scholarly journals Sea Buckthorn Vegetative Parts – A Good Source of Bioactive Compounds

2013 ◽  
Vol 67 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Elga Šnē ◽  
Ruta Galoburda ◽  
Dalija Segliņa
Keyword(s):  
Bioactive Compounds ◽  
Sea Buckthorn ◽  
Raw Material ◽  
Bioactive Substances ◽  
Wide Range ◽  
Anti Oxidant ◽  
Pharmaceutical Properties ◽  
Promising Source ◽  
Active Substances ◽  
Biological Active Substances

In recent years, due to the health problems and better life expectancy, natural sources of bioactive substances have gained wide interest. Sea buckthorn is well known as a valuable plant and is widely used in traditional medicine for the treatment of diseases and disorders. A considerable amount of literature has been published on sea buckthorn berries, although all parts of sea buckthorn plant are considered as a source of a large amount of biological active substances, and believed to have beneficial health effects. Therefore, vegetative parts would be a good raw material not only for medicinal, cosmetic and pharmaceutical properties, but also for the food industry. This has increased the research on different sea buckthorn vegetative parts and their extract activity and toxicity. Sea buckthorn leaves have attracted interest during the past few years as the most promising source of active compounds after berries. They contain a wide range of hydrophilic and lipophilic bioactive compounds, which exhibit remarkable anti-oxidant potential together with anti-bacterial, anti-viral, anti-tumour and anti-inflammatory activity. Therefore, extracts of the plant leaves could be used as natural replacements for synthetic additives and for food products with functional properties. This creates the need to investigate the biochemical content of sea buckthorn vegetative parts grown in Latvia.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

scholarly journals Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4504
Author(s):  
Muhanna Al-shaibani ◽  
Radin Maya Saphira Radin Mohamed ◽  
Nik Sidik ◽  
Hesham Enshasy ◽  
Adel Al-Gheethi ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Extreme Environments ◽  
Software Tool ◽  
Gene Clusters ◽  
Well Being ◽  
Bioactive Substances ◽  
Diverse Range ◽  
Wide Range ◽  
Potential Applications

The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioactive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive compounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being.

scholarly journals Identifying bioactive phytochemicals in spent coffee grounds for cosmetic application through global metabolite analysis

2017 ◽  
Author(s):  
◽  
Jihyun Park
Keyword(s):  
Bioactive Compounds ◽  
Raw Materials ◽  
Costa Rican ◽  
Raw Material ◽  
Spent Coffee Grounds ◽  
Metabolite Analysis ◽  
Coffee Grounds ◽  
Chemical Profiles ◽  
Anti Oxidant ◽  
Anti Inflammatory

Annually, more than 6 million tons of spent coffee grounds (SCG) are generated worldwide. The present study explores the possible use of spent coffee grounds as the raw materials for cosmetics industry. The main objective of this project are to investigate the chemical profiles and identify the bioactive compounds for cosmetics application through global metabolite analysis. The compounds extracted from SCG of Ethiopia coffee (Yirgacheffe), Costa Rican coffee (Tarrazu) and Hawaiian coffee (Kona) were analyzed by ultra-high pressure liquid chromatography coupled with mass spectrometry (UPLC-MS). The ion chromatograms were submitted to XCMS platform operated by Center for Metabolomics at the Scripps Research Institute. The peak detection, peak grouping, spectra extraction, and retention alignment were processed by XCMS. The spectra were annotated and the compounds were identified and categorized by integration with METLIN, the world's largest metabolite database. Multivariate and univariate statistical analysis including PCA and cloud-plot were performed by XCMS to compare the chemical profiles between the three coffee cultivars. These analyses indicated that each cultivar showed a specific cluster. Over 200 compounds related to anti-oxidant, anti-inflammatory, anti-tyrosinase and anti-tumor for skin care application were identified by XCMS. Therefore, the presence of bioactive compounds in SCG makes it a potential source of raw material for cosmetic application (e.g., anti-oxidant, anti-inflammatory, skin-whiting, and anti-aging).

scholarly journals Pathogenetic mechanisms of hirudotherapy and its use in otorhinolaryngology

2020 ◽  
pp. 83-93
Author(s):  
Dmytro I. Zabolotny ◽  
Nina S. Mishchanchuk ◽  
Oleg M. Borisenko ◽  
Andrej L. Bobrov
Keyword(s):  
Circulatory System ◽  
The Body ◽  
Medical Rehabilitation ◽  
Therapeutic Effects ◽  
Pathogenetic Mechanisms ◽  
Saliva Secretion ◽  
Advanced Technologies ◽  
Wide Range ◽  
Active Substances ◽  
Biological Active Substances

Data from studies on the pathogenetic mechanisms of saliva secretion of medical leeches, which is an important producer of unique biological active substances (BAS), is summarized. These substances have a wide range of therapeutic effects, providing a prodounced anti-inflammatory, bacteriostatic, bactericidal, fibrinolytic, neurotropic, regenerative, energetic, immunomodulatory, anti-sclerotic effects. They regulate homeostasis, the circulatory system, lymph flow, all types of metabolic processes in the body and have no analogues in nature. We have presented the results of more than 20 years of effective experience in the use of hirudotherapy in otorhinolaryngology patients for medical, rehabilitation, and health purposes. Promising is the further study and application of hirudotherapy as a type of naturopathy and homeopathy in the 21st century of advanced technologies, significantly changing the conditions of the internal and external environment of the inhabitants of our planet.

Metabolomic analysis of the pharmacological active substances in four ginger varieties

2020 ◽  
Author(s):  
Zhexin Li ◽  
Shao-Fei Dang ◽  
Yan-Ru Fan ◽  
Hong-Lei Li ◽  
Wen-Lin Zhang ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Metabolic Pathways ◽  
Kegg Pathway ◽  
Zingiber Officinale ◽  
P Value ◽  
Anti Oxidant ◽  
Hormone Biosynthesis ◽  
Further Development ◽  
Insight Into ◽  
Active Substances

Abstract Background: The bioactive compounds of ginger (Zingiber officinale), including gingerols, diarylheptanoids, and flavonoids, are important for human health because of their anticancer, anti-oxidant, and anti-inflammatory properties. Results: The UPLC/Q-TOF-MS profiles of four ginger samples, Zingiber officinale 'Yujiang No.1' (YJ), Zingiber officinale 'Shandong dajiang' (SD), Zingiber officinale 'Shandong xiaojiang' (SX) and Zingiber officinale 'Luoping xiaohuangjiang' (LP) were compared to gain insight into the differences in their rhizome content. A total of 1,810 metabolites were detected across the four varieties with 111, 72, 57, and 92 metabolites shared between the LP/YJ, SX/YJ, SX/SD and LP/SD ginger samples, respectively, with a p value of < 0.05 and a fold change of ≥1. Among the four libraries, 186 differentially expressed metabolites were identified. The metabolic pathways associated with the production of the bioactive compounds of ginger included those for stilbenoid, diarylheptanoid, and gingerol biosynthesis, flavonoid biosynthesis, steroid hormone biosynthesis, and diterpenoid biosynthesis. Among the differentially accumulated metabolites, gingerols and α-zingiberene were found in higher amounts in the SD and LP than in the SX and YJ varieties. The steroid hormones and terpenoids were found in higher amounts in LP than the other ginger samples. Conclusion: The LP and SD varieties could be utilized as a source of medicinal ginger, while SX and YJ are more suited to incorporation into food because of their lighter taste related to their lower content of gingerols. The differences in active ingredients combined with analysis of the KEGG pathway allowed prediction of the metabolite synthetic pathways involved in the ginger component biosynthesis and lays the foundation for the further development and use of specific ginger varieties as medicinal resources.

scholarly journals DEVELOPMENT OF A DRUG BASED ON THE FRUITS OF CHOKEBERRY (ARÓNIA MELANOCÁRPA (MICHX.) EL-LIOT) IMPROVING THE EFFICIENCY OF CANCER CHEMOTHERAPY

2020 ◽  
pp. 219-226
Author(s):  
Valeriya Yur'yevna Andreyeva ◽  
Vladimir Viktorovich Sheykin ◽  
Galina Il'inichna Kalinkina ◽  
Tat'yana Georgiyevna Razina ◽  
Yelena Petrovna Zuyeva ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Raw Materials ◽  
Combined Treatment ◽  
Latin Square ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Drugs ◽  
Raw Material ◽  
Black Chokeberry ◽  
Active Substances

Black chokeberry is an official drug raw material and is used as a multivitamin drug. Black chokeberry guarantees the supply of raw materials as it grows all over the Russian Federation end is a promising sourse of phenolic compounds for new drugs. Objective: to develop the most favorable conditions for extraction of bioactive compounds from black chokeberry and to assess its anti-metastatic activity. To extract bioactive compounds from black chokeberry the method of multistep repercolation with completed cycle was used. To assess the factors controlling the raw material extraction the technique of mathematic simulation for latin square. The technique of liquid anthocyanins and catechins rich black chokeberry extraction was given with the following parameters: extragent – 95% acidified alcohol, phase relation – 1 : 5, number of percolators – 5. The content of biologically active substances in the extract obtained with 95% acidified ethyl alcohol was determined by conventional methods. In the composition of the extract, the content of anthocyanins (5.83±0.25%), catechins (0.22±0.02%), tannins (4.65±0.30%), phenolic acids (0.27±0.01%) and other biologically active substances was determined. To assess the antitumor properties of the chokeberry fruit extract, the Lewis lung carcinoma model was used. It was found that the proposed extract reliably inhibits the development of metastases and increases the antimetastatic activity of cyclophosphamide in combined treatment, is of interest as a means for increasing the effectiveness of tumor chemotherapy.

scholarly journals Comparative study of phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine

2021 ◽  
pp. 66-75
Author(s):  
Iryna Sas ◽  
Andrii Hrytsyk ◽  
Taras Koliadzhyn ◽  
Oleh Koshovyi
Keyword(s):  
Phenolic Compounds ◽  
Comparative Study ◽  
Hydroxycinnamic Acids ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Drugs ◽  
Raw Material ◽  
Wide Range ◽  
Nitrogen Containing Compounds ◽  
Active Substances

Species of Betonica L. genus are widespread in Ukraine and contain different groups of biologically active substances: hydroxycinnamic acids, flavonoids, tannins, iridoids, terpenoids, steroids, essential oil, organic acids, vitamin K, nitrogen-containing compounds, phenylethanoid glycosides. Species of Betonica L. genus show a wide range of pharmacological activity (anti-inflammatory, antioxidant, choleretic, diuretic, sedative, antitumor, antihypertensive, etc.) and phenolic compounds are one of the most important and promising groups of biologically active substances of these plants. The aim. The aim of the work was to conduct a comparative study of the phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine. Materials and methods. The object of the study was the herb of Betonica peraucta and Betonica brachydonta harvested in the phase of mass flowering of the plant in Ivano-Frankivsk region. The study of phenolic compounds was carried out by paper chromatography, HPLC and spectrophotometry. Results. 7 components of tannins, 4 flavonoids, 5 hydroxycinnamic acids, 2 coumarins were identified and quantified by HPLC in the studied raw material. The quantitative content of the main groups of phenolic compounds in the herb of Betonica peraucta and Betonica brachydonta was determined by the method of absorption spectrophotometry: polyphenols – 5.96 % and 4.82 %, tannins – 1.62 % and 0.68 %, flavonoids – 2.07 % and 1.13 %, hydroxycinnamic acids – 7.01 % and 3.58 %, respectively. Conclusions. As a result of the conducted studies it was found that the content of phenolic compounds in the herb of Betonica peraucta is significantly higher than in the herb of Betonica brachydonta. Therefore, this species is promising for further research and creation of new drugs

scholarly journals TECHNOLOGICAL PARAMETERS OF COUNTERCURRENT EXTRACTION: DERIVING BIOACTIVE COMPOUNDS FROM PLANT RAW MATERIALS

2016 ◽  
pp. 8-15
Author(s):  
Sergey Garmashov ◽  
Sergey Garmashov ◽  
Alexander Izgaryshev ◽  
Alexander Izgaryshev ◽  
Egor Kashirskih ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Plant Material ◽  
Continuous Process ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Wild Plant ◽  
Countercurrent Extraction ◽  
Mineral Salts ◽  
Wide Range ◽  
Active Substances

Wild-growing plants produce a wide range of vitamins, macro- and microelements, mineral salts and other biologically active substances. Even in minute quantities, these constituents can mediate the healing effect on a human body. To date, the most promising method of extracting biologically active compounds from crude wild plant material is solvent extraction. The intensification of the extraction process has seen a new development in the last few years. This paper focuses on obtaining maximum yield of bioactive compounds from wild-growing plants, such as ordinary cowberry, prickly wild rose, sea-buckthorn, ordinary rowan, guelder-rose by a countercurrent extraction method, a continuous process where the plant material moves against the solvent. With that, it examines various extraction agents and their mixtures in relation to the extractives and total flavonoid content, the optimal time of the duration of the extraction. The optimal temperature of the process was found to be corresponding to the boiling point of the solvent. In the future, this study might contribute to the development of high quality new galenical preparations with maximum content of biologically active substances identical to the composition of the source plants to produce pharmaceutical drugs, food supplements, functional foods and cosmetics.

THE PREDICTION OF THE ANTIOXIDATIVE ACTIVITY OF GROSSULARIA RECLINATA LEAVES

2021 ◽  
pp. 17-22
Author(s):  
Sankova M.V. ◽  
Nesterova O.V.
Keyword(s):  
Medicinal Plants ◽  
Total Content ◽  
Biologically Active ◽  
Raw Material ◽  
Material Base ◽  
Alcohol Extract ◽  
Differential Spectrophotometry ◽  
Prophylactic Drugs ◽  
Promising Source ◽  
Active Substances

At present, in order to expand the raw material base, modern phyto-production is most interested in the use of medicinal plants' organs that were not previously used, but containing flavonoids. The Grossularia reclinata leaves, which are a cheap and affordable plant material, can become a promising source for the creation of phytopreparations containing flavonoid compounds. The aim of the study was to identify and quantify the sum of flavonoids' substances in terms of rutin in the Grossularia reclinata leaves. Material and methods. Qualitative reactions were selected to confirm the presence of flavonoids' substances; differential spectrophotometry was used for their quantitative assessment. Results. It was found that the total content of flavonoids in terms of rutin in alcohol extract from these leaves is on average 0.557 ± 0.0061%, which exceeds their content fruits that were used in medicine by 1.86 times. Comparative analysis of the flavonoids' sum of in the medicinal plants' leaves made it possible to determine that this group of biologically active substances in the Grossularia reclinata leaves is represented in greater quantities than in the motherwort herb (0.2%), wormwood (0.3%) and the tripartite series (0 ,five%). Conclusions: The results of the study allow us to consider this plant raw material promising for the production of new therapeutic and prophylactic drugs.

scholarly journals Synbiotic and antioxidant activity of fruit by-products and their effect on human health

Food Research ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 24-35
Author(s):  
B. Akter ◽  
Rabeta M.S.
Keyword(s):  
Human Health ◽  
Bioactive Compounds ◽  
Health Condition ◽  
Bioactive Components ◽  
Bioactive Substances ◽  
Food Ingredients ◽  
Functional Activities ◽  
Anti Oxidant ◽  
Alternative Sources ◽  
By Products

Food supplements are extensively used as a natural remedy to improve human health condition. Considerable progress has been reported recently by several studies to analyse the bioactive substances and their functional activities of fruit by-product. The food industry generates a vast amount of wastes during manufacturing or processing, which are mainly skins, kernels, and seeds. These by-products contain valuable bioactive compounds such as antioxidants, vitamins, minerals, and indigestible food ingredients called prebiotics. Peels from fruits like yellow rambutan, green kiwi, mango, and papaya exhibit a strong anti-proliferative, anti-cardiovascular, anti-oxidant, and hepatoprotective effects due to the presence of bioactive compounds namely flavonoid, B-type catechin dimer, and penta-O-galloyl-glucoside. This review will illustrate a new concept of functional foods by providing information on alternative sources of bioactive compounds from food by-product and their efficacy in human nutrition. This study will also recapitulate the presence of bioactive components in fruit by-product, their way of action, constitution, health benefits, and probable therapeutic action in the treatment of disease prevention.

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