fully included third molars and four specimens were attached in the first molars of the volunteers. The POLApositive control has only been bleached. Three experimental groups were bleached and treated with respective bioactive: NANO, CPP-ACP, and NovaMin. The Ra analyses were performed before and after the treatment using a rugosimeter. The obtained photomicrographs were analyzed using SEM (n = 3) by three examiners, and the study was double blind. Results The Ra results were analyzed by one-way analysis of variance and Tukey's post hoc test (p < 0.05). All experimental groups showed significant differences of the others; however, the experimental groups were not significantly different from each other. Conclusion The enamel morphology of the bioactive-treated groups had more regular surfaces, than the others. How to cite this article da Rosa Nogueira T, Alexandrino LD, de Lima Gomes YSB, de Melo Alencar C, Alves EB, Silva CM. An in situ evaluation of Bioactives on the morphology of bleached Enamel. J Contemp Dent Pract 2016;17(3):192-197.

scholarly journals The Effect of Eight Weeks of Hand-Selected Strength Exercises and the Cinnamon Supplementation on Inflammatory Biomarkers in Elderly Women with Osteoarthritis

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Shayesteh Hassani ◽  
Sedigheh Hosseinpour Delavare ◽  
Hassan Safikhani
Keyword(s):  
Elderly Women ◽  
Inflammatory Biomarkers ◽  
Joint Disease ◽  
Control Group ◽  
Hand Osteoarthritis ◽  
Significance Level ◽  
Strength Exercises ◽  
Resistance Exercises ◽  
Before And After ◽  
And Control

Background: Osteoarthritis is the most common joint disease (arthropathy) and a cause of disability in aging ages. The prevalence rate of the osteoarthritis is different and is related to different indicators. Objectives: The purpose of the present study was to investigate the effect of eight weeks of hand-selected exercises and cinnamon supplementation on inflammatory biomarkers in elderly women with osteoarthritis. Methods: The participants of this study were 48 women with hand-osteoarthritis. They divided into four groups (strength exercises, cinnamon-honey supplementation, combinatory and control) randomly. The first group underwent the hand-selected strength exercises. The second group used the supplementations for 8 weeks. The third group also applied hand-selected exercises and supplements simultaneously. The fourth group also participated as a control group without any exercise or supplementation. Patients’ TNfα and IL6 levels were measured before and after applying the independent variables and were compared. The dependent t-test was used to compare between pre and posttest and the ANOVA test to compare TNfα and IL6 levels between the four groups. The significance level P ≤ 0.05 was considered. Results: The results showed that by applying variables, the strength exercises and cinnamon-honey supplementary as well as the combination of exercises and supplementary have had a positive effect on inflammatory biomarkers and in fact, 8 weeks of resistance exercises and using cinnamon-honey supplements in women with hand osteoarthritis have led to a decrease in IL 6 and TNfα levels. Conclusions: Therefore, it is recommended to use wrist resistance exercises with supplements (cinnamon and honey) to accelerate the recovery of the disease and improve the wrist inflammatory.

scholarly journals Level Achieved in the Development of Skills for the Sexual and Reproductive Life of University Students After the Application of a Sexual Education Strategy

2021 ◽  
Author(s):  
Rosa Del Carmen Saeteros Hernández ◽  
Eida Ortiz Zayas ◽  
Angélica María Saeteros Hernández
Keyword(s):  
Sex Education ◽  
Life Skills ◽  
Sexuality Education ◽  
Control Group ◽  
Study Group ◽  
Significance Level ◽  
Education Strategy ◽  
Before And After ◽  
Reproductive Life ◽  
And Control

Introduction: Sexuality education must develop life skills. Methodology: The level of life skills was evaluated using a quasi- experimental design from before after with a control group, random   samples of   40   students   were selected in the study and control group, respectively. The sex education strategy was implemented in the study group and a pre and post test was applied; before and after the strategy. Statistical techniques were used for dependent and independent samples, with a significance level of p = 0,05. Results: The comparisons of the study and control groups before, the control group before and after, and the measurement after the implementation of the strategy of the satisfied needs of life skills in the study group, were within expectations, the most of the variables studied regarding the need to develop life skills are homogeneous in the study and control group before implementing the strategy; and no significant differences were found in the comparison of the control group before and after. Subsequent measurement regarding needs met or level achieved in the development of skills for sexual and reproductive life in the study group was high, even for some of them, 100% of students appreciated that they had achieved it. Conclusion: The sex education strategy was effective in developing skills for sexual and reproductive life due to the high level achieved by the students who participated in the strategy. Keywords: education, sex, life skills, sexual and reproductive health. RESUMEN Introducción: La educación sexual debe desarrollar habilidades para la vida. Metodología: Se evaluó el nivel de habilidades para la vida mediante un diseño cuasi experimental de antes después con grupo control, se seleccionaron muestras aleatorias de 40 estudiantes en el grupo de estudio y control respectivamente, se implementó la estrategia de educación sexual en el grupo de estudio y se aplicó una pre y post prueba; antes y después de la estrategia. Se utilizaron técnicas estadísticas para muestras dependientes e independientes, con un nivel de significación p = 0,05. Resultados: Las comparaciones de los grupos de estudio y control antes, grupo control antes y después y la medición posterior a la implementación de la estrategia de las necesidades satisfechas de habilidades para la vida en el grupo de estudio, estuvieron dentro de lo esperado, la mayoría de variables estudiadas respecto a la necesidad de desarrollar habilidades para la vida son homogéneas en el grupo de estudio y control antes de implementar la estrategia; y no se encontraron diferencias significativas en la comparación del grupo control antes y después. La medición posterior respecto a necesidades satisfechas o nivel conseguido en el desarrollo de habilidades para la vida sexual y reproductiva en el grupo de estudio fue elevado, incluso para algunas de ellas, el 100% de estudiantes apreció que lo había logrado. Conclusiones: La estrategia de educación sexual fue efectiva para desarrollar habilidades para la vida sexual y reproductiva debido al nivel elevado conseguido por los estudiantes que participaron en la estrategia. Palabras clave: educación sexual, habilidades para la vida, salud sexual, reproductiva.

scholarly journals Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat

Molekul ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 97
Author(s):  
Saryono Saryono ◽  
Hernayanti Hernayanti ◽  
Atikah Proverawati
Keyword(s):  
Liver Function ◽  
Defense Mechanism ◽  
Cell Damage ◽  
Negative Control ◽  
Effective Dosage ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Before And After ◽  
Post Test

Liver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five groups, i.e., groups of healthy control (A), negative control (B), and treatment (C-E) with dosages of 150, 300, and 600 mg/kg of P. pellucida, respectively. Each group comprises of 5 rats. The TNF-a, IL-12, and GSH were measured before and after a 14 days administration of P. pellucida. The data were analyzed by using one-way ANOVA test followed by Duncan's post hoc test with a significance level of 5%. The result showed that P. pellucida steeping can improve liver cell damage, which was shown from the parameters of liver function, inflammation, and antioxidants. The mean of TNF-a and IL-12 levels decreased while the total protein, albumin, and GSH levels increased significantly after administration of P. pellucida steeping. Our study concluded that P. pellucida steeping might reduce TNF-a and IL-12 levels, and increased GSH level in diabetic-induced rat. A 300 mg/kg was the most effective dosage to reduce IL-12 and increase GSH.

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