scholarly journals The history, current state and perspectives of aerosol therapy

2021 ◽  
Vol 72 (2) ◽  
pp. 225-243
Author(s):  
BARTŁOMIEJ ROSPOND ◽  
AGATA KRAKOWSKA ◽  
BOŻENA MUSZYŃSKA ◽  
WŁODZIMIERZ OPOKA
Keyword(s):  
21St Century ◽  
Respiratory Diseases ◽  
Tropane Alkaloids ◽  
Aerosol Therapy ◽  
Medicinal Substance ◽  
Routes Of Administration ◽  
Analgesic Effects ◽  
Current State ◽  
Ancient Times ◽  
The 19Th Century

Abstract Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane alkaloids with spasmolytic and analgesic effects was widely used. Undoubtedly, the invention of anasthesia in the 19th century had an influence on the development of this technique. It resulted in the search for devices that facilitated anasthesia such as pulveriser or hydronium. From the second half of the 21st century, when the first DPI and MDI inhalers were launched, the constant development of aerosol therapy has been noticed. This is due to the fact that nebulization, compared with other means of medicinal substance application (such as oral and intravenous routes of administration), is safer and it exhibits a positive dose/efficacy ratio connected to the reduction of the dose. It enables drugs administration through the lung and possesses very fast onset action. Therefore, various drugs prescribed in respiratory diseases (such as corticosteroids, β-agonists, anticholinergics) are present on the market in a form of an aerosol.

scholarly journals Max Weber's Heuristics About University and Education and The Challenges of the XXI Century

2021 ◽  
Vol 26 (2) ◽  
pp. 57-77
Author(s):  
Alexander Golikov ◽  
Sergey Golikov
Keyword(s):  
21St Century ◽  
Modern World ◽  
The Political ◽  
Current State ◽  
Ethics Of Responsibility ◽  
Science And Education ◽  
Social Orders ◽  
The University ◽  
University Science ◽  
The 19Th Century

The article is devoted to the study of Max Weber's view of the problems of education and the university in the light of its latest actualizations. The chosen subject is studied using both philosophical and sociological tools. Max Weber's concept is studied in the context of its historical conditions of formation and development, in comparison with classical and modern concepts, as well as in terms of its heuristic capabilities in describing, analyzing and explaining modern problems and challenges in the field of education in general and in the university world in particular. On the basis of the historical and cultural retrospective of Weber's Germany at the end of the 19th century, the prerequisites for the formation of the Weberian concept are studied and compared with the socio-cultural situation at the beginning of the 21st century. The authors of the article, critically approaching Weberian epistemologiсs, separately focus on the theoretical and methodological limitations and vulnerabilities of the application of the Weberian concept in the modern world, while pointing out the epistemological advantages and opportunities that it offers. Such subjects as the importance of the political in educational activities; perspectives of the university in the society of commodification; the importance of the worldview component in comparison with generally significant knowledge; place of scientific asceticism and its limitations are revealed. Weber's ethical concepts (“absolute ethics”, “ethics of persuasion”, “ethics of responsibility”) and their heuristic possibilities in the analysis of transformations of the university and education are analyzed in detail. The logical and epistemological gaps in Weber's concept are critically examined, its internal complexity is shown, built on the basis of the ontology of the plurality of social orders. A conclusion is made about the potential of Weber's concepts and ideas for analyzing the current state of the university, science and education.

Umbral Calculus

10.37236/24 ◽  
2002 ◽  
Vol 1000 ◽  
Author(s):  
A. Di Bucchianico ◽  
D. Loeb
Keyword(s):  
19Th Century ◽  
Finite Differences ◽  
State Of The Art ◽  
Umbral Calculus ◽  
Current State ◽  
Logical Foundation ◽  
Complete Bibliography ◽  
The 19Th Century ◽  
Mathematical Literature

We survey the mathematical literature on umbral calculus (otherwise known as the calculus of finite differences) from its roots in the 19th century (and earlier) as a set of “magic rules” for lowering and raising indices, through its rebirth in the 1970’s as Rota’s school set it on a firm logical foundation using operator methods, to the current state of the art with numerous generalizations and applications. The survey itself is complemented by a fairly complete bibliography (over 500 references) which we expect to update regularly.

scholarly journals Antioxidant Activity in Bee Products: A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 71
Author(s):  
Marianna Martinello ◽  
Franco Mutinelli
Keyword(s):  
Analytical Methods ◽  
Nutritional Value ◽  
Royal Jelly ◽  
Antioxidant Activities ◽  
Natural Antioxidants ◽  
Bioactive Substances ◽  
Current State ◽  
Wide Range ◽  
Ancient Times ◽  
Antioxidant Characteristics

Bee products have been used since ancient times both for their nutritional value and for a broad spectrum of therapeutic purposes. They are deemed to be a potential source of natural antioxidants that can counteract the effects of oxidative stress underlying the pathogenesis of many diseases. In view of the growing interest in using bioactive substances from natural sources to promote health and reduce the risk of developing certain illnesses, this review aims to update the current state of knowledge on the antioxidant capacity of bee products such as honey, pollen, propolis, beeswax, royal jelly and bee venom, and on the analytical methods used. The complex, variable composition of these products and the multitude of analytical methods used to study their antioxidant activities are responsible for the wide range of results reported by a plethora of available studies. This suggests the need to establish standardized methods to more efficiently evaluate the intrinsic antioxidant characteristics of these products and make the data obtained more comparable.

The Trickster in Serialized Television: An Anti-hero of Postmodern Mythologies

2021 ◽  
Author(s):  
Fuad Halwani
Keyword(s):  
21St Century ◽  
Character Development ◽  
Relevant Today ◽  
Ancient Times ◽  
Definition Of

Anti-heroes have become prevalent on the television home screen since the advent of cable in the late 90s. But the shift to Quality TV made the anti-hero even more dominant in its complex narratives. In order to understand why, I had to identify what an anti-hero really is. Carl Gustav Jung’s theory of the archetypes is one of the most comprehensive and referenced theories when it comes to character development and screenwriting, but the more complex contemporary narratives are becoming, the more the theory is proving to be outdated. However, a particularly perplexing Jungian archetype stands out: the trickster-figure. The investigation into the definition of the trickster yielded different attributes that render it a highly postmodern concept. This dissertation aims at identifying the contemporary TV anti-hero as the mythical player of tricks. Through a survey of 21st century semiotics, structural and poststructural theories, as well as contemporary theories on character and engagement in Serial TV consumption and “binge” culture, this dissertation aims to show how the trickster-figure is as relevant today as it was in ancient times.

scholarly journals Cannabinoids on the Brain

2002 ◽  
Vol 2 ◽  
pp. 632-648 ◽  
Author(s):  
Andrew J. Irving ◽  
Mark G. Rae ◽  
Angela A. Coutts
Keyword(s):  
Cannabinoid Receptor ◽  
Endocannabinoid System ◽  
Medicinal Uses ◽  
Cellular Targets ◽  
Analgesic Effects ◽  
Current State ◽  
History Of ◽  
New Type ◽  
Reward Pathways ◽  
The Brain

Cannabis has a long history of consumption both for recreational and medicinal uses. Recently there have been significant advances in our understanding of how cannabis and related compounds (cannabinoids) affect the brain and this review addresses the current state of knowledge of these effects. Cannabinoids act primarily via two types of receptor, CB1and CB2, with CB1receptors mediating most of the central actions of cannabinoids. The presence of a new type of brain cannabinoid receptor is also indicated. Important advances have been made in our understanding of cannabinoid receptor signaling pathways, their modulation of synaptic transmission and plasticity, the cellular targets of cannabinoids in different central nervous system (CNS) regions and, in particular, the role of the endogenous brain cannabinoid (endocannabinoid) system. Cannabinoids have widespread actions in the brain: in the hippocampus they influence learning and memory; in the basal ganglia they modulate locomotor activity and reward pathways; in the hypothalamus they have a role in the control of appetite. Cannabinoids may also be protective against neurodegeneration and brain damage and exhibit anticonvulsant activity. Some of the analgesic effects of cannabinoids also appear to involve sites within the brain. These advances in our understanding of the actions of cannabinoids and the brain endocannabinoid system have led to important new insights into neuronal function which are likely to result in the development of new therapeutic strategies for the treatment of a number of key CNS disorders.

scholarly journals Inlet and Nozzle Technology for 21st Century Fighter Aircraft

1996 ◽  
Author(s):  
Marvin C. Gridley ◽  
Steven H. Walker
Keyword(s):  
21St Century ◽  
Cost Reduction ◽  
State Of The Art ◽  
Aerodynamic Performance ◽  
Innovative Technology ◽  
Fighter Aircraft ◽  
Current State ◽  
Aircraft System ◽  
Year 2000 ◽  
System Volume

The focus of propulsion integration technology in the 21st century will be economy. USAF inlet and nozzle technology goals translate into 50% weight reduction and 25% acquisition cost reduction metrics for new aircraft system. Innovative technology to enable these reductions over current state-of-the-art systems in weight and cost is required. For inlet systems, compact diffusers that reduce system volume by 50% will demand fewer parts and improved aerodynamic performance. Exhaust systems will be fixed with fewer parts, requiring a technology like fluidics, for example, to provide area control and thrust vectoring capabilities. Cooperative programs for both inlet and nozzle systems are in place to insure that technologies required to meet weight and cost reduction goals are matured by the year 2000.

scholarly journals Bacteria in Cancer Therapy: Renaissance of an Old Concept

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Sebastian Felgner ◽  
Dino Kocijancic ◽  
Michael Frahm ◽  
Siegfried Weiss
Keyword(s):  
Treatment Options ◽  
Tumor Therapy ◽  
The Past ◽  
Novel Treatment ◽  
Vector Systems ◽  
Rising Incidence ◽  
Solid Foundation ◽  
Ancient Times ◽  
Therapeutic Compounds ◽  
The 19Th Century

The rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies.

scholarly journals UKRAINIAN LINGUO-FOLKLORE STUDIES: THEIR HISTORY, CURRENT STATE, AND PERSPECTIVES

Movoznavstvo ◽  
2021 ◽  
Vol 320 (5) ◽  
pp. 34-48
Author(s):  
N. O.  DANYLІUK ◽  
Keyword(s):  
Historical Linguistic ◽  
20Th Century ◽  
Object A ◽  
Current State ◽  
Separate Branch ◽  
Folklore Studies ◽  
Poetic Texts ◽  
Two Stages ◽  
The 19Th Century ◽  
Educational Course

The article is devoted to the evolution, present state and perspectives of development of the Ukrainian linguo-folklore studies that are conducted by Sv. Yеrmolenko, N. Zhuravliova, A. Moisiienko, T. Betsenko, Y. Diadyshcheva-Rosovetska, N. Kolesnyk, R. Serdeha and others. The main aspects of the analysis of the language of the Ukrainian folk poetic texts of the period from the end of the 19th century until the middle of the 20th century were considered. They are historical linguistic, linguo-stylistic, linguo-didactic, linguo-cultural, ethnolinguistic, linguo-conceptual, linguo-semiotic. Two stages in the development of linguo-folklore studies were distinguished: 1) 60s — 80s of the 20th c., and 2) 90s of the 20th c. — the early 21st c. It was pointed out that the Ukrainian linguo-folklore studies had already evolved into a separate branch of philology and an educational course with its own object (a linguostructural, artistic-figurative organization of folkloristic texts of various genres, peculiar features of a folkloristic style formation), and subject of research, tasks and trends. There were mentioned the present day approaches to the analysis of folk poetic texts, being based on the language layers (folklore stylistics of language units), language expressive means (folklore stylistics of language expressive means), genres (folklore stylistics of genres) and separate parts of linguistics. The following perspectives of the linguo-folklore studies were defined: the analysis of understudied language units and figurative means, used in the texts of various genres (not only the traditional but new ones as well), development of a folklore lexicography, folklore dialectology, folklore linguo-cognitology, folklore linguosemiotics, folklore communication, linguo-genderology, contrastive linguo-folklore studies, and other trends, as well as a wider application of modern systems of an automatic analysis of texts, dictionaries’ compilation, and data creation.

scholarly journals Confessional conversions on the territory of Belarus in the second half of the 19th – early 20th century: overview of historiography

2021 ◽  
pp. 82-89
Author(s):  
Marharyta M. Karol
Keyword(s):  
20Th Century ◽  
19Th Century ◽  
21St Century ◽  
State Policy ◽  
Early 20Th Century ◽  
General State ◽  
Present Stage ◽  
Religious Issues ◽  
Points Of View ◽  
The 19Th Century

The article examines the stages of the formation of historiography devoted to the problems of confessional conversions in the second half of the 19th century on the territory of the Belarusian provinces. The historiographic trends that formed from the end of the 19th century to the beginning of the 21st century were identified and analysed. The authour studies the peculiarities of Belarusian and foreign historiography at the present stage, when a large number of works on religious issues has appeared, including confessional conversions. It is argued that in Soviet times, the issue of transitions from Catholicism to Orthodoxy was practically not touched upon. In their approaches and assessments, some researchers continue the traditions of pre-revolutionary historiography, but the majority of modern scientists strive to give an objective picture of religious processes on the Belarusian lands, to show them in the context of general state policy. The relevance of the article is due to the coverage of various points of view on the problem of confessional conversions. It is noted that pre-revolutionary researchers, first of all, sought to prove the voluntariness of conversions to Orthodoxy, but during this period, works were also created in which this thesis was questioned.

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