scholarly journals Adverse effects of pharmacological therapy of benign prostatic hyperplasia on sexual function in men

2015 ◽  
Vol 143 (5-6) ◽  
pp. 284-289 ◽  
Author(s):  
Nebojsa Stojanovic ◽  
Ivan Ignjatovic ◽  
Nebojsa Djenic ◽  
Dragan Bogdanovic
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Sexual Function ◽  
Combined Therapy ◽  
Pharmacological Therapy ◽  
Dominant Mode ◽  
Control Group ◽  
Voiding Symptoms ◽  
Male Sexual Function ◽  
A Prospective Study

Introduction. The development of effective medications makes pharmacological therapy of BPH the dominant mode of treatment today. It improves urinary symptoms and prevents disease progression while producing side effects on male sexual function. Objective. The aim of the study is to present the effects of BPH pharmacological treatment on the occurrence of sexually adverse effects in men: changes in sexual desire, erectile, ejaculatory and the orgasmic function. Methods. A prospective study involving 156 BPH patients. The average age was 61.16?2.97. Four groups of 39 patients each were formed. The 4 groups were administered tamsulosin (alpha-blocker), finasteride (5-alpha reductase inhibitor), combination therapy (tamsulosin and finasteride) respectively, while the control group received no treatment. IPSS-QoL, IIEF and MSHQ-EjD questionnaires were used to evaluate the symptoms of voiding and sexual function. Follow-up examinations were performed 3 and 6 months into treatment. Results. Voiding symptoms improved in all groups receiving therapy. The side effects on the sexual function in all these groups include significant disorders of ejaculation and the orgasmic function. Ejaculation disorders: tamsulosin (-4.38?2.55; p<0.001), combined therapy (-3.89?2.84) and finasteride (-1.49?2.52). Orgasmic function disorders: tamsulosin (-1.03?1.94), combined therapy (-0.76?2.07) and finasteride (-0.54?1.68). Complete absence of ejaculation was experienced by 23% of patients on combined therapy, 15% on tamsulosin and 5% on finasteride. Conclusion. Pharmacological therapy of BPH improved voiding symptoms producing different effects on male sexual function. The main adverse effect on sexual function in men is the deterioration in ejaculation or the absence thereof. Clinical consideration of BPH should include the elements of male sexual function, patients? age, the characteristics and effects of each group of drugs.

scholarly journals Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongyu Zhong ◽  
Xiang Li ◽  
Wanqi Zhang ◽  
Xiaoxiao Shen ◽  
Yuangang Lu ◽  
...  
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Combined Therapy ◽  
Aloe Vera ◽  
Physical Method ◽  
Control Group ◽  
Severe Acne ◽  
Aloe Vera Gel ◽  
Before And After ◽  
Acne Therapy

Background: Acne is a chronic disorder that affects almost 80% of adolescents and young adults, causing psychological and emotional distress. However, the current treatments for acne are either ineffective or have many side effects. This study was designed to confirm and objectively quantify the effect of a new non-drug combined therapy on acne.Methods: This study innovatively utilized ultrasound, which enhanced the absorption of aloe vera gel, and soft mask to make a purely physical method without any drugs. In both the treatment group and control group, the number of papules/pustules and the area of hyperpigmented lesions were counted, and a smart mirror intelligent face system was used before and after the combined therapy. Alterations in the skin functional index were recorded and analyzed statistically.Results: In the treatment group, the combined therapy significantly reduced the number of papules and the area of hyperpigmented lesions and improved skin roughness and local blood circulation. In the control group, there was no obvious improvement over 2 months.Conclusion: This study suggests that the new non-drug combined therapy significantly improved acne, which provided experimental evidence and treatment guidance for patients with mild to severe acne, especially patients with moderate acne. This new therapy may possibly be an appropriate method for patients who seek topical treatments with mild side effects and low antibiotic resistance rates.

scholarly journals The Efficacy and Safety of Uractiv Control in Overactive Bladder Treatment

2020 ◽  
Vol 71 (1) ◽  
pp. 390-394
Author(s):  
Calin Bogdan Chibelean ◽  
Veronica Ghirca ◽  
Razvan-Cosmin Petca ◽  
Daniel Porav-Hodade ◽  
Ioan Alin Nechifor-Boila ◽  
...  
Keyword(s):  
Placebo Group ◽  
Side Effects ◽  
Overactive Bladder ◽  
Prospective Study ◽  
Treatment Option ◽  
Alternative Treatment ◽  
Control Group ◽  
Efficacy And Safety ◽  
A Prospective Study ◽  
Safe Treatment Option

The aim of this study is to evaluate the efficacy and safety of Uractiv Control as an alternative treatment with no side effects in Overactive Bladder (OAB). We performed a prospective study over a period of 15 months (May 2018- September 2019) in Department of Urology from Targu-Mureș. We included 165 patients diagnosed with OAB wet (129 patients) and dry form (36 patients) which were fully evaluated over a 3-month period of treatment. 48 patients were treated with placebo 1 month and were evaluated by the same parameters like Uractiv Control group. The frequency of micturition during the day and night after the treatment with Uractiv Control was improved compared to placebo group (p=0.0001) and also the loss of urine episodes (p=0.03). Patients did not report any significant side effects of the treatment. Uractiv Control represents a safe treatment option with no side effects and improvement of the storage in OAB.

scholarly journals Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Mina Mirnezami ◽  
Hoda Rahimi
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Acne Vulgaris ◽  
Control Group ◽  
Case Group ◽  
Omega 3 ◽  
Double Blind ◽  
Severe Acne ◽  
Double Blind Clinical Trial ◽  
And Control

Background. Acne vulgaris is an inflammatory disease of pilosebaceous units which may cause permanent dyspigmentation and/or scars if not treated. Isotretinoin is recommended in the treatment of recalcitrant or severe acne, but it is associated with common adverse effects that frequently result in patients incompliance and discontinuation of the drug. The present study was designed to assess the efficacy of oral omega-3 in decreasing the adverse effects of isotretinoin. Materials and Methods. In this randomized double-blind clinical trial, a total of 118 patients with moderate or severe acne were randomly divided into two (case and control) groups. The control group was treated with isotretinoin 0.5 mg/kg, and the case group was treated with the same dose of isotretinoin combined with oral omega-3 (1 g/day). The treatment was lasted for 16 weeks and mucocutaneous side effects of isotretinoin were recorded and compared between the two groups in weeks 4, 8, 12, and 16. Results. Cheilitis (at weeks 4, 8, and 12), xerosis, dryness of nose at all weeks, and dryness of eyes (at week 4) were less frequent in the group that received isotretinoin combined with oral omega-3 compared to the group that received isotretinoin alone. Conclusion. Administration of oral omega-3 in acne patients who are receiving isotretinoin decreases the mucocutaneous side effects of isotretinoin. This trial is registered with  IRCT201306238241N2.

The use of Sertraline in Psychiatric Practice

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
N. Zivlak - Radulovic ◽  
M. Miskovic ◽  
D. Zoric ◽  
T. Maglov ◽  
D. Ilic
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Adverse Effects ◽  
Prospective Study ◽  
Serotonin Reuptake ◽  
Routine Clinical Practice ◽  
Third Generation ◽  
The Third ◽  
A Prospective Study ◽  
First Time

Sertraline is an antidepressant of the third generation of the selective serotonin reuptake inhibitor (SSRI) class. It is simple to use and has a wide application in treating various psychiatric disorders, but with much less pronounced side effects.The aim of this study is to establish the frequency and adverse effects in users of sertraline during clinical treatment.The method of work was a prospective study which comprised 30 participants who came for a medical examination for the first time and who had a valid indication for drug suitability. The patients were observed during the following two control check-ups. The findings thus gathered were statistically analysed and shown on the graphs.Conclusion:The examination has shown that the possible side effects of sertraline are rare and mainly of temporary nature, and confirm the effectiveness and safety of sertraline in routine clinical practice.

scholarly journals EFFICACY OF NARROWBAND ULTRAVIOLET B 311 NM PLUS AN INHIBITOR OF PHOSPHODIESTERASE 4 (PDE4) COMBINED THERAPY IN PATIENTS WITH MODERATE TO SEVERE PLAQUE PSORIASIS

2019 ◽  
Vol 22 (5-6) ◽  
pp. 149-155
Author(s):  
Olga Yu. Olisova ◽  
E. V Grekova ◽  
D. A Svistunova
Keyword(s):  
Side Effects ◽  
Treatment Regimen ◽  
Plaque Psoriasis ◽  
Combined Therapy ◽  
Severe Psoriasis ◽  
Ultraviolet B ◽  
Control Group ◽  
Severe Plaque Psoriasis ◽  
Phosphodiesterase 4 ◽  
Study Participants

Objective. to determine the effectiveness and tolerability of narrowband ultraviolet (UV) B (311 nm) plus an inhibitor of phosphodiesterase 4 (PDE4) combined therapy in patients with moderate to severe plaque psoriasis. Material and methods. the first group consisted of 30 patients (18 women and 12 men) who were treated with UVB 311 nm and inhibitor of phosphodiesterase 4 (PDE4). The second (control) group was treated with UVB 311 nm and methotrexate (n = 30; 15 women and 15 men). The study participants were aged 32 to 67 (43.8 ± 4.34). Results. it was determined greater efficiency (PASI 100 43.3% of patients and PASI 90 46.7%) of the treatment plaque moderate to severe psoriasis patients with UVB 311 nm plus an inhibitor of PDE4 compared to UVB 311 nm plus methotrexate (PASI 100 10% of patients and PASI 90 40%). The treatment was well-tolerated. The side effects in both groups were mild, did not require the cancellation of the prescribed treatment regimen, and were often stopped on their own or with minimal corrective therapy.

scholarly journals Methotrexate-Loaded Biodegradable Polymeric Micelles for Lymphoma Therapy in Mouse Model

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 4181-4181
Author(s):  
Mengyao Wang ◽  
Ying Qu ◽  
Zhiyong Qian ◽  
Ting Niu
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Mouse Model ◽  
Tumor Growth ◽  
Water Solubility ◽  
Control Group ◽  
High Dose ◽  
Intracellular Enzyme ◽  
Therapeutic Efficiency ◽  
Adequate Hydration

Abstract Purpose: Methotrexate (MTX), a folate antimetabolite, competitively inhibits dihydrofolate reductase, the intracellular enzyme responsible for converting folic acid to folate cofactor, thus blocking the synthesis of thymine and purine, causing impairment of tumor growth and induction of cell death. High dose MTX (HD-MTX) is infused in doses of 3-5g/m2 and over a period of 6-24h to maintain the serum MTX at high levels, which shows benefit in the treatment of childhood leukemia and certain adult NHL, particularly the Burkitt type. However, the clinical implication of MTX is hampered for some reasons. On the one hand, the adverse effects of HD- MTX are severe, including bone marrow suppression, mucositis, hepatotoxicity, nephrotoxicity and neurological symptoms. On the other hand, leucovorin rescue, adequate hydration, urinary alkalization and monitoring of MTX concentration is required to avoid life-threating side effects of HD-MTX, which makes the administration rather complicated. In addition, the poor water solubility also impedes the application of MTX. To overcome these obstacles, a new drug delivery system is required to reduce the side effects of HD-MTX as well as to increase the solubility of the drug. So we designed a self-assembled micellar system to load MTX to overcome water solubility and to enhance therapeutic efficacy while reduce toxicity. Materials and Methods: Monomethyl poly (ethylene glycol)-poly (ε-caprolactone) (MPEG-PCL) our group previously synthesized was employed to load MTX through a one-step solid dispersion method. The preparation was done without any surfactants, organic solvents, or vigorous stirring. Results: MTX loaded micelles had a small particle size of 25.64±0.99nm and polydisperse index (PDI) of 0.176±0.05. Drug loading and encapsulation efficiency of MTX loaded micelle were 5.57±0.14% and 92.46±2.38%, respectively. Compared with free MTX, MTX loaded micelles demonstrated a much slower and sustained release behavior in vitro. MTT assay and cell apoptosis study suggested that MTX loaded micelles were more effective in inhibiting proliferation (IC50 value 137.8ug/ml vs 86.5ug/ml, p<0.05) and inducing apoptosis (p<0.01) on Raji lymphoma cells than MTX treatment, which was especially distinct in high dose groups (38.78% vs 22.17%). Cellular uptake study indicated that MPEG-PCL micelle had a 1.5 times higher uptake rate in Raji cells. As for in vivo studies, MTX loaded micelles were more competent to suppress tumor growth (p<0.01) and prolong survival time than MTX injection (p<0.05) in the subcutaneous Raji lymphoma mouse model. Notably, the high dose group of micelle formulation exhibited the strongest anti-tumor effect without additional toxicity. As for body weight, which represented systematic toxicity, no difference between control group and two kinds of MTX formulation group was observed (p >0.05). Furthermore, immunofluorescent and immunohistochemical studies showed that tumors of MPEG-PCL-MTX treated mice had more apoptotic cells (p<0.05) and fewer proliferative cells (p<0.01). Conclusions: In this work, MPEG-PCL-MTX micelle was fabricated with a thin-film hydration method to improve the water solubility of MTX and to meet the requirements of intravenous administration, which was stable, safe, effective, easy to produce and scale up, and showed potential clinical application. The enhanced therapeutic efficiency of MPEG-PCL-MTX micelle might be attributed to enhanced permeability and retention (EPR) effect, which increased drug accumulation in the tumor site. Besides, compared with MTX injection with highest concentration in our experiment, MPEG-PCL-MTX micelle with lowest concentration achieved similar or better therapeutic outcome, which indicated the amount of drug could be reduced to achieve the same therapeutic efficiency and alleviate adverse effects towards normal tissues and organs. Moreover, MPEG-PCL-MTX micelle of high dose (7mg/ml) achieved great therapeutic advantage without obvious toxicity, which makes micelle an effective and safe choice when HD-MTX is clinically employed. Disclosures No relevant conflicts of interest to declare.

scholarly journals Use of MTP kit (Mifepristone and Misoprostol combination pack) for 1st trimester MTP (up to 63 days) at GMERS Dharpur, Patan, Gujarat, India

2018 ◽  
Vol 7 (9) ◽  
pp. 3615
Author(s):  
Parul S. Jani
Keyword(s):  
Side Effects ◽  
Pregnancy Termination ◽  
Combined Therapy ◽  
Medical Abortion ◽  
Adult Women ◽  
Intrauterine Pregnancy ◽  
Surgical Interventions ◽  
Medical College ◽  
Medical Termination ◽  
A Prospective Study

Background: MTP has been legalized in India since 1971. MTP pill (Medical abortion) refers for early pregnancy termination (usually before 9 week gestation) performed without any primary surgical interventions. This study was called out to measure its effectiveness and safety as an abortificiant drug.Methods: This is a prospective study of 57 cases, conducted at OBSTETRIC and GYNECOLOGY Department, GMERS Medical College, Dharpur, Patan (N.G.) from April 2017 to April 2018.Results: In present study,61.4% women are of 20-30 years of age. Majority of women are (82.5%) of 2nd and 3rd para. Complete abortion was found in 91.2%. Incomplete abortion was in 7%. And there was no effect in 1.8%. Major side effects were bleeding (84.2%), abdominal pain (85.9%). Misoprostol related side effects are minimal.Conclusions: The present observational study demonstrates that mifepristone and misoprostol combined therapy is an effective and well tolerated medication in Indian adult women (≥18 years) requiring medical termination of intrauterine pregnancy (MTP) up to 63 days’ gestation.

Thermal ablation of saphenous veins is feasible and safe in patients older than 75 years: A prospective study (EVTA study)

2014 ◽  
Vol 30 (8) ◽  
pp. 525-532 ◽  
Author(s):  
C Hamel-Desnos ◽  
P Desnos ◽  
F-A Allaert ◽  
P Kern ◽  
Keyword(s):  
Side Effects ◽  
Prospective Study ◽  
Thermal Ablation ◽  
Cardiac Insufficiency ◽  
Control Group ◽  
Saphenous Veins ◽  
Group 2 ◽  
Multicenter Prospective Study ◽  
A Prospective Study ◽  
Group 1

Objectives To investigate the tolerance and safety of thermal ablation (TA), consisting of radiofrequency or endovenous laser (EVLA) of saphenous veins (SV) in elderly (group 1 ≥75 years), compared with a control group (group 2 <75 years). Method An Observational multicenter-prospective study was conducted, under the aegis of the French and Swiss Societies of Phlebology (18 centers). Ninety patients were included in group 1, 617 in group 2 (mean age 80 years and 53 years; 69% women in both groups), representing 863 SV. Mean trunk diameters were similar in both groups (small SV: 6 mm; great SV: 7 mm). In group 1, comorbidities were more frequent, particularly cardiac insufficiency, diabetes, history of thrombosis, and CEAP clinical class was significantly higher. Results EVLA was used in 86% of cases. Settings used were similar in both groups for each technique. Only 6% of TA was performed in an operating room for group 1 (14% group 2). Tumescent local anaesthesia (TLA) alone was used in 91% of cases in group 1 (85% group 2). The mean pain score was only 1.6 for the procedure itself (VASP 0–10; 10 max.) and 1.4 for the 10 days following the procedure. Side effects were few, but rate of paraesthesia was higher when general anaesthesia was used (11.8%) compared with TLA alone (2.2%). At three months, 100% of SV was occluded in group 1 (99.5% group 2), with high satisfaction score (9.3/10). Conclusion TA is safe and effective in elderly; it should be performed strictly under TLA to minimize side effects.

scholarly journals Combined Effects of Oligopeptides Isolated from Panax ginseng C.A. Meyer and Ostrea gigas Thunberg on Sexual Function in Male Mice

2021 ◽  
Vol 18 (5) ◽  
pp. 2349
Author(s):  
Di Li ◽  
Jinwei Ren ◽  
Lixia He ◽  
Jingqin Sun ◽  
Peng Liu ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Sexual Function ◽  
Whey Protein ◽  
Corpus Cavernosum ◽  
Vehicle Control ◽  
Control Group ◽  
Male Mice ◽  
Vehicle Control Group ◽  
Male Sexual Behavior ◽  
Male Sexual Function

Male sexual debility affects patients’ confidence and damages the relationship between the couples and thus affects the stability of the family. This study aimed to investigate the effects of oligopeptides isolated from ginseng and oyster (GOPs and OOPs), separately and in combination, on sexual function in male mice. In the first experiment, male mice were randomly divided into five groups: vehicle control group; whey protein (125.0 mg kg−1) group; and GOPs 62.5, 125.0, and 250.0 mg kg−1 groups. In the second experiment, male mice were randomly divided into five groups: vehicle control group, whey protein (160.0 mg kg−1) group, and OOPs 80.0, 160.0, and 320.0 mg kg−1 groups. In the third experiment, male mice were randomly divided into six groups: vehicle control group, whey protein (222.5 mg kg−1) group, and GOPs + OOPs 62.5 + 160.0, 62.5 + 320.0, and 125.0 + 160.0, 125.0 + 320.0 mg kg−1 groups. Test substances were given by gavage once a day for 30 days. The sexual behavior parameters, serum nitric oxide (NO), testosterone, cyclic guanosine monophosphate (cGMP), and phosphodiesterase-5 (PDE5) concentrations were detected. We found that GOPs at 250.0 mg kg−1 improved male sexual behavior, NO, and testosterone content, whereas GOPs at 62.5 and 125.0 mg kg−1 and OOPs at 80.0, 160, and 320 mg kg−1 did not have significant effects. The combination of 62.5 mg kg−1 GOPs + 160.0 mg kg−1 OOPs and the combination of 125.0 mg kg−1 GOPs + 320.0 mg kg−1 OOPs improved male sexual behavior, serum NO, testosterone, and cGMP contents and decreased PDE5 content. The combination of 62.5 mg kg−1 GOPs and 160.0 mg kg−1 OOPs had the best effects among four combined groups. These results suggested that GOPs in combination with OOPs had the synergistic effects of enhancing male sexual function, probably via elevating serum testosterone, NO, and corpus cavernosum cGMP level and decreasing the corpus cavernosum PDE5 level. GOPs and OOPs could be novel natural agents for improving male sexual function.

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