scholarly journals Sibr (Aloe barbadensis): A Short Description with Unani Approach

2021 ◽  
Vol 11 (2) ◽  
pp. 224-227
Author(s):  
Hilal Akhtar ◽  
Mohammad Wasi Akhtar ◽  
Mohammad Saad Ahmad Khan ◽  
Syed Zeba Husain
Keyword(s):  
Low Density Lipoprotein ◽  
Aloe Vera ◽  
Density Lipoprotein ◽  
Arid Environment ◽  
Deficiency Syndrome ◽  
Short Description ◽  
Herbal Drugs ◽  
Aloe Barbadensis ◽  
Essential Components ◽  
Medicinal Properties

In many parts of world, there is still a tradition of using herbal drugs to combat various diseases & infections. Sibr is one of the essential components of Unani system of medicine and used by Unani physicians due to it’s a lot of medicinal properties since ancient time. It is commonly called Aloe-vera and belongs to the Lilicaceal family. It is a cactus like herb and grows in hot and arid environment. Unani physicians have been using this drug as a laxative, purgative (phlegm/bile), brain tonic, stomach tonic, liver tonic, emmenogogue, anti-inflammatory, blood purifier, antibacterial, and carminative agent. Hence, this drug having a vital place in Unani system of medicine and text. It is also use to reducing Low density Lipoprotein, increasing High density Lipoprotein, minimizing frost-bite injury, reducing blood glucose level, fighting against Acquired Immuno Deficiency Syndrome (AIDS), allergies, and boosting immune system. This article was designed to lime light the Aloe barbadensis by describing its brief toxicology, contraindications, traditional, therapeutic and others uses. Keywords: Antibacterial, Aloe barbadensis, Sibr, therapeutic, Unani system of medicine.

scholarly journals In vivo and in silico investigations of the toxicological and analgesic properties of unprocessed Aloe vera gel in experimental rat models

2018 ◽  
Vol 70 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Subhashis Paul ◽  
Arnab Chakraborty ◽  
Debabrata Modak ◽  
Arnab Sen ◽  
Soumen Bhattacharjee
Keyword(s):  
Side Effects ◽  
Low Density Lipoprotein ◽  
Aloe Vera ◽  
Density Lipoprotein ◽  
Bioactive Molecules ◽  
Complementary Medicines ◽  
Aloe Vera Gel ◽  
Liver And Kidney ◽  
Aloe Gel

Aloe vera is a commonly used plant in both food and medicine industry. The potential toxicological side-effects of prolonged intake of Aloe extract have not been evaluated in detail. This work presents an in-depth toxicological study of the crude unprocessed A. vera gel in experimental rats. Acute and sub-chronic toxicity was evaluated in a 1 to 28-day long feeding schedule of the aqueous homogenized gel material. Hemoglobin, total protein, high density lipoprotein (HDL), low density lipoprotein (LDL), cholesterol, triglyceride, serum creatinine, serum alanine transaminase (SGPT), aspartate transaminase (SGOT) and alkaline phosphatase were examined and kidney and liver histology was performed. In the acute toxicity test, the behavioral aspects were also considered. A molecular docking assay was performed to investigate the binding affinities of pure A. vera compounds with liver and kidney toxicological marker enzymes, in order to assess the probable mode of action of selected Aloe constituents. Solubility factors for the active constituents were also studied to determine their possible miscibility with body fluids. The results from in vivo tests provided no major toxicological indications. Crude Aloe gel consumption up to 4 g/kg body weight (b.w.) showed no toxicological side effects. From the structural standpoint, Aloe-based bioactive molecules, such as Aloe-emodin, acetophenone, ?-sitosterol, cholestenol and squalene showed promising binding affinity to qualify as alternative and complementary medicines. The synergistic roles of all A. vera constituents remain to be validated in human disease models.

scholarly journals A Study Based on Controlled Drug Release by 3D Printed Aloe-Vera Bi-Layer Tablet

2021 ◽  
pp. 522-531
Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Integral Functional ◽  
Aloe Vera ◽  
Controlled Drug Release ◽  
Immediate Release ◽  
Aloe Barbadensis ◽  
3D Printed ◽  
Medicinal Properties ◽  
Printing Techniques

Aloe-Vera or Aloe barbadensis (botanical name) is a plant with many medicinal properties and have great importance in Ayurveda. Its leaves are succulent, erect, forming a thick rosette. The internal translucent pulp of Aloe-Vera is bound to a waxy crust or cuticle, and its vascular tissues transport minerals as well as water from the soil. Aloe Vera is being used as a major skin rejuvenating product, although it has varied medicinal properties also. In the present study, an attempt to make a method to create bi-layer tablets of Aloe-Vera, utilizing 3D printing techniques is presented. The method created doesnt affect the integral functional characteristics of the tablet. The method here contains creating an immediate release and sustained release tablet for making the Aloe-Vera to be used directly by the person for its numerous health effects. The tablet is designed so to be consumed by vegans as well since it is completely herbal.

scholarly journals Formulation and evaluation of multipurpose herbal cream

2019 ◽  
Vol 9 (2) ◽  
pp. 341-343
Author(s):  
ARCHANA DHYANI ◽  
Vikas Chander ◽  
Nardev Singh
Keyword(s):  
Curcuma Longa ◽  
Aloe Vera ◽  
Aloe Barbadensis ◽  
Neem Leaves ◽  
Medicinal Properties ◽  
Crude Drugs ◽  
Herbal Cosmetics ◽  
The Individual ◽  
Evaluation Parameters ◽  
Selection Of

Herbal cosmetics are the preparations used to improve the individual appearance. The aim of the present study was to prepare the herbal cream for the use of moistening, nourishing and cure of various disease of the skin. Different crude drugs like Aloe barbadensis (Aloe Vera leaves), Azadirachta Indica (Neem-leaves), Curcuma  longa  (Turmeric-rhizomes) and Emblica Officinali (Amla) are used to formulate the cream. The selection of ingredients based on the different medicinal properties of the agents.The cream is subjected to various evaluation parameters. Keywords: Cosmetics, herbal cream, Turmeric, Neem, Aloe Vera

Hypolipidemic drugs inhibiting the proprotein convertase of subtilisin/kexin type 9 (PCSK9): monoclonal antibodies, antisense oligonucleotides, small interfering ribonucleic acids

2021 ◽  
Vol 19 (1) ◽  
pp. 37-46
Author(s):  
Aleksey M. Chaulin
Keyword(s):  
Monoclonal Antibodies ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Main Task ◽  
Low Density ◽  
Proprotein Convertase ◽  
Ribonucleic Acids ◽  
Essential Components ◽  
Inflammatory Processes ◽  
Hypolipidemic Drugs

Hypolipidemic therapy is one of the essential components for the management of patients with cardiovascular diseases (CVD). In this regard, the main task of modern research is to find new targets for creating additional effective groups of hypolipidemic drugs. In 2003, canadian and french research groups led by N. Seidah and M. Abifadel discovered a new enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9), which later turned out to play an important role in lipid metabolism. The main mechanism of action of PCSK9 is to regulate the density of low-density lipoprotein receptors (LDLR) in the cell membrane of hepatocytes. Increased activity of PCSK9 significantly accelerates the degradation of LDL and leads to an increase in the concentration of atherogenic classes of lipoproteins-low-density lipoproteins (LDL). In contrast, reduced PCSK9 activity is accompanied by a decrease in LDL concentrations and a reduced risk of developing atherosclerosis and CVD. The second of the recently discovered and less studied mechanism of PCSK9 protearogenic action is an increase in inflammatory processes in the atherosclerotic plaque. Given this adverse contribution of PCSK9 to the development and progression of atherosclerosis and CVD, the main task of the researchers was to develop drugs that inhibit THIS enzyme. To date, several new groups of drugs have been developed that target the stages of biosynthesis and the function of PCSK9. In this article, we will focus in detail on discussing the mechanisms of action and effectiveness of the following groups of hypolipidemic drugs: anti-PCSK9 monoclonal antibodies (alirocumab, evolocumab), small interfering ribonucleic acids (incliciran), and antisense nucleotides.

scholarly journals Effect of Extraction Methods on Chemical and Physical Properties of Aloe Vera (Aloe Barbadensis Miller) Polysaccharides Fraction: Liguid Gel and Powders

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Traore Souleymane ◽  
Coulibaly Ibourahema ◽  
Agbo Adouko Edith ◽  
Grodji Albarin Gbogouri ◽  
Brou Kouakou ◽  
...  
Keyword(s):  
Physical Properties ◽  
Sugar Content ◽  
Aloe Vera ◽  
Extraction Methods ◽  
Aloe Barbadensis ◽  
Total Sugar Content ◽  
Molecular Weights ◽  
Medicinal Properties ◽  
Molecular Number ◽  
Kinetics Of

The aim of this study was to evaluate the influence of extraction methods on chemical and physical properties of Aloe vera polysaccharides. The study was conducted on two commercial products: Aloe vera powder and an extract liquid of whole leaf. The kinetics of hydrolysis is carried out on the Aloe vera products. Hot, cold extraction with water and boiled ethanol extraction were carried out to obtain polysaccharide fractions (A1, A2, A3, and A4). The molecular weights of each fraction were determined. Proteins, galacturonic acid and sugars were quantified. Results showed that approximately, 25% of sugars were present in Aloe vera powder. The best extraction method were cold extraction (pH 5.3, 25°C, 4h) which showed the higher extraction yields (69.4±0.1%) in polysaccharide (Poly) A, than other extraction methods. Interestly, results showed a decrease of molecular weights, molecular number, and protein contents from 150 to 30 kDa, from 97 to 29 kDa and from 4.9±0.1 to 0.00% respectively with polysaccharides fractionment methods. Moreover, the total sugar content increases in polysaccharide fraction: 29.2±0.1%, 76.6±0.1% and 93.4±0.4% for Poly A, A1 and A2 respectively. The highest sugar content were observed in Poly A3 ≈ 97.8±1.5% probably glucomannan, with 77.3±6.5% of mannose, 18.7±2.8% of glucose. The data suggest that the fractionment methods could lead to product the purified polysaccharide which could be use for nutritional, biological and medicinal properties. 

scholarly journals New groups of hypolipidemic medications based on inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9). Part 1

2021 ◽  
Vol 98 (11-12) ◽  
pp. 739-744
Author(s):  
A. M. Chaulin
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Mechanisms Of Action ◽  
Main Task ◽  
Low Density ◽  
Research Groups ◽  
Lipoprotein Receptors ◽  
Ribonucleic Acids ◽  
Essential Components ◽  
Increased Activity

Hypolipidemic therapy is one of the essential components for the management of patients with cardiovascular diseases (CVD). In this regard, the main task of modern research is to find new targets for creating additional effective groups of hypolipidemic medications. Canadian and French research groups led by N. Seidah and M. Abifadel discovered a new enzyme — proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003. It turned out to play an important role in lipid metabolism later. The main mechanism of action of PCSK9 is to regulate the density of low-density lipoprotein receptors (LDLR) in the cell membrane of hepatocytes. Increased activity of PCSK9 accelerates the degradation of LDL significantly, and leads to an increase in the concentration of atherogenic classes of lipoproteins — low-density lipoproteins (LDL). In contrast, reduced PCSK9 activity is accompanied by a decrease in LDL concentrations and a reduced risk of developing atherosclerosis and CVD. The second of the recently discovered and less studied mechanism of PCSK9 protearogenic action is an increase in inflammatory processes in the atherosclerotic plaque. Considering this adverse contribution of PCSK9 to the development and progression of atherosclerosis and CVD, the main task of the researchers was to develop medications that inhibit THIS enzyme. Several new groups of medications that target the stages of biosynthesis and the function of PCSK9 have been developed by now. In this article, we will focus on details discussing the mechanisms of action and effectiveness of the following groups of hypolipidemic medications: anti-PCSK9 monoclonal antibodies (alirocumab, evolocumab), small interfering ribonucleic acids (incliciran), and antisense nucleotides.

scholarly journals PENGARUH VITAMIN C TERHADAP KADAR LOW DENSITY LIPOPROTEIN (LDL) LANJUT USIA SETELAH PEMBERIAN JUS LIDAH BUAYA (Aloe barbadensis Miller)

2014 ◽  
Vol 3 (4) ◽  
pp. 770-776
Author(s):  
Yuhud Tri Hapsari ◽  
Aryu Candra Kusumastuti
Keyword(s):  
Vitamin C ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Design ◽  
T Test ◽  
Low Density ◽  
Aloe Barbadensis ◽  
Post Test ◽  
Quasi Experimental ◽  
Test Control

Latar Belakang : Tingginya kadar LDL dapat menyebabkan terjadinya aterosklerosis yang merupakan awal terjadinya PJK. Kandungan zat gizi dari jus lidah buaya dan antioksidan dari vitamin C dapat menurunkan kadar LDL. Penelitian ini bertujuan menganalisis pengaruh vitamin C setelah pemberian jus lidah buaya terhadap kadar LDL lansia.Metode : Jenis penelitian adalah quasi experimental dengan rancangan pre-post test control design yang melibatkan lansia sebagai subyek. Penelitian dilakukan di Unit Rehabilitasi Sosial “Pucang Gading” Semarang. Seluruh subyek mendapatkan jus lidah buaya sebanyak 200 ml/hari selama 14 hari. Hari ke-15 dilanjutkan dengan intervensi yaitu pemberian vitamin C 750 mg/hari selama 3 hari pada kelompok perlakuan dan pemberian plasebo pada kelompok kontrol. Jumlah sampel tiap kelompok adalah 10. Analisis kadar LDL dilakukan dengan metode enzimatik. Uji normalitas data menggunakan Saphiro-Wilk, analisis statistik menggunakan dependent t-test dan WilcoxonHasil : Rerata penurunan kolesterol LDL setelah pemberian jus lidah buaya pada kelompok perlakuan sebesar 13,30 mg/dl (9,69%) dan kontrol sebesar 13,50 mg/dl (10,74%). Rerata penurunan kadar LDL setelah pemberian vitamin C kelompok kelompok perlakuan sebesar 13,20 mg/dl (11,91%) sedangkan kontrol sebesar 4,40 mg/dl (4,01%). Tidak ada perbedaan kadar LDL antara kelompok perlakuan dan kelompok kontrol setelah pemberian vitamin C (p>0,05).Kesimpulan : Pemberian jus lidah buaya menurunkan kadar LDL secara bermakna. Namun dalam penelitian ini pemberian vitamin C tidak terbukti mempertahankan penurunan kadar LDL.

scholarly journals PENGARUH PEMBERIAN JUS LIDAH BUAYA (ALOE VERA) TERHADAP KADAR KOLESTEROL LOW DENSITY LIPOPROTEIN (LDL) DAN HIGH DENSITY LIPOPROTEIN (HDL)

2012 ◽  
Vol 1 (1) ◽  
pp. 241-248
Author(s):  
Yulika Sianipar ◽  
Muflihah Isnawati
Keyword(s):  
Low Density Lipoprotein ◽  
Aloe Vera ◽  
Density Lipoprotein ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Consecutive Sampling ◽  
Post Test ◽  
True Experiment ◽  
Paired T Test

Latar Belakang: Dislipidemia merupakan salah satu faktor  risiko terjadinya penyakit jantung koroner. Lidah buaya (Aloe vera) mengandung beberapa bahan aktif  dapat menurunkan kolesterol dalam darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus lidah buaya dengan dosis bertingkat terhadap kolesterol LDL dan kolesterol HDL pada wanita dislipidemia. Metode : Penelitian ini merupakan true experiment dengan  pre test - post test with control group design. Subjek penelitian adalah karyawati di Dinas Koperasi dan UKM Provinsi Jawa Tengah serta Balai Latihan Koperasi dan UKM Provinsi Jawa Tengah yang diambil secara consecutive sampling, besar sampel adalah 43 orang yang dibagi secara acak dalam tiga kelompok. Kelompok kontrol tidak diberi lidah buaya, kelompok perlakuan 1 dan kelompok perlakuan 2 diberikan lidah buaya sebanyak 100 mg/hari dan 200 mg/hari yang diberikan dalam bentuk jus selama 14 hari. Kadar kolesterol LDL dan kadar kolesterol LDL diukur sebelum dan sesudah intervensi. Analisis kolesterol LDL dan kolestrol HDL menggunakan metode enzimatik. Data yang diperoleh dianalisis menggunakan uji paired t-test dan anova pada derajat kemaknaan 5%. Hasil : Pada  pemberian jus Aloe vera 200 mg menyebabkan penurunan kadar kolesterol LDL dan meningkatkan kadar kolesterol HDL secara bermakna (p<0,05). Kadar kolesterol LDL menurun sebesar 20,36% dan kadar kolesterol HDL meningkat sebesar 18,87% setelah diberikan jus lidah buaya selama 14 hari. Pemberian jus Aloe vera 100 mg dapat menurunkan kadar kolesterol LDL tetapi juga mengalami penurunan kadar kelosterol HDL tetapi tidak bermakan (P>0,05) . Simpulan: Pemberian jus lidah buaya 200 mg/hari dapat menurunkan kadar kolesterol LDL dan meningkatkan kolesterol HDL secara bermakna.

scholarly journals New groups of hypolipidemic drugs based on inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9). Part 1

2021 ◽  
Vol 6 (1) ◽  
pp. 54-60
Author(s):  
Aleksey M. Chaulin ◽  
Nikolay A. Svechkov ◽  
Dmitry V. Duplyakov
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Main Task ◽  
Low Density ◽  
Proprotein Convertase ◽  
Ribonucleic Acids ◽  
Lipid Lowering Drugs ◽  
Essential Components ◽  
Inflammatory Processes

The hypolipidemic therapy is one of the essential components for the management of patients with cardiovascular diseases (CVD). In this regard, the main task of modern research is to find new targets for creating additional effective groups of lipid-lowering drugs. In 2003, a Canadian and French research team led by N. Seidah and M. Abifadel discovered a new enzyme, proprotein convertase subtilisin-kexin type 9 (PCSK9), which plays an important role in lipid metabolism. The main mechanism of action of PCSK9 is to regulate the density of low-density lipoprotein receptors (LDLR) in the cell membrane of hepatocytes. The increased activity of PCSK9 significantly accelerates the degradation of LDLR and leads to an increase in the concentration of atherogenic classes of lipoproteins the low-density lipoproteins (LDL). A reduced activity of PCSK9, on the contrary, is accompanied by a decrease in the concentration of LDL and a decrease in the risk of developing atherosclerosis and CVD. The second, recently discovered and less studied, mechanism of the protearogenic action of PCSK9 is the enhancement of inflammatory processes in the atherosclerotic plaque. Given this unfavorable contribution of PCSK9 to the development and progression of atherosclerosis and CVD, the main task of the researchers was to develop drugs that inhibit this enzyme. To date, several new drug groups have been developed that target the biosynthesis steps and the function of PCSK9. In this article, we will focus in detail on the discussion of the mechanisms of action and effectiveness of the following groups of lipid-lowering drugs: anti-PCSK9 monoclonal antibodies (alirocumab, evolocumab), small interfering ribonucleic acids (incliciran) and antisense nucleotides.

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

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