scholarly journals Klasterisasi Spasial Keragaman Spesies Tuna di Perairan Selatan Jawa

2021 ◽  
Vol 23 (1) ◽  
pp. 9
Author(s):  
Ledhyane Ika Harlyan ◽  
Abu Bakar Sambah ◽  
Feni Iranawati ◽  
Rani Ekawaty
Keyword(s):  
Hierarchical Clustering ◽  
Wiener Index ◽  
P Value ◽  
Thunnus Albacares

Terjadinya penurunan produktivitas perikanan tuna di Perairan Selatan Jawa salah satunya disebabkan oleh adanya kondisi tangkap lebih yang terjadi akibat ketidaktersediaannya informasi geografis akurat terkait jumlah dan jenis spesies. Pendekatan spasial keragaman habitat spesies mampu memberikan prediksi akurat tentang jenis dan jumlah spesies pada suatu daerah penangkapan. Penelitian ini bertujuan untuk menghasilkan peta klasterisasi spasial keragaman spesies tuna berdasarkan data hasil tangkapan tuna dan data lokasi penangkapan di Perairan Selatan Jawa yang diperoleh dari kapal rawai tuna yang menangkap ikan di Samudera Hindia dan mendaratkan  tangkapannya di Pelabuhan Perikanan Samudera (PPS) Benoa pada bulan September-November 2019 dengan menggunakan beberapa analisis yaitu: (1) analisis keragaman spesies (Shannon-wiener index dan Menhinick index) dan analisis klasterisasi spasial (ward-hierarchical clustering dengan bootstrapped p-value). Berdasarkan kedua hasil analisis tersebut diperoleh tiga klaster pola sebaran daerah penangkapan tuna di Perairan Selatan Jawa yaitu: (1) klaster yang didominasi oleh spesies Thunnus albacares, (2) klaster yang didominasi oleh Thunnus obessus, dan (3) klaster dengan jumlah spesies tuna yang berimbang. Informasi mengenai ketiga klaster daerah penangkapan ini selanjutnya dapat digunakan sebagai rujukan penentuan pengelolaan perikanan tuna dan upaya pembatasan kapasitas penangkapan khususnya pada spesies tuna yang mengalami penurunan stok.

scholarly journals The Feasibility of a Novel Dose Painting Procedure to Treat Prostate Cancer Based on mpMR Images and Hierarchical Clustering

2021 ◽  
Author(s):  
Seyed Masoud Rezaeijo ◽  
Bijan Hashemi ◽  
Bahram Mofid ◽  
Mohsen Bakhshandeh ◽  
Arash Mahdavi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hierarchical Clustering ◽  
Post Treatment ◽  
P Value ◽  
Agglomerative Clustering ◽  
Dose Painting ◽  
Significant Difference ◽  
Target Volumes ◽  
Adc Values

Abstract BackgroundWe aimed to assess the feasibility of a novel dose painting (DP) procedure for treating prostate cancer with dominant intraprostatic lesions (DILs) based on mpMR images and hierarchical clustering with a machine learning technique. MethodsThe mpMR images of 120 patients were used to create hierarchical clustering and draw a dendrogram. Three clusters were selected for performing agglomerative clustering. Then, the DIL acquired from the mpMR images of 20 patients were categorized into three groups to have them treated with a novel DP procedure being composed of three planning target volumes (PTVs) determined as PTV1, PTV2, and PTV3 in treatment plans. The DP procedure was carried out on the patients wherein a total dose of 80, 85, and 91 Gy were delivered to the PTV1, PTV2, and PTV3, respectively. Dosimetric and radiobiologic parameters (TCP & NTCP) of the DP procedure were compared with those of the conventional IMRT and 3DCRT procedures carried out on another group of 20 patients. A post-treatment follow-up was also made four months after the radiotherapy procedures.ResultsAll the dosimetric variables and the NTCPs of the organs at risks revealed no significant difference between the DP and IMRT procedures. Regarding the TCP of three investigated PTVs, significant differences were observed between the DP vs. IMRT and also DP vs. 3DCRT procedures. At post-treatment follow-up, the DIL volumes and ADC values in the DP group differed significantly (p-value<0.001) from those of the IMRT. However, the whole prostate ADC and PSA indicated no significant difference (p-value>0.05) between the DP vs. IMRT. ConclusionsThe results of this comprehensive clinical trial illustrated the feasibility of our novel DP procedure for treating prostate cancer based on mpMR images validated with acquired patients’ dosimetric and radiobiologic assessment and their follow-ups. This study confirms significant potential of the proposed DP procedure as a promising treatment planning to achieve effective dose escalation and treatment for prostate cancer.Trial registrationIRCT20181006041257N1; Iranian Registry of Clinical Trials, Registered: 23 Oct. 2019, https://en.irct.ir/trial/34305

scholarly journals Daerah Penangkapan Potensial Tuna Madidihang Thunnus albacares, Bonnaterre, 1788 (Teleostei:Scombridae) di Laut Seram

2020 ◽  
Vol 23 (2) ◽  
pp. 207-216
Author(s):  
Jacobus Bunga Paillin ◽  
Delly Dominggas Paulina Matrutty ◽  
Stany Rachel Siahainenia ◽  
Ruslan Husen Saban Tawari ◽  
Haruna Haruna ◽  
...  
Keyword(s):  
Surface Temperature ◽  
Sea Surface Temperature ◽  
Chlorophyll A ◽  
Yellowfin Tuna ◽  
Sea Surface ◽  
P Value ◽  
Thunnus Albacares ◽  
Test Analysis ◽  
Medium Potential

This research aims are to determine the potential fishing grounds of yellowfin tuna based on the approach of sea surface temperature, chlorophyll-a and catches in the Ceram Sea. Overall catches of 407 Individuals. In January the total catches were 66 individuals (14.44%), in February 67 individuals (14.66%), in March 84 individuals (18.38%), in April 116 individuals (25.38%) and in May 124 individuals (27.13%). The distribution of sea surface temperature and chlorophyll-a in the Ceram Sea in January-May 2019 looks varied. In January the average sea surface temperature was 29.13 oC, in February sea surface temperature was 29.54 oC, in March sea surface temperature was 30.12 oC, in April sea surface temperature was 30.12 oC, in May sea surface temperature was 29.77 oC. Chlorophyll-a concentration in January and February was 0.21 mg/m3, March was 0.20 mg/m3, April was 0.16 mg/m3, and May was 0.25 mg/m3. The results of the t-test analysis showed the P-value of sea surface temperature was 0.009<0.05, chlorophyll-a P-value 0.00048<0.05. Determination of potential fishing areas based on sea surface temperature, chlorophyll-a, and CPUE indicators shows that potential fishing areas are found in January, February, March, and May, while in April are in the medium potential category. Penelitian ini dilaksanakan dengan tujuan menentukan daerah penangkapan potensial Tuna madidihang berdasarkan pendekatan suhu permukaan laut, klorofil-a dan hasil tangkapan di Laut Seram.  Secara keseluruhan hasil tangkapan ikan tuna madidihang sebanyak 407 Individu. Bulan Januari total hasil tangkapan sebanyak 66 individu (14.44%), bulan Februari 67 individu (14.66%), bulan Maret 84 individu (18.38%), bulan April 116 individu (25.38%) dan bulan Mei 124 individu (27.13%). Sebaran suhu permukaan laut dan klorofil-a di Laut Seram pada bulan Januari-Mei 2019 terlihat bervariasi. Bulan Januari rata-rata suhu permukaan laut sebesar 29.13 oC, bulan Februari suhu permukaan laut 29.54 o, bulan Maret suhu permukaan laut 30.12 oC, bulan April suhu permukaan laut 30.12 oC, bulan Mei suhu permukaan laut 29.77 oC. Konsentrasi klorofil-a pada bulan Januari dan Februari sebesar 0.21 mg/m3, bulan Maret sebesar 0.20 mg/m3, bulan April sebesar 0.16 mg/m3, dan bulan Mei sebesar 0.25 mg/m3.  Hasil analisis uji t menunjukan nilai P-value suhu permukaan laut sebesar 0,009<0,05, klorofil-a P-value 0,00048<0,05. Penentuan daerah penangkapan ikan potensial berdasarkan indikator suhu permukaan laut, klorofil-a dan CPUE menunjukkan daerah penangkapan ikan potensial terdapat pada bulan Januari, Februari, Maret, dan Mei, sedangkan pada bulan April berada dalam kategori potensial sedang. 

scholarly journals Otolith shape as a tool for representing different growth in young and adult yellowfin tuna (Thunnus albacares, Bonnaterre, 1788)

2021 ◽  
Vol 322 ◽  
pp. 05011
Author(s):  
Ririk Kartika Sulistyaningsih ◽  
Bram Setyadji ◽  
Hety Hartaty ◽  
Arief Wujdi
Keyword(s):  
Population Structure ◽  
Yellowfin Tuna ◽  
P Value ◽  
Thunnus Albacares ◽  
Multivariate Statistical ◽  
Otolith Shape ◽  
Principal Coordinates ◽  
The Indian Ocean ◽  
Study Sites ◽  
The Individual

The stock status of yellowfin tuna (Thunnus albacares) (YFT) in the Indian Ocean is currently concluded overfished and is subject to overfishing. The information about the YFT population structure is fundamental for effective fisheries management and conservation. The otolith shape as a tool for estimating population structure is the cheapest technique compared to other methods, such as genetic, parasite, and otolith chemistry, especially for analyzing the large samples. This study investigates the use of otolith shapes to determine the yellowfin stock from two different locations. Data collection was carried out at two locations, namely Kedonganan and Benoa, throughout 2018. Total samples collected from the two study sites were 314 otoliths, but only 147 whole otoliths could be analyzed. Image analysis was performed using ANOVA-like permutation (n=1000 to determine whether the individual can be reclassified to their sample origin. The subsequent analysis is the variations in the shape of the otolith with multivariate statistical methods using cluster analysis with Canonical Analysis of Principal Coordinates. The result shows that the YFT otolith Benoa is significantly different from the YFT otolith Kedonganan with the P-value = 0.0015.

Apoptosis Taqman Low-Density Array: Analysis of Programmed Cell Death Patway in CLL.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3369-3369
Author(s):  
Agostino Cortelezzi ◽  
Umberto Gianelli ◽  
Valentina Vaira ◽  
Maria Cristina Pasquini ◽  
E. Fasoli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Hierarchical Clustering ◽  
Euclidean Distance ◽  
Hierarchical Cluster ◽  
Differentially Expressed ◽  
P Value ◽  
Apoptotic Pathway ◽  
Cell Death Pathway

Abstract The clinical course of CLL is highly heterogeneous: some patients progress rapidly thus requiring early chemotherapy whereas others exhibit a stable disease over years. Gene expression studies have identified a relatively small number of genes that are differentially expressed between these subsets. Resistance to programmed cell death seems to be one of the preferential pathways of neoplastic B cells to survive and to develop resistance to therapy. We investigated by MicroFluidic Card™ technology patients affected by untreated CLL cells for alterations of agonist and antagonist apoptosis genes. Our aim was to shed light on programmed cell death pathway in this particular subset of patients. Methods 34 CLL and 30 normal controls were evaluated. Highly purified (>90%) B-CLL cells were obtained from all the patients after magnetic cell separation (CD19+ microbeads, Miltenyi Biotech). 92 human apoptosis-related genes as well as 4 reference genes were analyzed in duplicate by MicroFluidic Card method based on TaqMan™ technology (Applied Biosystems). Raw data from the analysis were converted to relative gene expression quantity (RQ) by GeneNorm software. RQs were median normalized, log2 transformed, and variations among patients were investigated by both unsupervised (hierarchical clustering) and supervised methods. Selection of significant genes between normal and neoplastic samples was accomplished by the following criteria: a ratio between the averages of the two groups ≥ 2 or ≤ 0.5 and a p value of Welch T test ≤0.01. Results Unsupervised hierarchical clustering (dChip software) with the complete gene dataset revealed the homogeneity of normal samples (Euclidean distance, average linkage method p=0.0012). 14 were differently regulated in CLL, in particular 7 genes (CASP8AP2, TNFRSF4, TNFSF14, BCL2, CD40LG, CDKN2A and ZAP-70) were up regulated and 7 (CASP10, BIRC5, LTB, BCL2A1, TNFSF10, TNFRSF8 and BID) were down modulated. ZAP-70+ and ZAP-70- groups showed 5 genes differentially expressed (p≤ 0.01, BIK, LTBR, TNFSF11, TNFRSF1A and BCL2L2), with all the targets up regulated in the ZAP-70 subset. When the chromosome status was investigated, ANOVA test revealed 5 genes differentially regulated (p< 0.05, TNFRSF1B, BIRC6, BCL2, BCL2L2 and TNFRSF10D) between the groups (11q-, 13q- and negative sets). Hierarchical cluster revealed the formation of specific sample groups for specimens with β2microglobulin increase (>2,2 mg/l) and for those with mutated IgVH(Euclidean distance, p=0.0074 and p=0.0006, respectively). Conclusions Indolent CLL is poorly characterized in its molecular aspects. The comprehensive profiling of gene expression in CLL can provide a molecular framework for understanding the pathophysiology of this disease. Significant alterations of the apoptotic pathway at both the extrinsic and the intrinsic levels among asymptomatic CLL patients were found. The system uses only 2 ng of sample and small volumes of reagent, and the precaptured primers and probes avoided labor-intensive pipetting steps. This procedure could be an useful method to identify targets associated with clinical outcome.

Total Hospital Costs and Readmission Rate of Patient-Specific Instrument in Total Knee Arthroplasty Patients

2020 ◽  
Author(s):  
Stephen Thomas ◽  
Ankur Patel ◽  
Corey Patrick ◽  
Gary Delhougne
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Hospital Cost ◽  
Readmission Rate ◽  
Hospital Costs ◽  
Patient Specific ◽  
P Value ◽  
Total Hospital Cost ◽  
Total Hospital ◽  
Total Knee

AbstractDespite advancements in surgical technique and component design, implant loosening, stiffness, and instability remain leading causes of total knee arthroplasty (TKA) failure. Patient-specific instruments (PSI) aid in surgical precision and in implant positioning and ultimately reduce readmissions and revisions in TKA. The objective of the study was to evaluate total hospital cost and readmission rate at 30, 60, 90, and 365 days in PSI-guided TKA patients. We retrospectively reviewed patients who underwent a primary TKA for osteoarthritis from the Premier Perspective Database between 2014 and 2017 Q2. TKA with PSI patients were identified using appropriate keywords from billing records and compared against patients without PSI. Patients were excluded if they were < 21 years of age; outpatient hospital discharges; evidence of revision TKA; bilateral TKA in same discharge or different discharges. 1:1 propensity score matching was used to control patients, hospital, and clinical characteristics. Generalized Estimating Equation model with appropriate distribution and link function were used to estimate hospital related cost while logistic regression models were used to estimate 30, 60, and 90 days and 1-year readmission rate. The study matched 3,358 TKAs with PSI with TKA without PSI patients. Mean total hospital costs were statistically significantly (p < 0.0001) lower for TKA with PSI ($14,910; 95% confidence interval [CI]: $14,735–$15,087) than TKA without PSI patients ($16,018; 95% CI: $15,826–$16,212). TKA with PSI patients were 31% (odds ratio [OR]: 0.69; 95% CI: 0.51–0.95; p-value = 0.0218) less likely to be readmitted at 30 days; 35% (OR: 0.65; 95% CI: 0.50–0.86; p-value = 0.0022) less likely to be readmitted at 60 days; 32% (OR: 0.68; 95% CI: 0.53–0.88; p-value = 0.0031) less likely to be readmitted at 90 days; 28% (OR: 0.72; 95% CI: 0.60–0.86; p-value = 0.0004) less likely to be readmitted at 365 days than TKA without PSI patients. Hospitals and health care professionals can use retrospective real-world data to make informed decisions on using PSI to reduce hospital cost and readmission rate, and improve outcomes in TKA patients.

Isolated Liner Revision for Total Knee Arthroplasty Instability: A Road That Should Remain Less Taken

2020 ◽  
Author(s):  
Jason D. Tegethoff ◽  
Rafael Walker-Santiago ◽  
William M. Ralston ◽  
James A. Keeney
Keyword(s):  
Total Knee Arthroplasty ◽  
Femoral Component ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
P Value ◽  
Surgical Morbidity ◽  
Exact Test ◽  
Total Knee ◽  
Component Revision

AbstractIsolated polyethylene liner exchange (IPLE) is infrequently selected as a treatment approach for patients with primary total knee arthroplasty (TKA) prosthetic joint instability. Potential advantages of less immediate surgical morbidity, faster recovery, and lower procedural cost need to be measured against reoperation and re-revision risk. Few published studies have directly compared IPLE with combined tibial and femoral component revision to treat patients with primary TKA instability. After obtaining institutional review board (IRB) approval, we performed a retrospective comparison of 20 patients treated with IPLE and 126 patients treated with tibial and femoral component revisions at a single institution between 2011 and 2018. Patient demographic characteristics, medical comorbidities, time to initial revision TKA, and reoperation (90 days, <2 years, and >2 years) were assessed using paired Student's t-test or Fisher's exact test with a p-value <0.01 used to determine significance. Patients undergoing IPLE were more likely to undergo reoperation (60.0 vs. 17.5%, p = 0.001), component revision surgery (45.0 vs. 8.7%, p = 0.002), and component revision within 2 years (30.0 vs. 1.6%, p < 0.0001). Differences in 90-day reoperation (p = 0.14) and revision >2 years (p = 0.19) were not significant. Reoperation for instability (30.0 vs. 4.0%, p < 0.001) and infection (20.0 vs. 1.6%, p < 0.01) were both higher in the IPLE group. IPLE does not provide consistent benefits for patients undergoing TKA revision for instability. Considerations for lower immediate postoperative morbidity and cost need to be carefully measured against long-term consequences of reoperation, delayed component revision, and increased long-term costs of multiple surgical procedures. This is a level III, case–control study.

Motivasi dan kepuasan kerja pegawai puskesmas BLUD dan non-BLUD Kabupaten Semarang

2018 ◽  
Vol 2 (3) ◽  
pp. 111
Author(s):  
Aswindar Adhi Gumilang ◽  
Tri Pitara Mahanggoro ◽  
Qurrotul Aini
Keyword(s):  
Public Health ◽  
Job Satisfaction ◽  
Financial Management ◽  
Work Motivation ◽  
P Value ◽  
The Public ◽  
The Status ◽  
The Difference ◽  
Demand For Health ◽  
Public Demand

The public demand for health service professionalism and transparent financial management made some Puskesmas in Semarang regency changed the status of public health center to BLUD. The implementation of Puskesmas BLUD and non-BLUD requires resources that it can work well in order to meet the expectations of the community. The aim of this study is to know the difference of work motivation and job satisfaction of employees in Puskesmas BLUD and non-BLUD. Method of this research is a comparative descriptive with a quantitative approach. The object of this research are work motivation and job satisfaction of employees in Puskesmas BLUD and non-BLUD Semarang regency. This Research showed that Sig value. (P-value) work motivation variable was 0.019 smaller than α value (0.05). It showed that there was a difference of work motivation of employees in Puskemas BLUD and non-BLUD. Sig value (P-value) variable of job satisfaction was 0.020 smaller than α value (0.05). It showed that there was a difference of job satisfaction of BLUD and non-BLUD. The average of non-BLUD employees motivation were 76.59 smaller than the average of BLUD employees were 78.25. The average of job satisfaction of BLUD employees were 129.20 bigger than the average of non-BLUD employee were 124.26. Job satisfaction of employees in Puskesmas BLUD was higher than non-BLUD employees.

HUBUNGAN LAMA WAKTU MENDERITA STROKE DENGAN TINGKAT KEMANDIRIAN KLIEN DALAM MELAKUKAN AKTIVITAS PEMENUHAN KEBUTUHAN SEHARI-HARI

2018 ◽  
Vol 1 (2) ◽  
pp. 58
Author(s):  
Setia Budi ◽  
Ria Dila Syahfitri
Keyword(s):  
Data Analysis ◽  
Univariate Analysis ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Stroke Incidence ◽  
Bivariate Data ◽  
Cross Sectional Design ◽  
Interviewing Techniques ◽  
Need For Rehabilitation

The rate of stroke incidence is about 200 per 100,000 people throughout the world. This study aims to determine the Relation Suffer Stroke With Independence Level In Neurology Polyclinic TK II DR Ak Gani Palembang Year Hospital 2017. The research method used is descriptive quantitative with cross sectional design that is done by interviewing techniques with questionnaires on 42 respondents with Accidental sampling technique. This research was conducted in August 2017. Data analysis used is univariate data analysis and bivariate data analysis with one way anova test result. The results of univariate analysis showed that the duration of the respondents suffering from stroke was between 2.10 years to 3.38 years. Also found that most respondents were at the level of independence f; independent, except bathing, dressing, moving, and one other function with a total of 12 respondents. The results showed that there was a significant relationship between the long suffering stroke with the level of independence with the value of p value 0.025. For that the need for rehabilitation to patients and families of patients in order to help improve the independence of stroke patients in doing their daily activities. Keywords : Long Suffer Stroke, Level of Independence

HUBUNGAN FAKTOR-FAKTOR INTERNAL PERAWAT DENGAN PENGETAHUAN PERAWAT TENTANG PENERAPAN STRATEGI PELAKSANAAN PADA PASIEN DENGAN GANGGUAN HALUSINASI

2018 ◽  
Vol 1 (1) ◽  
pp. 60
Author(s):  
Widya Arisandy
Keyword(s):  
Strategy Implementation ◽  
Analytic Approach ◽  
P Value ◽  
Sample Collection ◽  
Cross Sectional ◽  
Internal Factors ◽  
Is Research ◽  
Knowledge Strategy ◽  
Independent Variable ◽  
Research Nurses

Knowledge is the result of �know� and this is happening after they made a sensing towards an object certain .Sensing towards an object occur through panca human senses the sight , hearing , of smell , taste and touched with own .Knowledge about the implementation of the nurse strategy is obliged to understandable and in understand by a nurse soul .Many things can affect knowledge a nurse soul both internally and externally.Strategy the implementation of the act of nursing is a in made as a guide by a nurse if when interacting with disorder patients hallucinations.The purpose of research to know relations factors internal a nurse with knowledge nurse in the application of the implementation of the strategy in patients with disorder hallucinations in inpatient Rooms Hospital Ernaldi Bahar The Province Of South Sumatera 2017 . The kind of research done is research quantitative by using the method survey analytic approach in cross sectional .Technique the sample collection that is using a technique the sample collection total of sampling , the number of the sample are always 33 people .To research this independent variable consists of education , length of employment and the days of while dependent variable is knowledge nurse about strategy the implementation of the hallucinations . the results of this research was obtained one variable are associated than 3 variable internal factors researched namely working time with the results of p-value 0,011. Researchers hope from the results of this research , nurses can identify any factor that could affect the knowledge nurses and also can be used to understand the science of psychiatric Keywords : Nurses Knowledge, Strategy Implementation Hallucinations

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