scholarly journals Rare Cellulite On Mucormycosis

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Joumany Brahim Salem ◽  
Imane Tarib ◽  
Mahdi Khammaily ◽  
Sidi Dahi ◽  
Mohamed El Habib bahlou ◽  
...  
Keyword(s):  
Fungal Infection ◽  
High Mortality ◽  
Diabetic Patients

Mucormycosis is a serious fungal infection that is associated with high mortality, but is rarely reported in ophthalmology. It is a disease with various presentations, this is why it is important to think about it in unbalanced diabetic patients. We report the case of a 27-year-old patient admitted for febrileke to acidosis decompensation of anorbito-facial cellulitis.

scholarly journals A case series on post-covid deadly fungal infection: mucormycosis

2021 ◽  
Vol 7 (9) ◽  
pp. 1503
Author(s):  
Kalpana G. ◽  
Amol A. Patil ◽  
Manohar Shaan ◽  
Mitusha Verma ◽  
Gayatri Harshe
Keyword(s):  
Fungal Infection ◽  
Opportunistic Infection ◽  
Surgical Intervention ◽  
Case Series ◽  
Medical Intervention ◽  
Morbidity And Mortality ◽  
Diabetic Patients ◽  
High Morbidity ◽  
Per Se

<p class="abstract">The prevailing pandemic situation by SARS-CoV-2 infection is not only worrisome by the disease per se but also for the accompanying opportunistic infection are in the rise especially in diabetic patients. We presented a case series of post-covid rhino orbital cerebral mucormycosis infection in diabetic patients resulting in high morbidity. The need to present this was to emphasis on the timely surgical and medical intervention needed to reduce morbidity and mortality by the infection. The study highlighted the importance of surgical intervention in the deadly infection.</p>

scholarly journals Pattern of Cutaneous Dermatoses in Type 2 Diabetes Mellitus in a Tertiary Hospital: A Cross Sectional Study

2019 ◽  
Vol 31 (1) ◽  
pp. 21-28
Author(s):  
Mahfuza Akhter ◽  
Ishrat Bhuiyan ◽  
Zubaida Akter ◽  
Homayra Tahseen Hossain ◽  
Syed Ghulam Mogni Mowla
Keyword(s):  
Diabetes Mellitus ◽  
Bacterial Infection ◽  
Viral Infection ◽  
Fungal Infection ◽  
Parasitic Infection ◽  
Parasitic Infections ◽  
Diabetic Patients ◽  
Cutaneous Manifestations ◽  
Female Patients

Background: Diabetes mellitus (DM) continues to be a major public health problem. Multiple factors have a role in the skin manifestations of DM. Cutaneous manifestations of DM are very important to the clinician. Methods: Current study was carried out in the Department of Dermatology and Venereology, Shaheed Suhrawrdy Medical College Hospital, Dhaka, spanning from 1st January 2017 till 30th June 2017 over a period of six months. Adult patients already diagnosed to be suffering from type 2 DM presenting with cutaneous manifestations were included in the study. Results: Majority (68.0%) patients had diabetes >5 years, 16.7% had < 1 year and 15.3% had 1-5 years. Family history of DM was found in 70.7% in this study. In this study bacterial infection and fungal infection were more common in female patients (60.0% vs 62.0% respectively). Regarding types of dermatoses, fungal infection was more common in this study 50(33.3%). Others were bacterial infection 20(13.3%), viral infection 7(4.7%) and parasitic infection 7(4.7%). Papulo squamous disease was found 31(20.7%) patients, other diseases were 32(21.3%).Viral infection was more in male patients (71.4%). Parasitic infection was high in female patients 6(85.7%). Papulo squamous diseases was found 21(67.7%) in female patients. Conclusion: In this study fungal infection, bacterial infection, viral infection and parasitic infections were found to be the more common cutaneous dermatoses among adult diabetic patients. Bacterial infection and fungal infection were more common in female patients. TAJ 2018; 31(1): 21-28

scholarly journals 1731. Immune Dysregulation in Mucormycosis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S634-S634
Author(s):  
Chhavi Gupta ◽  
Shukla Das ◽  
Gargi Rai ◽  
Praveen K Singh ◽  
Sajad Dar ◽  
...  
Keyword(s):  
T Cell ◽  
Fungal Infection ◽  
Therapeutic Option ◽  
Immune Dysregulation ◽  
Diabetic Patients ◽  
Becton Dickinson ◽  
Chronic Inflammatory Response ◽  
Cell Parameters ◽  
Immune Parameters ◽  
Healthy Control

Abstract Background Mucormycosis is a fatal fungal infection with unique predisposition to infect diabetics. Dysregulated adaptive immunity contributes to the pathogenesis in all fungal diseases, but activated Th17 cells have laid a new dimension to chronic inflammatory response which was previously attributed to uncontrolled Th1 response. We attempted to study the Th17 and T regulatory (Treg) immune response in diabetic patients with mucormycosis and compared the data with a healthy control and a T2DM case without fungal infection. In addition we could follow-up one patient post 6-month treatment and performed immunological studies. Methods 2 mL of blood samples were collected in EDTA vial from two patients who were suffering from diabetes with mucormycosis for immunological investigations. Samples were also taken from age-matched T2DM patient without fungal infection and a healthy volunteer as controls for T-cell parameters. Repeat blood sample was taken to study immune parameters in one patient who was followed up after 6 months. The expression of various T-cell markers was analyzed by immunostaining with the antibodies against CD3, CD4, CD25, CD161, IL-23R [Becton Dickinson (BD) PharMingen]. Fluorescence profiles were analyzed using Flow Jo software (BD Biosciences). The results are expressed as a percentage of positive cells. Results The percentages of CD4+ cells were low in both patients when compared with and healthy control but it is much higher in diabetes case when compared with others. CD161+ cell population was higher in both patients when compared with healthy control and diabetic patient without fungal infection. The percentage of IL23R+ cells was significantly high in patient before treatment when compared with, healthy control and diabetics. and decline after treatment. The percentage positivity of CD25+ cells was highest in healthy control when compared with others. The profile of CD25+ cells was comparatively similar in patient before treatment and diabetics but we found a higher percentage, in patients after treatment. Conclusion The findings in this study imminently indicate the mechanism of immune dysregulation involving Th17 and Treg pathways in mucormycosis and provide evidence that restoration of Th17/Treg may be considered as a therapeutic option for long-term benefit in diabetics. Disclosures All authors: No reported disclosures.

Cutaneous Mucormycosis: Case Report

2020 ◽  
pp. 1-3
Author(s):  
Maya Korem ◽  
Oshrat Ayalon ◽  
Ruba Ibrahim ◽  
Michal Neumark ◽  
Maya Korem
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Treatment Modality ◽  
Clinical Presentation ◽  
Diabetic Patients ◽  
Antimitotic Agent ◽  
Direct Inoculation ◽  
Cutaneous Mucormycosis

Treatment with 5-FU cream, an antimitotic agent, is primarily used for the treatment of superficial keratinocytic lesions. This treatment modality has the potential to cause severe localized inflammation with subsequent erythema, pain and crusted erosions. Cutaneous mucormycosis is an opportunistic emerging fungal infection. It is rapidly progressive and affects immunosuppressed or poorly controlled diabetic patients primarily by direct inoculation or secondarily by dissemination. The clinical presentation can be challenging due to its initial nonspecific features and therefore leading to a delay in the diagnosis. Herein, we report a case of mucormycosis of the scalp following treatment with topical 5-FU.

scholarly journals Genes, Pathways, and Mechanisms Involved in the Virulence of Mucorales

Genes ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 317 ◽  
Author(s):  
Carlos Lax ◽  
Carlos Pérez-Arques ◽  
María Isabel Navarro-Mendoza ◽  
José Tomás Cánovas-Márquez ◽  
Ghizlane Tahiri ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Virulence Factors ◽  
High Mortality ◽  
Genetic Study ◽  
Molecular Mechanisms ◽  
Gene Manipulation ◽  
Pathogenic Potential ◽  
Limited Knowledge ◽  
New Genes

The order Mucorales is a group of ancient fungi with limited tools for gene manipulation. The main consequence of this manipulation unwillingness is the limited knowledge about its biology compared to other fungal groups. However, the emerging of mucormycosis, a fungal infection caused by Mucorales, is attracting the medical spotlight in recent years because the treatments available are not efficient in reducing the high mortality associated with this disease. The result of this renewed interest in Mucorales and mucormycosis is an extraordinarily productive effort to unveil their secrets during the last decade. In this review, we describe the most compelling advances related to the genetic study of virulence factors, pathways, and molecular mechanisms developed in these years. The use of a few genetic study models has allowed the characterization of virulence factors in Mucorales that were previously described in other pathogens, such as the uptake iron systems, the mechanisms of dimorphism, and azole resistances. More importantly, recent studies are identifying new genes and mechanisms controlling the pathogenic potential of Mucorales and their interactions with the host, offering new alternatives to develop specific strategies against mucormycosis.

scholarly journals Clinicopathological study of diabetic foot in Bundelkhand area with special reference to fungal infection in asymptomatic feet of diabetic patients

2017 ◽  
Vol 4 (11) ◽  
pp. 3690
Author(s):  
Mayank Mishra ◽  
Dinesh Pratap
Keyword(s):  
Fungal Infection ◽  
Diabetic Patient ◽  
Diabetic Foot ◽  
Morbidity And Mortality ◽  
Control Group ◽  
Diabetic Patients ◽  
Foot Care ◽  
Clinicopathological Study ◽  
Foot Lesions ◽  
Foot Disease

Background: As with substantial increasing in incidence of diabetes mellitus in present century and with huge prevalence in population; the incidence of one of the dreadful complication of diabetes i.e. diabetic foot also increases, leading to increase morbidity and mortality. Fungal infection in foot is one of the underweighted cause of foot ulceration. These microulceration in conjunction with diabetes may leads to fulminant infection. The study comprised of 66 cases out of which 16 served as control. Aim and objectives of our study is to study the incidence of fungal infection in asymptomatic feet of diabetic patients, identification of the type of fungus, comparison with nondiabetics and clinicopathological study of the patients.Methods: The present study was carried at Department of Surgery, MLB. Medical College, Jhansi, the study group was classified into two groups. Control group; this group comprised of non-diabetic patients with foot lesions. Disease group; diabetic patients with foot lesions. Webs scrapings were inoculated in Sabouraud’s media slopes. Cultured media were examined after 3 days for the growth. Identification depends on colonial appearance and the morphology of the spores and by Gram, s and AFB Staining.Results: By this study we conclude that fungal infection in asymptomatic foot of diabetes patient are significantly more than non-diabetic patients which is accentuated by duration, type, glycaemic control and practice of bare foot walking which makes diabetic patient more prone for diabetic foot. So, the foot care of patients of diabetes should include the prophylactic steps to prevent fungal growth.Conclusions: By above study, we reasonably conclude that fungal infection in diabetic patients plays a pivotal role in formation of diabetic foot disease, so by eradication of fungal infection in asymptomatic foot of diabetic patient by general preventive methods and/or pharmacological methods may be beneficial in reducing morbidity and mortality in diabetic foot patients.

scholarly journals Effects of COVID 19 Pandemic on Diabetic Patients

2021 ◽  
pp. 76-81
Author(s):  
Khalid Farhan Alshammari ◽  
Nuseibah Saleh Almakhalfi ◽  
Fadyah Mohammed Alradaddi ◽  
Maha Qasem Almutairi ◽  
Raghad Abdullah Almeshari ◽  
...  
Keyword(s):  
Healthcare System ◽  
High Mortality ◽  
Death Rate ◽  
Home Visits ◽  
Mortality Rates ◽  
Psychological Effects ◽  
Diabetic Patients ◽  
Large Group ◽  
The Future

Ever since the pandemic started in March 2020, the whole world and the healthcare system were overburdened with an extremely difficult task of curbing COVID-19 as much as possible to decrease the death rate and to understand its effects. Diabetic patients are no different as they constitute a large group globally. Therefore, understanding the biggest factors that affects their day-to-day life is crucial to be able to treat them well and decrease the chances of having high mortality rates among diabetics. COVID-19 in diabetes is susceptible to high mortality rates making them prone to develop nutritional and psychological effects. Further studies are needed to provide better care in the future for diabetic patient’s psychological and nutritional wellbeing and alleviate their healthcare by developing targeted programs, awareness and scheduled home visits.

scholarly journals The double trouble: COVID-19 associated mucormycosis a focused review and future perspectives

2021 ◽  
Vol 16 ◽  
pp. 4
Author(s):  
Arun Kumar Agnihotri ◽  
Monika Vij ◽  
Okezie I. Aruoma ◽  
Vipul D Yagnik ◽  
Theeshan Bahorun ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Paranasal Sinuses ◽  
Fungal Infections ◽  
Fungal Spores ◽  
Diabetic Patients ◽  
Corticosteroid Administration ◽  
Uncontrolled Diabetes ◽  
The Family ◽  
Need To Evaluate ◽  
The Many

Mucormycosis, a deadly fungal infection, has affected thousands of COVID-19 patients in India. Mucormycosis, formerly known as zygomycosis, is caused by the many fungi that belong to the family “Mucorales.” These molds are commonly found in soil, air, and damp walls and frequently colonize oral mucosa, nose, paranasal sinuses, and throat. The pathophysiological consequences of diabetes combined with the acute inflammatory surge in COVID-19 and steroid treatment weakens person’s immunity and renders susceptibility to fungal infections. Patients treated for severe COVID-19 have damaged lungs and suppressed immune system, an environment that supports fungal infection. Fungal spores can grow in airways or sinuses, and invade bodies’ tissues, explaining why the nasal cavity and paranasal sinuses are the most common site of mucormycosis infection, the consequential spread to the eyes can cause blindness, or causing headaches or seizures if the infection spreads to the brain. Poorly controlled diabetes often results in acidosis in tissues a suitable environment for Mucorales fungi to grow, exacerbating the risk for mucormycosis. This becomes clinically important, especially in India that has an increased prevalence of undiagnosed and uncontrolled diabetes. Given that a significant increase in the cases of mucormycosis in the diabetic patients treated for COVID-19 is strongly associated with corticosteroid administration, there is a need to evaluate use of dietary nutraceuticals with immune boosting potentials that modulate metabolic abnormalities in the management of COVID-19 associated mucormycosis.

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