scholarly journals Pattern of Cutaneous Dermatoses in Type 2 Diabetes Mellitus in a Tertiary Hospital: A Cross Sectional Study

2019 ◽  
Vol 31 (1) ◽  
pp. 21-28
Author(s):  
Mahfuza Akhter ◽  
Ishrat Bhuiyan ◽  
Zubaida Akter ◽  
Homayra Tahseen Hossain ◽  
Syed Ghulam Mogni Mowla
Keyword(s):  
Diabetes Mellitus ◽  
Bacterial Infection ◽  
Viral Infection ◽  
Fungal Infection ◽  
Parasitic Infection ◽  
Parasitic Infections ◽  
Diabetic Patients ◽  
Cutaneous Manifestations ◽  
Female Patients

Background: Diabetes mellitus (DM) continues to be a major public health problem. Multiple factors have a role in the skin manifestations of DM. Cutaneous manifestations of DM are very important to the clinician. Methods: Current study was carried out in the Department of Dermatology and Venereology, Shaheed Suhrawrdy Medical College Hospital, Dhaka, spanning from 1st January 2017 till 30th June 2017 over a period of six months. Adult patients already diagnosed to be suffering from type 2 DM presenting with cutaneous manifestations were included in the study. Results: Majority (68.0%) patients had diabetes >5 years, 16.7% had < 1 year and 15.3% had 1-5 years. Family history of DM was found in 70.7% in this study. In this study bacterial infection and fungal infection were more common in female patients (60.0% vs 62.0% respectively). Regarding types of dermatoses, fungal infection was more common in this study 50(33.3%). Others were bacterial infection 20(13.3%), viral infection 7(4.7%) and parasitic infection 7(4.7%). Papulo squamous disease was found 31(20.7%) patients, other diseases were 32(21.3%).Viral infection was more in male patients (71.4%). Parasitic infection was high in female patients 6(85.7%). Papulo squamous diseases was found 21(67.7%) in female patients. Conclusion: In this study fungal infection, bacterial infection, viral infection and parasitic infections were found to be the more common cutaneous dermatoses among adult diabetic patients. Bacterial infection and fungal infection were more common in female patients. TAJ 2018; 31(1): 21-28

scholarly journals Cutaneous manifestations of diabetes mellius: a clinico epidemiological study

2019 ◽  
Vol 5 (1) ◽  
pp. 179
Author(s):  
S. Venkatesh ◽  
S. Thamizhselvi ◽  
Tharini .
Keyword(s):  
Diabetes Mellitus ◽  
Bacterial Infections ◽  
Acanthosis Nigricans ◽  
Fungal Infections ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cutaneous Manifestations ◽  
Type 2 Diabetic

<p class="abstract"><strong>Background:</strong> Diabetes mellitus is one of the commonest non communicable diseases seen all over the world, constituting 49% from India, i.e., 72 million patients according to the Indian Council of Medical Research. The aim of the study was to study the various skin manifestations in diabetic patients and to correlate them with glycemic levels.</p><p class="abstract"><strong>Methods:</strong> Patients for the study were chosen among those who were on treatment for diabetes mellitus and presented to the skin department with various cutaneous manifestations.<strong></strong></p><p class="abstract"><strong>Results:</strong> Infections were commonest cutaneous manifestations in both type 1 and type 2. Among infections, fungal infections were commoner followed by bacterial infections. Among house wives, the commoner was candidal dermatosis intertrigo-toe/finger cleft followed by chronic paronychia. Among bacterial infections, erythrasma was commonly followed by pyoderma. Among pyodermas, furunculosis was common. Most common associated dermatoses were acanthosis nigricans and acrochordons. Treatment-related manifestations were not found.</p><p><strong>Conclusions:</strong> In type 2 diabetic patients, infections were commonly followed by acanthosis nigricans, acrochordons, and generalized pruritus. Glycemic levels were higher in those with candidiasis and also with pyodermas. </p>

scholarly journals Somatotype Characteristics of Female Patients with Type 2 Diabetes Mellitus / Характеристика Соматотипа Жен Щин, Больных Сахарным Диабетом Типа 2

Folia Medica ◽  
2013 ◽  
Vol 55 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Atanas G. Baltadjiev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Diabetic Patients ◽  
Old Patients ◽  
Female Patients ◽  
Arm Circumference ◽  
The Mean

Abstract The AIM of the present study was to determine the somatotype of females patients with type 2 diabetes mellitus. MATERIAL AND METHODS: Two-hundreds and twelve female patients with type 2 diabetes mellitus were measured. The patients were of Bulgarian ethnicity and were divided into two age groups: Group 1: 40-60 years of age and Group 2: 61-80 years of age. The control group comprised healthy females of Bulgarian ethnicity without any metabolic, neoplastic, or other disease divided into age matched groups. Measurements obtained directly were height, body weight, biepicondylar width of humerus, biepicondylar width of femur, arm circumference in relaxed state, arm circumference in contracted state, and calf circumference. Skin folds: subscapular, suprailiac, over triceps and calf. Parameters calculated: the components of the Heath-Carter anthrpometric somatotype. RESULTS: The mean somatotype of 40-60-year-old female diabetics was mesomorph endomorph, (meso 6.09; endo 6.59; ecto 1.57). The mean somatotype of 40-60-year-old female controls was mesomorphic endomorph (meso 5.65; endo 6.82; ecto 2.75). The mean somatotype of 61-80-year-old diabetic females was endomorphic mesomorph (endo-mesomorph), (meso 9.41; endo 5.39; ecto 1.55). The mean somatotype of 61-80-year-old female controls was mesomorph-endomorph (meso 6.70; endo 6.66; ecto 2.95). Between-age comparison of female diabetics: the endomorph component dominated in the group of 40-60-year-old patients, and the mesomorph component dominated in the group of 61-80-year-old patients. In both groups ectomorphy markedly lagged behind. CONCLUSION: The mean somatotype of diabetic females aged 40-60 years is mesomoph-endomorph; it differs from the mesomorphic mesomorph somatotype of the control subjects. Endomorphy and mesomorphy dominate clearly, and ectomorphy significantly lags behind. This was the reason we get a distorted somatoplot with a sharp shift to endomorphy and mesomorhpy. The mean somatotype of diabetic women aged 60-80 years was endomorphic mesomorphy with the mesomorphy component leading. It differed from the somatotype of the controls, where mesomorphy and endomorphy scored equally (mesomorph-endomorph). The somatotype of female diabetics suggests that they have a relatively massive skeleton with well-developed muscles and greater body weight relative to height. Unlike the results of studies in other countries presenting with markedly dominating endomorphy, in our study the Bulgarian diabetic females presented with dominating mesomorphy. This can be regarded as a peculiarity of the Bulgarian diabetic patients. The somatotype of the Bulgarian diabetic females is more favorable on the risk, course and prognosis of the disease.

scholarly journals A study on the dermatological manifestations in type 2 diabetes mellitus patients in a tertiary care hospital in a rural setting

2017 ◽  
Vol 3 (1) ◽  
pp. 69
Author(s):  
M. Sandeepthi ◽  
B. Narayan Reddy ◽  
G. K. Prasad
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Status ◽  
Rural Setting ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Cutaneous Manifestations ◽  
Skin Changes ◽  
Cutaneous Infections ◽  
The Past

<p class="abstract"><strong>Background:</strong> Diabetes mellitus is very common metabolic disorder seen in our developing world. Skin is affected by both acute metabolic derangements and the chronic degenerative complications of diabetes. It is suggested that these skin changes may eventually be used as a reflection of the patient’s current as well as the past metabolic status<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> 200 diabetic patients were examined and their various cutaneous manifestations were analysed with parameters like age, sex, type of infection, HbA1c etc.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 200 diabetic patients with cutaneous manifestations were enrolled in our study. Majority were in 6th decade (34.5%) and 7th decade (30%) respectively. Males constituted 66% of the cases with a male to female ratio was 1.89:1 Among the cutaneous infections, out of the 132 cases with cutaneous infections, fungal infections (46%) were most frequent, followed by bacterial infections (16.5%) and viral infections (3.5%)<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> This study showed demographic, social factors &amp; prevalence of dermatological manifestations in type 2 DM patients. It is suggested that the various skin changes may eventually be used as a reflection of the patient’s current as well as the past metabolic status<span lang="EN-IN">.</span></p>

Association of Major Dietary Patterns with General and Abdominal Obesity in Iranian Patients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 85 (3-4) ◽  
pp. 145-155 ◽  
Author(s):  
Marjan Ghane Basiri ◽  
Gity Sotoudeh ◽  
Mahmood Djalali ◽  
Mohammad Reza Eshraghian ◽  
Neda Noorshahi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Abdominal Obesity ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Diabetic Patients ◽  
General Obesity ◽  
Healthy Dietary Pattern

Abstract. Background: The aim of this study was to identify dietary patterns associated with general and abdominal obesity in type 2 diabetic patients. Methods: We included 728 patients (35 - 65 years) with type 2 diabetes mellitus in this cross-sectional study. The usual dietary intake of individuals over 1 year was collected using a validated semi-quantitative food frequency questionnaire. Weight, height, and waist circumference were measured according to standard protocol. Results: The two major dietary patterns identified by factor analysis were healthy and unhealthy dietary patterns. After adjustment for potential confounders, subjects in the highest quintile of the healthy dietary pattern scores had a lower odds ratio for the general obesity when compared to the lowest quintile (OR = 0.45, 95 % CI = 0.26 - 0.79, P for trend = 0.02), while patients in the highest quintile of the unhealthy dietary pattern scores had greater odds for the general obesity (OR = 3.2, 95 % CI = 1.8 - 5.9, P for trend < 0.001). There were no significant associations between major dietary patterns and abdominal obesity, even after adjusting for confounding factors. Conclusion: This study shows that in patients with type 2 diabetes mellitus, a healthy dietary pattern is inversely associated and an unhealthy dietary pattern is directly associated with general obesity.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

scholarly journals A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 183
Author(s):  
Anna Izzo ◽  
Elena Massimino ◽  
Gabriele Riccardi ◽  
Giuseppe Della Pepa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly Population ◽  
The Elderly ◽  
Narrative Review ◽  
Macrovascular Complications ◽  
Diabetic Patients ◽  
Age Related

Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly population, affecting approximately 25% of people over the age of 65 years. This percentage is expected to increase dramatically in the next decades in relation to the increased longevity of the population observed in recent years. Beyond microvascular and macrovascular complications, sarcopenia has been described as a new diabetes complication in the elderly population. Increasing attention has been paid by researchers and clinicians to this age-related condition—characterized by loss of skeletal muscle mass together with the loss of muscle power and function—in individuals with T2DM; this is due to the heavy impact that sarcopenia may have on physical and psychosocial health of diabetic patients, thus affecting their quality of life. The aim of this narrative review is to provide an update on: (1) the risk of sarcopenia in individuals with T2DM, and (2) its association with relevant features of patients with T2DM such as age, gender, body mass index, disease duration, glycemic control, presence of microvascular or macrovascular complications, nutritional status, and glucose-lowering drugs. From a clinical point of view, it is necessary to improve the ability of physicians and dietitians to recognize early sarcopenia and its risk factors in patients with T2DM in order to make appropriate therapeutic approaches able to prevent and treat this condition.

scholarly journals Fermented pork fat (Sa-um) and lifestyle risk factors as potential indicators for type 2 diabetes among the Mizo population, Northeast India

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Freda Lalrohlui ◽  
Souvik Ghatak ◽  
John Zohmingthanga ◽  
Vanlal Hruaii ◽  
Nachimuthu Senthil Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cox Regression ◽  
Control Group ◽  
Diabetic Patients ◽  
Lifestyle Habits ◽  
Pork Fat

AbstractOver the last few decades, Mizoram has shown an increase in cases of type 2 diabetes mellitus; however, no in-depth scientific records are available to understand the occurrence of the disease. In this study, 500 patients and 500 healthy controls were recruited to understand the possible influence of their dietary and lifestyle habits in relation with type 2 diabetes mellitus. A multivariate analysis using Cox regression was carried out to find the influence of dietary and lifestyle factors, and an unpaired t test was performed to find the difference in the levels of biochemical tests. Out of 500 diabetic patients, 261 (52.3%) were males and 239 (47.7%) were females, and among the control group, 238 (47.7%) were males and 262 (52.3%) were females. Fermented pork fat, Sa-um (odds ratio (OR) 18.98), was observed to be a potential risk factor along with tuibur (OR 0.1243) for both males and females. Creatinine level was found to be differentially regulated between the male and female diabetic patients. This is the first report of fermented pork fat and tobacco (in a water form) to be the risk factors for diabetes. The unique traditional foods like Sa-um and local lifestyle habits like tuibur of the Mizo population may trigger the risk for the prevalence of the disease, and this may serve as a model to study other populations with similar traditional practices.

scholarly journals The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Julie M. Steinbrink ◽  
Rachel A. Myers ◽  
Kaiyuan Hua ◽  
Melissa D. Johnson ◽  
Jessica L. Seidelman ◽  
...  
Keyword(s):  
Immune Response ◽  
Bacterial Infection ◽  
Viral Infection ◽  
Fungal Infection ◽  
Host Response ◽  
Hospitalized Patients ◽  
Neutrophil Activation ◽  
Heme Biosynthesis ◽  
Transcriptional Analysis ◽  
Diagnostic Approaches

Abstract Background Candidemia is one of the most common nosocomial bloodstream infections in the United States, causing significant morbidity and mortality in hospitalized patients, but the breadth of the host response to Candida infections in human patients remains poorly defined. Methods In order to better define the host response to Candida infection at the transcriptional level, we performed RNA sequencing on serial peripheral blood samples from 48 hospitalized patients with blood cultures positive for Candida species and compared them to patients with other acute viral, bacterial, and non-infectious illnesses. Regularized multinomial regression was utilized to develop pathogen class-specific gene expression classifiers. Results Candidemia triggers a unique, robust, and conserved transcriptomic response in human hosts with 1641 genes differentially upregulated compared to healthy controls. Many of these genes corresponded to components of the immune response to fungal infection, heavily weighted toward neutrophil activation, heme biosynthesis, and T cell signaling. We developed pathogen class-specific classifiers from these unique signals capable of identifying and differentiating candidemia, viral, or bacterial infection across a variety of hosts with a high degree of accuracy (auROC 0.98 for candidemia, 0.99 for viral and bacterial infection). This classifier was validated on two separate human cohorts (auROC 0.88 for viral infection and 0.87 for bacterial infection in one cohort; auROC 0.97 in another cohort) and an in vitro model (auROC 0.94 for fungal infection, 0.96 for bacterial, and 0.90 for viral infection). Conclusions Transcriptional analysis of circulating leukocytes in patients with acute Candida infections defines novel aspects of the breadth of the human immune response during candidemia and suggests promising diagnostic approaches for simultaneously differentiating multiple types of clinical illnesses in at-risk, acutely ill patients.

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Yangyang Cheng ◽  
Xiaohui Du ◽  
Bilin Zhang ◽  
Junxia Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lower Extremity ◽  
Interleukin 6 ◽  
Atherosclerotic Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Newly Diagnosed

Abstract Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear. Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric parameters, blood pressure and some biochemical parameters were obtained. Body composition was detected by bioelectrical impedance analysis (BIA). Levels of serum insulin were determined by radioimmunoassay. Serum WISP1 and interleukin 6 (IL-6) levels were determined using an enzyme-linked immunosorbent assay. Results It was shown that serum WISP1 levels in diabetic patients with LEAD were higher than those without LEAD (P<0.001). Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026). Compared with the lowest tertile, the odds ratio of the middle tertile for LEAD incidence was 3.27 (95% CI, 1.24–8.64) and 4.46 (95% CI, 1.62–12.29) for the highest tertile after adjusting confounding factors. Conclusion The results suggest that increased serum WISP1 levels independently contribute to the incidence of LEAD in patients with newly diagnosed T2DM.

scholarly journals Risk stratification score for acute myocardial infarction and sudden cardiac death in type 2 diabetes mellitus

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
S Lee ◽  
J Zhou ◽  
CL Guo ◽  
WKK Wu ◽  
WT Wong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiac Death ◽  
Adverse Outcomes ◽  
Risk Scores ◽  
Diabetic Patients ◽  
Type 2 Diabetic

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Acute myocardial infarction (AMI) and sudden cardiac death (SCD) are major cardiovascular adverse outcomes in patients with type 2 diabetic mellitus. Although there are many risk scores on composite outcomes of major cardiovascular adverse outcomes or cardiovascular mortality for diabetic patients, these existing scores did not account for the difference in pathogenesis and prognosis between acute coronary syndrome and lethal ventricular arrhythmias. Furthermore, recent studies reported that HbA1c and lipid levels, which were often accounted for in these risk scores, have J/U-shaped relationships with adverse outcomes. Purpose The present study aims to evaluate the application of incorporating non-linear J/U-shaped relationships between mean HbA1c and cholesterol levels into risk scores for predicting for AMI and non-AMI related SCD respectively, amongst type 2 diabetes mellitus patients. Methods This was a territory-wide cohort study of patients with type 2 diabetes mellitus above the age 40 and free from prior AMI and SCD, with or without prescriptions of anti-diabetic agents between January 1st, 2009 to December 31st, 2009 at government-funded hospitals and clinics in Hong Kong. Risk scores were developed for predicting incident AMI and non-AMI related SCD. The performance of conditional inference survival forest (CISF) model compared to that of random survival forests (RSF) model and multivariate Cox model. Results This study included 261308 patients (age = 66.0 ± 11.8 years old, male = 47.6%, follow-up duration = 3552 ± 1201 days, diabetes duration = 4.77 ± 2.29 years). Mean HbA1c and high-density lipoprotein-cholesterol (HDL-C) were significant predictors of AMI under multivariate Cox regression and were linearly associated with AMI. Mean HbA1c and total cholesterol were significant multivariate predictors with a J-shaped relationship with non-AMI related SCD. The AMI and SCD risk scores had an area-under-the-curve (AUC) of 0.666 (95% confidence interval (CI)= [0.662, 0.669]) and 0.677 (95% CI= [0.673, 0.682]), respectively. CISF significantly improves prediction performance of both outcomes compared to RSF and multivariate Cox models. Conclusions A holistic combination of demographic, clinical, and laboratory indices can be used for the risk stratification of type 2 diabetic patients against AMI and SCD.

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