Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients

2020 ◽  
Vol 21 (2) ◽  
pp. 101-110
Author(s):  
Wenyan Li ◽  
Ping Zhao ◽  
Liwen Chen ◽  
Xiaoyin Lai ◽  
Guohua Shi ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Warfarin Dose ◽  
Multiple Linear Regression Analysis ◽  
Han Chinese ◽  
Chinese Patients ◽  
Individual Variations ◽  
Elderly Chinese ◽  
The Individual ◽  
The Impact ◽  
Dose Variation

Aim: To analyze the impact of nongenetic factors and gene polymorphisms on warfarin dose requirements in elderly Shanghai Han Chinese patients. Materials & methods: Genotypes of CYP2C9 (rs1799853 and rs1057910), FPGS (rs7856096), ApoE (rs7412 and rs429358), GGCX (rs699664 and rs12714145), EPHX1 (rs4653436, rs1877724, rs1051740 and rs1131873), NQO1 (rs1800566 and rs10517), ABCB1 (rs1045642), VKORC1 (rs9923231) and CYP4F2 (rs2108622) in 214 patients with stable warfarin dose were determined and their demographic characteristics were recorded. Results: Multiple linear regression analysis revealed that VKORC1 rs9923231, CYP2C9*3 rs1057910, ApoE rs7412, age, BMI and concomitant amiodarone could explain 37.0% of the individual variations of daily stable warfarin dose. Conclusion: VKORC1 rs9923231, CYP2C9*3 rs1057910, ApoE rs7412, age, BMI and concomitant amiodarone play an important role in stable dose variation of warfarin in elderly Shanghai Han Chinese patients, whereas ABCB1 rs1045642 is not a significant genetic factor.

The Impact of Financial Distress, Corporate Governance, and Auditor Switching on Audit Delay

2021 ◽  
Vol 6 (2) ◽  
pp. 108-117
Author(s):  
Sylvi Angelia ◽  
Rizal Mawardi
Keyword(s):  
Corporate Governance ◽  
Financial Services ◽  
Financial Distress ◽  
Audit Committee ◽  
Stock Exchange ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Auditor Switching ◽  
Analysis Technique ◽  
The Impact

Objective – The purpose of this study is to examine the effect between financial distress, corporate governance, auditor switching and audit delay. This research sample using data on a manufacturing company on the Indonesia Stock Exchange. Methodology – The analysis technique used is multiple linear regression analysis technique. Findings– The research finding show that financial distress and the size of the audit committee have a significant effect on audit delay, while the concentration of ownership, managerial ownership, change of directors, and auditor switching has no significant effect on audit delay. Second finding explain that consideration for companies listed on the Indonesia Stock Exchange to pay attention to the timeliness of submitting financial reports and independent auditor reports so as not to get sanctions from the Financial Services Authority. Novelty – Our novelty research using the relationship of Financial Distress, Corporate Governance and Auditor Switching on new research model to Audit Delay. Type of Paper: Empirical JEL Classification: M41, M42 Keywords: Financial Distress, Corporate Governance, Auditor Switching, Audit Delay

Cooperative activation in cardiac muscle: impact of sarcomere length

2002 ◽  
Vol 282 (3) ◽  
pp. H1055-H1062 ◽  
Author(s):  
David P. Dobesh ◽  
John P. Konhilas ◽  
Pieter P. de Tombe
Keyword(s):  
Sarcomere Length ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Significant Function ◽  
Cardiac Myofilament ◽  
Data Points ◽  
On Line ◽  
The Impact ◽  
Cooperative Activation ◽  
Force Relationship

This study was undertaken to determine the impact of sarcomere length (SL) on the level of cooperative activation of the cardiac myofilament at physiological [Mg2+]. Active force development was measured in skinned rat cardiac trabeculae as a function of free [Ca2+] at five SLs (1.85–2.25 μm; 1 mM free [Mg2+]; 15°C). Only muscle preparations with minimal force rundown during the entire protocol were included in the analysis (average 7.2 ± 1.7%). Median SL was measured by on-line computer video micrometry and controlled within 0.01 μm. Care was taken to ensure a sufficient number of data points in the steep portion of the [Ca2+]-force relationship at every SL to allow for accurate fit of the data to a modified Hill equation. Multiple linear regression analysis of the fit parameters revealed that both maximum, Ca2+-saturated force and Ca2+sensitivity were a significant function of SL ( P < 0.001), whereas the level of cooperativity did not depend on SL ( P = 0.2). Further analysis of the [Ca2+]-force relationships revealed a marked asymmetry that, also, was not affected by SL ( P = 0.2–0.6). Finally, we found that the level of cooperativity in isolated skinned myocardium was comparable to that reported for intact, nonskinned myocardium. Our results suggest that an increase in SL induces an increase in the Ca2+ responsiveness of the cardiac sarcomere without affecting the level of cooperativity.

scholarly journals Pengaruh Kecerdasan Emosional Dan Ethical Sensitivity Terhadap Persepsi Etis Mahasiswa Sebagai Calon Akuntan

2020 ◽  
Vol 2 (4) ◽  
pp. 3840-3857
Author(s):  
Ridho Irmas Ferdian ◽  
Mayar Afriyenti
Keyword(s):  
Emotional Intelligence ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Multiple Linear Regression Analysis ◽  
Accounting Students ◽  
Ethical Sensitivity ◽  
Ethical Perceptions ◽  
City College ◽  
The Individual ◽  
Positive Effect

This study wanted to determine the ethical perceptions of students from the individual side of accounting students at FE UNP, namely from the emotional intelligence and ethical sensitivity of students. The author makes students the object of research because an accountant's ethical perceptions can also be influenced by several factors. One of them is external factors, namely the environment. The environment affects the formation of a person's character so that it affects their behavior. This research is classified as a causative research. The population used in this study were accounting students at the Padang City College. Samples were taken using purposive stratified sampling technique. Where is the sampling by taking samples of people selected by the author according to specific characteristics and certain characters. The analysis used in this study is multiple linear regression analysis used in this study is to use the SPSS 21 computer program. . The results of this study are that emotional intelligence has a positive effect on students' ethical perceptions as prospective accountants and ethical sensitivity has a positive effect on students' ethical perceptions as prospective accountants.

scholarly journals ANALISIS DAMPAK PENERAPAN IJIN USAHA TOKO MODERN TERHADAP KEBERADAAN PASAR TRADISIONAL DI KABUPATEN SLEMAN

2019 ◽  
Vol 3 (2) ◽  
pp. 224
Author(s):  
IRNI SEPTIANI ◽  
INSIATININGSIH INSIATININGSIH
Keyword(s):  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Social Aspects ◽  
Validity And Reliability ◽  
Independent Variables ◽  
Business Location ◽  
Traditional Markets ◽  
Traditional Market ◽  
The Impact ◽  
Research Analysis

The growth of Modern Stores in Indonesia is very rapid, experiencing growth from year to year, this condition is offset by demand from large communities and increasingly enjoys the convenience and comfort of shopping in modern stores. However, Sleman Regency D.I. Yogyakarta provides a number of rules as outlined in Regional Regulation No. 18 of 2012 concerning Licensing of Shopping Centers and Modern Stores, which it is hoped that this regulation will have a significant impact on equitable distribution between modern shops and traditional markets in Sleman Regency, YogyakartaReferring to the Regional Regulation, this research was carried out to see the impact of the application of the Modern Shop business permit to the existence of traditional markets in Sleman Regency D.I. Yogyakarta. In this study 200 samples were taken by distributing 250 questionnaires with a distribution of 125 questionnaires to managers and modern shop owners and 125 questionnaires to traditional shop owners in the traditional market of Sleman Regency D.I. Yogyakarta, which finally received 200 questionnaires. The method used for sampling is a non probability sampling method that is sampling by specifying specific criteria on respondents. Data collection techniques using questionnaires that have been tested for validity and reliability. Data analysis techniques using multiple linear regression analysis and data processed with SPSS software. The variables used in this study are 4 independent variables namely Business Location Aspects, Social Aspects, Partnership Aspects with MSMEs and Use of Local Workers Aspects, and 1 dependent variable namely the Existence of Traditional Markets. From the results of the research analysis it was concluded that the business location aspect variable (X1) had no impact on the existence of traditional markets with negative B1 (- 0.799) and t count was smaller than t table, Variable Social Aspects (X2) had no impact on the existence of Traditional Markets with B2 negative (-1,334) and t count smaller than t table, Variable Aspects of Partnership with MSME (X3) have an impact on the existence of Traditional Markets with positive B3 (9,153) and t count is greater than t table, Variable Aspects of Use of Power Local Work (X4) has an impact on the existence of Traditional Markets with positive B4 (1,646) and t count is greater than t table, and the four Independent Variables together have an impact on the dependent variable The existence of Traditional Market Sleman DIY Regency is allegedly also influenced by variables other variables not examined in this study.Keywords : modern shop, traditional market, Sleman Regency D.I. Yogyakarta, Existence of Traditional Markets

scholarly journals ANALISIS DAMPAK KEBERADAAN TOKO SWALAYAN TERHADAP OMZET PENJUALAN KIOS–KIOS KECIL DI KOTA MATARAM

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Basri Basri
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Product Diversification ◽  
Sampling Techniques ◽  
Study Guide ◽  
Validity And Reliability ◽  
The Impact ◽  
Level 2

The objective of the study was to evaluate the impact of stores existence toward sales turnover of stalls in Mataram city. Associative research design was adopted as the study guide. Purposive sampling techniques were used in which 100 copies of the research instrument were administered to stalls owner in Mataram city, out of which 100 copies of questionnaire were filled and returned. Test of validity and reliability, classical assumption test, and multiple linear regression analysis was used to analyse the data generated from respondents. The findings revealed that stores existence variable consisted of services, product diversification, price, and comfortable of consumer have significant influence on sales turnover of stalls at 0,05 level (2-tailed). The result of the research shows the variables negatively affecting sales turnover of stalls. Furthermore, price ranks the first follow by comfortable, product diversification, and services. This research will help the owner of stalls to understand and recognize the ranking of variables affecting sales turnover of stalls in Mataram city. Keywords:   Stores Existence, Stall, and Sales Turnover.

scholarly journals ANALISIS PERSEPSI PETANI TERHADAP PROGRAM KAWASAN RUMAH PANGAN LESTARI DI KAMPUNG DOSAI DISTRIK SENTANI BARAT KABUPATEN JAYAPURA PROVINSI PAPUA

2019 ◽  
Vol 15 (2) ◽  
pp. 128
Author(s):  
Edison Ayakeding ◽  
Keppi Sukesi ◽  
Yayuk Yuliati
Keyword(s):  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Individual Characteristics ◽  
Influential Factors ◽  
Community Empowerment ◽  
Program Testing ◽  
Food Research ◽  
Food And Nutrition ◽  
Observation Method ◽  
The Individual

<p><em>Papua is one of the provinces in Indonesia which has the characteristics of a different man in the business of fulfilling the needs of the family. The program of the Ministry of agriculture through community empowerment efforts to optimize the benefits of the grounds as a source of food family. Jayapura Regency is one of the areas that are also experiencing food security problems. Adequacy of food and nutrition is one of the most influential factors in producing quality human resources. The purpose of this research is to analyze the perceptions and the factors that influence the perception of farmers against the program Area Homes Preserved Food.  Research conducted in the Western County of Sentani Dosai district of Jayapura of Papua by engaging 25 respondents who implement programs KRPL in 2013. The technique of collecting data through observation method, Now as well as granting interviews specifically. Type a descriptive quantitative data. The measurement of perception of farmers using likert scale gauge. The results of the measurements indicate that the level of perception of farmers against very low KRPL program. Testing free variables using multiple linear regression analysis. The results of the analysis showed that the fulfillment of the needs and knowledge of the real effect, While the individual characteristics, experience factor farmer KRPL and support agencies have no effect on real. The value of R-sq (adj) indicates the magnitude of the influence of variables against the perception that is free of 46.83%, While the 53.17% influenced by other factors outside of this research.</em></p><p><strong>Abstrak: </strong>Papua merupakan salah satu provinsi di Indonesia yang memiliki karakteristik manusia yang berbeda-beda dalam usaha pemenuhan kebutuhan keluarga. Program Kementerian Pertanian melalui upaya pemberdayaan masyarakat untuk mengoptimalkan manfaat pekarangan sebagai sumber pangan keluarga. Kabupaten Jayapura merupakan salah satu daerah yang juga mengalami masalah ketahanan pangan. Kecukupan pangan dan gizi merupakan salah satu faktor yang berpengaruh dalam menghasilkan sumber daya manusia yang berkualitas. Tujuan penelitian ini adalah menganalisis persepsi dan faktor-faktor yang mempengaruhi persepsi petani terhadap program Kawasan Rumah Pangan Lestari. Penelitian dilakukan di Kampung Dosai Distrik Sentani Barat Kabupaten Jayapura Papua dengan melibatkan 25 responden yang melaksanakan program KRPL pada tahun 2013. Teknik Pengumpulan data melalui metode observasi, pemberian angket serta wawancara  secara spesifik. Jenis data deskriptif kuantitatif. Pengukuran persepsi petani menggunakan alat ukur skala likert. Hasil pengukuran menunjukkan bahwa tingkat persepsi petani terhadap program KRPL sangat rendah. Pengujian variabel bebas menggunakan alat analisis regresi linier berganda. Hasil analisis menunjukkan bahwa faktor pemenuhan kebutuhan dan pengetahuan berpengaruh nyata sedangkan faktor karakteristik individu, pengalaman usaha tani KRPL dan dukungan instansi tidak berpengaruh nyata. Nilai R-sq(adj) menunjukan besarnya pengaruh variabel bebas terhadap persepsi yaitu sebesar 46,83%, sedangakan 53,17% dipengaruhi faktor-faktor lain diluar dari pada penelitian ini.</p><p><em><br /></em></p>

scholarly journals The Impact of Leadership, Motivation and Discipline on Employee Performance (a Study on Employees of PT Surabaya Marine)

2021 ◽  
Author(s):  
Eva Trisnawati Chumairoh ◽  
Trianggoro Wiradinata
Keyword(s):  
Regression Analysis ◽  
Data Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Employee Performance ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Independent Variables ◽  
Leadership Motivation ◽  
The Impact

This purpose of this study was to determine the effect of leadership, motivation and discipline on employee performance. The independent variables were leadership (X1), motivation (X1) and discipline (X3). The dependent variable was employee performance (Y). This was explanatory research with a quantitative approach. The study was conducted at PT Surabaya Marine with employees. Data analysis was carried out through multiple linear regression analysis with the F test and t test. Employee performance was strongly influenced by leadership, motivation and discipline. Keywords: leadership, motivation, discipline, employee performance

scholarly journals Evaluation of Lumbar Stiffness after Long-Level Fusion  for Degenerative Lumbar Scoliosis in Chinese population

2020 ◽  
Author(s):  
Xinling Zhang ◽  
Lei Yuan ◽  
Yan Zeng ◽  
Zhongqiang Chen ◽  
Weishi Li ◽  
...  
Keyword(s):  
Internal Consistency ◽  
Chinese Population ◽  
Chinese Patients ◽  
Personal Hygiene ◽  
Degenerative Lumbar Scoliosis ◽  
Lumbar Scoliosis ◽  
Patient Reported ◽  
Elderly Chinese ◽  
The Impact ◽  
Level Fusion

Abstract Study Design: a retrospective study.Summary of Background Data: Long-level spinal instrumented fusion for DLS by intention eliminated spinal motion in an attempt to alleviate pain, improve deformity, and reduce disability. However, this surgery considerably impaired performance of activities of daily living (ADL) due to the resulting stiffness. The lumbar stiffness disability index (LSDI) was a validated measure of the effect of lumbar stiffness on functional activity, however, which might not be fully applicable to elderly Chinese population because of their several special lifestyles.Objective: To evaluate the lumbar stiffness in patients with degenerative lumbar scoliosis (DLS) after long-level fusion by Chinese-LSDI (C-LSDI).Methods: 129 DLS patients underwent long-level (≧4 levels) fusion surgery with at least one-year follow-up were included. The C-LSDI was designed by modifying LSDI and Korean-LSDI (K-LSDI) considering elderly Chinese lifestyles, and the patient-reported outcome questionnaire measuring the impact of lumbar stiffness on functional abilities in elderly Chinese with DLS was assessed for internal consistency and retest repeatability.Results: All patients showed increased lumbar stiffness with significantly improvement in pain and deformity postoperatively, and for items of performing personal hygiene after toileting and getting out of a car, people performed more inconvenient with increasing fixed levels. Compared with LSDI and K-LSDI, the C-LSDI demonstrated high internal consistency (Cronbach’s alpha=0.902) and retest reliability (ICC=0.904) in the elderly Chinese population. Conclusion: This study demonstrated that the C-LSDI questionnaire was a reliable and valid instrument for assessing functional limitations due to lumbar stiffness among elderly Chinese patients with DLS after long-level fusion. Although the effects of stiffness did trend toward greater impacts among patients underwent longer fusions, most patients were satisfied with trade-offs of function and pain relief in exchange for perceived increases in lumbar stiffness.

scholarly journals The Influence of Good Corporate Governance and Capital Structure on Firm Value: The Mediation Role of Financial Performance

2020 ◽  
Vol 35 (2) ◽  
pp. 230
Author(s):  
Ridwan Nurazi ◽  
Intan Zoraya ◽  
Akram Harmoni Wiardi
Keyword(s):  
Corporate Governance ◽  
Capital Structure ◽  
Financial Performance ◽  
Firm Value ◽  
Stock Exchange ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Company Value ◽  
Good Corporate Governance ◽  
The Impact

<pre>The objective of this study is empirically identify the impacts of Good Corporate Governance and capital structure on firm value with financial performance as intervening variable. We operate quantitative approach within the scope of manufacturing company of metal, chemical, and plastic packaging sector which listed in Indonesia Stock Exchange during the 2017-2018 periods as the population. Samples are chosen by purposive sampling method inwhich the company must report the financial statement in a row, obtained 79 observations. The data analysis technique used is financial ratio analysis to determine the condition of the business financial ratios of the variables studied. Data were analyzed using multiple linear regression analysis. The result shows that corporate governance and capital structure influence the firm value, moreover the use of institutional ownership ratio and capital structure will increase the value of the firm. The result also shows that the impact of Corporate governance and capital structure on the company value are mediated by financial performance. It means that the value of the firm can increase if the company able became an effective monitoring tool.</pre>

scholarly journals Dampak Hubungan Karyawan dan Kedisiplinan Kerja terhadap Kinerja Karyawan

2019 ◽  
Vol 1 (2) ◽  
pp. 382-393
Author(s):  
Rizki Akbari ◽  
Kokom Komariah ◽  
Dicky Jhoansyah
Keyword(s):  
Employee Performance ◽  
Linear Regression Analysis ◽  
Correlation Coefficients ◽  
Multiple Linear Regression Analysis ◽  
Test Reliability ◽  
Coefficient Of Determination ◽  
Employee Relations ◽  
Analysis Technique ◽  
Multiple Correlation Coefficients ◽  
The Impact

The purpose of this study was to determine the impact of employee relations (variable X1) and Work Discipline (variable X2) on Employee Performance (variable Y). The method used in this research is to use descriptive and associative methods. Data collection techniques used by researchers in this study are through observation, questionnaire interviews, documentation and literature studies. The data analysis technique used is the validity test, reliability test, multiple linear regression analysis, including the test of the coefficient of determination and multiple correlation coefficients. The results of the test of the coefficient of determination seen from the value (Adjusted R2) of 0.531 can be interpreted that the impact of employee relations and working discipline on employee performance is equal to 53.1%. The remaining 46.9% is influenced by other factors outside this study. Conclusion, there is a moderate relationship between employee relations and work discipline with employee performance. Keywords: Employee Relations, Work Discipline, Employee Performance

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