scholarly journals Uninvestigated Dyspepsia and Heartburn Overlap Syndrome at Industrial Hub of Eastern Siberia

2021 ◽  
Vol 31 (4) ◽  
pp. 21-30
Author(s):  
V. V. Tsukanov ◽  
A. V. Vasiutin ◽  
J. L. Tonkikh ◽  
E. V. Kasparov ◽  
O. V. Smirnova
Keyword(s):  
Overlap Syndrome ◽  
Ethical Standards ◽  
Eastern Siberia ◽  
Prevention Measures ◽  
Treatment And Prevention ◽  
Central District ◽  
The World ◽  
Study Population ◽  
Prokinetic Therapy ◽  
Rome Iv

Aim. A study of the overlap syndrome of uninvestigated dyspepsia and heartburn at an industrial hub city of Eastern Siberia.Materials and methods. A total of 1,382 subjects (684 men and 698 women, mean age 40.6 years) were randomly selected and examined for the central district of Krasnoyarsk. The clinical check-up and interviewing results were registered with a standard questionnaire. Heartburn was diagnosed as per the Montreal Consensus. Since no endoscopic patient examination had been performed, dyspepsia was assumed uninvestigated. Dyspepsia was diagnosed as per the Rome IV criteria. The study conduction complied with ethical standards. Each participant signed an informed examination consent, in accordance to the regulations by the World Medical Association’s Declaration of Helsinki. The survey data were analysed with common statistical methods.Results. Heartburn, uninvestigated dyspepsia and their overlap syndrome had prevalence of 12.4, 21.1 and 5% in study population, respectively. Uninvestigated dyspepsia was registered in 40.4% patients with and 18.4% — without heartburn (p < 0.001). The risk factors of overlap syndrome were age >40 years (p = 0.002), obesity (p = 0.002), nonsteroidal anti-inflammatory drug and/or aspirin intake (p = 0.004) and tobacco smoking (p = 0.007). Among total patients with the heartburn/uninvestigated dyspepsia overlap syndrome, only 33.3% systemically had proton pump inhibitors, and only 17.4% had a prokinetic therapy.Conclusion. The heartburn/uninvestigated dyspepsia overlap syndrome is an actual issue in the Krasnoyarsk population. Attention is warranted to this problem to optimise treatment and prevention measures.

ADDRESSING THE ISSUE OF СOVID-19, SARS-COV-2 VIRUS AND THE DISEASE

2020 ◽  
Vol 99 (6) ◽  
pp. 15-31
Author(s):  
A.A. Korenkova ◽  
◽  
E.M. Mayorova ◽  
V.V. Bahmetjev ◽  
M.V. Tretyak ◽  
...  
Keyword(s):  
Public Health ◽  
Immune Responses ◽  
Molecular Mechanisms ◽  
Herd Immunity ◽  
Significant Problem ◽  
Prevention Measures ◽  
Optimal Therapy ◽  
The World ◽  
Public Health Challenge ◽  
Coronavirus Infection

The new coronavirus infection has posed a major public health challenge around the world, but new data on the disease raises more questions than answers. The lack of optimal therapy is a significant problem. The article examines the molecular mechanisms of SARS-CoV-2 infection and the pathogenesis of COVID-19, special attention is paid to features of pathological processes and immune responses in children. COVID-19 leads to a wide diversity of negative outcomes, many of which can persist for at least months. Many of the consequences have yet to be identified. SARS-CoV-2 may provoke autoimmune reactions. Reinfection, herd immunity, vaccines and other prevention measures are also discussed in this review.

scholarly journals From the Infection to the Immunotherapy in Cervical Cancer: Can We Stop the Natural Course of the Disease?

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 597
Author(s):  
Daniela Luvero ◽  
Salvatore Lopez ◽  
Giorgio Bogani ◽  
Francesco Raspagliesi ◽  
Roberto Angioli
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Risk Factor ◽  
Hpv Vaccine ◽  
Global Market ◽  
Cancer Death ◽  
Prevention Measures ◽  
Primary And Secondary Prevention ◽  
The World ◽  
Prevention And Treatment

Cervical cancer (CC) is the second leading cause of cancer death in women aged 20–39 years. Persistent infection with oncogenic types of human papillomavirus (HPV) represents the most important risk factor for the development of cervical cancer. Three HPVs vaccines are currently on the global market: bivalent, quadrivalent, and nonavalent. The nonavalent vaccine provides protection against almost 90% of HPV-related CC. Despite availability of primary and secondary prevention measures, CC persists as one of the most common cancers among women around the world. Although CC is a largely preventable disease, management of persistent or recurrent CC no longer amenable to control with surgery or radiation therapy has not improved significantly with the progress of modern chemotherapy and disseminated carcinoma of the cervix remains a discouraging clinical entity with a 1-year survival rate between 10% and 15%. Over the last few years, there has been increasing interest in immunotherapy as a strategy to fight tumors. This article focuses on recent discoveries about the HPV vaccine and immunotherapies in the prevention and treatment of CC, highlighting the future view.

scholarly journals A New Transmission Route for the Propagation of the SARS-CoV-2 Coronavirus

Biology ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 10
Author(s):  
Antoine Danchin ◽  
Tuen Wai Ng ◽  
Gabriel Turinici
Keyword(s):  
Compartmental Model ◽  
Transmission Route ◽  
Future Trends ◽  
Prevention Measures ◽  
Public Records ◽  
Specific Strategy ◽  
Virus Tropism ◽  
The World ◽  
Novel Coronavirus ◽  
Existing Data

Background: Starting late 2019, a novel coronavirus spread from the capital of the Hubei province in China to the rest of the country, then to most of the world. To anticipate future trends in the development of the pandemic, we explore here, based on public records of infected persons, how variation in the virus tropism could end up in different patterns, warranting a specific strategy to handle the epidemic. Methods: We use a compartmental model to describe the evolution of an individual through several possible states: susceptible, infected, alternative infection, detected, and removed. We fit the parameters of the model to the existing data, taking into account significant quarantine changes where necessary. Results: The model indicates that Wuhan quarantine measures were effective, but that alternative virus forms and a second propagation route are compatible with available data. For the Hong Kong, Singapore, and Shenzhen regions, the secondary route does not seem to be active. Conclusions: Hypotheses of an alternative infection tropism (the gut tropism) and a secondary propagation route are discussed using a model fitted by the available data. Corresponding prevention measures that take into account both routes should be implemented to the benefit of epidemic control.

scholarly journals Research Progress of Desertification and Its Prevention in Mongolia

2021 ◽  
Vol 13 (12) ◽  
pp. 6861
Author(s):  
Xiya Liang ◽  
Pengfei Li ◽  
Juanle Wang ◽  
Faith Ka Shun Chan ◽  
Chuluun Togtokh ◽  
...  
Keyword(s):  
Model Development ◽  
Mitigation Strategies ◽  
Research Progress ◽  
Prevention Measures ◽  
Interdisciplinary Approaches ◽  
The World ◽  
Impacting Factors ◽  
Decoupling Analysis ◽  
And Control ◽  
The Relationship

Mongolia is a globally crucial region that has been suffering from land desertification. However, current understanding on Mongolia’s desertification is limited, constraining the desertification control and sustainable development in Mongolia and even other parts of the world. This paper studied spatiotemporal patterns, driving factors, mitigation strategies, and research methods of desertification in Mongolia through an extensive review of literature. Results showed that: (i) remote sensing monitoring of desertification in Mongolia has been subject to a relatively low spatial resolution and considerable time delay, and thus high-resolution and timely data are needed to perform a more precise and timely study; (ii) the contribution of desertification impacting factors has not been quantitatively assessed, and a decoupling analysis is desirable to quantify the contribution of factors in different regions of Mongolia; (iii) existing desertification prevention measures should be strengthened in the future. In particular, the relationship between grassland changes and husbandry development needs to be considered during the development of desertification prevention measures; (iv) the multi-method study (particularly interdisciplinary approaches) and desertification model development should be enhanced to facilitate an in-depth desertification research in Mongolia. This study provides a useful reference for desertification research and control in Mongolia and other regions of the world.

scholarly journals The Formulation of Epidemic Prevention Work of COVID-19 for Colleges and Universities: Priorities and Recommendations

2021 ◽  
Vol 13 (4) ◽  
pp. 2081
Author(s):  
Wan-Chi Jackie Hsu ◽  
Huai-Wei Lo ◽  
Chin-Cheng Yang
Keyword(s):  
Disease Transmission ◽  
Colleges And Universities ◽  
College Campuses ◽  
Prevention Measures ◽  
Campus Environment ◽  
Overseas Students ◽  
Entry Points ◽  
The World ◽  
Criteria Weights ◽  
Multiple Experts

As the Coronavirus disease 2019 (COVID-19) epidemic spreads all over the world, governments of various countries are actively adopting epidemic prevention measures to curb the spread of the disease. However, colleges and universities are one of the most likely places for cluster infections. The main reason is that college students have frequent social activities, and many students come from different countries, which may very likely cause college campuses to be entry points of disease transmission. Therefore, this study proposes a framework of epidemic prevention work, and further explores the importance and priority of epidemic prevention works. First of all, 32 persons in charge of epidemic prevention from various universities in Taiwan were invited to jointly formulate a campus epidemic prevention framework and determined 5 dimensions and 36 epidemic prevention works/measures/criteria. Next, Bayesian best worst method (BWM) was used to generate a set of optimal group criteria weights. This method can not only integrate the opinions of multiple experts, but also effectively reduce the complexity of expert interviews to obtain more reliable results. The results show that the five most important measures for campus epidemic prevention are the establishment of a campus epidemic prevention organization, comprehensive disinfection of the campus environment, maintenance of indoor ventilation, proper isolation of contacts with confirmed cases, and management of immigration regulations for overseas students. This study provides colleges and universities around the world to formulate anti-epidemic measures to effectively reduce the probability of COVID-19 transmission on campuses to protect students’ right to education.

Modern aspects of epidemiology and prevention of typhoid infection (review)

2021 ◽  
pp. 16-26
Author(s):  
Alla Nikolaevna Kaira ◽  
Vyacheslav Fedorovich Lavrov ◽  
Oksana Anatolievna Svitich
Keyword(s):  
Typhoid Fever ◽  
Natural Disasters ◽  
Risk Groups ◽  
Poverty Line ◽  
Epidemiological Surveillance ◽  
Prevention Measures ◽  
Labor Migrants ◽  
Antibiotic Resistant ◽  
The World ◽  
Resistant Strains

Typhoid fever is still an urgent infection, especially in countries where the majority of the population lives below the poverty line, with limited resources, and without the ability to comply with basic hygiene rules. About 11 million cases of typhoid fever are registered worldwide every year, and about 400 people die from this infection every day. The global development of international relations activates migration processes, tourism, and provides rapid movement of significant masses of people around the world, which makes the risk of widespread typhoid infection quite real. In recent years, due to the emergence of antibiotic-resistant strains of S. typhi, treatment of typhoid fever has become less effective. Natural disasters in the form of earthquakes and floods, man-made disasters, as well as military conflicts that occur in different parts of the world, are fertile «soil» for the emergence and spread of typhoid infection, which actualizes the implementation of appropriate prevention measures, including immunoprophylaxis of the disease. Despite the obvious success in the fight against typhoid fever, which consists in a significant reduction in cases of typhoid infection in the world, this dangerous infectious disease still remains an urgent problem, both for health authorities and the population of many countries. Children and young people are still ill, and there is a real risk of infection spreading to any country. Natural disasters pose a real threat of typhoid outbreaks and epidemics. Mass appearance of antibiotic-resistant strains of S. typhi significantly complicates the treatment of patients, dictates the need for constant monitoring of the pathogen’s resistance to antibiotics and the introduction of typhoid immunoprophylaxis for epidemic indications among professional risk groups, labor migrants, and tourists traveling to countries with typhoid-affected countries. There is also a need for reliable epidemiological surveillance of this infection, carried out on an ongoing basis.

SARS-COV-2 CORONAVIRUS: NOMENCLATURE, CLASSIFICATION, STRUCTURE, HISTORY, SYMPTOMS EPIDEMIOLOGY, PATHOGENESIS, ETIOLOGY, DIAGNOSES, TREATMENT, AND PREVENTION

2021 ◽  
Author(s):  
Hanan Al-Khalaifah ◽  
Mohammad Al-Otaibi ◽  
Abdulaziz Al-Ateeqi
Keyword(s):  
Food Security ◽  
Social Economic ◽  
Animal Production ◽  
Effective Vaccine ◽  
Poultry Production ◽  
Treatment And Prevention ◽  
The World ◽  
Economic Health ◽  
Production Industry ◽  
Classification Structure

With the onset of the coronavirus pandemic in December 2019 in China, and the alarming rate at which it has spread across the world has unleashed not only fear, but has taken a toll on social, economic, health, and governing capabilities of the various countries infected with the virus. The pandemic is affecting all aspects of life, including industries such as the animal production industry all over the world. This includes plant, livestock and poultry production. Food security is accordingly impacted, as these industries are vital elements that are contributing to securing food to populations worldwide. In this review, light is shed on the origin of coronaviruses with special emphasis on COVID-19. It also includes introduction of symptoms, epidemiology and pathogenesis, etiology, and prevention. As the disease progresses, scientists are working around the clock in the hope of an effective vaccine, and they managed to introduce some to the worldwide populations. The world faces challenges on a day-to-day basis until most people are vaccinated.

scholarly journals Larva of greater wax moth Galleria mellonella is a suitable alternative host for the fish pathogen Francisella noatunensis subsp. orientalis

2019 ◽  
Author(s):  
Winarti Achmad Sarmin Djainal ◽  
Khalid Shahin ◽  
Alexandra Adams ◽  
Andrew Desbois
Keyword(s):  
Galleria Mellonella ◽  
Dependent Manner ◽  
Alternative Host ◽  
Prevention Measures ◽  
Suitable Alternative ◽  
Treatment And Prevention ◽  
Greater Wax Moth ◽  
Important Food Source ◽  
Dose Dependent ◽  
Lethal Doses

Abstract Background Francisella noatunensis subsp. orientalis (Fno) is the etiological agent of francisellosis in cultured warm water fish, such as tilapia. Antibiotics are administered to treat the disease but a better understanding of Fno infection biology will inform improved treatment and prevention measures. However, studies with native hosts are costly and considerable benefits would derive from access to a practical alternative host. Here, larvae of Galleria mellonella were assessed for suitability to study Fno virulence. Results Larvae were killed by Fno in a dose-dependent manner but the insects could be rescued from lethal doses of bacteria by antibiotic therapy. Infection progression was assessed by histopathology (haematoxylin and eosin staining, Gram Twort and immunohistochemistry) and enumeration of bacteria recovered from the larval haemolymph on selective agar. Fno was phagocytosed and could survive intracellularly, which is consistent with observations in fish. Virulence of five Fno isolates showed strong agreement between G. mellonella and red Nile tilapia hosts. Conclusions This study shows that an alternative host, G. mellonella, can be applied to understand Fno infections, which will assist efforts to identify solutions to piscine francisellosis thus securing the livelihoods of tilapia farmers worldwide and ensuring the production of this important food source.

scholarly journals Prevalence and risk factors of irritable bowel syndrome in Irkutsk

2021 ◽  
pp. 152-157
Author(s):  
V. V. Tsukanov ◽  
A. V. Vasyutin ◽  
E. V. Onuchina ◽  
I. L. Petrun’ko ◽  
E. V. Kasparov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Irritable Bowel Syndrome ◽  
Randomized Study ◽  
Careful Attention ◽  
Female Sex ◽  
The World ◽  
Undifferentiated Type ◽  
Irritable Bowel ◽  
New Criteria ◽  
Rome Iv

Introduction. The study of the problem of irritable bowel syndrome (IBS) in recent years has been very dynamic. In the Rome IV criteria, new criteria for the diagnosis of this pathology were proposed. Along with the existence of ethnic and geographic differ­ences, this has led to an increase in the activity of studies on the prevalence of IBS.Aim. To study the prevalence and risk factors of irritable bowel syndrome in Irkutsk.Materials and methods. A single-stage observational non-randomized study was performed on the basis of three medical institu­tions in Irkutsk. Interviewing and clinical examination were performed in 1 529 people: 724 men and 805 women, average age 51.0 years. The questionnaire contained questions to determine the presence of alarm symptoms. The diagnosis of IBS was based on the Rome IV criteria. IBS with a predominance of diarrhea, IBS with a predominance of constipation and mixed and undiffer­entiated IBS were distinguished. Taking into account the position of the Rome IV criteria and the recommendations of the American College of Gastroenterology (2021), we used a positive diagnosis of IBS in our study and did not perform an instrumental examination of patients.Results. The prevalence of IBS was 12.3%. Among the subtypes of IBS, IBS prevailed with a predominance of constipation (preva­lence 5.7%) and IBS of mixed and undifferentiated type (prevalence 4.6%). Risk factors for IBS were female sex (OR = 0.73; CI 0.53-0.99; p = 0.05), age over 50 years (OR = 0.66; CI 0.48-0.90; p = 0.01) and obesity (OR = 0.46; CI 0.31-0.69; p < 0.001). Risk factors for IBS with a predominance of constipation were female sex (OR = 0.46; CI 0.29-0.73; p = 0.001), age over 50 years (OR = 0.46; CI 0.29-0.73; p = 0.001) and obesity (OR = 0.41; CI 0.23-0.72; p = 0.002).Conclusions. In general, our results are consistent with data from other regions of the world. It should be emphasized that the prevalence of IBS in Irkutsk is quite high, which requires careful attention to this problem. 

scholarly journals ADMINISTRATIVE AND LEGAL MECHANISM OF PREVENTING THE SUICIDE IN UKRAINE

2019 ◽  
pp. 87-93
Author(s):  
S.S. Filonenko
Keyword(s):  
Suicide Prevention ◽  
Causes Of Death ◽  
Scientific Research ◽  
The Elderly ◽  
Prevention Measures ◽  
Foreign Countries ◽  
The World ◽  
The Usa ◽  
Suicide Prevention Programs ◽  
Legal Mechanism

The article focuses on the study of suicide worldwide and Ukraine in particular. The phenomenon of suicide is relevant in all corners of the world, it affects people of all nations, cultures, religions, articles, and classes. The scientific community in many countries around the world demonstrates indifference to the problem of suicide; Accordingly, suicide is gradually becoming one of the leading causes of death worldwide. Thus, suicide ranks 15th among the leading causes of death. WHO statistics show that suicide is committed twice as often as murder, and emphasizes that this phenomenon is global and reaches critical levels every year. We have analyzed the regulatory framework for suicide at the global level. For example, over the last decades, since 2000, due to the incredible efforts of WHO, this problem has begun to receive national attention. In the developed world, many regulations on suicide prevention have been developed and adopted. In the course of scientific research, we found out that suicide and Ukraine is the seventh cause of death, which confirms the criticality of the problem and the need for its fastest solution. We believe that there is a need today to support such categories of persons as children and young people, servicemen, convicts, and the elderly. The article examines the experience of such foreign countries as the USA, Azerbaijan, Israel, Canada, Australia, New Zealand, Great Britain, and other European countries of the world. Finding out what prevention and prevention measures they have implemented in national suicide prevention programs, we see the possibility of their implementation in Ukraine and are convinced of their effectiveness. According to the results of scientific research, we will develop an administrative and legal mechanism for suicide prevention in Ukraine, which can work if all the steps of the algorithm for reducing suicide rates are fulfilled. Keywords: suicide, administrative and legal mechanism, the algorithm of actions, statistics, suicide rate.

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